Konstantin Krasagakis

Summary

Affiliation: University of Crete
Country: Greece

Publications

  1. ncbi KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece
    J Cell Physiol 226:1099-109. 2011
  2. ncbi Interferon-alpha inhibits proliferation and induces apoptosis of merkel cell carcinoma in vitro
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece
    Cancer Invest 26:562-8. 2008
  3. ncbi Analysis of epidemiology, clinical features and management of erysipelas
    Konstantin Krasagakis
    Department of Dermatology, University Hospital of Heraklion, Greece
    Int J Dermatol 49:1012-7. 2010
  4. ncbi Bullous erysipelas: clinical presentation, staphylococcal involvement and methicillin resistance
    Konstantin Krasagakis
    Department of Dermatology, University Hospital of Heraklion, Heraklion, Greece
    Dermatology 212:31-5. 2006
  5. ncbi Local complications of erysipelas: a study of associated risk factors
    K Krasagakis
    Department of Dermatology, University Hospital of Heraklion, Heraklion, Greece
    Clin Exp Dermatol 36:351-4. 2011
  6. ncbi Proliferation of human melanoma cells is under tight control of protein kinase C alpha
    Konstantin Krasagakis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Berlin, Germany
    J Cell Physiol 199:381-7. 2004
  7. ncbi Overview of Merkel cell carcinoma and recent advances in research
    Konstantin Krasagakis
    Department of Dermatology, University General Hospital of Heraklion, Crete, Greece
    Int J Dermatol 42:669-76. 2003
  8. ncbi Early development of multiple epithelial neoplasms in Netherton syndrome
    K Krasagakis
    Department of Dermatology, University General Hospital of Heraklion, Heraklion, Greece
    Dermatology 207:182-4. 2003
  9. ncbi Identification of the M541L sequence variation of the transmembrane KIT domain in Merkel cell carcinoma
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, GR 71003 Heraklion, Greece
    Anticancer Res 31:807-11. 2011
  10. ncbi Lack of protein kinase C (PKC)-beta and low PKC-alpha, -delta, -epsilon, and -zeta isozyme levels in proliferating human melanoma cells
    Konstantin Krasagakis
    Department of Dematology, University Medical Center Bejamin Franklin, Free University of Berlin, Germany
    Int J Oncol 20:865-71. 2002

Collaborators

Detail Information

Publications24

  1. ncbi KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece
    J Cell Physiol 226:1099-109. 2011
    ..Blockade of KIT and the downstream signaling cascade at various levels results in inhibition of Merkel cell carcinoma growth in vitro, suggesting targets for therapy of this cancer...
  2. ncbi Interferon-alpha inhibits proliferation and induces apoptosis of merkel cell carcinoma in vitro
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece
    Cancer Invest 26:562-8. 2008
    ..These findings suggest that IFN-alpha may have antitumor activity against Merkel cell carcinoma...
  3. ncbi Analysis of epidemiology, clinical features and management of erysipelas
    Konstantin Krasagakis
    Department of Dermatology, University Hospital of Heraklion, Greece
    Int J Dermatol 49:1012-7. 2010
    ..The purpose of the study was to investigate the epidemiological, clinical, and laboratory features of erysipelas and to compare the results of treatment with penicillin vs. other antibiotic regimens...
  4. ncbi Bullous erysipelas: clinical presentation, staphylococcal involvement and methicillin resistance
    Konstantin Krasagakis
    Department of Dermatology, University Hospital of Heraklion, Heraklion, Greece
    Dermatology 212:31-5. 2006
    ..Erysipelas is a bacterial infection of the dermis and hypodermis, mostly of streptococcal origin. Bullous erysipelas represents a severe form of the disease...
  5. ncbi Local complications of erysipelas: a study of associated risk factors
    K Krasagakis
    Department of Dermatology, University Hospital of Heraklion, Heraklion, Greece
    Clin Exp Dermatol 36:351-4. 2011
    ..Local complications of erysipelas include haemorrhagic, bullous, abscessing and necrotic lesions. The risk factors predisposing patients to local complications are not fully known...
  6. ncbi Proliferation of human melanoma cells is under tight control of protein kinase C alpha
    Konstantin Krasagakis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Berlin, Germany
    J Cell Physiol 199:381-7. 2004
    ..The presented data demonstrate a cause-effect relationship between PKC-alpha and melanoma cell growth, whereby PKC-alpha reversely influences the rate of cell proliferation...
  7. ncbi Overview of Merkel cell carcinoma and recent advances in research
    Konstantin Krasagakis
    Department of Dermatology, University General Hospital of Heraklion, Crete, Greece
    Int J Dermatol 42:669-76. 2003
  8. ncbi Early development of multiple epithelial neoplasms in Netherton syndrome
    K Krasagakis
    Department of Dermatology, University General Hospital of Heraklion, Heraklion, Greece
    Dermatology 207:182-4. 2003
    ..The occurrence of cutaneous neoplasia has been reported in syndromes with congenital ichthyosis and suggests that the underlying genetic defects may cause the development of cancer in prone patients...
  9. ncbi Identification of the M541L sequence variation of the transmembrane KIT domain in Merkel cell carcinoma
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, GR 71003 Heraklion, Greece
    Anticancer Res 31:807-11. 2011
    ..KIT mutations are considered to play a key role in the pathogenesis of various neoplasms, but have not been found so far in MCC. The aim of the present study was therefore to investigate the presence of KIT mutations in MCC...
  10. ncbi Lack of protein kinase C (PKC)-beta and low PKC-alpha, -delta, -epsilon, and -zeta isozyme levels in proliferating human melanoma cells
    Konstantin Krasagakis
    Department of Dematology, University Medical Center Bejamin Franklin, Free University of Berlin, Germany
    Int J Oncol 20:865-71. 2002
    ..These data suggest that certain PKC isozymes are involved in the intracellular signalling that regulates melanoma cell proliferation, and may function as suppressors of tumour cell growth...
  11. ncbi Co-expression of KIT receptor and its ligand stem cell factor in Merkel cell carcinoma
    Konstantin Krasagakis
    Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece
    Dermatology 218:37-43. 2009
    ..Merkel cell carcinoma (MCC) is a rare KIT-positive cutaneous tumor. We investigated the co-expression of KIT and its ligand stem cell factor (SCF) in MCC...
  12. ncbi Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta
    Melanthia Stavroulaki
    Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece
    J Cell Physiol 214:363-70. 2008
    ..This may represent an important mechanism for expansion of melanocytes exposed to PKC-targeting tumor promoters...
  13. ncbi Prehistological evaluation of benign and malignant pigmented skin lesions with optical computed tomography
    Athanasios Kokolakis
    University of Crete, University Hospital of Heraklion, Pigmented Lesion and Melanoma Clinic, Department of Dermatology, 71110, Voutes, Heraklion, Crete, Greece
    J Biomed Opt 17:066004. 2012
    ..Our results suggest that optical-CT can be important for the immediate prehistological evaluation of biopsies, assisting the physician for a rapid assessment of malignancy and of the thickness of a melanocytic lesion...
  14. ncbi Invasive cutaneous infection with Geotrichum candidum: sequential treatment with amphotericin B and voriconazole
    Andreas Sfakianakis
    Department of Dermatology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Med Mycol 45:81-4. 2007
    ....
  15. ncbi The role of endothelial cell apoptosis in the effect of etanercept in psoriasis
    G Avramidis
    Department of Dermatology, University General Hospital of Heraklion, GR 71110 Heraklion Crete, Greece
    Br J Dermatol 163:928-34. 2010
    ..Tumour necrosis factor (TNF)-α is a proinflammatory cytokine that can induce antiapoptotic proteins and endothelial cell activation factors in psoriasis...
  16. ncbi Langerhans' cell histiocytosis and haemophagocytic lymphohistiocytosis in an elderly patient
    D Ioannidou
    Department of Dermatology, Heraklion University General Hospital, Crete, Greece
    J Eur Acad Dermatol Venereol 17:702-5. 2003
    ..The present case of Langerhans' cell histiocytosis is of particular interest because of the previously unreported development of haemophagocytic lymphohistiocytosis in the elderly population...
  17. ncbi Retiform hemangioendothelioma presenting as bruise-like plaque in an adult woman
    Despina Ioannidou
    Department of Dermatology, Heraklion University General Hospital, Heraklion, Crete, Greece
    Int J Dermatol 45:53-5. 2006
  18. ncbi Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy
    George Evangelou
    Department of Dermatology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Photodermatol Photoimmunol Photomed 27:254-6. 2011
    ..We report on the successful treatment of a 69-year-old patient with a relapse of long-standing cutaneous leishmaniasis using intralesional aminolevulinic acid-PDT...
  19. ncbi Direct effects on proliferation, antigen expression and melanin synthesis of cultured normal human melanocytes in response to UVB and UVA light
    M Badawy Abdel-Naser
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Photodermatol Photoimmunol Photomed 19:122-7. 2003
    ..As epidermal melanocytes are seen as the major targets of UV light, the present study was conducted to evaluate the direct effects of UVA and UVB irradiation on melanocytes in vitro...
  20. ncbi Primary care and pattern of skin diseases in a Mediterranean island
    Emmanouil K Symvoulakis
    Department of Social Medicine, Faculty of Medicine, University of Crete, Greece
    BMC Fam Pract 7:6. 2006
    ....
  21. ncbi Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge
    Despina I Ioannidou
    Department of Dermatology, University General Hospital of Heraklion, Crete, Greece
    J Am Acad Dermatol 52:41-4. 2005
    ..This case is unique in that the periorbital swelling remained as the sole clinical manifestation of scleredema during the 5-year follow-up and was complicated with partial vision blockage...
  22. ncbi Growth and characterization of a cell line from a human primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma) in culture and as xenograft
    K Krasagakis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    J Cell Physiol 187:386-91. 2001
    ..The MCC-1 line may thus serve as a model for studying the biology and the metastatic potential of Merkel cell carcinoma...
  23. ncbi Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro
    J Eberle
    Department of Dermatology, Benjamin Franklin University Medical Center, The Free University of Berlin, Germany
    Int J Cancer 71:396-401. 1997
    ..Cultures of congenital melanocytic nevi exhibited intermediate expression of eIF-4A1. Thus, eIF-4A1 overexpression seems to be an important feature of melanoma cells and might contribute to their malignant transformation...
  24. ncbi Cutaneous small vessel vasculitis: an entity with frequent renal involvement
    Despina J Ioannidou
    Arch Dermatol 138:412-4. 2002