Andrew N Margioris

Summary

Affiliation: University of Crete
Country: Greece

Publications

  1. pmc The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress
    Alicia Arranz
    Department of Clinical Chemistry, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Mol Cancer 9:261. 2010
  2. pmc Total and corrected antioxidant capacity in hemodialyzed patients
    Niki Malliaraki
    Departments of Clinical Chemistry, University of Crete, School of Medicine, and University Hospital, Heraklion, GR 71110, Greece
    BMC Nephrol 4:4. 2003
  3. doi request reprint Fatty acids and postprandial inflammation
    Andrew N Margioris
    Department of Clinical Chemistry, School of Medicine, University of Crete, Crete, Greece
    Curr Opin Clin Nutr Metab Care 12:129-37. 2009
  4. doi request reprint Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression
    Vassiliki Zacharioudaki
    Department of Clinical Chemistry, Graduate Program on Molecular Basis of Human Disease, School of Medicine, University of Crete, Crete, Greece
    J Immunol 182:6444-51. 2009
  5. ncbi request reprint Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner
    Erini Dermitzaki
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Biochem Biophys Res Commun 327:828-36. 2005
  6. pmc Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness
    Ariadne Androulidaki
    Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece
    Mol Cancer 8:30. 2009
  7. ncbi request reprint Neurosteroid dehydroepiandrosterone exerts anti-apoptotic effects by membrane-mediated, integrated genomic and non-genomic pro-survival signaling pathways
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    J Neurochem 107:1457-69. 2008
  8. doi request reprint Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide
    Alicia Arranz
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion GR 710 03, Crete, Greece
    Mol Immunol 45:2970-80. 2008
  9. ncbi request reprint Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, University of Crete, Greece
    J Immunol 176:1869-77. 2006
  10. ncbi request reprint Peripheral factors in the metabolic syndrome: the pivotal role of adiponectin
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, University of Crete, Heraklion GR 710 03, Crete, Greece
    Ann N Y Acad Sci 1083:185-95. 2006

Collaborators

Detail Information

Publications35

  1. pmc The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress
    Alicia Arranz
    Department of Clinical Chemistry, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Mol Cancer 9:261. 2010
    ..The aim of the present study was to assess the significance of peripheral CRF on tumor growth as a mediator of the response to stress in vivo...
  2. pmc Total and corrected antioxidant capacity in hemodialyzed patients
    Niki Malliaraki
    Departments of Clinical Chemistry, University of Crete, School of Medicine, and University Hospital, Heraklion, GR 71110, Greece
    BMC Nephrol 4:4. 2003
    ..Studies, analyzing either discrete analytes and antioxidant substances, or the integrated total antioxidant activity of human plasma during hemodialysis, give contradictory results...
  3. doi request reprint Fatty acids and postprandial inflammation
    Andrew N Margioris
    Department of Clinical Chemistry, School of Medicine, University of Crete, Crete, Greece
    Curr Opin Clin Nutr Metab Care 12:129-37. 2009
    ..Purpose of this review is to describe this exciting new area of research and its repercussions in the way we, the consumers, and the food industry evaluate the type and quantity of fat in food...
  4. doi request reprint Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression
    Vassiliki Zacharioudaki
    Department of Clinical Chemistry, Graduate Program on Molecular Basis of Human Disease, School of Medicine, University of Crete, Crete, Greece
    J Immunol 182:6444-51. 2009
    ..In conclusion, our data demonstrate that IRAK-M is a major mediator of gAd-induced endotoxin tolerance in primary macrophages, expression of which depends on the activation of Tpl2/ERK and PI3K/Akt1 signaling pathways...
  5. ncbi request reprint Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner
    Erini Dermitzaki
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Biochem Biophys Res Commun 327:828-36. 2005
    ....
  6. pmc Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness
    Ariadne Androulidaki
    Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece
    Mol Cancer 8:30. 2009
    ..CRF can affect breast cancer cells in an autocrine or paracrine manner via its production from innervating sympathetic neurons or immune cells...
  7. ncbi request reprint Neurosteroid dehydroepiandrosterone exerts anti-apoptotic effects by membrane-mediated, integrated genomic and non-genomic pro-survival signaling pathways
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    J Neurochem 107:1457-69. 2008
    ..Our findings suggest that the neurosteroid DHEA affects neural crest-derived cell survival by multiple pro-survival signaling pathways comprising an integrated system of non-genomic and genomic mechanisms...
  8. doi request reprint Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide
    Alicia Arranz
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion GR 710 03, Crete, Greece
    Mol Immunol 45:2970-80. 2008
    ..Moreover, in vivo administration of VIP in C57BL/6 mice resulted in lower IL-6 production upon treatment with LPS. Overall, the results indicate that VIP promotes endotoxin tolerance by downregulating TLR4 expression via Akt1...
  9. ncbi request reprint Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, University of Crete, Greece
    J Immunol 176:1869-77. 2006
    ..In conclusion, our data suggest that CRF peptides play an important role on macrophage function. They augment the effect of LPS by inducing Tlr4 gene expression, through CRF2, via activation of the transcription factors PU.1 and AP-1...
  10. ncbi request reprint Peripheral factors in the metabolic syndrome: the pivotal role of adiponectin
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, University of Crete, Heraklion GR 710 03, Crete, Greece
    Ann N Y Acad Sci 1083:185-95. 2006
    ..Lowering of its high levels, as a consequence of increased body mass index (BMI), renders macrophages sensitive to any proinflammatory insult...
  11. ncbi request reprint Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    FEBS Lett 579:4259-64. 2005
    ..In conclusion, our data suggest that endogenous CRFR2 ligands exert an anti-inflammatory effect via induction of macrophage apoptosis...
  12. ncbi request reprint G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    FASEB J 20:577-9. 2006
    ..In conclusion, our findings suggest that neural crest-derived cells possess specific DHEA membrane binding sites coupled to G proteins. Binding to these sites confers neuroprotection...
  13. ncbi request reprint Corticotropin releasing factor receptor 1 (CRF1) and CRF2 agonists exert an anti-inflammatory effect during the early phase of inflammation suppressing LPS-induced TNF-alpha release from macrophages via induction of COX-2 and PGE2
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece
    J Cell Physiol 210:774-83. 2007
    ..Hence, the reported anti-inflammatory effect of CRF-peptides appears to involve macrophages and is confined at the early stage of inflammation...
  14. pmc The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    Ariadne Androulidaki
    Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece
    Immunity 31:220-31. 2009
    ..These results indicate that Akt1 regulates the response of macrophages to LPS by controlling miRNA expression...
  15. ncbi request reprint Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Biochem Biophys Res Commun 335:1254-63. 2005
    ..Our data suggest that adiponectin constant presence in the circulation in high levels (in lean subjects) renders macrophages resistant to pro-inflammatory stimuli, including its own...
  16. ncbi request reprint Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion 71110, Greece
    Ann N Y Acad Sci 1088:139-52. 2006
    ..These findings suggest that neurosteroids may act as endogenous neuroprotective factors. The decline of neurosteroid levels during aging may leave the brain unprotected against neurotoxic challenges...
  17. ncbi request reprint Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    Neuroendocrinology 84:49-57. 2006
    ..We propose that a UCN-based system may affect local inflammatory phenomena in the liver acting in a paracrine manner...
  18. pmc Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
    Christos Tsatsanis
    Department of Clinical Chemistry, and Graduate Program on the Molecular Basis of Human Disease, School of Medicine, University of Crete, Heraklion, 710 03 Crete, Greece
    Proc Natl Acad Sci U S A 105:2987-92. 2008
    ..As a result, Tpl2, a potent oncogene, functions as a tumor suppressor gene in chronically stimulated T cells...
  19. ncbi request reprint Neuronal differentiation of PC12 cells abolishes the expression of membrane androgen receptors
    Vassilia Ismini Alexaki
    Laboratories of Experimental Endocrinology, University of Crete, School of Medicine, P O Box 2208, Heraklion 71003, Greece
    Exp Cell Res 312:2745-56. 2006
    ....
  20. ncbi request reprint Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Clin Chim Acta 379:31-5. 2007
    ..We studied molecules involved in angiogenesis (MMP-9, HGF, VEGF) in relation to disease stage, extent of bone destruction, and markers of bone turnover (Ntx and PICP)...
  21. pmc A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts
    Olga Rassouli
    Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece
    PLoS ONE 6:e21654. 2011
    ..Our data suggest that the immunomodulatory effects of CRH may include an important, albeit not explored yet, role in epidermal tissue remodeling and regeneration and maintenance of tissue homeostasis...
  22. doi request reprint Neurosteroids as modulators of neurogenesis and neuronal survival
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion 71003, Greece
    Trends Endocrinol Metab 19:300-7. 2008
    ....
  23. pmc Corticotropin-releasing hormone augments proinflammatory cytokine production from macrophages in vitro and in lipopolysaccharide-induced endotoxin shock in mice
    Sofia Agelaki
    Deparment of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece
    Infect Immun 70:6068-74. 2002
    ..Our data suggest that the diffuse neuroendocrine system via CRH directly affects the immune system at the level of macrophage activation and cytokine production...
  24. pmc Expression of the Tpl2/Cot oncogene in human T-cell neoplasias
    Anna V Christoforidou
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete and University Hospital of Heraklion, 71110 Heraklion, Crete, Greece
    Mol Cancer 3:34. 2004
    ....
  25. ncbi request reprint Evaluation of bone disease in multiple myeloma: a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients
    Michael G Alexandrakis
    Department of Haematology, University Hospital of Crete, Heraklion, Greece
    Clin Chim Acta 325:51-7. 2002
    ..In this study, these markers were studied in relation to bone disease severity and other clinical parameters of MM activity...
  26. ncbi request reprint The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity
    George N Tzanakakis
    Department of Histology, School of Medicine, University of Crete, Heraklion, Greece
    Int J Gastrointest Cancer 34:27-38. 2003
    ..The aim of the present work was to examine the correlation between cathepsin B activity and the metastatic potential of human pancreatic cancer...
  27. ncbi request reprint The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications
    Achille Gravanis
    Departments of Pharmacology, School of Medicine, University of Crete, Heraklion 71110, Greece
    Curr Med Chem 12:1503-12. 2005
    ..These two examples illustrate the potential therapeutic significance of the CRH in regulating inflammatory phenomena in an ad hoc approach without affecting the rest of the immune system...
  28. pmc Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion 71110, Greece
    Proc Natl Acad Sci U S A 101:8209-14. 2004
    ..Our findings suggest that decline of DHEA(S) and Allo during aging or stress may leave the adrenal medulla unprotected against proapoptotic challenges...
  29. ncbi request reprint Signalling networks regulating cyclooxygenase-2
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Int J Biochem Cell Biol 38:1654-61. 2006
    ..Finally, cyclooxygenease-2 can be affected directly at its enzymatic activity by nitric oxide and nitric oxide synthase (iNOS). Each step of cyclooxygenease-2 regulation can be used as potential therapeutic target...
  30. doi request reprint The calcineurin-nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis
    Eirini Dermitzaki
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece
    J Cell Physiol 227:1861-72. 2012
    ..In conclusion, our data suggest that CRF(1) and CRF(2) ligands activate the transcription factor NFAT and its activation is prerequisite for CRF-induced catecholamine production from chromaffin cells...
  31. doi request reprint Elderly patients with trochanteric hip fracture have lower serum Vitamin D levels compared to patients with cervical hip fracture
    Olga E Dretakis
    Department of Clinical Chemistry, School of Medicine, University of Crete, Campus at Voutes, Main Building, GR 71003 Heraklion, Crete, Greece
    Arch Gerontol Geriatr 52:e15-8. 2011
    ..e., 35.9 nmol/l vs 55.2 nmol/l (p=0.015) while the group of those with cervical hip fracture do not appear to differ from the controls...
  32. ncbi request reprint Systemic levels of interleukin-6 and matrix metalloproteinase-9 in patients with multiple myeloma may be useful as prognostic indexes of bone disease
    Aikaterini Sfiridaki
    Blood Bank Center, Venizelion General Hospital Heraklion, Crete, Greece
    Clin Chem Lab Med 43:934-8. 2005
    ..03, p<0.003, p<0.002, p<0.003 and p<0.001, respectively). Levels of MMP-9 and of IL-6 in multiple myeloma correlate well with bone turnover rate and may be useful in disease evaluation...
  33. ncbi request reprint Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase
    Erini Dermitzaki
    Departments of Clinical Chemistry Biochemistry and Pharmacology, School of Medicine, University of Crete, Heraklion, Crete GR 711 10, Greece
    J Biol Chem 277:12280-7. 2002
    ..Thus, CRH promotes PC12 apoptosis via the CRH type 1 receptor, which induces Fas ligand production via activation of p38...
  34. ncbi request reprint Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis
    Helen A Papadaki
    Department of Hematology University of Crete School of Medicine, University Hospital of Heraklion, P O Box 1352, Heraklion, Crete, Greece
    J Bone Miner Metab 22:577-87. 2004
    ....
  35. ncbi request reprint Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease
    George E Vrentzos
    Department of Internal Medicine, University Hospital of Crete, Crete, Greece
    J Nephrol 16:535-9. 2003
    ..This study aimed to evaluate the efficacy of an intravenous (i.v.) B12 regimen in ESRD patients and compare it with the conventional regimen...