J P Ioannidis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi request reprint Comparison of viral load and human leukocyte antigen statistical and neural network predictive models for the rate of HIV-1 disease progression across two cohorts of homosexual men
    J P Ioannidis
    HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 20:129-36. 1999
  2. ncbi request reprint State of the evidence: current status and prospects of meta-analysis in infectious diseases
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Clin Infect Dis 29:1178-85. 1999
  3. ncbi request reprint Predictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawi
    J P Ioannidis
    HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Int J Epidemiol 28:769-75. 1999
  4. ncbi request reprint Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy
    T R O'Brien
    Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    AIDS 14:821-6. 2000
  5. ncbi request reprint Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infections
    D G Contopoulos-Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Antimicrob Chemother 48:691-703. 2001
  6. ncbi request reprint Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/ml
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Infect Dis 183:539-45. 2001
  7. ncbi request reprint Statistical issues for HIV surrogate endpoints: point/counterpoint. An NIAID workshop
    J M Albert
    Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 7620, USA
    Stat Med 17:2435-62. 1998
  8. ncbi request reprint Predictive modeling and heterogeneity of baseline risk in meta-analysis of individual patient data
    T A Trikalinos
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Clin Epidemiol 54:245-52. 2001
  9. pmc Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies
    A B Haidich
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMC Med Res Methodol 1:4. 2001
  10. ncbi request reprint Replication validity of genetic association studies
    J P Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Nat Genet 29:306-9. 2001

Detail Information

Publications28

  1. ncbi request reprint Comparison of viral load and human leukocyte antigen statistical and neural network predictive models for the rate of HIV-1 disease progression across two cohorts of homosexual men
    J P Ioannidis
    HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 20:129-36. 1999
    ..The correlation between viral load and HLA markers suggests a possible HLA effect on setting viral load levels...
  2. ncbi request reprint State of the evidence: current status and prospects of meta-analysis in infectious diseases
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Clin Infect Dis 29:1178-85. 1999
    ..The increasing applications of meta-analytic methods in the study of infectious diseases may enhance data sharing and international collaborations...
  3. ncbi request reprint Predictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawi
    J P Ioannidis
    HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Int J Epidemiol 28:769-75. 1999
    ..A better understanding of the characteristics and the impact of women and children lost to follow-up is needed...
  4. ncbi request reprint Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy
    T R O'Brien
    Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    AIDS 14:821-6. 2000
    ..In comparison with subjects with other genotypes, the prognosis for HIV-1-infected CCR5-delta32 heterozygotes is more favorable and that for CCR5 promoter allele 59029A homozygotes is less favorable...
  5. ncbi request reprint Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infections
    D G Contopoulos-Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Antimicrob Chemother 48:691-703. 2001
    ....
  6. ncbi request reprint Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/ml
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Infect Dis 183:539-45. 2001
    ..Perinatal HIV-1 transmission occurs in only 1% of treated women with RNA virus loads <1000 copies/mL and may be almost eliminated with antiretroviral prophylaxis accompanied by suppression of maternal viremia...
  7. ncbi request reprint Statistical issues for HIV surrogate endpoints: point/counterpoint. An NIAID workshop
    J M Albert
    Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 7620, USA
    Stat Med 17:2435-62. 1998
    ..These issues will be critical in the proper assessment and use of future therapies for HIV disease...
  8. ncbi request reprint Predictive modeling and heterogeneity of baseline risk in meta-analysis of individual patient data
    T A Trikalinos
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Clin Epidemiol 54:245-52. 2001
    ..Predictive modeling can be a major strength of MIPD, when performed and interpreted with standardized approaches. All models consistently show that MIPD may be a study design with extreme heterogeneity of patient baseline risk...
  9. pmc Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies
    A B Haidich
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMC Med Res Methodol 1:4. 2001
    ..Analyses were performed in two datasets: one included all studies and substudies (n = 475, total enrollment 69,992 patients) and the other included only main studies (n = 352, total enrollment 57,563 patients)...
  10. ncbi request reprint Replication validity of genetic association studies
    J P Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Nat Genet 29:306-9. 2001
    ..We conclude that a systematic meta-analytic approach may assist in estimating population-wide effects of genetic risk factors in human disease...
  11. ncbi request reprint Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data
    J P Ioannidis
    HIV Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 178:349-59. 1998
    ....
  12. pmc Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions
    G N Papanikolaou
    Clinical Trials and Evidence Based Medicine Unit, and Social Medicine and Public Health Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMC Med Res Methodol 1:3. 2001
    ....
  13. ncbi request reprint Patterns of patient enrollment in randomized controlled trials
    A B Haidich
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Clin Epidemiol 54:877-83. 2001
    ..Early enrollment offers strong evidence on the feasibility of a trial and is indicative of its future pace of recruitment...
  14. ncbi request reprint Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections
    J P Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Antimicrob Chemother 48:677-89. 2001
    ..Convenience of dosing should be balanced against the increased cost of this regimen for the treatment of these common infections, where often no antibiotic may be indicated at all...
  15. ncbi request reprint Effect of early patient enrollment on the time to completion and publication of randomized controlled trials
    A B Haidich
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 154:873-80. 2001
    ..Ongoing unpublished studies and their enrollment rates may need to be considered when interpreting the accumulated evidence...
  16. ncbi request reprint Issues in comparisons between meta-analyses and large trials
    J P Ioannidis
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    JAMA 279:1089-93. 1998
    ..The extent of concordance between meta-analyses and large trials on the same topic has been investigated with different protocols. Inconsistent conclusions created confusion regarding the validity of these major tools of clinical evidence...
  17. ncbi request reprint Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials
    J P Ioannidis
    HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 279:281-6. 1998
    ..Medical evidence may be biased over time if completion and publication of randomized efficacy trials are delayed when results are not statistically significant...
  18. ncbi request reprint Pathways for inappropriate dispensing of antibiotics for rhinosinusitis: a randomized trial
    D G Contopoulos-Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Clin Infect Dis 33:76-82. 2001
    ..Inappropriate recommendations regarding antibiotic use were very common in the studied setting. Antibiotics were more likely to be offered to persons who did not have a prescription when they were less likely to be clinically indicated...
  19. pmc Appendicectomies in Albanians in Greece: outcomes in a highly mobile immigrant patient population
    A Tatsioni
    Department of Hygiene and Epidemiology, Medical School, University of loannina, 451 10 Ioannina, Greece
    BMC Health Serv Res 1:5. 2001
    ..We used data from 6 hospitals in the Greek prefecture of Epirus that is bordering Albania...
  20. ncbi request reprint Completeness of safety reporting in randomized trials: an evaluation of 7 medical areas
    J P Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 285:437-43. 2001
    ..Current standards for safety reporting in randomized trials should be revised to address this inadequacy...
  21. ncbi request reprint Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Ann Intern Med 135:782-95. 2001
    ..Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results...
  22. ncbi request reprint Discontinuation of Pneumocystis carinii prophylaxis in patients infected with human immunodeficiency virus: a meta-analysis and decision analysis
    T A Trikalinos
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
    Clin Infect Dis 33:1901-9. 2001
    ..Comparative results were similar for patients with prior PCP. Discontinuation of PCP prophylaxis in patients with adequate immune recovery is a useful strategy that should be widely considered...
  23. ncbi request reprint Bias in uncontrolled therapeutic trials in rheumatology due to selection of populations with extreme characteristics
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    J Rheumatol 28:1881-7. 2001
    ..To assess the prevalence of biases from selection of patients with extreme characteristics in recent uncontrolled therapeutic studies in rheumatology...
  24. pmc Evidence on interventions to reduce medical errors: an overview and recommendations for future research
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Gen Intern Med 16:325-34. 2001
    ..Evidence on reduction of medical errors needs to be better categorized, replicated, and tested in study designs maximizing protection from bias. Emphasis should be placed on serious errors...
  25. pmc Arabian nights-1001 tales of how pharmaceutical companies cater to the material needs of doctors: case report
    I A Giannakakis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMJ 321:1563-4. 2000
    ..To describe how pharmaceutical companies cater to the material needs of doctors...
  26. ncbi request reprint Uncontrolled pearls, controlled evidence, meta-analysis and the individual patient
    J P Ioannidis
    Therapeutics Research Program, DAIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Epidemiol 51:709-11. 1998
    ..Concurrent progress in basic sciences revolutionizing our predictive power for disease outcomes will heighten the importance of considering individual heterogeneity...
  27. ncbi request reprint The importance of independent risk-factors for long-term mortality prediction after cardiac surgery
    I K Toumpoulis
    College of Physicians and Surgeons of Columbia University, New York, USA
    Eur J Clin Invest 36:599-607. 2006
    ..EuroSCORE is a good predictor of long-term mortality after cardiac surgery. We developed and validated a model using selected preoperative, intra-operative and post-operative variables that has better discriminatory ability...
  28. ncbi request reprint Accuracy and clinical effect of out-of-hospital electrocardiography in the diagnosis of acute cardiac ischemia: a meta-analysis
    J P Ioannidis
    Evidence-based Practice Center, Division of Clinical Care Research, New England Medical Center, Boston, MA 02115, USA
    Ann Emerg Med 37:461-70. 2001
    ..Out-of-hospital thrombolysis achieves time savings and improves short-term mortality, but the effect on long-term mortality is unknown...