Michael Koutsilieris


Affiliation: University of Athens
Country: Greece


  1. Sfakianoudis K, Simopoulou M, Maziotis E, Giannelou P, Tsioulou P, Rapani A, et al. Evaluation of the Second Follicular Wave Phenomenon in Natural Cycle Assisted Reproduction: A Key Option for Poor Responders through Luteal Phase Oocyte Retrieval. Medicina (Kaunas). 2019;55: pubmed publisher
  2. Simopoulou M, Sfakianoudis K, Maziotis E, Grigoriadis S, Giannelou P, Rapani A, et al. The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review. Int J Mol Sci. 2019;20: pubmed publisher
    ..The conduction of well-designed prospective cohort studies is an absolute necessity in order to define the impact of the different types of autoantibodies on IVF outcome. ..
  3. Sfakianoudis K, Simopoulou M, Nitsos N, Rapani A, Pappas A, Pantou A, et al. Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause. J Clin Med. 2018;8: pubmed publisher
    ..This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation. ..
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    Karavitakis M, Msaouel P, Michalopoulos V, Koutsilieris M. Pattern of somatostatin receptors expression in normal and bladder cancer tissue samples. Anticancer Res. 2014;34:2937-42 pubmed
    ..Our results demonstrate, for the first time, that there is expression of SSTR in normal and bladder cancer urothelium. Further studies are required to evaluate the prognostic and therapeutic significance of these findings. ..
  5. Simopoulou M, Sfakianoudis K, Bakas P, Giannelou P, Papapetrou C, Kalampokas T, et al. Postponing Pregnancy Through Oocyte Cryopreservation for Social Reasons: Considerations Regarding Clinical Practice and the Socio-Psychological and Bioethical Issues Involved. Medicina (Kaunas). 2018;54: pubmed publisher
  6. Papageorgiou E, Philippou A, Armakolas A, Christopoulos P, Dimakakos A, Koutsilieris M. The human Ec peptide: the active core of a progression growth factor with species-specific mode of action. Hormones (Athens). 2016;15:423-434 pubmed publisher
    ..By analyzing the bioactivity of synthetic hEc fragments, we documented that hEc's active core is located in the last 4aa of its C-terminal end. The hEc peptide is an important progression factor for human PC-3 prostate cancer cells. ..
  7. Philippou A, Maridaki M, Tenta R, Koutsilieris M. Hormonal responses following eccentric exercise in humans. Hormones (Athens). 2017;16:405-413 pubmed publisher
  8. Nitsa A, Toutouza M, Machairas N, Mariolis A, Philippou A, Koutsilieris M. Vitamin D in Cardiovascular Disease. In Vivo. 2018;32:977-981 pubmed publisher
    ..However, it is still unclear whether the plasma 25-hydroxyvitamin D level can be used as a biomarker for future cardiovascular disease. Herein we review the studies reporting a causative role for vitamin D in cardiovascular disease. ..
  9. Mourmouras N, Philippou A, Christopoulos P, Kostoglou K, Grivaki C, Konstantinidis C, et al. Differential Expression of IGF-I Transcripts in Bladder Cancer. Anticancer Res. 2018;38:3453-3459 pubmed publisher
    ..These findings suggest that IGF-IEc expression and putative Ec product may possess discrete biological role in disease progression beyond IGF-I. ..

More Information


  1. Christopoulos P, Msaouel P, Koutsilieris M. The role of the insulin-like growth factor-1 system in breast cancer. Mol Cancer. 2015;14:43 pubmed publisher
    ..In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies. ..
  2. Armakolas N, Armakolas A, Antonopoulos A, Dimakakos A, Stathaki M, Koutsilieris M. The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology. Crit Rev Oncol Hematol. 2016;108:137-145 pubmed publisher
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    Gkioka E, Msaouel P, Philippou A, Vlaghogiannis N, Vogkou C, Margiolis A, et al. Review: The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma. In Vivo. 2015;29:637-49 pubmed
    ..Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth. ..
  4. Vassilakos G, Philippou A, Koutsilieris M. Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans. Growth Horm IGF Res. 2017;32:22-28 pubmed publisher
    ..The findings of this study possibly imply that the post-translational modification of the IGF-1Ec pro-peptide may regulate the bioavailability and activity of the processing product(s). ..
  5. Philippou A, Christopoulos P, Koutsilieris D. Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer. Mutat Res Rev Mutat Res. 2017;772:105-122 pubmed publisher
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    Christopoulos P, Vlachogiannis N, Vogkou C, Koutsilieris M. The Role of the Androgen Receptor Signaling in Breast Malignancies. Anticancer Res. 2017;37:6533-6540 pubmed
    ..Herein, we review the role of AR signaling in BrCa and the molecular cross-talk mechanisms with other molecules/pathways, as well as its therapeutic implications in the different subtypes of the disease...
  7. Gravani F, Papadaki I, Antypa E, Nezos A, Masselou K, Ioakeimidis D, et al. Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren's syndrome: prevalence, clinical and laboratory associations. Arthritis Res Ther. 2015;17:99 pubmed publisher
    ..Wnt signaling mediators are potentially involved in the pathogenesis of both entities. ..
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    Papaoiconomou E, Lymperi M, Petraki C, Philippou A, Msaouel P, Michalopoulou F, et al. Kiss-1/GPR54 protein expression in breast cancer. Anticancer Res. 2014;34:1401-7 pubmed
    ..Herein, we investigated the protein expression of Kiss-1 and its receptor GPR54 in breast cancer tissues compared to non-cancerous mammary tissues...
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    Christopoulos P, Papageorgiou E, Petraki C, Koutsilieris M. The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells. Anticancer Res. 2017;37:2899-2912 pubmed
    ..hEc stimulates the proliferation and migration of MCF-7 breast cancer cells and enhances the intracellular ERK1/2 signaling. ..