Vassiliki Magafa

Summary

Affiliation: University of Patras
Country: Greece

Publications

  1. doi request reprint Synthesis and biological activity of oxytocin analogues containing unnatural amino acids in position 9: structure activity study
    Vassiliki Magafa
    Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500, Patras, Greece
    Amino Acids 38:1549-59. 2010
  2. ncbi request reprint Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7
    Maria Fragiadaki
    Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, GR 26500 Patras, Hellas, Greece
    Eur J Med Chem 42:799-806. 2007
  3. doi request reprint In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights
    Zinovia Spyranti
    Department of Pharmacy, University of Patras, 26500, Patras, Greece
    Amino Acids 39:539-48. 2010
  4. ncbi request reprint Synthesis and biological evaluation of oxytocin analogues containing L-alpha-t-butylglycine [Gly(Bu t)] in positions 8 or 9
    Maria Fragiadaki
    Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, GR 26500 Patras, Greece
    Peptides 24:1425-31. 2003
  5. doi request reprint Synthesis and sst(2) binding profiles of new [Tyr(3)]octreotate analogs
    Christos Petrou
    Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, Hellas, Greece
    J Pept Sci 14:725-30. 2008
  6. pmc Pleiotrophin expression and role in physiological angiogenesis in vivo: potential involvement of nucleolin
    Marina Koutsioumpa
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras GR 26504, Greece
    Vasc Cell 4:4. 2012
  7. ncbi request reprint Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship
    Georgios A Spyroulias
    Department of Pharmacy, University of Patras, Greece
    Eur J Biochem 270:2163-73. 2003
  8. ncbi request reprint Gonadotropin-releasing hormone analogues alter gene expression of metalloproteinases and their tissue inhibitors in human breast cancer epithelial cells
    Fotini N Lamari
    Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500 Patras, Greece
    Anticancer Res 26:4615-21. 2006

Collaborators

Detail Information

Publications8

  1. doi request reprint Synthesis and biological activity of oxytocin analogues containing unnatural amino acids in position 9: structure activity study
    Vassiliki Magafa
    Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500, Patras, Greece
    Amino Acids 38:1549-59. 2010
    ..The analogue having the highest anti-oxytocic activity was [Mpa(1), D-Tyr(Et)(2), Deg(9)]OT (pA(2) = 8.68 +/- 0.26); this analogue was also selective...
  2. ncbi request reprint Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7
    Maria Fragiadaki
    Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, GR 26500 Patras, Hellas, Greece
    Eur J Med Chem 42:799-806. 2007
    ..The analogue having the highest antioxytocic activity was [Mpa(1), D-Tyr(Et)(2), D-Tic(7), Aib(9)]OT having pA(2)=8.31+/-0.19; this analogue was also selective...
  3. doi request reprint In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights
    Zinovia Spyranti
    Department of Pharmacy, University of Patras, 26500, Patras, Greece
    Amino Acids 39:539-48. 2010
    ..The MS and HPLC indicate the presence of a single molecule/peptide, and NMR data thus suggest that this second set of peaks is due to the cis conformation...
  4. ncbi request reprint Synthesis and biological evaluation of oxytocin analogues containing L-alpha-t-butylglycine [Gly(Bu t)] in positions 8 or 9
    Maria Fragiadaki
    Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, GR 26500 Patras, Greece
    Peptides 24:1425-31. 2003
    ..The analogues were tested for rat uterotonic activity in vitro, in the rat pressor assay and for binding affinity to human OTR...
  5. doi request reprint Synthesis and sst(2) binding profiles of new [Tyr(3)]octreotate analogs
    Christos Petrou
    Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, Hellas, Greece
    J Pept Sci 14:725-30. 2008
    ..The binding affinities were determined during competition binding assays in sst(2)-positive rat acinar pancreatic AR4-2J cell membranes using [(125)I-Tyr(3)]octreotide as the radioligand...
  6. pmc Pleiotrophin expression and role in physiological angiogenesis in vivo: potential involvement of nucleolin
    Marina Koutsioumpa
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras GR 26504, Greece
    Vasc Cell 4:4. 2012
    ..abstract:..
  7. ncbi request reprint Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship
    Georgios A Spyroulias
    Department of Pharmacy, University of Patras, Greece
    Eur J Biochem 270:2163-73. 2003
    ....
  8. ncbi request reprint Gonadotropin-releasing hormone analogues alter gene expression of metalloproteinases and their tissue inhibitors in human breast cancer epithelial cells
    Fotini N Lamari
    Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500 Patras, Greece
    Anticancer Res 26:4615-21. 2006
    ..The impact of the observed changes on the expression of MMPs and TIMPs warrants further investigation on the effects of GnRH analogues on the invasiveness and metastatic potential of breast cancer cells...