I E Koutroubakis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. pmc Colonic tuberculosis mimicking Crohn's disease: case report
    Constantinos Chatzicostas
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    BMC Gastroenterol 2:10. 2002
  2. pmc A case of sigmoid endometriosis difficult to differentiate from colon cancer
    Philippos Dimoulios
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    BMC Gastroenterol 3:18. 2003
  3. ncbi The patient with persistent perianal fistulae
    Ioannis E Koutroubakis
    Department of Gastroenterology University Hospital Heraklion, P O Box 1352, 71110 Heraklion, Crete, Greece
    Best Pract Res Clin Gastroenterol 21:503-18. 2007
  4. ncbi Active inflammatory bowel disease: evaluation with 99mTc (V) DMSA scintigraphy
    Ioannis E Koutroubakis
    Departments of Gastroenterology and Nuclear Medicine, University Hospital Heraklion, Voutes, 71110 Heraklion, Crete, Greece
    Radiology 229:70-4. 2003
  5. ncbi Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anaemia: a pilot study
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 18:421-5. 2006
  6. pmc Serum laminin and collagen IV in inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology University Hospital Heraklion, 71110 Heraklion, Crete, Greece
    J Clin Pathol 56:817-20. 2003
  7. ncbi Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Greece
    Eur J Clin Invest 36:127-32. 2006
  8. ncbi The spectrum of segmental colitis associated with diverticulosis
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Int J Colorectal Dis 20:28-32. 2005
  9. ncbi Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, P O Box 1352, Heraklion 71110, Greece
    Dig Dis Sci 49:1433-7. 2004
  10. ncbi Pancreatic autoantibodies in Greek patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital, Heraklion, Greece
    Dig Dis Sci 50:2330-4. 2005

Collaborators

  • Niki Malliaraki
  • Dimitrios Drygiannakis
  • Ioannis G Vlachonikolis
  • Anastasia Kapsoritaki
  • I A Mouzas
  • A N Kapsoritakis
  • John Mouzas
  • Alexandra Giatromanolaki
  • G Kolios
  • E Vardas
  • Elias A Kouroumalis
  • Konstantinos Karmiris
  • Angeliki Theodoropoulou
  • Maria I Stathaki
  • L A Bourikas
  • Nikolaos S Karkavitsas
  • Sophia I Koukouraki
  • Philippos Dimoulios
  • Aekaterini Sfiridaki
  • G Tsiolakidou
  • M Tzardi
  • Costas Xidakis
  • Maria Polychronaki
  • Demetrios N Samonakis
  • Pavlos Antoniou
  • Maria Tzardi
  • Constantinos Chatzicostas
  • Despina S Kyriakou
  • Joanna A Moschandreas
  • Aekaterini Boumpaki
  • Konstantinos P Karmiris
  • E A Kouroumalis
  • Gregorios Paspatis
  • Pantelis Oustamanolakis
  • A Hatzidakis
  • Aekaterini Livadiotaki
  • Theodora Voudouri
  • John Romanos
  • Ioannis M Matalliotakis
  • Emmanouel Matalliotakis
  • George Chalkiadakis
  • Freda H Passam
  • Taxiarchis V Kourelis
  • Orestis N Manoussos
  • Panagiotis Prassopoulos
  • Kalliopi Foundouli
  • Michael G Alexandrakis
  • Maria Roussomoustakaki

Detail Information

Publications47

  1. pmc Colonic tuberculosis mimicking Crohn's disease: case report
    Constantinos Chatzicostas
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    BMC Gastroenterol 2:10. 2002
    ..Intestinal tuberculosis is a diagnostic challenge, especially when active pulmonary infection is absent. It may mimic many other abdominal diseases...
  2. pmc A case of sigmoid endometriosis difficult to differentiate from colon cancer
    Philippos Dimoulios
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    BMC Gastroenterol 3:18. 2003
    ....
  3. ncbi The patient with persistent perianal fistulae
    Ioannis E Koutroubakis
    Department of Gastroenterology University Hospital Heraklion, P O Box 1352, 71110 Heraklion, Crete, Greece
    Best Pract Res Clin Gastroenterol 21:503-18. 2007
    ..In persistent complex perianal fistulae where medical treatment initially fails, examination under anaesthesia and placement of non-cutting setons, when necessary, combined with medical treatment results in higher healing rates...
  4. ncbi Active inflammatory bowel disease: evaluation with 99mTc (V) DMSA scintigraphy
    Ioannis E Koutroubakis
    Departments of Gastroenterology and Nuclear Medicine, University Hospital Heraklion, Voutes, 71110 Heraklion, Crete, Greece
    Radiology 229:70-4. 2003
    ..To evaluate the use of pentavalent (V) technetium 99m (99mTc) dimercaptosuccinic acid (DMSA) scintigraphy for the assessment of disease activity in patients with inflammatory bowel disease (IBD)...
  5. ncbi Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anaemia: a pilot study
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 18:421-5. 2006
    ..Darbepoetin-alpha (DPO) has a three-fold longer terminal half-life than erythropoietin. The purpose of this pilot study was to determine whether darbepoetin-alpha is also effective for the treatment of refractory anaemia in IBD...
  6. pmc Serum laminin and collagen IV in inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology University Hospital Heraklion, 71110 Heraklion, Crete, Greece
    J Clin Pathol 56:817-20. 2003
    ....
  7. ncbi Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Greece
    Eur J Clin Invest 36:127-32. 2006
    ..The aim of the study was to evaluate the serum markers of angiogenesis angiopoietin-2 (Ang-2) and soluble angiopoietin receptor Tie-2 in patients with ulcerative colitis (UC) and Crohn's disease (CD)...
  8. ncbi The spectrum of segmental colitis associated with diverticulosis
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Int J Colorectal Dis 20:28-32. 2005
    ..Distinguishing this condition from inflammatory bowel disease may be difficult. Our aim was to evaluate the epidemiological and clinical characteristics of SCAD in our area...
  9. ncbi Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, P O Box 1352, Heraklion 71110, Greece
    Dig Dis Sci 49:1433-7. 2004
    ..The decreased antioxidant defenses may be a primary phenomenon severely compromising the mucosa and therefore increase susceptibility to oxidative tissue damage...
  10. ncbi Pancreatic autoantibodies in Greek patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital, Heraklion, Greece
    Dig Dis Sci 50:2330-4. 2005
    ..In contrast to these studies we found also increased prevalence of PAbs in UC patients. These findings suggest that PAbs should be considered as a specific marker for IBD rather than for CD...
  11. ncbi Increased serum levels of YKL-40 in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, P O Box 1352, 71110 Heraklion, Crete, Greece
    Int J Colorectal Dis 18:254-9. 2003
    ..YKL-40 has been proposed as a new serum marker of fibrosis. We studied compared the serum levels of YKL-40 in patients with ulcerative colitis or Crohn's disease with inflammatory and healthy controls...
  12. pmc Role of scintigraphy in inflammatory bowel disease
    Maria I Stathaki
    Department of Gastroenterology, Medicine University Hospital of Heraklion, PO Box 1352, 71110 Heraklion, Crete, Greece
    World J Gastroenterol 15:2693-700. 2009
    ..Positron emission tomography alone or with computed tomography using fluorine-18 fluorodeoxyglucose appears to be a promising method of measuring inflammation in IBD patients...
  13. ncbi Role of thrombotic vascular risk factors in inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Greece
    Dig Dis 18:161-7. 2000
    ..In conclusion the resultant gene-gene and gene-environment interactions between risk factors are the key to the understanding of why an IBD patient develops thrombosis at a specific point in time...
  14. ncbi Genetic risk factors in patients with inflammatory bowel disease and vascular complications: case-control study
    I E Koutroubakis
    Department of Gastroenterology University Hospital Heraklion, Crete, Greece
    Inflamm Bowel Dis 13:410-5. 2007
    ..The aim of the present study was to investigate the role of mutations associated with cardiovascular disease in IBD patients with or without vascular complications compared with thrombotic and healthy controls (HC)...
  15. ncbi Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Gastroenterology 121:561-5. 2001
    ..Aim of this study was to assess this hypothesis investigating the role of acquired and hereditary thrombotic risk factors in patients with definite diagnosis of colon ischemia...
  16. ncbi Increased levels of lipoprotein (a) in Crohn's disease: a relation to thrombosis?
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 13:1415-9. 2001
    ....
  17. ncbi Therapy insight: Vascular complications in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Nat Clin Pract Gastroenterol Hepatol 2:266-72. 2005
    ..Antithrombotic treatment of IBD patients with venous thromboembolism is similar to that of thrombotic non-IBD patients...
  18. ncbi Circulating soluble vascular adhesion protein 1 in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110 Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 14:405-8. 2002
    ....
  19. ncbi Role of appendicitis and appendectomy in the pathogenesis of ulcerative colitis: a critical review
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Inflamm Bowel Dis 8:277-86. 2002
    ..Further investigation of the role of appendectomy in UC is expected to open new fields for basic scientific research and may lead to the improvement of our understanding for the disease pathogenesis...
  20. ncbi Role of angiogenesis in inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece
    Inflamm Bowel Dis 12:515-23. 2006
    ..This review outlines the evidence that the rate of angiogenesis is increased in the inflamed intestine in IBD and proposes lines for future research in this field...
  21. ncbi Serum angiogenin in inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece
    Dig Dis Sci 49:1758-62. 2004
    ..Serum angiogenin is elevated in patients with IBD. The increased serum angiogenin suggests that angiogenin may mediate angiogenesis and vascular permeability in the mucosa of patients with IBD...
  22. ncbi Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease
    Konstantinos Karmiris
    Department of Gastroenterology, University Hospital, Heraklion, Crete, Greece
    Inflamm Bowel Dis 12:100-5. 2006
    ....
  23. ncbi Anti-Saccharomyces cerevisiae mannan antibodies and antineutrophil cytoplasmic autoantibodies in Greek patients with inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Am J Gastroenterol 96:449-54. 2001
    ..Measurement of pANCA and ASCA together has a rather limited value in the differential diagnosis between UC and CD but may be of help in studying disease heterogeneity...
  24. doi Increased expression of VEGF and CD146 in patients with inflammatory bowel disease
    G Tsiolakidou
    Departments of Gastroenterology and Pathology, University Hospital Heraklion, Crete, Greece
    Dig Liver Dis 40:673-9. 2008
    ..We investigated the expression of tissue vascular endothelial growth factor, CD34 and CD146 in the inflamed mucosa of patients with active inflammatory bowel disease compared with no inflamed mucosa of healthy controls...
  25. ncbi Association between enhanced soluble CD40 ligand and prothrombotic state in inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology University Hospital Heraklion and Regional Blood Bank Center Venizelion Hospital Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 16:1147-52. 2004
    ....
  26. ncbi Mean platelet volume: a useful marker of inflammatory bowel disease activity
    A N Kapsoritakis
    Department of Gastroenterology, University Hospital of Crete, Greece
    Am J Gastroenterol 96:776-81. 2001
    ..We propose that mean platelet volume provides a useful marker of activity in inflammatory bowel disease...
  27. ncbi The effect of infliximab on circulating levels of leptin, adiponectin and resistin in patients with inflammatory bowel disease
    Konstantinos Karmiris
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 19:789-94. 2007
    ..Infliximab is a well established antitumour necrosis factor alpha treatment in IBD...
  28. doi Plasma thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 levels in inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 20:912-6. 2008
    ..As plasminogen activator inhibitor-1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) are inhibitors of fibrinolysis, we studied TAFI as well as PAI-1 plasma levels in IBD patients compared with healthy controls...
  29. doi Leptin, adiponectin, resistin, and ghrelin--implications for inflammatory bowel disease
    Konstantinos Karmiris
    Department of Gastroenterology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Mol Nutr Food Res 52:855-66. 2008
    ..A specific role for hypertrophic WAT has also been implicated in CD. Further efforts with experimental and clinical studies are needed to better understand the role of adipokines in IBD...
  30. doi Effects of tumor necrosis factor alpha inhibition with infliximab on lipid levels and insulin resistance in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 21:283-8. 2009
    ..The aim of this study was to assess the in-vivo TNF-alpha-mediated regulation of insulin resistance and of lipid levels in patients with IBD...
  31. doi Safety and efficacy of total-dose infusion of low molecular weight iron dextran for iron deficiency anemia in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece
    Dig Dis Sci 55:2327-31. 2010
    ..Low molecular weight (LMW) iron dextran has the ability to administer the patient's total iron requirement in a single infusion...
  32. ncbi Active inflammatory bowel disease: head-to-head comparison between 99mTc-hexamethylpropylene amine oxime white blood cells and 99mTc(V)-dimercaptosuccinic acid scintigraphy
    Maria I Stathaki
    Department of Nuclear Medicine, University Hospital of Heraklion, Medical School, University of Crete, Crete, Greece
    Nucl Med Commun 29:27-32. 2008
    ....
  33. ncbi Anti-TNF and fistulizing perianal Crohn's disease: use in clinical practice
    L A Bourikas
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Curr Drug Targets 11:187-97. 2010
    ..Large randomised studies are required for the long-term evaluation of the efficacy in modifying the disease course of this combined approach...
  34. ncbi Small bowel perforation due to non-Hodgkin-lymphoma in a patient with ulcerative colitis and systemic lupus erythematosus
    L A Bourikas
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Dig Liver Dis 40:144. 2008
  35. pmc Is there a role for Tc-99m (V) DMSA scintigraphy in ischemic colitis?
    Maria I Stathaki
    University Hospital Heraklion, Department of Gastroenterology, Heraklion, Crete, Greece
    World J Gastroenterol 14:5432-5. 2008
    ..To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis...
  36. ncbi Resistin: another rising biomarker in inflammatory bowel disease?
    Konstantinos Karmiris
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 19:1035-7. 2007
    ....
  37. ncbi Acquired inhibitors to coagulation factors in patients with gastrointestinal diseases
    Despina S Kyriakou
    Department of Haematology, University Hospital of Heraklion, Crete, Greece
    Eur J Gastroenterol Hepatol 14:1383-7. 2002
    ..To study the frequency and specificity of acquired coagulation inhibitors in inflammatory and malignant gastrointestinal diseases...
  38. pmc Ischemic colitis: clinical practice in diagnosis and treatment
    Angeliki Theodoropoulou
    Gastroenterology Unit Venizelion General Hospital of Heraklion, Heraklion 71110, Crete, Greece
    World J Gastroenterol 14:7302-8. 2008
    ..Most cases of the non-gangrenous form are transient and resolve spontaneously without complications. On the other hand, high morbidity and mortality and urgent operative intervention are the hallmarks of gangrenous ischemic colitis...
  39. doi Genetic risk factors in young patients with ischemic colitis
    Angeliki Theodoropoulou
    Gastroenterology Unit, Venizelion General Hospital of Heraklion, Heraklion, Crete, Greece
    Clin Gastroenterol Hepatol 6:907-11. 2008
    ..The aim of this study was to investigate the prevalence and possible role of mutations associated with cardiovascular morbidity in young patients with IC...
  40. ncbi Hypercoagulable states in patients with hepatocellular carcinoma
    Demetrios N Samonakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Dig Dis Sci 49:854-8. 2004
    ..In conclusion, thrombophilic defects are common in HCC patients and they might contribute to the observed thrombotic complications in this malignancy...
  41. ncbi The emerging role of adipocytokines as inflammatory mediators in inflammatory bowel disease
    Konstantinos Karmiris
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Inflamm Bowel Dis 11:847-55. 2005
    ..Moreover, modulators of mesenteric adipose function have been suggested as potential therapeutic drugs in IBD. In this review, the importance of white adipose tissue function and adipocytokines, is discussed with respect to IBD...
  42. ncbi Inherited thrombophilia and thrombosis in inflammatory bowel disease
    Ioannis E Koutroubakis
    Am J Gastroenterol 101:403; author reply 403-4. 2006
  43. ncbi (99m)Tc-Leucoscan in the evaluation of inflammatory bowel disease
    Andreas N Kapsoritakis
    Eur J Nucl Med Mol Imaging 29:1098. 2002
  44. ncbi Antibodies against cyclic citrullinated peptide (CCP) in inflammatory bowel disease patients with or without arthritic manifestations
    Ioannis E Koutroubakis
    Inflamm Bowel Dis 13:504-5. 2007
  45. ncbi Treatment of oesophageal Crohn's disease with infliximab
    Angeliki Theodoropoulou
    Eur J Gastroenterol Hepatol 16:431-2. 2004
  46. ncbi Low plasma protein Z levels in patients with ischemic colitis
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Dig Dis Sci 48:1673-6. 2003
    ..2%) compared to one with diverticulitis (7.7%) and one healthy control (3.0%). In conclusion, our results suggest that low plasma protein Z levels may play a role in the disease development in some cases with ischemic colitis...
  47. ncbi Acquired and hereditary thrombotic risk factors in patients with acute mesenteric vein thrombosis
    Philippos Dimoulios
    Am J Gastroenterol 97:768-9. 2002