Research Topics
Genomes and GenesSpecies | Gerasimos E KrassasSummaryAffiliation: University of Athens Country: Greece Publications
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Detail Information
Publications
Clinical and endocrine responses to pituitary radiotherapy in pediatric Cushing's disease: an effective second-line treatmentHelen L Storr
Department of Endocrinology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London EC1A 7BE, United Kingdom
J Clin Endocrinol Metab 88:34-7. 2003..GH deficiency occurred in 86% patients. Long-term follow-up suggests some recovery of GH secretion and preservation of other anterior pituitary function...
Thyroid disease and male reproductive functionG E Krassas
Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki, Greece
J Endocrinol Invest 26:372-80. 2003..The effects of hypothyroidism on male reproduction appear to be more subtle than those of hyperthyroidism and reversible. Severe, prolonged hypothyroidism in childhood may be associated with permanent abnormalities in gonadal function...
Gonadal effect of radiation from 131I in male patients with thyroid carcinomaG E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Arch Androl 51:171-5. 2005..Sperm banking should be considered in patients likely to be given cumulative doses greater than 14 GBq of 131I. However, the patient's threshold for sperm banking might be even lower than that...
Prevalence and trends of obesity in children and adults of South EuropeThemistoklis Tzotzas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki-Greece
Pediatr Endocrinol Rev 1:448-54. 2004..Genetic factors could also play a role. Preventive and treatment strategies are urgently needed to stop the obesity epidemic in children of Southern European countries...
[Body composition analysis in obesity: radionuclide and non radionuclide methods]Themistoklis Tzotzas
Clinic of Endocrinology, Diabetes and Metabolism, Panagia Hospital, N Plastira 22, 551 32 N Krini, Thessaloniki, Macedonia, Greece
Hell J Nucl Med 11:63-71. 2008..Measurements of skin fold thickness combined with BIA are quite sufficient for routine clinical practice. However, in specialized clinics and in research, more sophisticated methods like ADP or DEXA are used...
Pharmacological treatment of hyperthyroidism during lactation: review of the literature and novel dataSpiros Karras
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Pediatr Endocrinol Rev 8:25-33. 2010..Its use might be accepted in the first trimester of pregnancy for severe thyrotoxicosis or for patients with previous MMI adverse reactions. Considering the potential harmful effects of PTU, MMI should be used instead during lactation...
Smoking and autoimmune thyroid disease: the plot thickensGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Tsimiski 92, Thessaloniki 54622, Greece
Eur J Endocrinol 154:777-80. 2006..There is concern also about the effect of passive smoking on autoimmune thyroid disease. In a recent study it has been shown that the latter may have a deleterious effect on childhood GO...
Prevalence of overweight and obesity among children and adolescents in Thessaloniki-Greece and Kayseri-TurkeyGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki Greece
Pediatr Endocrinol Rev 1:460-4. 2004..Differences in lifestyle and socioeconomic status in the two regions are most probably responsible for these results...
Do obese children become obese adults: childhood predictors of adult diseaseGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki Greece
Pediatr Endocrinol Rev 1:455-9. 2004..Avoidance of accelerated weight gain in children should be investigated as a toll of adult obesity prevention...
Endocrine abnormalities in Anorexia NervosaGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Pediatr Endocrinol Rev 1:46-54. 2003..Dexamethasone suppression test is abnormal. Sex steroids are decreased. Finally leptin levels are decreased in patients with AN while ghrelin levels are elevated. Both leptin and ghrelin levels return to control values after renutrition...
Childhood Graves' ophthalmopathy: results of a European questionnaire studyG E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Tsimiski 92, Thessaloniki, Greece 54622
Eur J Endocrinol 153:515-21. 2005..Evaluation of the frequency of Graves' ophthalmopathy (GO) and its management in children and adolescents up to 18 years old with Graves' hyperthyroidism...
Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body compositionGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Eur J Endocrinol 153:217-21. 2005..To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results...
The cost of immunosuppressive therapies currently used in patients with thyroid eye diseaseG E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
J Endocrinol Invest 27:919-23. 2004..Germany is by far the most expensive country as regards the costs of the main remedies, whereas Greece is the cheapest. Denmark is the most expensive country concerning radiotherapy, while Germany is the cheapest...
Recent developments in the medical treatment of thyroid eye diseaseG E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, N Krini Thessaloniki, Greece
Orbit 25:117-22. 2006..Such analogs are now available and under investigation in different diseases with very promising results...
Resistin levels are normal in hypothyroidism and remain unchanged after attainment of euthyroidism: relationship with insulin levels and anthropometric parametersG E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece 55132
J Endocrinol Invest 29:606-12. 2006..Resistin is not associated with serum insulin and HOMA-IR index, as well as BMI, BF, WC and BW...
Thyroid-associated ophthalmopathy in juvenile Graves' disease--clinical, endocrine and therapeutic aspectsGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
J Pediatr Endocrinol Metab 19:1193-206. 2006..Retrobulbar irradiation, which has proved beneficial in adults with TED, has no place in the treatment of juvenile GO, in view of the theoretical risk of tumor induction. The same applies to orbital decompression...
Thyroid function and human reproductive healthG E Krassas
Department of Endocrinology, Diabetes, and Metabolism, Panagia General Hospital, N Plastira 22, N Krini, 55132 Thessaloniki, Greece
Endocr Rev 31:702-55. 2010..Thyrotoxicosis during pregnancy is due to Graves' disease and gestational transient thyrotoxicosis. All antithyroid drugs cross the placenta and may potentially affect fetal thyroid function...
Corticosteroids in the medical treatment of thyroid ophthalmopathy: when and how? Somatostatin analogues: where we stand todayGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Pediatr Endocrinol Rev 7:204-9. 2010..More potent analogues, like SOM230, could prove to be the treatment of choice in moderately severe cases of GO. The latter, in contrast to the thus far used analogues, has a rather high affinity for all SM receptors except SM receptor 4...
Hypothyroidism has an adverse effect on human spermatogenesis: a prospective, controlled studyGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Thyroid 18:1255-9. 2008..Abnormalities of spermatogenesis are associated with numerous diseases and aging. The objective of this study was to investigate the impact of hypothyroidism on human spermatogenesis and different sperm function tests...
Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat?Gerasimos E Krassas
Department of Endocrinology, Diabetes, and Metabolism, Panagia General Hospital, North Plastira 22, North Krini, 55132 Thessaloniki, Greece
J Clin Endocrinol Metab 93:1815-9. 2008..Erectile dysfunction (ED) is associated with numerous diseases and aging...
Prevention of thyroid associated-ophthalmopathy in children and adults: current views and management of preventable risk factorsGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Pediatr Endocrinol Rev 4:218-24. 2007..Passive smoking seems to exacerbate autoimmune thyroid disease (AITD) in general, and may have a deleterious effect on childhood GO in particular, therefore avoidance of passive smoking is likely to be beneficial...
Appetite, adiposity, and thyroid functionGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Thyroid 17:411-2. 2007
Seasonality of month of birth of patients with Graves' and Hashimoto's diseases differ from that in the general populationGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, N Plastira 22, Thessaloniki 55132, Greece
Eur J Endocrinol 156:631-6. 2007..We aimed to test the viral hypothesis in the pathogenesis of autoimmune thyroid disease (AITD)...
Report of the 31st European Thyroid Association (ETA) annual meeting, held in Naples-Italy 2-6 September 2006Gerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Pediatr Endocrinol Rev 4:160-2. 2006
Somatostatin analogs: a new tool for the management of Graves' ophthalmopathyG E Krassas
Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki, Greece
J Endocrinol Invest 27:281-7. 2004..However, prospective placebo-controlled studies with large numbers of patients are needed before their role in the treatment of Graves' opthalmopathy is definitely established...
Male reproductive function in relation with thyroid alterationsGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, N Plastira 22, N Krini, 55132 Thessaloniki, Greece
Best Pract Res Clin Endocrinol Metab 18:183-95. 2004....
A prospective controlled study of the impact of hyperthyroidism on reproductive function in malesG E Krassas
Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132, Greece
J Clin Endocrinol Metab 87:3667-71. 2002..Restoration of sperm parameters was independent of the treatment provided for the hyperthyroid syndrome. Moreover, seminal plasma elements, such as fructose, Zn, and Mg, did not correlate with sperm density, motility, or morphology...
Determinants of body mass index in Greek children and adolescentsG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
J Pediatr Endocrinol Metab 14:1327-33; discussion 1365. 2001..These measures should be directed at families that are affected and/or concerned with obesity...
Prevalence and trends in overweight and obesity among children and adolescents in Thessaloniki, GreeceG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
J Pediatr Endocrinol Metab 14:1319-26; discussion 1365. 2001..This study demonstrates that the prevalence of overweight and obesity among schoolchildren is 22.2% and 4.1%, respectively, and has been increasing in the last decades, especially among boys...
Octreoscan in thyroid-associated ophthalmopathyGerasimos E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
Thyroid 12:229-31. 2002..It remains to be seen if orbital octreoscan will become a widely available tool in the management of patients with TAO...
Age-related changes in bone density among healthy Greek malesG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
J Endocrinol Invest 24:326-33. 2001..Currently available data are sparse and much more research is needed to increase our understanding concerning the etiology of this condition as well as illuminating the relationship between bone density and fracture...
Immunosuppressive therapy in patients with thyroid eye disease: an overview of current conceptsG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
Eur J Endocrinol 144:311-8. 2001..Other studies have argued in favor of orbital radiotherapy; however, the benefits appear to be limited to improvement of extraocular muscle dysfunction...
Thyroid disease and female reproductionG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
Fertil Steril 74:1063-70. 2000..Also to register the consequences of (131)I therapy, which is used widely in the treatment of Graves' disease and thyroid cancer, on subsequent pregnancies and on fertility in these patients...
Idiopathic juvenile osteoporosisG E Krassas
Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Ann N Y Acad Sci 900:409-12. 2000..Sex steroids are contraindicated. Bisphosphonates, calcitriol, fluoride, and calcitonin have been administered therapeuticlly, but the results were equivocal. Usually the disease remits by itself...
Disturbances of menstruation in hypothyroidismG E Krassas
Department of Endocrinology, Panagia Hospital, Thessaloniki, Greece
Clin Endocrinol (Oxf) 50:655-9. 1999..The aim of this study was to determine the frequency and type of menstrual irregularities in premenopausal hypothyroid patients...
Serum levels of tumor necrosis factor-alpha, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and soluble interleukin-1 receptor antagonist in patients with thyroid eye disease undergoing treatment with somatostatin anG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki, Greece
Thyroid 11:1115-22. 2001..In conclusion, serum levels of TNF-a, sICAM-1, and sIL-1RA were elevated in patients with active TED compared to controls. Furthermore, sICAM-1 and sVICAM-1 levels declined during the treatment with SM-a in patients with active TED...
Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye diseaseG E Krassas
Department of Endocrinology and Metabolism, Panagia General Hospital, 55132 Thessaloniki, Greece
J Clin Endocrinol Metab 88:132-5. 2003..The increased IGF levels in retrobulbar tissues previously described, appear to be independent of serum IGFs concentration and probably represent autocrine and/or paracrine activity...
Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'G E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Eur J Endocrinol 150:407-14. 2004..Until long-term data on safety are available, specifically for young children, differences between the physicians in different countries will remain...
Growth hormone, insulin growth factor-1, and igf binding protein-3 axis relationship with bone mineral density among healthy menG E Krassas
Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Arch Androl 49:191-9. 2003..No correlation was found between BMD and GH levels in the 4 skeletal sites. A positive correlation was found between BMD and IGF-I levels in 3 skeletal sites and IGFBP-3 in 2 skeletal sites...
Toxicological considerations for antithyroid drugs in childrenSpiros Karras
Panagia General Hospital, Department of Endocrinology, Diabetes and Metabolism, N Plastira, 22, N Krini 55132, Thessaloniki, Greece
Expert Opin Drug Metab Toxicol 7:399-410. 2011..That being said, PTU may be the treatment of choice during, and just before, the first trimester of pregnancy...
Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistanceThemistoklis Tzotzas
Department of Endocrinology, Diabetes, and Metabolism, Panagia General Hospital, 55132 Thessaloniki, Greece
J Clin Endocrinol Metab 95:4251-7. 2010..The objective of the study was to examine changes of 25-hydroxy-vitamin D (25OHD) and PTH blood levels 4 and 20 wk after low-calorie diet-induced weight loss...
Ophthalmic complications in juvenile Graves' Disease - clinic and therapeutic approachesGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Pediatr Endocrinol Rev 1:223-9; discussion 229. 2003..The results using SM-a in the treatment of TED seem promising, but studies with larger numbers of patients are needed before we reach any final conclusions...
Propylthiouracil hepatitis: report of a case and extensive review of the literatureEleni Memi
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
J Pediatr Endocrinol Metab 25:331-43. 2012..Finally, after recent recommendations from American Thyroid Association (ATA) and European Thyroid Association (ETA), PTU should be administered only in the first trimester of pregnancy and in cases of drug allergy to methimazole...
Basic endocrine products of adipose tissue in states of thyroid dysfunctionNikolaos Pontikides
Department of Endocrinology, Diabetes, and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Thyroid 17:421-31. 2007..The aim of this review is to summarize our current knowledge on the role of basic peptides of adipose tissue, such as adiponectin, interleukin-6, tumor necrosis factor-alpha, and resistin, in states of altered thyroid function...
Epidemiology and predisposing factors of obesity in Greece: from the Second World War until todayMaria L Roditis
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Greece
J Pediatr Endocrinol Metab 22:389-405. 2009..Other predisposing factors in Greek children are parental obesity, frequent television viewing, low rates of breastfeeding and, in adolescent girls, smoking and alcohol consumption. Emerging measures are needed to confront this epidemic...
Use of somatostatin analogues in obesityThemistoklis Tzotzas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Drugs 68:1963-73. 2008....
Serum leptin values in relation to bone density and growth hormone-insulin like growth factors axis in healthy menF Papadopoulou
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Arch Androl 50:97-103. 2004..A positive correlation was found between BMD and leptin levels in FN and T, and a negative one between leptin and IGF-1 levels. Further studies are needed before we reach final conclusions...
Pathogenesis of propylthiouracil-related hepatotoxicity in children: present conceptsSpiros Karras
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
J Pediatr Endocrinol Metab 25:623-30. 2012..Genetic factors that affect drug biotransformation could also be implicated in this mechanistic model of PTU-related hepatotoxicity. Further studies are needed to fully understand the pathophysiology of PTU-induced liver damage...
The use of sibutramine in the management of obesity and related disorders: an updateKonstantinos Tziomalos
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Vasc Health Risk Manag 5:441-52. 2009..To review the major trials that evaluated the efficacy and safety of the use of sibutramine for weight loss and the impact of this agent on obesity-related disorders...
Consequences of an intracranial germ cell-tumor in a young adolescentThemistoklis Kaltsas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki-Greece
Pediatr Endocrinol Rev 1:501-4. 2004..However, it has to be noted that 6 years is insufficient follow-up to assess late post radiation effects...
Giant prolactinoma presented as unilateral exophthalmos in a prepubertal boy: response to cabergolineG E Krassas
Department of Endocrinology and Metabolism, Panagia Hospital, Thessaloniki
Horm Res 52:45-8. 1999..It is a noninvasive treatment that can preserve and restore vision, as well as pituitary function, and is preferable to surgery or radiation in the treatment of prolactin-secreting macroadenoma in childhood and adolescence...
The efficacy of somatostatin analogues in the treatment of diabetic retinopathy and thyroid eye diseaseGerasimos E Krassas
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Clin Ophthalmol 1:209-15. 2007..This is also true for adolescent patients with thyroid eye disease, as well as for adults who also suffer from diabetes mellitus...
Imaging somatostatin receptor activity in patients with active thyroid eye disease using Tc-99m depreotideArgyrios S Doumas
Hippocrates Nuclear Medicine Center, Panagia General Hospital, Thessaloniki, Greece
Clin Nucl Med 28:439-40. 2003
Extramedullary hemopoiesis in a thyroid nodule with extensive bone metaplasia and mature bone formationNikolaos Pontikides
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Thyroid 13:877-80. 2003....
Thyroid autoimmunity and miscarriageAthina Kaprara
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
Hormones (Athens) 7:294-302. 2008....
[Selenium and thyroidal function; the role of immunoassays]Athena Kaprara
Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, N Plastora 22, 551 32 Kalamaria, Thessaloniki, Macedonia, Greece
Hell J Nucl Med 9:195-203. 2006..It is concluded that selenium plays an important role in regulating thyroid function, as well as in the homeostasis of thyroid hormones through the action of selenoproteins, in which it incorporates as selenocystein...
Orbital irradiation for thyroid-associated orbitopathy: conventional dose, low dose or no dose?Petros Perros
Endocrine Unit, Freeman Hospital, Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 56:689-91. 2002
Thyroid societies across the worldCharles H Emerson
Thyroid 18:683-5. 2008
Re: "clinical features and treatment of graves ophthalmopathy in pediatric patients"Gerasimos E Krassas
Ophthal Plast Reconstr Surg 22:405-6. 2006
A questionnaire survey concerning the most favourable treatment for Graves' disease in children and adolescentsGerasimos E Krassas
Eur J Endocrinol 151:155-6. 2004..Most of them were from Turkey and the rest, except for one who came from the USA, were Europeans. Sixty-one out of the 120 physicians responded...
Consensus statement of the European Group on Graves' orbitopathy (EUGOGO) on management of GOLuigi Bartalena
Department of Clinical Medicine, University of Insubria, 21100 Varese, Italy
Eur J Endocrinol 158:273-85. 2008
