Research Topics
| Lia MalettouSummaryAffiliation: University of Athens Country: Greece Publications
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Detail Information
Publications
Evaluation of six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trialHelen Gogas
First Department of Medicine, University of Athens, Medical School, Athens, Greece
J Transl Med 8:108. 2010..Specific CTLA-4 polymorphisms have previously shown an association with response to CTLA-4 blockade in patients with metastatic melanoma and the development of autoimmunity...- A randomized phase II study of carboplatin plus pegylated liposomal doxorubicin versus carboplatin plus paclitaxel in platinum sensitive ovarian cancer patients: a Hellenic Cooperative Oncology Group studyDimitrios Bafaloukos
1st Oncology Department, Metropolitan Hospital, Athens, Greece
BMC Med 8:3. 2010..This randomized phase II study was undertaken in order to compare the combination of carboplatin and pegylated liposomal doxorubicin (LD) with carboplatin and paclitaxel (CP) in this setting... - Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors modelAristotelis Bamias
Department of Clinical Therapeutics, Athens University, Medical School, Athens, Greece
BMC Cancer 10:45. 2010..We studied the prognostic significance of baseline characteristics and we compared the risk stratification with the established Memorial Sloan Kettering Cancer Center (MSKCC) model... 
Paclitaxel and gemcitabine, as first-line chemotherapy, combined with trastuzumab in patients with advanced breast cancer: a phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG)George Fountzilas
1 st Department of Internal Medicine, Oncology Section, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
Cancer Invest 22:655-62. 2004..This combination is the first to demonstrate a survival advantage in this group of patients. To improve on these results, we investigated a triplet, paclitaxel-gemcitabine-trastuzumab (TGH), in a phase II study...- Combination chemotherapy with cisplatin, etoposide and irinotecan in patients with extensive small-cell lung cancer: A phase II study of the Hellenic Co-operative Oncology GroupD Pectasides
Second Department of Internal Medicine Propaedeutic, Oncology Section, University General Hospital Attikon, Athens, Greece
Lung Cancer 58:355-61. 2007..The purpose of this study was to evaluate the efficacy and toxicity of cisplatin, etoposide and irinotecan as first-line treatment in patients with extensive small-cell lung cancer (E-SCLC)... - Docetaxel and gemcitabine combination, as first-line treatment, in patients with extensive disease small-cell lung cancer. A phase II study of the Hellenic Cooperative Oncology GroupDimosthenis Vasilios Skarlos
Henry Dynan Hospital, Athens, Greece
Lung Cancer 41:107-11. 2003..In conclusion, docetaxel-gemcitabine showed a modest response rate in chemotherapy-naive patients with ED SCLC... - Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancerE Samantas
Agii Anargyri Cancer Hospital, Athens, Greece
Lung Cancer 23:159-68. 1999..Therapy with this regimen, though less toxic, may not be a reliable alternative in elderly patients with visceral metastases and ECOG performance status > or = 2... - Combination chemotherapy with gemcitabine and ifosfamide as second-line treatment in metastatic urothelial cancer. A phase II trial conducted by the Hellenic Cooperative Oncology GroupD Pectasides
First Department of Medical Oncology, Metaxas Memorial Cancer Hospital, Piraeus Greece
Ann Oncol 12:1417-22. 2001..The aim of the study was to evaluate the efficacy and safety of the combination of gemcitabine and ifosfamide as a second-line treatment for advanced urothelial cancer... - Randomized comparison of early versus late hyperfractionated thoracic irradiation concurrently with chemotherapy in limited disease small-cell lung cancer: a randomized phase II study of the Hellenic Cooperative Oncology Group (HeCOG)D V Skarlos
Athens Medical Center, Greece
Ann Oncol 12:1231-8. 2001..Given these results, the Hellenic Cooperative Oncology Group (HeCOG) performed a multicenter randomized phase II study in patients with LD SCLC to evaluate the timing of HTRT (early vs. late) when given concurrently with chemotherapy... - Phase II study of pegylated liposomal doxorubicin: inactive in recurrent small-cell lung cancer. A Hellenic Cooperative Oncology Group StudyE Samantas
Agii Anargiri Cancer Hospital, Athens, Greece
Ann Oncol 11:1395-7. 2000..The objective of this multicenter phase II study was to evaluate the safety, tolerance and anti-tumour activity of Caelyx as monotherapy in patients with recurrent SCLC... - Ifosfamide plus oral etoposide salvage chemotherapy for platinum-resistant paclitaxel-pretreated ovarian cancerG Aravantinos
Hellenic Co operative Oncology Group, Athens, Greece
Ann Oncol 11:607-12. 2000..The prognosis of platinum resistant ovarian cancer is very poor and the treatment of choice has not been clearly defined... - Postoperative radiation and concomitant bolus fluorouracil with or without additional chemotherapy with fluorouracil and high-dose leucovorin in patients with high-risk rectal cancer: a randomized phase III study conducted by the Hellenic Cooperative OncoG Fountzilas
Aristotle University of Thessaloniki Medical School, Greece
Ann Oncol 10:671-6. 1999..However, this difference in response rate did not translate into a survival benefit... - Anthracycline-based chemotherapy of primary non-Hodgkin's lymphoma of the testis: the hellenic cooperative oncology group experienceD Pectasides
Hellenic Cooperative Oncology Group HeCoG, Athens, Greece
Oncology 58:286-92. 2000..Because the relapse rate in the CNS and contralateral testis is quite high in most studies, prophylactic CNS treatment and radiotherapy to the other testis should be included in the management of testicular lymphoma... - Second-line chemotherapy with weekly oxaliplatin and high-dose 5-fluorouracil with folinic acid in metastatic colorectal carcinoma: a Hellenic Cooperative Oncology Group (HeCOG) phase II feasibility studyJ Janinis
Third Department of Clinical Oncology, St Anargiri Cancer Center, Athens, Greece
Ann Oncol 11:163-7. 2000..The HeCOG performed a multicenter phase II study of a weekly oxaliplatin administration schedule in patients with previously treated MCC to evaluate the antitumor efficacy and toxicity of this combination... - A randomized phase III trial of adjuvant chemotherapy with irinotecan, leucovorin and fluorouracil versus leucovorin and fluorouracil for stage II and III colon cancer: a Hellenic Cooperative Oncology Group studyChristos A Papadimitriou
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece
BMC Med 9:10. 2011..In this multicenter adjuvant phase III trial, we evaluated the addition of irinotecan to weekly 5FU plus LV in patients with stage II or III colon cancer... - Serum concentrations of soluble ICAM-1 and VCAM-1 in patients with colorectal cancer. Clinical implicationsK Giannoulis
3rd Department of Surgery, AHEPA University Hospital, Thessaloniki, Greece
Tech Coloproctol 8:s65-7. 2004..In colorectal cancer (CRC), serum levels of adhesion molecules ICAM-1 and VCAM-1 increase with progressing disease. Our aim was to investigate the effect of treatment in serum ICAM-1 and VCAM-1... - Survival improvement of young patients, aged 16-23, with Hodgkin lymphoma (HL) during the last three decadesA A Koumarianou
Second Department of Internal Medicine Propaedeutic, Medical Oncology Unit, Attikon University Hospital, Athens University, Rimini 1, 12462 Athens, Greece
Anticancer Res 27:1191-7. 2007..Current controversial issues surrounding this disease, including the role of radiotherapy, positron emission tomography (PET), bone marrow biopsy and stem cell transplantation are discussed... - Systemic therapy in metastatic or recurrent endometrial cancerD Pectasides
Second Department of Internal Medicine, Oncology Section, University of Athens, Attikon University Hospital, Haidari, 1 Rimini, Athens, Greece
Cancer Treat Rev 33:177-90. 2007..Research in better understanding the signal transduction pathways in endometrial carcinogenesis will allow the development of specific and selective molecularly targeted inhibitors... - HER-2/neu status of primary breast cancer and corresponding metastatic sites in patients with advanced breast cancer treated with trastuzumab-based therapyD Pectasides
Second Department of Internal Medicine Propaedeutic, Oncology Section, Attikon University Hospital, Athens, Greece
Anticancer Res 26:647-53. 2006..The utility of serological assays for HER-2/neu in such patients was also studied... - Low-grade mucosa-associated lymphoid tissue lymphoma: a retrospective analysis of 97 patients by the Hellenic Cooperative Oncology Group (HeCOG)G Papaxoinis
Second Department of Internal Medicine, University General Hospital Attikon, University of Athens, Haidari, Greece
Ann Oncol 19:780-6. 2008..The aim was to examine characteristics and treatment results of patients with mucosa-associated lymphoid tissue (MALT) non-Hodgkin's lymphomas... 
Merkel cell carcinoma of the skin: a retrospective study of 24 cases by the Hellenic Cooperative Oncology GroupD Pectasides
2nd Department of Internal Medicine, Propaedeutic, Oncology Section, University of Athens, Attikon University Hospital, Haidari, Athens, Greece
Oncology 72:211-8. 2007..The purpose of this retrospective study was to present the epidemiological and clinical characteristics of 24 patients with Merkel cell carcinoma of the skin (MCC) and their response to various therapeutic modalities...- Carboplatin and paclitaxel in advanced or metastatic endometrial cancerD Pectasides
Second Department of Internal Medicine, Propaedeutic, Oncology Section, University of Athens, Attikon University Hospital, Haidari, 1 Rimini, Athens, Greece
Gynecol Oncol 109:250-4. 2008..The purpose of this study was to evaluate the activity and toxicity of carboplatin and paclitaxel combination in advanced or recurrent endometrial carcinoma... - Adult granulosa cell tumors of the ovary: a clinicopathological study of 34 patients by the Hellenic Cooperative Oncology Group (HeCOG)D Pectasides
Second Department of Internal Medicine, Propaeduetic, Oncology Section, University of Athens, Attikon University Hospital, Haidari, Athens, Greece
Anticancer Res 28:1421-7. 2008..Granulosa cell tumors (GCT) are rare malignant neoplasms of the ovaries with, usually, indolent biological behavior... - A randomised phase III trial of adjuvant radio-chemotherapy comparing Irinotecan, 5FU and Leucovorin to 5FU and Leucovorin in patients with rectal cancer: a Hellenic Cooperative Oncology Group StudyH P Kalofonos
Department of Medicine, Division of Oncology, University Hospital, University of Patras Medical School, Rion 26504, Patras, Greece
Eur J Cancer 44:1693-700. 2008..IRI added to adjuvant radiochemotherapy with LV and bolus 5FU was not shown to improve survival, whereas the incidence of severe leucopaenia was significantly higher in the IRI arm... - CEOP-21 versus CEOP-14 chemotherapy with or without rituximab for the first-line treatment of patients with aggressive lymphomas: results of the HE22A99 trial of the Hellenic Cooperative Oncology GroupT Economopoulos
Department of Medicine, Yale University, New Haven, CT, USA
Cancer J 13:327-34. 2007..In a secondary analysis we evaluated the impact of adding rituximab to CEOP-14/CEOP-21 chemotherapy... - Optimal therapy for platinum-resistant recurrent ovarian cancer: doxorubicin, gemcitabine or topotecan?D Pectasides
Second Department of Internal Medicine, Athens University, Attikon University Hospital, Rimini 1, Haidari, Athens, Greece
Expert Opin Pharmacother 7:975-87. 2006..In this review, the data for second-line therapy in this latter group of patients will be summarised and recommendations for their optimal management will be made... - Merkel cell cancer of the skinD Pectasides
Second Department of Internal Medicine, Oncology Section, University of Athens, Attikon University Hospital, Haidari, 1 Rimini, Athens, Greece
Ann Oncol 17:1489-95. 2006..Adjuvant chemotherapy (CT) should be considered as part of the initial management. In case of metastatic disease CT based on regimens used for small-cell lung cancer is the standard treatment of care... - Treatment of intermediate- and high-grade non-Hodgkin's lymphoma using CEOP versus CNOPT Economopoulos
Second Department of Internal Medicine - Propaedeutic, Athens University, Evangelismos Hospital, Greece
Eur J Haematol 68:135-43. 2002..Therefore, new improved therapeutic approaches should be developed for the treatment of high IPI risk patients... - Neoadjuvant chemotherapy with a combination of pegylated liposomal doxorubicin (Caelyx) and paclitaxel in locally advanced breast cancer: a phase II study by the Hellenic Cooperative Oncology GroupH Gogas
First Department of Medicine, Laiko Hospital, University of Athens, Greece
Ann Oncol 13:1737-42. 2002..To determine the activity and safety of the combination of paclitaxel and pegylated liposomal doxorubicin (Caelyx) in patients with locally advanced breast cancer... - Survival and prognostic factors after initiation of treatment in Waldenstrom's macroglobulinemiaM A Dimopoulos
Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
Ann Oncol 14:1299-305. 2003..Although several studies have evaluated possible prognostic factors of this disease, few have focused on the survival and prognosis of symptomatic patients after the initiation of treatment... - Treatment of intermediate and advanced stage Hodgkin's disease with modified baseline BEACOPP regimen: a Hellenic Co-operative Oncology Group StudyT Economopoulos
Second Department of Internal Medicine Propaedeutic, Evangelismos Hospital, Athens University, Athens, Greece
Eur J Haematol 71:257-62. 2003..Further follow up time is required to evaluate long-term toxicity... - Paclitaxel and epirubicin versus paclitaxel and carboplatin as first-line chemotherapy in patients with advanced breast cancer: a phase III study conducted by the Hellenic Cooperative Oncology GroupG Fountzilas
Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
Ann Oncol 15:1517-26. 2004..To compare survival between patients with advanced breast cancer (ABC) treated with epirubicin/paclitaxel (Taxol) or paclitaxel/carboplatin (Cp) chemotherapy... - Paclitaxel and gemcitabine vs. paclitaxel and pegylated liposomal doxorubicin in advanced non-nasopharyngeal head and neck cancer. An efficacy and cost analysis randomized study conducted by the Hellenic Cooperative Oncology GroupG Fountzilas
Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Macedonia, Greece
Ann Oncol 17:1560-7. 2006..In the present randomized phase III trial we compared two new combinations containing new drugs with proven activity in phase II studies with patients with HNC... - Comparison of docetaxel and docetaxel-irinotecan combination as second-line chemotherapy in advanced non-small-cell lung cancer: a randomized phase II trialD Pectasides
Second Department of Internal Medicine Propaedeutic, Athens University Medical School, Attikon University Hospital, 15342 Athens, Greece
Ann Oncol 16:294-9. 2005..The aim of this study was to evaluate whether docetaxel (taxotere) treatment with or without irinotecan improved patient outcomes with similar toxicity in recurrent non-small-cell lung cancer (NSCLC)... - T-cell-rich B-cell lymphoma. Analysis of clinical features, response to treatment, survival and comparison with diffuse large B-cell lymphomaP Tsirigotis
Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens, Greece
Oncology 61:257-64. 2001.... - Carboplatin plus gemcitabine in patients with inoperable or metastatic pancreatic cancer: a phase II multicenter study by the Hellenic Cooperative Oncology GroupN Xiros
Second Department of Internal Medicine, Propaedeutic and Research Institute, University General Hospital Attikon, University of Athens, Greece
Ann Oncol 16:773-9. 2005..In the present phase II multicenter study, we assessed the efficacy and tolerability of the combination of gemcitabine and carboplatin in patients with advanced pancreatic cancer... - Primary non-Hodgkin's lymphoma of the bladder: report of two cases and review of the literatureD Pectasides
2nd Department of Internal Medicine, Oncology Section, University of Athens, Attikon University Hospital, Rimini 1, Haidari, Athens, Greece
J BUON 13:277-9. 2008..We present herein 2 cases of non-Hodgkin's lymphoma (NHL) of the bladder and discuss their clinical-pathological features and management... - Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II studyH P Kalofonos
Patras University Hospital, Patras, Greece
Ann Oncol 16:869-77. 2005.... - The prevalence of hepatitis C and hepatitis G virus infection in patients with B cell non-Hodgkin lymphomas in Greece: a Hellenic Cooperative Oncology Group StudyE Giannoulis
AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
Acta Haematol 112:189-93. 2004..The increased prevalence of HGV infection detected in patients with NHL could imply the potential participation of HGV in the pathogenesis of NHL... - A unique case of splenic marginal zone-cell lymphoma with synchronous clonal T-cell large granular lymphocyte proliferation: an immunologic, immunohistochemical and genotypic studyT Papadaki
Hemopathology Department and Immunology Laboratory, Evangelismos Hospital, Athens University, Athens, Greece
Leuk Res 27:85-7. 2003..The pathogenetic mechanisms which may be responsible for the concomitant appearance of these two rather infrequent entities in the same anatomic sites are discussed... - Monoclonal gammopathies in B-cell non-Hodgkin's lymphomasT Economopoulos
Second Department of Internal Medicine, Propaedeutic, Athens University, Evangelismos Hospital, Athens 10676, Greece
Leuk Res 27:505-8. 2003..2% of cases with B-cell NHL. IgG-MG was more frequent in cases with aggressive NHL, while IgM in cases with low risk NHL. MG was mostly associated with advanced stage and had not any prognostic significance on survival... - Non-Hodgkin's lymphomas in Greece according to the WHO classification of lymphoid neoplasms. A retrospective analysis of 810 casesT Economopoulos
University General Hospital Attikon, Haidari, Greece
Acta Haematol 113:97-103. 2005..There were no important differences in the incidence of the remaining histological subtypes between Greece and other European countries... - Treatment of Waldenstrom's macroglobulinemia with single-agent thalidomide or with the combination of clarithromycin, thalidomide and dexamethasoneM A Dimopoulos
Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
Semin Oncol 30:265-9. 2003..Our preliminary data indicate that this combination may be a useful salvage regimen for some patients with heavily pretreated macroglobulinemia... - Analysis of p53 protein expression levels on ovarian cancer tissue microarray using automated quantitative analysis elucidates prognostic patient subsetsA Psyrri
Department of Medical Oncology, Yale Cancer Center, New Haven, CT 06520, USA diamando psyrri yale edu
Ann Oncol 18:709-15. 2007..Here, we sought to determine the prognostic value of p53 in ovarian cancer using a novel method of compartmentalized in situ protein analysis... - Renal failure in multiple myeloma: incidence, correlations, and prognostic significanceV Eleutherakis Papaiakovou
Department of Clinical Therapeutics, University of Athens, School of Medicine, Greece
Leuk Lymphoma 48:337-41. 2007..When corrected for stage, renal failure had no impact on survival... - Sublingual use of olanzapine in combination with alprazolam to treat agitation in a terminally ill patient receiving parenteral nutritionA Douzenis
Department of General Hospital Psychiatry, Athens University Medical School, Attikon Hospital, Athens, Greece
Eur J Cancer Care (Engl) 16:289-90. 2007..Olanzapine (orally disintegrating tablets) in combination with alprazolam was used successfully to relieve this terminally ill patient's anxiety and tension improving his relationship with his physicians and his daily life...