Research Topics
Genomes and Genes | Georgios M HadjigeorgiouSummaryAffiliation: University of Thessaly Country: Greece Publications
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Publications
Pesticide exposure and lymphohaematopoietic cancers: a case-control study in an agricultural region (Larissa, Thessaly, Greece)Maria Kokouva
Department of Hygiene and Epidemiology, Medical Faculty, University of Thessaly, Larissa, Greece
BMC Public Health 11:5. 2011..The aim of this study was to investigate the relationships between exposure to pesticides and LHC in an agricultural region of Greece...
Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesionsGeorgios M Hadjigeorgiou
Neurogenetics Unit, Department of Neurology, School of Medicine, University of Thessaly, Larissa 41222, Greece
J Orthop Res 25:1087-93. 2007..43; 95%CI = 1.04-1.97; p for trend = 0.03). We conclude that individuals with PON1 192QQ genotype may have increased risk for ONFH and WMLeOn...- Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onsetGeorgios M Hadjigeorgiou
Neurogenetics Unit, Department of Neurology, Medical School, University of Thessaly, Larissa, Greece
Mov Disord 21:534-9. 2006..For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD... - IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injuryG M Hadjigeorgiou
Department of Neurology, University Hospital of Larissa, Medical School, University of Thessaly, Larissa 41222, Greece
Neurology 65:1077-82. 2005..To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI)... - Genetic association studies in osteonecrosis of the femoral head: mini review of the literatureGeorgios Hadjigeorgiou
Department of Neurology, Medical School, Larissa University Hospital, University of Thessaly, 22 Papakyriazi Street, Larissa 41222, Greece
Skeletal Radiol 37:1-7. 2008 - Increased frequency of white matter lesions in patients with osteonecrosis (WMLeOn) of the femoral headGeorgios M Hadjigeorgiou
Department of Neurology, Medical School, Larissa University Hospital, University of Thessaly, Larissa 41222, Greece
Eur J Radiol 50:278-84. 2004..Although, the clinical significance of WMLeON is still unknown, this finding supports, at least, the hypothesis that non-traumatic osteonecrosis is indeed a multisystem disorder rather than a disease of human skeleton... - Low RLS prevalence and awareness in central Greece: an epidemiological surveyG M Hadjigeorgiou
Department of Neurology, Medical School of Larissa, University of Thessaly, Larissa, Greece
Eur J Neurol 14:1275-80. 2007..We provide further evidence for low prevalence of RLS in south-east Europe and a low level of awareness of RLS in our region... - Evidence of increased muscle atrophy and impaired quality of life parameters in patients with uremic restless legs syndromeChristoforos D Giannaki
Department of Nephrology, University of Thessaly, Larissa, Thessaly, Greece
PLoS ONE 6:e25180. 2011..Increased evidence of muscle atrophy is also observed in the RLS group and possibly can be attributed to the lack of restorative sleep... - Molecular genetic study of myophosphorylase deficiency (McArdle's disease) in two Yemenite-Jewish familiesGeorgios M Hadjigeorgiou
Department of Neurology, University of Thessaly, Larissa, Greece
Neuromuscul Disord 12:824-7. 2002..This first molecular genetic study of McArdle's disease in Yemenite-Jewish patients expands the already remarkable genetic heterogeneity of McArdle's disease and suggests the existence of ethnic or private mutations within this group... 
Association between AKT1 gene and Parkinson's disease: a protective haplotypeGeorgia Xiromerisiou
University of Thessaly, Medical School, Department of Neurology, Neurogenetics Unit, Papakyriazi 22 Street, Larissa 41222, Greece
Neurosci Lett 436:232-4. 2008..The data presented here suggest the involvement of AKT1 in protection of PD through many possible mechanisms involving different signaling pathways that could be potential therapeutic targets in the future...- Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucomaEvangelia E Tsironi
Department of Ophthalmology, School of Medicine, University of Thessaly, Larissa, Greece
Mol Vis 15:2890-5. 2009..To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients... - Non-pharmacological management of periodic limb movements during hemodialysis session in patients with uremic restless legs syndromeChristoforos D Giannaki
Department of Nephrology, School of Medicine, University of Thessaly, Larissa, Greece
ASAIO J 56:538-42. 2010..Independent of intensity, a single bout of intradialytic exercise reduces PLM/hHD in hemodialysis patients with RLS. Further research is needed to establish the acute role of exercise in ameliorating the RLS symptoms... - Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhageEfthimios Dardiotis
Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece
Pharmacogenet Genomics 21:136-41. 2011..The objective of this study was to clarify the influence of the ACE gene region on the risk of ICH by genotyping tag polymorphisms along ACE gene in two independent ethnically different cohorts... - Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritisAspasia Tsezou
Department of Biology, Laboratory of Cytogenetics and Medical Genetics, Medical School, University of Thessaly, 41 222 Larissa, Greece
J Orthop Res 24:1900-5. 2006.... - The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysisElias Zintzaras
Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222, Larissa, Greece
J Hum Genet 50:560-6. 2005..The meta-analysis results suggest that the involvement of the BDNF gene in susceptibility to PD merits further exploration with larger and more rigorous population association studies... - Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysisElias Zintzaras
Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
J Hum Genet 49:474-81. 2004..Therefore, the pooled results of the meta-analysis supported that there was an association between PON1-55M/L polymorphism and PD and that PON1-192Q/R polymorphism was unlikely to be a major risk factor for susceptibility to PD... - Genetic association studies in patients with traumatic brain injuryEfthimios Dardiotis
Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece
Neurosurg Focus 28:E9. 2010.... - Absence of aprataxin gene mutations in a Greek cohort with sporadic early onset ataxia and normal GAA triplets in frataxin geneC Daiou
Laboratory of Neurogenetics, Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessalia, Larissa, Greece
Neurol Sci 31:393-7. 2010..It is still questionable whether the screening for aprataxin mutation in Greek patients' Friedreich ataxia phenotype is of clinical importance; larger, multicenter studies are necessary to clarify this issue... - Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionalityGiorgos K Sakkas
Department of Nephrology, School of Medicine, University of Thessaly, Greece
Nephrol Dial Transplant 23:336-44. 2008..We tested the hypothesis that apneic dialysis patients due to the lack of restorative sleep will have a further reduced functional capacity and further compromised quality of life compared to their non-apneic counterparts... - Retroclival epidural hematoma secondary to a longitudinal clivus fractureKonstantinos N Paterakis
Department of Neurosurgery, Larissa University Hospital, Mesourlo, Greece
Clin Neurol Neurosurg 108:67-72. 2005.... - Perimetric and retinal nerve fiber layer findings in patients with Parkinson's diseaseEvangelia E Tsironi
Department of Ophthalmology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Mezourlo 41222 Larissa, Greece
BMC Ophthalmol 12:54. 2012.... - Cognitive impairment in heart failureEfthimios Dardiotis
Department of Neurology, University of Thessaly, University Hospital of Larissa, P O Box 1400, Larissa, Greece
Cardiol Res Pract 2012:595821. 2012..Future studies should focus on elucidating the mechanisms that underlie CI in HF and establishing preventive strategies and treatment approaches... - Network analysis of randomized controlled trials in multiple sclerosisElias Zintzaras
Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Larissa, Greece
Clin Ther 34:857-869.e9. 2012..The optimal treatment of multiple sclerosis (MS) is not yet well-defined... - Genetic factors influencing outcome from neurotraumaEfthimios Dardiotis
Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece
Curr Opin Psychiatry 25:231-8. 2012..The bibliographic databases MEDLINE, EMBASE and PsycINFO were searched to identify relevant studies... - A new stop codon mutation (Y52X) in the myophosphorylase gene in a Greek patient with McArdle's diseaseGeorgios M Hadjigeorgiou
Department of Neurology, University of Thessaly, Larissa, Greece
J Neurol Sci 194:83-6. 2002..Our data further expand the already remarkable genetic heterogeneity of McArdle's disease. The prevalence of the Y52X mutation in Greek patients with McArdle's disease remains to be determined... - Role of endoscopic third ventriculostomy in treatment of selected patients with normal pressure hydrocephalusKostas N Fountas
Department of Neurosurgery, University Hospital of Larissa, University of Thessaly, Larissa, Greece
Acta Neurochir Suppl 113:129-33. 2012..The purpose of our study was to evaluate the results of endoscopic third ventriculostomy (ETV) in the management of patients with idiopathic normal pressure hydrocephalus (INPH)... - THAP1 mutations and dystonia phenotypes: genotype phenotype correlationsGeorgia Xiromerisiou
Department of Molecular Neuroscience and Reta Lila Weston Institute, University College London Institute of Neurology, London, London, United Kingdom Department of Neurology, Faculty of Medicine University of Thessaly, Larissa, Greece
Mov Disord 27:1290-4. 2012..Greater mutation numbers in different populations will be important and mutation-specific functional studies will be essential to identify the pathogenicity of the various THAP1 mutations. © 2012 Movement Disorder Society... - Cervical spinal cord intramedullary teratomaKonstantinos N Paterakis
Department of Neurosurgery, Larissa University Hospital, Mesourlo, Larissa 411 10, Greece
Clin Neurol Neurosurg 108:514-7. 2006..The purpose of this case report is to describe the highly unusual localization of the intramedullary teratoma associated with other vertebral malformations. A review of the literature is also presented... - Primary spinal intradural extramedullary cysticercosisKonstantinos N Paterakis
Department of Neurosurgery, Larissa University Hospital, 411 10 Larissa, Greece
Surg Neurol 68:309-11; discussion 312. 2007..Spinal cysticercosis represents an uncommon localization of a common parasitic disease and, in most cases, is associated with intracranial involvement. Once confirmed, the entire neuraxis should be evaluated... - Quantitative spectral analysis of vigilance EEG in patients with obstructive sleep apnoea syndrome: EEG mapping in OSAS patientsAthanasios G Xiromeritis
Department of Psychiatry, School of Medicine, University of Thessaly, University Hospital of Larissa, GR 411 10, Larissa, Greece
Sleep Breath 15:121-8. 2011..The aim of the study was to determine electroencephalogram (EEG) alterations related to the severity of OSA in patients with OSAS and the effect of the nasal continuous positive air pressure (nCPAP) treatment... - Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot studyGiorgos K Sakkas
Department of Nephrology, School of Medicine, University of Thessaly, Greece
ASAIO J 54:185-90. 2008..03), and sleep quality (p = 0.01). In the Con-group no changes were observed. In conclusion, aerobic exercise training is safe and efficacious in reducing RLS symptoms and improving quality of life in patients with RLS on HD... - Family-based association study of the restless legs syndrome loci 2 and 3 in a European populationDavid Kemlink
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:207-12. 2007..0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS... - Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international studyAlexis Elbaz
INSERM, Unit 708, Paris, France
Lancet Neurol 5:917-23. 2006..INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease... - The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populationsSonja W Scholz
Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Building 35, Room 1A 1012, Bethesda, MD 20892, USA
Neurosci Lett 395:227-9. 2006..No association between genotypes in codon 129 and IPD was detected in three distinct populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD... - Re: Lack of association between the IL1A gene (-889) polymorphism and outcome after head injury. Tanriverdi T et al. Surg Neurol 2006;65:7-10; discussion 10Efthimios Dardiotis
Surg Neurol 66:334-5. 2006 - Autoantibodies to alpha-synuclein in inherited Parkinson's diseaseKaterina K Papachroni
Laboratory of Biological Chemistry, University of Athens Medical School, Athens, Greece
J Neurochem 101:749-56. 2007..We hypothesise that these AAb could be involved in pathogenesis of the inherited form of PD... - Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)Claudia Trenkwalder
Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
Mov Disord 22:S495-504. 2007..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols... - Serum levels of adipokine retinol-binding protein-4 in relation to renal function: response to Ziegelmeier et alVasileios Papavasileiou
Diabetes Care 31:e23; author reply e24. 2008 - Genetics of restless legs syndrome (RLS): State-of-the-art and future directionsJuliane Winkelmann
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:S449-58. 2007..One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies... - Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndromeDiego Garcia-Borreguero
Fundacion Jimenez Diaz, Madrid, Spain
Sleep Med 8:455-63. 2007..The changes in each dimension are summed to give an ASRS total score...