Georgia Levidou

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. doi request reprint The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma
    Anastasios Stofas
    First Department of Pathology, Laiko Hospital, University of Athens, Medical School, 75 Mikras Asias Street, 11527 Athens, Greece
    BMC Cancer 14:149. 2014
  2. doi request reprint A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides
    Georgia Levidou
    Department of Pathology, University of Athens, Medical School, Athens, Greece
    J Am Acad Dermatol 69:375-84. 2013
  3. doi request reprint TRAIL and osteoprotegerin (OPG) expression in bladder urothelial carcinoma: correlation with clinicopathological parameters and prognosis
    Georgia Levidou
    First Department of Pathology, Laiko General Hospital, Athens, University School of Medicine, Athens, Greece
    Pathology 45:138-44. 2013
  4. doi request reprint Replication protein A in nonearly ovarian adenocarcinomas: correlation with MCM-2, MCM-5, Ki-67 index and prognostic significance
    Georgia Levidou
    First Department of Pathology, Medical School, Laiko Hospital, Athens, Greece
    Int J Gynecol Pathol 31:319-27. 2012
  5. pmc ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
    Georgia Levidou
    Department of Pathology, National and Kapodistrian University of Athens, Medical School, 75 Mikras Asias Street, Greece
    World J Surg Oncol 10:47. 2012
  6. doi request reprint Prognostic significance of replication protein A (RPA) expression levels in bladder urothelial carcinoma
    Georgia Levidou
    National and Kapodistrian University of Athens, Laiko Hospital, First Department of Pathology, Athens, Greece
    BJU Int 108:E59-65. 2011
  7. pmc Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature
    Georgia Levidou
    National and Kapodistrian University of Athens, Department of Pathology, Athens, 11527, Greece
    Diagn Pathol 5:59. 2010
  8. doi request reprint P53 immunoexpression as a prognostic marker for human astrocytomas: a meta-analysis and review of the literature
    Georgia Levidou
    Medical School, Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
    J Neurooncol 100:363-71. 2010
  9. doi request reprint D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance
    Georgia Levidou
    First Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
    J Cancer Res Clin Oncol 136:1563-71. 2010
  10. ncbi request reprint Expression of nuclear factor kappaB in human gastric carcinoma: relationship with I kappaB a and prognostic significance
    Georgia Levidou
    Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens, 11517, Greece
    Virchows Arch 450:519-27. 2007

Collaborators

Detail Information

Publications39

  1. doi request reprint The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma
    Anastasios Stofas
    First Department of Pathology, Laiko Hospital, University of Athens, Medical School, 75 Mikras Asias Street, 11527 Athens, Greece
    BMC Cancer 14:149. 2014
    ..SOCS (suppressor of cytokine signaling)-3 is a negative regulator of cytokine-driven responses, contributing to interferon-α resistance commonly used to treat advanced RCC with limited information regarding its expression in RCC...
  2. doi request reprint A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides
    Georgia Levidou
    Department of Pathology, University of Athens, Medical School, Athens, Greece
    J Am Acad Dermatol 69:375-84. 2013
    ..Although the expression pattern of phosphorylated (p)-mTOR pathway components has attracted scientific interest in several neoplasms, to our knowledge, there is no published information regarding its significance in mycosis fungoides (MF)...
  3. doi request reprint TRAIL and osteoprotegerin (OPG) expression in bladder urothelial carcinoma: correlation with clinicopathological parameters and prognosis
    Georgia Levidou
    First Department of Pathology, Laiko General Hospital, Athens, University School of Medicine, Athens, Greece
    Pathology 45:138-44. 2013
    ....
  4. doi request reprint Replication protein A in nonearly ovarian adenocarcinomas: correlation with MCM-2, MCM-5, Ki-67 index and prognostic significance
    Georgia Levidou
    First Department of Pathology, Medical School, Laiko Hospital, Athens, Greece
    Int J Gynecol Pathol 31:319-27. 2012
    ..Moreover, RPA2 protein may play an important role in ovarian tumorigenesis, and may serve as a useful independent molecular marker for stratifying patients with OC in terms of prognosis...
  5. pmc ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
    Georgia Levidou
    Department of Pathology, National and Kapodistrian University of Athens, Medical School, 75 Mikras Asias Street, Greece
    World J Surg Oncol 10:47. 2012
    ..Colorectal (CRC) carcinogenesis through various morphological stages has been linked to several genetic and epigenetic changes. The Raf/MEK/ERK (MAPK) signal transduction cascade is an important mediator of a number of cellular fates...
  6. doi request reprint Prognostic significance of replication protein A (RPA) expression levels in bladder urothelial carcinoma
    Georgia Levidou
    National and Kapodistrian University of Athens, Laiko Hospital, First Department of Pathology, Athens, Greece
    BJU Int 108:E59-65. 2011
    ..To elucidate the role of replication protein A (RPA) in both superficial (Ta-T1) and muscle-invasive (T2-T4) urothelial carcinomas (UCs), investigating its potential prognostic usefulness...
  7. pmc Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature
    Georgia Levidou
    National and Kapodistrian University of Athens, Department of Pathology, Athens, 11527, Greece
    Diagn Pathol 5:59. 2010
    ..Gliomas are a very rare subtype of pineal region tumours, whereas oligodendrogliomas of the pineal region are exceedingly rare, since there have been only 3 cases of anaplastic oligodedrogliomas reported this far...
  8. doi request reprint P53 immunoexpression as a prognostic marker for human astrocytomas: a meta-analysis and review of the literature
    Georgia Levidou
    Medical School, Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
    J Neurooncol 100:363-71. 2010
    ..100) and was not statistically significant. After almost 20 years of research, published evidence does not substantiate the usefulness of p53 immunohistochemical expression as a prognostic marker in patients with astrocytic neoplasms...
  9. doi request reprint D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance
    Georgia Levidou
    First Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
    J Cancer Res Clin Oncol 136:1563-71. 2010
    ..To elucidate the role of D-type cyclins in both superficial (Ta-T1) and muscle-invasive (T2-T4) urothelial carcinomas (UCs), investigating their potential prognostic usefulness...
  10. ncbi request reprint Expression of nuclear factor kappaB in human gastric carcinoma: relationship with I kappaB a and prognostic significance
    Georgia Levidou
    Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens, 11517, Greece
    Virchows Arch 450:519-27. 2007
    ....
  11. doi request reprint Clinical significance of nuclear factor (NF)-kappaB levels in urothelial carcinoma of the urinary bladder
    Georgia Levidou
    Department of Pathology, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens 11527, Greece
    Virchows Arch 452:295-304. 2008
    ..Moreover, NF-kappaB nuclear expression emerges as an independent prognosticator of adverse significance, conveying information beyond that obtained by standard clinicopathological prognosticators...
  12. doi request reprint Spiradenoma reminiscent of thymoma: report of a case and review of the literature
    Georgia Levidou
    Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
    J Cutan Pathol 36:246-50. 2009
    ..However, there is little information available about the nature and maturity of the lymphocytes comprising these spaces...
  13. ncbi request reprint Leptomeningeal melanoma of unknown primary site: two cases with an atypical presentation of acute meningitis
    G Levidou
    Department of Pathology, National and Kapodistrian University of Athens, Greece
    Clin Neuropathol 26:299-305. 2007
    ..Clinical, radiological and histological findings are discussed with a review of the literature...
  14. doi request reprint Phosphorylated 4E-binding protein 1 (p-4E-BP1): a novel prognostic marker in human astrocytomas
    Penelope Korkolopoulou
    First Department of Pathology, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece
    Histopathology 61:293-305. 2012
    ..To investigate the significance of the mammalian target of rapamycin (mTOR) pathway in astrocytic tumours, published information in this context being limited, especially regarding phosphorylated 4E-binding protein (p-4E-BP) 1...
  15. doi request reprint Replication protein A: a reliable biologic marker of prognostic and therapeutic value in human astrocytic tumors
    Dimitrios Kanakis
    First Department of Pathology, Medical School, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
    Hum Pathol 42:1545-53. 2011
    ..Moreover, replication protein A2 protein seems to be a useful prognostic indicator in patients with astrocytomas...
  16. doi request reprint Expression of pERK and pAKT in human astrocytomas: correlation with IDH1-R132H presence, vascular endothelial growth factor, microvascular characteristics and clinical outcome
    Angelica A Saetta
    First Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens, Medical School, 75 Mikras Asias Street, Athens, Greece
    Virchows Arch 458:749-59. 2011
    ..Moreover, the importance of cytoplasmic pAKT immunoexpression in patients' prognosis and nuclear pERK immunoexpression in glioblastomas is confirmed...
  17. pmc Expression of interleukin-8 receptor CXCR2 and suppressor of cytokine signaling-3 in astrocytic tumors
    Penelope Korkolopoulou
    First Department of Pathology, Laiko Hospital, University of Athens Medical School, Athens, Greece
    Mol Med 18:379-88. 2012
    ..Our data implicate IL-8/CXCR2 signaling pathway in the progression and regulation of angiogenesis in astrocytomas and provide a rationale for CXCR2 therapeutic exploitation in these tumors...
  18. doi request reprint Analysis of interleukin (IL)-8 expression in human astrocytomas: associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry
    Vassilis Samaras
    Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Laiko Hospital, Athens 11527, Greece
    Hum Immunol 70:391-7. 2009
    ..Moreover, our study seems to be the first attempt to link IL-8 expression by tumor cells with histological grade, implicating its potent role in gliomagenesis...
  19. doi request reprint Expression of nuclear factor-kappaB in human astrocytomas: relation to pI kappa Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival
    Penelope Korkolopoulou
    First Department of Pathology, Medical School, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
    Hum Pathol 39:1143-52. 2008
    ....
  20. ncbi request reprint Immunohistochemical expression and prognostic significance of CCND3, MCM2 and MCM7 in Hodgkin lymhoma
    Andreas Marnerides
    Department of Pathology, Laikon General Hospital, National and Kapodistrian University of Athens, Greece
    Anticancer Res 31:3585-94. 2011
    ..Increased proliferation rate may be associated with inferior outcome in patients with Hodgkin lymphoma (HL). Minichromosome maintenance proteins (MCMs) and D-type cyclins are essential for DNA replication...
  21. doi request reprint Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: correlation with IL-6, VEGF and microvessel morphometry
    Christina Piperi
    Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
    Cytokine 55:387-95. 2011
    ..The prognostic significance of IL-8 expression and its correlation with p-STAT-3 and VEGF implicates this novel signaling pathway in astroglial tumors progression providing new targets for effective immunotherapy...
  22. ncbi request reprint TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder
    Angelica A Saetta
    Department of Pathology, Medical School, National and Kapodistrian University of Athens, Greece
    Pathology 39:425-32. 2007
    ....
  23. doi request reprint A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma
    Penelope Korkolopoulou
    First Department of Pathology, Laiko General Hospital, Athens, University School of Medicine, Athens, Greece
    BJU Int 110:E1237-48. 2012
    ..Finally, the present study indicates PIK3CA/AKT1 mutational status as a potential predictive marker for time-to-recurrence...
  24. doi request reprint Activation of extracellular regulated kinases (ERK1/2) predicts poor prognosis in urothelial bladder carcinoma and is not associated with B-Raf gene mutations
    Maria Karlou
    Department of Pathology, Medical School, National and Kapodistrian University of Athens, Goudi, Athens, Greece
    Pathology 41:327-34. 2009
    ..The analysis of the presence of B-Raf gene mutations in relation to ERK1/2 activation in bladder urothelial carcinoma (UC), in order to determine their potential role in tumour aggressiveness and patients' survival...
  25. ncbi request reprint Expression and prognostic significance of cyclin D3 in ovarian adenocarcinomas
    Georgia Levidou
    Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Int J Gynecol Pathol 26:410-7. 2007
    ....
  26. doi request reprint A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features
    Eleni Andriana Trigka
    First Department of Pathology, University of Athens Medical School, Laiko General Hospital, 11527 Athens, Greece
    Oncol Rep 30:623-36. 2013
    ..Our data demonstrate the significance of p‑4E‑BP1 immunoexpression as a molecular marker of prognostic value in adenocarcinomas, particularly when combined with p-AKT...
  27. pmc High incidence of MGMT and RARbeta promoter methylation in primary glioblastomas: association with histopathological characteristics, inflammatory mediators and clinical outcome
    Christina Piperi
    Department of Biological Chemistry, Medical School, University of Athens, 11527 Athens, Greece
    Mol Med 16:1-9. 2010
    ..0474). Our study highlights the implication of MGMT and RARbeta methylation in the aggressive phenotype of primary glioblastomas. The association of MGMT methylation with clinical outcome indicates its potential prognostic value...
  28. doi request reprint Association of aberrant DNA methylation with clinicopathological features in breast cancer
    Aggeliki Tserga
    First Department of Pathology, Medical School, National and Kapodistrian University of Athens, and First Propaedeutic Department of Surgery, Hippocration University Hospital, Athens, Greece
    Oncol Rep 27:1630-8. 2012
    ..Our results suggest that GSTP1, RASSF1, DAPK1 and MGMT may be implicated in the acquisition of a more aggressive phenotype in breast cancer...
  29. doi request reprint Apoptotic and proliferative characteristics of proliferation centers in lymph node sections of patients with chronic lymphocytic leukemia
    Sotirios Sachanas
    Department of Hematology, Athens Medical Center, Athens, Greece
    Leuk Lymphoma 55:571-82. 2014
    ..Multivariate analysis demonstrated that concurrent overexpression of Fas/FasL/c-FLIP in the PCs was correlated with worse outcome for progression-free survival as well as for overall survival...
  30. doi request reprint Isolated central nervous system relapses in primary mediastinal large B-cell lymphoma after CHOP-like chemotherapy with or without Rituximab
    Sotirios G Papageorgiou
    Second Department of Internal Medicine, Propaedeutic, Hematology Unit, National and Kapodistrian University of Athens, Medical School, University General Hospital Attikon, Haidari, Greece
    Hematol Oncol 31:10-7. 2013
    ..Established risk factors for CNS involvement in aggressive lymphomas may not be helpful in assessing the risk of CNS recurrence in this disease. Routine CNS prophylaxis is not probably required in PMLBCL...
  31. doi request reprint Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue
    Katerina K Papachroni
    Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
    J Cell Mol Med 14:2460-9. 2010
    ..These findings suggest that deposition of excess collagen in PCO tissue that induces cystogenesis may, in part, be due to AGE-mediated stimulation of LOX activity...
  32. pmc Gastrointestinal stromal tumor
    Michael Stamatakos
    4th Department of Surgery, University of Athens, School of Medicine, Attikon General Hospital, Athens, Greece
    World J Surg Oncol 7:61. 2009
    ..GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity and the literature on these stromal tumors has rapidly expanded...
  33. pmc The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
    Elias A El Habr
    First Department of Pathology, Laiko Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, Greece
    Neurol Res Int 2012:454957. 2012
    ..Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors...
  34. ncbi request reprint Accumulation of dietary glycotoxins in the reproductive system of normal female rats
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Medical School, University of Athens, Athens, Greece
    J Mol Med (Berl) 85:1413-20. 2007
    ....
  35. ncbi request reprint Application of the ELISPOT method for comparative analysis of interleukin (IL)-6 and IL-10 secretion in peripheral blood of patients with astroglial tumors
    Vassilis Samaras
    Department of Pathology, University of Athens Medical School, M Asias 75, Goudi 11527, Athens, Greece
    Mol Cell Biochem 304:343-51. 2007
    ..This study demonstrates for the first time the usefulness of ELISPOT in estimating the secretion of IL-6 and IL-10 from peripheral blood and the correlation of their expression in neoplastic cells...
  36. doi request reprint Kikuchi's lymphadenopathy: a relatively rare but important cause of lymphadenopathy in Greece, potentially associated with the antiphospholipid syndrome
    Theodoros P Vassilakopoulos
    First Department of Internal Medicine and Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, 17 Ag Thoma Street, Goudi, Athens, 11527, Greece
    Rheumatol Int 30:925-32. 2010
    ..In this setting, autoimmune disorders, mainly lupus and APLS, should be considered and excluded by the appropriate laboratory work-up...
  37. doi request reprint CD138 expression helps distinguishing Waldenström's macroglobulinemia (WM) from splenic marginal zone lymphoma (SMZL)
    Marie Christine Kyrtsonis
    Hematology Section of the First Department of Propedeutic Internal Medicine, National and Kapodistrian University of Athens, Laikon University Hospital, Athens, Greece
    Clin Lymphoma Myeloma Leuk 11:99-102. 2011
    ..0008 and, .00021 respectively). Moreover, CD138 expression was related to serum IgM levels in WM patients (P=.0006). In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL...
  38. doi request reprint Systemic mastocytosis accompanied by a non-secretory plasma cell dyscrasia and nephrotic syndrome-level proteinuria in a 76-year-old patient
    Vasiliki Papadopoulou
    First Department of Internal Medicine, University of Athens, General Hospital Laïko, Greece
    Acta Haematol 131:78-83. 2014
    ..This is a unique report of systemic mastocytosis with a non-secretory plasma cell dyscrasia and nephrotic syndrome. The pathophysiological relevance between these entities along with the probability of occult amyloidosis is discussed. ..
  39. doi request reprint The efficacy and safety of gonadotropin-releasing hormone analog treatment in childhood and adolescence: a single center, long-term follow-up study
    Maria Alexandra Magiakou
    Division of Endocrinology, Athens University Medical School, Aghia Sophia Children s Hospital, 11527 Athens, Greece
    J Clin Endocrinol Metab 95:109-17. 2010
    ..The objective of the study was to evaluate the long-term effect of GnRH analog (GnRHa) treatment on final height (FH), body mass index (BMI), body composition, bone mineral density (BMD), and ovarian function...