Research Topics
Genomes and GenesSpecies | J P LekakisSummaryAffiliation: University of Athens Country: Greece Publications
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Publications
Peripheral vascular endothelial dysfunction in patients with angina pectoris and normal coronary arteriogramsJ P Lekakis
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
J Am Coll Cardiol 31:541-6. 1998..We sought to determine endothelium-dependent vasodilator function in the brachial artery of patients with microvascular angina pectoris...- Myocardial adrenergic denervation in patients with primary (AL) amyloidosisJohn Lekakis
Department of Clinical Therapeutics, Athens University School of Medicine, Athens, Greece
Amyloid 10:117-20. 2003.... - Scleroderma heart disease: an unusual cause of positive antimyosin cardiac imagingJ Lekakis
Department of Clinical Therapeutics Athens University, Greece
J Nucl Cardiol 6:91-2. 1999..In these patients with positive antimyosin study results, intense pharmacologic treatment with vasodilators may be warranted... - Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosisJ P Lekakis
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Am J Cardiol 85:949-52. 2000..Femoral artery and carotid bulb are independent predictors of CAD extent and the inclusion of these measurements would add information to that provided by the common carotid artery... - Oral L-arginine improves endothelial dysfunction in patients with essential hypertensionJohn P Lekakis
Department of Clinical Therapeutics, Athens University, Alexandra Hospital, Greece
Int J Cardiol 86:317-23. 2002.... - Comparison of low-density lipoprotein cholesterol lowering by pravastatin to <100 mg/dl versus >100 mg/dl on brachial artery vasoreactivity in patients with severe hypercholesterolemia and previous atherosclerotic events or diabetes mellitusJohn P Lekakis
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Am J Cardiol 89:857-60. 2002 - Pulse pressure in normotensives: a marker of cardiovascular diseaseN A Zakopoulos
Department of Clinical Therapeutics, Division of Medicine, Athens University, Greece
Am J Hypertens 14:195-9. 2001.... - Reproducibility of ambulatory blood pressure measurements in essential hypertensionN A Zakopoulos
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, National and Kapodestrial University, Athens, Greece
Blood Press Monit 6:41-5. 2001..These findings suggest that ambulatory blood pressure monitoring is a reliable tool to monitor blood pressure changes... - Impaired endothelium-dependent vasodilatation in women with previous gestational diabetesE Anastasiou
1st Endocrine Section and Diabetes Centre, Alexandra University Hospital, Athens, Greece
Diabetes Care 21:2111-5. 1998..To assess whether otherwise healthy women with a history of gestational diabetes mellitus (GDM) may have abnormalities in endothelial function at a very early stage, before glucose intolerance occurs... - Acute effects of renin-angiotensin system blockade on arterial function in hypertensive patientsK A Aznaouridis
Vascular Laboratory, Department of Clinical Therapeutics, Athens Medical School, Alexandra Hospital, Athens, Greece
J Hum Hypertens 21:654-63. 2007..Further studies are needed to investigate whether these acute arterial effects of quinapril are clinically significant... 
Diurnal variation of endothelial function and arterial stiffness in hypertensionG E Kollias
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, University of Athens Medical School, Athens, Greece
J Hum Hypertens 23:597-604. 2009..Endothelial function is decreased in the early morning in hypertensive patients, whereas arterial stiffness is increased in the evening. Changes in BP-dependent passive artery distension may be involved in this phenomenon...- Arterial compliance is an independent factor predicting acute hemodynamic performance of intra-aortic balloon counterpulsationT G Papaioannou
Department of Clinical Therapeutics, Alexandra Hospital, Medical School, Athens University, Greece
Int J Artif Organs 24:478-83. 2001..03), while arterial blood pressure did not significantly differ. Arterial compliance is an independent factor affecting hemodynamics during IABC. RTI values higher than 20.6% may predict a better acute hemodynamic response to IABC... - The combined effect of augmentation index and carotid intima-media thickness on cardiovascular risk in young and middle-aged men without cardiovascular diseaseK S Stamatelopoulos
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Glyfada, Athens, Greece
J Hum Hypertens 20:273-9. 2006..In conclusion, young and middle-aged men without overt cardiovascular disease with both high IMT and AI are in high cardiovascular risk, as assessed by FRS. Epidemiological studies are needed to further validate this combination... - The Athens stroke registry: results of a five-year hospital-based studyK N Vemmos
Department of Clinical Therapeutics, University of Athens School of Medicine, Alexandra Hospital, Athens, Greece
Cerebrovasc Dis 10:133-41. 2000..The overall hospital mortality was 15.2% (from 0.6% for lacunar stroke to 34% for ICH). In our population, cardioembolism is the most frequent subtype of stroke. NVAF is the most likely source, especially in older patients... - Heart rate effect on hemodynamics during mechanical assistance by the intra-aortic balloon pumpT G Papaioannou
Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodestrian University of Athens, Athens, Greece
Int J Artif Organs 25:1160-5. 2002..In contrast, IABC operating at 80-110 bpm resulted in optimum hemodynamic performance. In conclusion, the effect of heart rate on IABC performance is non-linear indicating that IABC may be more effective when operating within 80-110 bpm... - The androgen receptor gene CAG polymorphism is associated with the severity of coronary artery disease in menM Alevizaki
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Clin Endocrinol (Oxf) 59:749-55. 2003..The aim of this study was to investigate the effect of this polymorphism of the AR gene in the extent of CAD in male patients... - Impact of cardiac transplantation in 24 hours circadian blood pressure and heart rate profileV T Kotsis
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodestrial University, Athens, Greece
Transplant Proc 37:2244-6. 2005..They also had increased 24-h/daytime/nighttime heart rate and decreased heart rate variability. Also, diminished nocturnal decrease of BP was found in transplant recipients... - Effect of nebivolol and atenolol on brachial artery flow-mediated vasodilation in patients with coronary artery diseaseJohn P Lekakis
Department of Clinical Therapeutics, Alexandra University Hospital, Athens University, 12 Iridanou str, 11528, Greece
Cardiovasc Drugs Ther 19:277-81. 2005..6 +/- 2.9% vs. 3.4 +/- 3.2%, p = 0.041).Beta(1) blockade by nebivolol but not atenolol improves endothelial dysfunction in patients with CAD, an effect that might further reduce the risk for cardiovascular events in patients with CAD... - Effect of coffee on endothelial function in healthy subjects: the role of caffeineChris M Papamichael
Vascular Laboratory, Department of Clinical Therapeutics, University of Athens, Alexandra Hospital, Athens 15561, Greece
Clin Sci (Lond) 109:55-60. 2005..This effect might be attributed to caffeine, given that decaffeinated coffee was not associated with any change in the endothelial performance... - Divergent effects of rofecoxib on endothelial function and inflammation in acute coronary syndromesJohn P Lekakis
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, 12 Iridanou str, Athens 11528, Greece
Int J Cardiol 112:359-66. 2006..The lack of improvement in FMD despite the improvement in inflammation and oxidative stress could be viewed in association to the recent observations on the adverse effects of COX-2 inhibition on the cardiovascular system... - Long-term prognostic role of flow-mediated dilatation of the brachial artery after acute coronary syndromes without ST elevationEmmanouil N Karatzis
The Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Am J Cardiol 98:1424-8. 2006..In conclusion, endothelium-dependent dilation of the brachial artery is a strong independent predictor of adverse outcome in survivors of acute coronary syndromes without ST-segment elevation... - Acute combined effects of olive oil and wine on pressure wave reflections: another beneficial influence of the Mediterranean diet antioxidants?Christos M Papamichael
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Greece
J Hypertens 26:223-9. 2008..We sought to determine the combined postprandial effects of wine and olive oil on wave reflections and central haemodynamics... - Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritisIgnatios Ikonomidis
2nd Department of Cardiology, University of Athens, Attikon Hospital, Athens, Greece
Circulation 117:2662-9. 2008..Interleukin-1 increases nitrooxidative stress. We investigated the effects of a human recombinant interleukin-1a receptor antagonist (anakinra) on nitrooxidative stress and vascular and left ventricular function... - Oral folic acid enhances endothelial function in patients with hypercholesterolaemia receiving statinsJohn P Lekakis
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Greece
Eur J Cardiovasc Prev Rehabil 11:416-20. 2004..In the present study we tested the hypothesis that folic acid supplementation improves endothelial function in patients with hypercholesterolaemia and treatment with statins... - Endothelial dysfunction and type of cigarette smoked: the impact of 'light' versus regular cigarette smokingChristos M Papamichael
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Vasc Med 9:103-5. 2004..In conclusion, acute smoking of both regular and light cigarettes leads to temporary vasomotor dysfunction; its duration is shorter after smoking a 'light' cigarette... - Oral administration of ascorbic acid attenuates endothelial dysfunction after short-term cigarette smokingKimon S Stamatelopoulos
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Int J Vitam Nutr Res 73:417-22. 2003..Oral administration of ascorbic acid attenuates endothelial dysfunction after short-term cigarette smoking by shortening its duration... - Ascorbic acid does not improve endothelium-dependent flow-mediated dilatation of the brachial artery in patients with Raynaud's phenomenon secondary to systemic sclerosisMyron E Mavrikakis
Department of Clinical Therapeutic, Alexandra University Hospital, Athens, Greece
Int J Vitam Nutr Res 73:3-7. 2003..The use of different antioxidants or different dosing of ascorbic acid may be required to show a beneficial effect on endothelial vasodilator function... - Cardiac hypertrophy in hypertension: relation to 24-h blood pressure profile and arterial stiffnessJohn P Lekakis
Department of Clinical Therapeutics, Alexandra University Hospital, 12 Iridanou Street, 11528 Athens, Greece
Int J Cardiol 97:29-33. 2004..In the present study 24-h blood pressure profile and central hemodynamics were examined to evaluate mechanical loading factors as determinants of cardiac hypertrophy in mild to moderate untreated essential hypertension... - The relative impact of different measures of adiposity on markers of early atherosclerosisKimon S Stamatelopoulos
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Int J Cardiol 119:139-46. 2007..This study examines the relative impact of different measures of adiposity on markers of early atherosclerosis. In particular weight changes over time have been poorly assessed in this setting... - High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensivesVassiliki C Pitiriga
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, National and Kapodistrial University, Vas. Sofias and Lourou Str, Athens 11528, Greece
Atherosclerosis 167:231-5. 2003..pneumoniae antibody titers and carotid IMT were increased in subjects with white-coat hypertension. The preceding associations strengthen prior evidence in favor of the opinion that white-coat hypertension is not an innocent phenomenon... - Central blood pressures: do we need them in the management of cardiovascular disease? Is it a feasible therapeutic target?Athanase D Protogerou
Diagnostic and Therapeutic Center, Hotel Dieu Hospital, Paris, France
J Hypertens 25:265-72. 2007.... - Myocardial perfusion and adrenergic innervation in patients with RBBB and LAfB: the effect of altering the activation sequence with right ventricular apical pacingEmmanuel N Simantirakis
Cardiology Department, University Hospital of Heraklion, Crete, Greece
Pacing Clin Electrophysiol 26:1202-7. 2003..To a smaller degree these patients reveal myocardial perfusion disturbances in which pacing has a limited medium-term effect... - Is increased brachial pulse pressure a reliable predictor of cardiovascular risk in old hypertensive subjects with metabolic syndrome?Athanase D Protogerou
Am J Hypertens 20:1024-5; author reply 1025-6. 2007 - White-coat effect in normotension and hypertensionNikos A Zakopoulos
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapoestrial University of Athens, Greece
Blood Press Monit 7:271-6. 2002..In this study, we investigated (i) the magnitude of the white-coat effect in subjects with different daytime ambulatory blood pressure levels, and (ii) the association of the white-coat effect with left ventricular mass... - Assessment of vascular wall shear stress and implications for atherosclerotic diseaseTheodore G Papaioannou
Unit of Biomedical Engineering, First Department of Cardiology, Hippocration Hospital, Medical School, National and Kapodistrian University of Athens, Iak Patatsou 13, Nea Kipseli, 113 63 Athens, Greece
Int J Cardiol 113:12-8. 2006.... - Abnormal endothelial function in female patients with hypothyroidism and borderline thyroid functionAnna G Dagre
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, 23 Ikarias Street, 14578 Ekali, Athens, Greece
Int J Cardiol 114:332-8. 2007..The aim of this study was to assess non-invasively NO-dependent endothelial function of resistance arteries in subjects with hypothyroidism of varying severity... - Indium-111 monoclonal antimyosin cardiac scintigraphy in suspected acute myocarditis: evolution and diagnostic impactZafiria J Margari
University of Athens School of Medicine, Department of Clinical Therapeutics, Alexandra' Hospital, Athens, Greece
Int J Cardiol 90:239-45. 2003..CONCLUSIONS: In patients with suspected AM a positive antimyosin scintigraphy accompanied by a non-dilated left ventricle is highly suggestive of AM, both at the early phase and 1 year after disease onset... - Common carotid artery intima-media thickness in patients with brain infarction and intracerebral haemorrhageKonstantinos N Vemmos
Department of Clinical Therapeutics, University of Athens, Alexandra Hospital, Athens, Greece
Cerebrovasc Dis 17:280-6. 2004..1 mm CCA-IMT increase was 1.29 (95% CI: 1.03-1.61). The present results demonstrate the possible predictive power of non-invasive measurement of the CCA-IMT with respect to BI versus ICH and deserve further investigation... - Effect of ascorbic acid on forearm reactive hyperaemia in patients with hypercholesterolaemiaAthanassios D Protogerou
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Eur J Cardiovasc Prev Rehabil 11:149-54. 2004..Reactive hyperaemia seems to be at least partly endothelium-dependent. Endothelial dysfunction has been described in patients with hypercholesterolaemia, and has been reversed with ascorbic acid administration... - Transmission of calibration errors (input) by generalized transfer functions to the aortic pressures (output) at different hemodynamic statesTheodore G Papaioannou
Unit of Biomedical Engineering, First Department of Cardiology, Hippokration Hospital, and Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National University of Athens, Greece
Int J Cardiol 110:46-52. 2006.... - Tamoxifen improves endothelial function and reduces carotid intima-media thickness in postmenopausal womenKimon S Stamatelopoulos
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece
Am Heart J 147:1093-9. 2004..Although the presence of a history with tamoxifen treatment is related to a lower intima-media thickness (IMT) of the common carotid artery, data from controlled follow-up studies are lacking to support this observation... - Red wine acutely induces favorable effects on wave reflections and central pressures in coronary artery disease patientsKalliopi N Karatzi
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
Am J Hypertens 18:1161-7. 2005.... - Arterial stiffness assessed by pulse wave analysis in essential hypertension: relation to 24-h blood pressure profileJohn P Lekakis
Department of Clinical Therapeutics, Alexandra University Hospital, 12 Iridanou Str 11528 Athens, Greece
Int J Cardiol 102:391-5. 2005..The purpose of the present study was to relate systemic arterial stiffness assessed by pulse wave analysis to variables of 24-h ambulatory blood pressure monitoring (ABPM) in patients with essential hypertension... - New aspects on the role of blood pressure and arterial stiffness in mechanical assistance by intra-aortic balloon pump: in-vitro data and their application in clinical practiceTheodoros G Papaioannou
Laboratory of Biofluid Mechanics and Biomedical Technology, Fluids Section, School of Mechanical Engineering, National Technical University of Athens, Athens, Greece
Artif Organs 28:717-27. 2004..The present study provides evidence concerning the hemodynamic conditions, which might lead to optimization of IABP or to the prediction of its acute hemodynamic performance, based on both measurements of AC and blood pressure... - Arterial wave reflection is associated with severity of extracoronary atherosclerosis in patients with coronary artery diseaseJohn P Lekakis
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Greece
Eur J Cardiovasc Prev Rehabil 13:236-42. 2006..We investigated whether arterial wave reflection may detect atherosclerosis of peripheral arteries in patients with documented coronary artery disease (CAD)...