Affiliation: University of Ioannina
- Ioannidis J. Genetic associations: false or true?. Trends Mol Med. 2003;9:135-8 pubmed..However, a sizeable proportion of identified genetic associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative synthesis of all the available data, might help us to separate the true from the false. ..
- Ioannidis J. Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers. Circ Cardiovasc Genet. 2009;2:7-15 pubmed publisher..Clinical use of such markers currently would be premature. ..
- Ioannidis J, Thomas G, Daly M. Validating, augmenting and refining genome-wide association signals. Nat Rev Genet. 2009;10:318-29 pubmed publisher..Even in cases for which replication proves that an effect exists, confident localization of the causal variant often remains elusive. ..
- Ioannidis J, Allison D, Ball C, Coulibaly I, Cui X, Culhane A, et al. Repeatability of published microarray gene expression analyses. Nat Genet. 2009;41:149-55 pubmed publisher..Repeatability of published microarray studies is apparently limited. More strict publication rules enforcing public data availability and explicit description of data processing and analysis should be considered. ..
- Ioannidis J. Effect of formal statistical significance on the credibility of observational associations. Am J Epidemiol. 2008;168:374-83; discussion 384-90 pubmed publisher..Bayes factors may be used routinely to interpret "significant" associations. ..
- Ioannidis J. Limitations are not properly acknowledged in the scientific literature. J Clin Epidemiol. 2007;60:324-9 pubmed..To facilitate this, journals should give better guidance and promote the discussion of limitations. Otherwise, we are facing an important loss of context for the scientific literature. ..
- Ioannidis J. Contradicted and initially stronger effects in highly cited clinical research. JAMA. 2005;294:218-28 pubmed..Controversies are most common with highly cited nonrandomized studies, but even the most highly cited randomized trials may be challenged and refuted over time, especially small ones. ..
- Ioannidis J. Calibration of credibility of agnostic genome-wide associations. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:964-72 pubmed publisher..Credibility calibration may be used in conjunction with qualitative criteria for the appraisal of the cumulative evidence that take into consideration the amount, consistency, and protection from bias in the data. ..
- Patsopoulos N, Ioannidis J. Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis. Ann Rheum Dis. 2010;69:561-6 pubmed publisher..Furthermore, these markers may not be the true causative loci but rather be in linkage disequilibrium with the true ones. ..
- Ioannidis J, Contopoulos Ioannidis D, Rosenberg P, Goedert J, De Rossi A, Espanol T, et al. Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis. AIDS. 2003;17:1631-8 pubmed..The CCR5-delta32 and CCR2-64I alleles are associated with a decreased risk of death among perinatally infected children, but only for the first years of life. ..
- Ioannidis J, Ralston S, Bennett S, Brandi M, Grinberg D, Karassa F, et al. Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA. 2004;292:2105-14 pubmed..Our study demonstrates the value of adequately powered studies with standardized genotyping and clinical outcomes in defining effects of common genetic variants on complex diseases. ..