Evangelia Kitsiou

Summary

Affiliation: University of Ioannina
Country: Greece

Publications

  1. ncbi Non-replication and inconsistency in the genome-wide association setting
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Biomedical Research Institute Foundation for Research and Technology Hellas, Ioannina, Greece
    Hum Hered 64:203-13. 2007
  2. ncbi Measuring co-authorship and networking-adjusted scientific impact
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    PLoS ONE 3:e2778. 2008
  3. ncbi Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Trials 11:85. 2010
  4. ncbi Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, Athens, Greece
    Behav Brain Funct 4:46. 2008
  5. ncbi Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions
    G N Papanikolaou
    Clinical Trials and Evidence Based Medicine Unit, and Social Medicine and Public Health Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMC Med Res Methodol 1:3. 2001
  6. ncbi Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment
    Ajay Yesupriya
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    BMC Med Res Methodol 8:31. 2008
  7. ncbi Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies
    A B Haidich
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMC Med Res Methodol 1:4. 2001
  8. ncbi International ranking systems for universities and institutions: a critical appraisal
    John P A Ioannidis
    BMC Med 5:30. 2007
  9. ncbi Appendicectomies in Albanians in Greece: outcomes in a highly mobile immigrant patient population
    A Tatsioni
    Department of Hygiene and Epidemiology, Medical School, University of loannina, 451 10 Ioannina, Greece
    BMC Health Serv Res 1:5. 2001
  10. ncbi A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi Non-replication and inconsistency in the genome-wide association setting
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Biomedical Research Institute Foundation for Research and Technology Hellas, Ioannina, Greece
    Hum Hered 64:203-13. 2007
    ..A list of options is presented for consideration in each of these scenarios...
  2. ncbi Measuring co-authorship and networking-adjusted scientific impact
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    PLoS ONE 3:e2778. 2008
    ..Cautious adoption of adjustments for co-authorship and networking in scientific appraisals may offer incentives for more accountable co-authorship behaviour in published articles...
  3. ncbi Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Trials 11:85. 2010
    ..A standardized and transparent approach to HTE assessment and reporting could substantially improve clinical trial utility and interpretability...
  4. ncbi Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, Athens, Greece
    Behav Brain Funct 4:46. 2008
    ..abstract:..
  5. ncbi Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions
    G N Papanikolaou
    Clinical Trials and Evidence Based Medicine Unit, and Social Medicine and Public Health Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMC Med Res Methodol 1:3. 2001
    ....
  6. ncbi Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment
    Ajay Yesupriya
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    BMC Med Res Methodol 8:31. 2008
    ..Transparent reporting of study methods and results allows readers to better assess the validity of study findings. Here, we document reporting practices of human genome epidemiology studies...
  7. ncbi Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies
    A B Haidich
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMC Med Res Methodol 1:4. 2001
    ..Analyses were performed in two datasets: one included all studies and substudies (n = 475, total enrollment 69,992 patients) and the other included only main studies (n = 352, total enrollment 57,563 patients)...
  8. ncbi International ranking systems for universities and institutions: a critical appraisal
    John P A Ioannidis
    BMC Med 5:30. 2007
    ..We make some suggestions on how focused and standardized evaluations of excellence could be improved and placed in proper context...
  9. ncbi Appendicectomies in Albanians in Greece: outcomes in a highly mobile immigrant patient population
    A Tatsioni
    Department of Hygiene and Epidemiology, Medical School, University of loannina, 451 10 Ioannina, Greece
    BMC Health Serv Res 1:5. 2001
    ..We used data from 6 hospitals in the Greek prefecture of Epirus that is bordering Albania...
  10. ncbi A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  11. ncbi Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
  12. ncbi Heterogeneity in meta-analyses of genome-wide association investigations
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS ONE 2:e841. 2007
    ..Between-study heterogeneity is important to document and may point to interesting leads...
  13. ncbi An exploratory test for an excess of significant findings
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit and Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Clin Trials 4:245-53. 2007
    ..The published clinical research literature may be distorted by the pursuit of statistically significant results...
  14. ncbi Genetic and molecular epidemiology
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Epidemiol Community Health 61:757-8. 2007
    ....
  15. ncbi Selective discussion and transparency in microarray research findings for cancer outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Cancer 43:1999-2010. 2007
    ..Only three studies had scanned images, raw and processed data available. Processing details varied. Public transparency and unbiased interpretation of findings can be improved in microarray research...
  16. ncbi Molecular evidence-based medicine: evolution and integration of information in the genomic era
    J P A Ioannidis
    University of Ioannina School of Medicine, Greece
    Eur J Clin Invest 37:340-9. 2007
    ..Research efforts should be integrated across teams in an open, sharing environment. Most research in the future may be designed, performed, and integrated in the public cyberspace...
  17. ncbi The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey
    John P A Ioannidis
    Tufts University School of Medicine, Boston, Mass, USA
    CMAJ 176:1091-6. 2007
    ..Inappropriate application can generate misleading inferences about publication bias. We aimed to measure, in a survey of meta-analyses, how frequently the application of these tests would be not meaningful or inappropriate...
  18. ncbi Is molecular profiling ready for use in clinical decision making?
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Oncologist 12:301-11. 2007
    ..Overall, molecular profiling is a fascinating and promising technology, but its incorporation into clinical decision making requires careful planning and robust evidence...
  19. ncbi Why most published research findings are false
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Med 2:e124. 2005
    ..In this essay, I discuss the implications of these problems for the conduct and interpretation of research...
  20. ncbi Molecular bias
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Eur J Epidemiol 20:739-45. 2005
    ..Issues of plausibility (in particular biological plausibility), replication, and credibility that form the theoretical basis of epidemiology and etiological inference can now be approached with large-scale empirical data...
  21. ncbi Open letter to the leader of academic medicine
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMJ 334:191-3. 2007
  22. ncbi Indirect comparisons: the mesh and mess of clinical trials
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Lancet 368:1470-2. 2006
  23. ncbi Extreme between-study homogeneity in meta-analyses could offer useful insights
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 59:1023-32. 2006
    ..Meta-analyses are routinely evaluated for the presence of large between-study heterogeneity. We examined whether it is also important to probe whether there is extreme between-study homogeneity...
  24. ncbi Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 164:609-14. 2006
    ..These collaborative studies ideally should be designed up front to also assess more complex gene-gene and gene-environment interactions...
  25. ncbi Commentary: grading the credibility of molecular evidence for complex diseases
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 35:572-8; discussion 593-6. 2006
  26. ncbi Limitations are not properly acknowledged in the scientific literature
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 60:324-9. 2007
    ..To facilitate this, journals should give better guidance and promote the discussion of limitations. Otherwise, we are facing an important loss of context for the scientific literature...
  27. ncbi Uncertainty in heterogeneity estimates in meta-analyses
    John P A Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMJ 335:914-6. 2007
  28. ncbi Expectations, validity, and reality in omics
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    J Clin Epidemiol 63:945-9. 2010
    ..Given the exponential growth of collected data, understanding is often drowning in the sea of measurements...
  29. ncbi A compendium of genome-wide associations for cancer: critical synopsis and reappraisal
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Natl Cancer Inst 102:846-58. 2010
    ..At present, the utility of GWA-identified risk loci in risk stratification for cancer is limited...
  30. ncbi Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Sci Transl Med 1:7ps8. 2009
    ..Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently...
  31. ncbi Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Circ Cardiovasc Genet 2:7-15. 2009
    ..Genome-wide association (GWA) platforms have yielded a rapidly increasing number of new genetic markers. The ability of these markers to improve prediction of clinically important outcomes is debated...
  32. ncbi Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
    Nikolaos A Patsopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 69:561-6. 2010
    ..Furthermore, additional independent studies have investigated the same or highly linked polymorphisms in the same regions...
  33. ncbi Repeatability of published microarray gene expression analyses
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Nat Genet 41:149-55. 2009
    ..Repeatability of published microarray studies is apparently limited. More strict publication rules enforcing public data availability and explicit description of data processing and analysis should be considered...
  34. ncbi Interpretation of tests of heterogeneity and bias in meta-analysis
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Eval Clin Pract 14:951-7. 2008
    ..Suggestions are made on how to avoid these flaws, use these tests properly and learn from them...
  35. ncbi Why most discovered true associations are inflated
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Epidemiology 19:640-8. 2008
    ....
  36. ncbi Effect of formal statistical significance on the credibility of observational associations
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 168:374-83; discussion 384-90. 2008
    ..Bayes factors may be used routinely to interpret "significant" associations...
  37. ncbi Perfect study, poor evidence: interpretation of biases preceding study design
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Semin Hematol 45:160-6. 2008
    ..The concerted presence of such biases may have a multiplicative, detrimental impact on the scientific literature. These issues should be considered carefully when interpreting research results...
  38. ncbi Reasons or excuses for avoiding meta-analysis in forest plots
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece
    BMJ 336:1413-5. 2008
  39. ncbi Some main problems eroding the credibility and relevance of randomized trials
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece 45110
    Bull NYU Hosp Jt Dis 66:135-9. 2008
    ....
  40. ncbi Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and the Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Philos Ethics Humanit Med 3:14. 2008
    ....
  41. ncbi Calibration of credibility of agnostic genome-wide associations
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Med Genet B Neuropsychiatr Genet 147:964-72. 2008
    ..Credibility calibration may be used in conjunction with qualitative criteria for the appraisal of the cumulative evidence that take into consideration the amount, consistency, and protection from bias in the data...
  42. ncbi Nested randomized trials in large cohorts and biobanks: studying the health effects of lifestyle factors
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Epidemiology 19:75-82. 2008
    ..The aim should be to combine carefully the strengths of both observational epidemiology and randomized research without compounding their limitations...
  43. ncbi Is there a glass ceiling for highly cited scientists at the top of research universities?
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
    FASEB J 24:4635-8. 2010
    ..0. The participation of highly cited scientists in the top leadership of universities is limited. This could have consequences for the research and overall mission of universities...
  44. ncbi A network of investigator networks in human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:302-4. 2005
    ....
  45. ncbi Microarrays and molecular research: noise discovery?
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Lancet 365:454-5. 2005
  46. ncbi Genetic associations: false or true?
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Trends Mol Med 9:135-8. 2003
    ..However, a sizeable proportion of identified genetic associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative synthesis of all the available data, might help us to separate the true from the false...
  47. ncbi Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 292:2105-14. 2004
    ..Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results...
  48. ncbi Large scale evidence and replication: insights from rheumatology and beyond
    J P A Ioannidis
    Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 64:345-6. 2005
  49. ncbi The value of meta-analysis in rheumatology research
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
    Autoimmun Rev 3:S57-9. 2004
  50. ncbi Evaluation of the association of autoantibodies with mortality in the very elderly: a cohort study
    J P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Rheumatology (Oxford) 42:357-61. 2003
    ..To evaluate whether autoantibodies in the absence of rheumatic diseases increase the risk of mortality among very elderly subjects who are otherwise in good functional condition...
  51. ncbi Global estimates of high-level brain drain and deficit
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    FASEB J 18:936-9. 2004
    ..Scientific deficit is only likely to help perpetuate these adverse conditions...
  52. ncbi Predictors of sustained amenorrhea from pulsed intravenous cyclophosphamide in premenopausal women with systemic lupus erythematosus
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Rheumatol 29:2129-35. 2002
    ..To identify predictors of intravenous cyclophosphamide (IC) induced sustained amenorrhea, especially in young premenopausal women with systemic lupus erythematosus (SLE)...
  53. ncbi Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:99-108. 2004
    ....
  54. ncbi Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 17:1631-8. 2003
    ..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis...
  55. ncbi Genetic associations in large versus small studies: an empirical assessment
    John P A Ioannidis
    Department of Hygiene, University of Ioannina School of Medicine, Ioannina, Greece
    Lancet 361:567-71. 2003
    ..Our aim was to assess how often large studies arrive at different conclusions than smaller studies, and whether this situation arises more frequently when findings of first published studies disagree with those of subsequent research...
  56. ncbi Mortality risk conferred by small elevations of creatine kinase-MB isoenzyme after percutaneous coronary intervention
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and the Biomedical Research Institute, Foundation for Research and Technology, Hellas Ioannina, Greece
    J Am Coll Cardiol 42:1406-11. 2003
    ..The aim of this study was to assess whether small creatine kinase-MB isoenzyme (CK-MB) elevations after percutaneous coronary intervention (PCI) affect the subsequent mortality risk...
  57. ncbi 'Racial' differences in genetic effects for complex diseases
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Nat Genet 36:1312-8. 2004
    ..Genetic markers for proposed gene-disease associations vary in frequency across populations, but their biological impact on the risk for common diseases may usually be consistent across traditional 'racial' boundaries...
  58. ncbi Mortality in systemic sclerosis: an international meta-analysis of individual patient data
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Med 118:2-10. 2005
    ..Studies on mortality associated with systemic sclerosis have been limited by small sample sizes. We aimed to obtain large-scale evidence on survival outcomes and predictors for this disease...
  59. ncbi HIV lipodystrophy case definition using artificial neural network modelling
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Antivir Ther 8:435-41. 2003
    ..We aimed to evaluate whether artificial neural networks could improve the diagnostic accuracy...
  60. ncbi Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Arthritis Rheum 46:741-7. 2002
    ..We sought to determine the incidence and predictors of adverse long-term outcomes to achieve a rational predictive classification of the syndrome...
  61. ncbi Replication validity of genetic association studies
    J P Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Nat Genet 29:306-9. 2001
    ..We conclude that a systematic meta-analytic approach may assist in estimating population-wide effects of genetic risk factors in human disease...
  62. ncbi Comparison of large versus smaller randomized trials for mental health-related interventions
    Despina G Contopoulos-Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Psychiatry 162:578-84. 2005
    ..The extent of disagreement between large and smaller randomized, controlled trials on mental health issues is unknown. The authors aimed to compare the results of large versus smaller trials on mental health-related interventions...
  63. ncbi Bias in uncontrolled therapeutic trials in rheumatology due to selection of populations with extreme characteristics
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    J Rheumatol 28:1881-7. 2001
    ..To assess the prevalence of biases from selection of patients with extreme characteristics in recent uncontrolled therapeutic studies in rheumatology...
  64. ncbi Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/ml
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Infect Dis 183:539-45. 2001
    ..Perinatal HIV-1 transmission occurs in only 1% of treated women with RNA virus loads <1000 copies/mL and may be almost eliminated with antiretroviral prophylaxis accompanied by suppression of maternal viremia...
  65. ncbi Validating, augmenting and refining genome-wide association signals
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Rev Genet 10:318-29. 2009
    ..Even in cases for which replication proves that an effect exists, confident localization of the causal variant often remains elusive...
  66. ncbi Contradicted and initially stronger effects in highly cited clinical research
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 294:218-28. 2005
    ..Controversy and uncertainty ensue when the results of clinical research on the effectiveness of interventions are subsequently contradicted. Controversies are most prominent when high-impact research is involved...
  67. ncbi Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials
    John P A Ioannidis
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Clin Epidemiol 58:543-9. 2005
    ..We hypothesized that controversial data are attractive to investigators and editors, and thus the most extreme, opposite results would appear very early rather than late, as data accumulate, provided data can be generated rapidly...
  68. ncbi Safety reporting in randomized trials of mental health interventions
    Panagiotis N Papanikolaou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Psychiatry 161:1692-7. 2004
    ..CONCLUSIONS: Safety reporting is largely neglected across trials of mental-health-related interventions, thus hindering the assessment of risk-benefit ratios for rational decision making in mental health care...
  69. ncbi Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    J Bone Miner Res 17:2048-60. 2002
    ..In summary, we have found that XX homozygotes may have higher BMD and also a decreased risk of fractures when compared with carriers of the x allele, whereas the PvuII polymorphism is not associated with either BMD or fracture risk...
  70. ncbi Association of polymorphisms of the oestrogen receptor alpha gene with the age of menarche
    I Stavrou
    Division of Endocrinology, Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Hum Reprod 17:1101-5. 2002
    ..We evaluated whether the XbaI and PvuII polymorphisms of the estrogen receptor alpha gene are associated with the age of menarche...
  71. ncbi CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis
    Nikolaos A Patsopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Pharmacogenet Genomics 15:151-8. 2005
    ..003). CYP2D6 loss of function alleles may predispose to tardive dyskinesia in patients with schizophrenia under treatment, but bias cannot be excluded...
  72. ncbi Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis
    Despina G Contopoulos-Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Grece
    J Acquir Immune Defic Syndr 32:70-6. 2003
    ..Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child...
  73. ncbi Concordance of functional in vitro data and epidemiological associations in complex disease genetics
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Genet Med 8:583-93. 2006
    ..We provide suggestions for improving the design and reporting of studies addressing both in vitro and epidemiological effects...
  74. ncbi Selective reporting biases in cancer prognostic factor studies
    Panayiotis A Kyzas
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    J Natl Cancer Inst 97:1043-55. 2005
    ..We recommend that meta-analyses thereof should maximize retrieval of information and standardize definitions...
  75. ncbi Association of the CYP17 gene polymorphism with the risk of prostate cancer: a meta-analysis
    Christos Ntais
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Cancer Epidemiol Biomarkers Prev 12:120-6. 2003
    ..Previously reported associations may reflect publication bias, although it is also possible that the polymorphism may be important in subjects of African descent...
  76. ncbi Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis
    Fotini K Kavvoura
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
    Hum Genet 116:192-9. 2005
    ..083). The Ala45Thr polymorphism of the NEUROD1 gene has no effect on susceptibility to T2D. It may however be a risk factor for susceptibility to T1D, in particular for subjects of Asian descent, although bias cannot be totally excluded...
  77. ncbi Randomised trials comparing chemotherapy regimens for advanced non-small cell lung cancer: biases and evolution over time
    J P A Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110, Ioannina, Greece
    Eur J Cancer 39:2278-87. 2003
    ..The proportion of enrolled patients with a performance status of 2 or worse decreased significantly over time (12.9% per decade, P<0.001). Randomised evidence in this field is fragmented and subject to considerable selection biases...
  78. ncbi Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies
    Konstantinos C M Siontis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Hum Genet 18:832-7. 2010
    ..15-0.43). Overall, few of the numerous genetic associations proposed in the candidate gene era have been replicated in GWASs, but those that have been conclusively replicated have large genetic effects that should not be discarded...
  79. ncbi Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis
    Christos Ntais
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Cancer Epidemiol Biomarkers Prev 14:176-81. 2005
    ..For GSTT1, larger studies gave different results than smaller ones. The meta-analysis shows that these three polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis...
  80. ncbi Quality of reporting of cancer prognostic marker studies: association with reported prognostic effect
    Panayiotis A Kyzas
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Natl Cancer Inst 99:236-43. 2007
    ..Issues of reported study quality have not been addressed empirically with large-scale data in the cancer prognostic literature...
  81. ncbi Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis
    Ermioni T Panidou
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:2153-61. 2004
    ..Current guidelines widely recommending the use of antiretroviral resistance testing in clinical practice are not commensurate with the available evidence...
  82. ncbi Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
    ....
  83. ncbi Vitamin D receptor gene polymorphisms and risk of prostate cancer: a meta-analysis
    Christos Ntais
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Cancer Epidemiol Biomarkers Prev 12:1395-402. 2003
    ..03 (95% CI, 0.86-1.23; no between-study heterogeneity) for the f versus F allele. The meta-analysis shows that these four polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis...
  84. ncbi Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners
    Georgios I Tsianos
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45 110, Greece
    J Appl Physiol 108:567-74. 2010
    ..BDKRB2 rs1799722 and ADRB2 rs1042713 have some support for being implicated in endurance performance among habitual runners and require further investigation...
  85. ncbi Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer
    Davide Mauri
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Natl Cancer Inst 100:1780-91. 2008
    ..Many systemic nonhormonal regimens have been evaluated across several hundreds of randomized trials in advanced breast cancer. We aimed to quantify the relative merits of these regimens in prolonging survival...
  86. ncbi Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission
    Anastasia Polycarpou
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    AIDS Res Hum Retroviruses 18:741-6. 2002
    ..79; p = 0.030) were retained as independent predictors of transmission. HLA alleles, and in particular the class I concordance between maternal and neonatal HLA, may regulate the risk of perinatal HIV-1 transmission...
  87. ncbi Commentary: meta-analysis of individual participants' data in genetic epidemiology
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Ioannina Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece
    Am J Epidemiol 156:204-10. 2002
    ..For questions that justify the required intensive effort, the MIPD method is a useful tool to help clarify the role of candidate genes in complex human diseases...
  88. ncbi Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Arthritis Rheum 60:1710-21. 2009
    ..To examine these associations, we performed a large-scale meta-analysis of individual-level data...
  89. ncbi CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis
    Fotini K Kavvoura
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:3-16. 2005
    ..99, 95% CI: 0.64, 1.55) or the *T allele of the C(-318)T polymorphism (OR = 0.92, 95% CI: 0.45, 1.89). This meta-analysis demonstrates that the CTLA-4*G genotype is associated with type 1 diabetes...
  90. ncbi Establishment of genetic associations for complex diseases is independent of early study findings
    Thomas A Trikalinos
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Hum Genet 12:762-9. 2004
    ..Conversely, many genuine epidemiological associations would be missed, if research were abandoned after early underpowered 'negative' studies...
  91. ncbi The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studies
    Anna-Bettina Haidich
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 57:341-8. 2004
    ..010). CONCLUSION: The Gini coefficient may be easily and routinely incorporated in the description of the characteristics of a clinical study and may provide insights about its enrollment pattern...
  92. ncbi Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
    Thomas A Trikalinos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45100, Greece
    Am J Epidemiol 163:300-9. 2006
    ..Postulated genetic associations with modest-sized odds ratios and borderline statistical significance may not be robust in such sensitivity analyses...
  93. ncbi Evaluating novel agent effects in multiple-treatments meta-regression
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 29:2369-83. 2010
    ....
  94. ncbi Unavailability of online supplementary scientific information from articles published in major journals
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    FASEB J 19:1943-4. 2005
    ..Here we show that in 4.7% and 9.6% of articles with online supplementary material, some of the supplements became unavailable within 2 and 5 years of their publication, respectively...
  95. ncbi Levels of absolute survival benefit for systemic therapies of advanced cancer. a call for standards
    J P A Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Eur J Cancer 39:1194-8. 2003
    ..These standardised levels may be incorporated into clinical practice guidelines for individual care and policy-making...
  96. ncbi An empirical assessment of validation practices for molecular classifiers
    Peter J Castaldi
    Institute for Clinical Research and Health Policy Studies at Tufts Medical Center, USA
    Brief Bioinform 12:189-202. 2011
    ....
  97. ncbi HEGESMA: genome search meta-analysis and heterogeneity testing
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa 41222, Greece
    Bioinformatics 21:3672-3. 2005
    ..Furthermore, the program performs heterogeneity analyses restricted to the bins with similar average ranks. AVAILABILITY: http://biomath.med.uth.gr...
  98. ncbi Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  99. ncbi Required sample size and nonreplicability thresholds for heterogeneous genetic associations
    Ramal Moonesinghe
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Proc Natl Acad Sci U S A 105:617-22. 2008
    ..Therefore, some true associations may not be practically possible to replicate with consistency, no matter how large studies are conducted. Efforts should be made to minimize between-study heterogeneity in targeted genetic effects...
  100. ncbi Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  101. ncbi Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
    ....