Alexandra Giatromanolaki

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi request reprint The use of an electromechanical device for treatment of constipation in the elderly
    David Galinsky
    J Am Geriatr Soc 52:475-6. 2004
  2. ncbi request reprint A viral kinetic study using pegylated interferon alfa-2b and/or lamivudine in patients with chronic hepatitis B/HBeAg negative
    Vassiliki Anastasia Sypsa
    Athens University Medical School, Greece
    Hepatology 42:77-85. 2005
  3. pmc Impact of hiatal hernia on histological pattern of non-erosive reflux disease
    Anthie Gatopoulou
    Endoscopy Unit, Democritus University of Thrace, Dragana, GR 68100 Alexandroupolis, Greece
    BMC Gastroenterol 5:2. 2005
  4. ncbi request reprint Hepatitis C virus survival curve analysis in naïve patients treated with peginterferon alpha-2b plus ribavirin. A randomized controlled trial for induction with high doses of peginterferon and predictability of sustained viral response from early virologi
    Konstantinos Mimidis
    Department of Medicine, Democritus University of Thrace, 8, Chrisostomou Smirnis Str, GR 68100 Alexandroupolis, Greece
    J Gastrointestin Liver Dis 15:213-9. 2006
  5. ncbi request reprint Gastrocolic fistula secondary to nonsteroidal anti-inflammatory drugs abuse in a cirrhotic patient
    Konstantinos Mimidis
    First Department of Internal Medicine, 8 Chrisostomou Smirnis Str, GR 68 100 Alexandroupolis, Greece
    Rom J Gastroenterol 13:39-41. 2004
  6. ncbi request reprint Alterations of platelet function, number and indexes during acute pancreatitis
    K Mimidis
    First Department of Internal Medicine, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Pancreatology 4:22-7. 2004
  7. ncbi request reprint Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system
    Konstantinos Mimidis
    First Department of Internal Medicine, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    JOP 5:132-7. 2004
  8. ncbi request reprint Efficacy of polyethylene glycol in constipated CAPD patients
    Konstantinos Mimidis
    First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Perit Dial Int 25:601-3. 2005
  9. ncbi request reprint Use of a device that applies external kneading-like force on the abdomen for treatment of constipation
    Konstantinos Mimidis
    Democritus University of Thrace, Alexandroupolis, Greece
    World J Gastroenterol 11:1971-5. 2005
  10. ncbi request reprint Thymidine phosphorylase expression in patients with chronic viral hepatitis
    Konstantinos Mimidis
    First Department of Internal Medicine, Chrisostomou Smirnis 8, 68100 Alexandroupolis, Greece
    Rom J Gastroenterol 14:27-31. 2005

Collaborators

Detail Information

Publications80

  1. ncbi request reprint The use of an electromechanical device for treatment of constipation in the elderly
    David Galinsky
    J Am Geriatr Soc 52:475-6. 2004
  2. ncbi request reprint A viral kinetic study using pegylated interferon alfa-2b and/or lamivudine in patients with chronic hepatitis B/HBeAg negative
    Vassiliki Anastasia Sypsa
    Athens University Medical School, Greece
    Hepatology 42:77-85. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  3. pmc Impact of hiatal hernia on histological pattern of non-erosive reflux disease
    Anthie Gatopoulou
    Endoscopy Unit, Democritus University of Thrace, Dragana, GR 68100 Alexandroupolis, Greece
    BMC Gastroenterol 5:2. 2005
    ..This study evaluated the association between the presence of (HH) and the histological findings in symptomatic patients with NERD...
  4. ncbi request reprint Hepatitis C virus survival curve analysis in naïve patients treated with peginterferon alpha-2b plus ribavirin. A randomized controlled trial for induction with high doses of peginterferon and predictability of sustained viral response from early virologi
    Konstantinos Mimidis
    Department of Medicine, Democritus University of Thrace, 8, Chrisostomou Smirnis Str, GR 68100 Alexandroupolis, Greece
    J Gastrointestin Liver Dis 15:213-9. 2006
    ..To evaluate the significance of induction with high doses of pegylated interferon -2b (Peg-IFNalpha-2b) and the predictability of sustained virologic response (SVR) in naïve patients with chronic hepatitis C...
  5. ncbi request reprint Gastrocolic fistula secondary to nonsteroidal anti-inflammatory drugs abuse in a cirrhotic patient
    Konstantinos Mimidis
    First Department of Internal Medicine, 8 Chrisostomou Smirnis Str, GR 68 100 Alexandroupolis, Greece
    Rom J Gastroenterol 13:39-41. 2004
    ..Review of the literature shows that this condition warrants a complete diagnostic work-up to exclude more ominous underlined diseases...
  6. ncbi request reprint Alterations of platelet function, number and indexes during acute pancreatitis
    K Mimidis
    First Department of Internal Medicine, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Pancreatology 4:22-7. 2004
    ....
  7. ncbi request reprint Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system
    Konstantinos Mimidis
    First Department of Internal Medicine, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    JOP 5:132-7. 2004
    ..Acute pancreatitis constitutes a systemic inflammatory process which is often accompanied by thrombosis and bleeding disorders. The role of platelets in the pathophysiology of the disease remains to be elucidated...
  8. ncbi request reprint Efficacy of polyethylene glycol in constipated CAPD patients
    Konstantinos Mimidis
    First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Perit Dial Int 25:601-3. 2005
  9. ncbi request reprint Use of a device that applies external kneading-like force on the abdomen for treatment of constipation
    Konstantinos Mimidis
    Democritus University of Thrace, Alexandroupolis, Greece
    World J Gastroenterol 11:1971-5. 2005
    ..To evaluate the efficacy of a recently developed device that applies kneading-like motion on the abdomen in improving constipation in elderly long-term care patients...
  10. ncbi request reprint Thymidine phosphorylase expression in patients with chronic viral hepatitis
    Konstantinos Mimidis
    First Department of Internal Medicine, Chrisostomou Smirnis 8, 68100 Alexandroupolis, Greece
    Rom J Gastroenterol 14:27-31. 2005
    ..In the present study we investigated TP expression in chronic viral hepatitis due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection...
  11. ncbi request reprint Predisposing factors and clinical symptoms in HIV-negative patients with Candida oesophagitis: are they always present?
    K Mimidis
    Department of Internal Medicine, Endoscopy Unit, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Clin Pract 59:210-3. 2005
    ..05). Thus, CO can be discovered in patients without apparent predisposing risk factors and clinical symptoms. Further studies are needed to elucidate the mechanisms of transition from colonisation to infection...
  12. ncbi request reprint c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
    Alexandra Giatromanolaki
    Department of Pathology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 10:7972-7. 2004
    ....
  13. ncbi request reprint Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer Sci 97:582-8. 2006
    ..Identification of specific patterns of the hypoxia molecular cascade activated in cancer cells might help in developing specific therapeutic policies...
  14. doi request reprint Bevacizumab, capecitabine, amifostine, and preoperative hypofractionated accelerated radiotherapy (HypoArc) for rectal cancer: a Phase II study
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 80:492-8. 2011
    ..We assessed the feasibility and efficacy of preoperative radiochemotherapy combined with bevacizumab in patients with rectal cancer...
  15. ncbi request reprint Hypoxia inducible factor (HIf1alpha and HIF2alpha) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Int J Radiat Biol 84:47-52. 2008
    ..We investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and carbonic anhydrase CA9) in HNC resistance to accelerated and hypofractionated radiotherapy...
  16. pmc Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Arthritis Res Ther 5:R193-201. 2003
    ..The activation of the HIF-alpha pathway occurs in both RA and OA, although for unrelated reasons...
  17. doi request reprint Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Leuk Lymphoma 49:2181-6. 2008
    ..It is concluded that LDH5 is highly upregulated in B-cell non-Hodgkin lymphomas and is in direct relation to HIFs expression. LDH5 expression is linked with activated VEGFR2/KDR expression in both lymphoid lesions...
  18. ncbi request reprint Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace Medical School, 68100 Alexandroupolis, Greece
    Clin Exp Metastasis 22:25-30. 2005
    ..It is concluded that a high LDH5 content in tumor cells is directly related to an up-regulated HIF pathway and is linked with an aggressive phenotype in colorectal adenocarcinomas...
  19. ncbi request reprint DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer
    Alexandra Giatromanolaki
    Departments of Pathology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    J Pathol 200:222-8. 2003
    ..It is suggested that loss of DEC1 expression is an early event in the development of lung cancer, while DEC1 gene expression occurs in a subset of tumours and parallels the overexpression of other hypoxia-regulated proteins...
  20. ncbi request reprint Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 59:67-71. 2004
    ..Furthermore, the ability of tumors to upregulate hypoxia-regulated molecular pathways may affect radiosensitivity by mechanisms independent of the traditional concept of "oxygen effect."..
  21. doi request reprint c-erbB-2 and the "triple-state" in early breast carcinomas
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, P O Box 12, Alexandroupolis, 68100, Greece
    Med Oncol 27:578-84. 2010
    ..Elucidation of these pathways may determine subgroups of patients with tumors requiring different targeted agents...
  22. ncbi request reprint Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients
    Michael I Koukourakis
    Department of Radiotherapy, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Cancer Res 63:5376-80. 2003
    ....
  23. ncbi request reprint Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
    Alexandra Giatromanolaki
    Departments of Pathology, Dermatology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Melanoma Res 13:493-501. 2003
    ..HIF2alpha, VEGF and, to a lesser extent, VD are important prognostic factors in these cutaneous tumours...
  24. ncbi request reprint Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, PO Box 12, Alexandroupolis 68100, Greece
    Cancer Res 66:632-7. 2006
    ..Tumors survive and grow because they are capable of organizing the regional fibroblasts and endothelial cells into a harmoniously collaborating metabolic domain...
  25. ncbi request reprint Oxygen and glucose consumption in gastrointestinal adenocarcinomas: correlation with markers of hypoxia, acidity and anaerobic glycolysis
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace Medical School, Dragana, Alexandroupolis, Greece
    Cancer Sci 97:1056-60. 2006
    ..These in vivo data confirm the importance of HIFs and their downstream regulated genes in tumor metabolism, particularly in glycolysis and carbon dioxide buffering...
  26. ncbi request reprint The effect of trastuzumab/docatexel combination on breast cancer angiogenesis: dichotomus effect predictable by the HIFI alpha/VEGF pre-treatment status?
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Surgery and Pathology, Democritus University of Thrace, Medical School, Alexandroupolis 68100, Greece
    Anticancer Res 23:1673-80. 2003
    ..Adjustment of the chemotherapy regimen accordingly would prove of clinical importance...
  27. doi request reprint Postmastectomy hypofractionated and accelerated radiation therapy with (and without) subcutaneous amifostine cytoprotection
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 85:e7-13. 2013
    ..More aggressive radiation therapy schemes may, however, be necessary in specific subgroups, provided they are safely administered. We report the tolerance and efficacy of a highly accelerated and hypofractionated regimen (HypoARC)...
  28. ncbi request reprint The angiogenetic effect of intramuscular administration of b-FGF and a-FGF on cardiac muscle: the influence of exercise on muscle angiogenesis
    Anna Efthimiadou
    Departments of Physiology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    J Sports Sci 24:849-54. 2006
    ..In conclusion, both the intramuscular administration of b-FGF and exercise increased significantly angiogenesis in the heart in contrast to the intramuscular administration of a-FGF, which was ineffective...
  29. ncbi request reprint Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Medical School, PO Box 12, Alexandroupolis 68100, Greece, and John Radcliffe Hospital, Oxford, UK
    Gynecol Oncol 103:912-8. 2006
    ..In this study, the expression of LDH-5 was assessed in the normal and malignant endometrium. Its role in prognosis and tumor angiogenesis and hypoxia was also examined...
  30. ncbi request reprint Intramyocardial injection of low-dose basic fibroblast growth factor or vascular endothelial growth factor induces angiogenesis in the infarcted rabbit myocardium
    Ioannis Bougioukas
    Department of Cardiothoracic Surgery, School of Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68 100 Alexandroupolis, Greece
    Cardiovasc Pathol 16:63-8. 2007
    ....
  31. ncbi request reprint Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group
    Michael I Koukourakis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    J Clin Oncol 24:4301-8. 2006
    ..Several studies have shown that serum LDH may be an ominous prognostic marker in malignant tumors. The clinical significance of tissue LDH-5, however, remains largely unexplored...
  32. doi request reprint Concurrent liposomal cisplatin (Lipoplatin), 5-fluorouracil and radiotherapy for the treatment of locally advanced gastric cancer: a phase I/II study
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Pathology and Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 78:150-5. 2010
    ..We investigated the feasibility of the combination of 5-fluorouracil/lecovorin-based radio-chemotherapy with the administration of high weekly dose of a liposomal platinum formulation (Lipoplatin)...
  33. ncbi request reprint Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer 95:1055-63. 2002
    ....
  34. ncbi request reprint Long-term angiogenic activity of free grafts and pedicle flap in a rabbit urethroplasty model
    George Vaos
    Department of Pediatric Surgery, Alexandroupolis University Hospital, Democritus University of Thrace School of Medicine, 68100, Alexandroupolis, Greece
    World J Urol 31:919-24. 2013
    ..We studied the late angiogenic activity of free grafts and a pedicle flap in a rabbit urethroplasty model to determine whether angiogenic activity plays a role in late outcomes of urethral reconstruction in rabbits...
  35. doi request reprint Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas
    Georgia Karpathiou
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    APMIS 121:592-604. 2013
    ..Furthermore, we showed important correlations between glucolysis and autophagy, guiding new pathways in future lung carcinoma research...
  36. ncbi request reprint Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Anticancer Res 28:3035-40. 2008
    ..This is a report on the feasibility and efficacy of hypofractionated accelerated radiotherapy combined with amifostine cytoprotection (hypoARC) and capecitabine in the treatment of rectal adenocarcinoma...
  37. ncbi request reprint Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma
    Michael I Koukourakis
    Department of Radiotherapy and Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer Biol Ther 6:1476-9. 2007
    ..The development of agents exploiting such cancer specific metabolic pathways may prove of importance in the treatment of lung cancer...
  38. doi request reprint Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab
    Michael I Koukourakis
    Departments of Pathology, and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 15:7069-76. 2009
    ..Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in patients with metastatic colorectal cancer...
  39. ncbi request reprint Postoperative accelerated radiotherapy with cytoprotection followed by three-dimensional conformal boost in patients with early endometrial/cervical cancer
    Michael I Koukourakis
    Department of Radiotherapy and Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Tumori 95:455-60. 2009
    ..Adjuvant external beam radiotherapy is highly recommended for uterine carcinomas invading beyond the inner half of the myometrium or cervical stage IIa carcinomas. The addition of a booster intracavitary dose is widely used...
  40. pmc The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Cancer Biol Ther 13:1284-9. 2012
    ..These findings support and extend our previous studies on energy recycling between the aerobic stroma and the anaerobic cancer cells within the framework of Warburg effect...
  41. doi request reprint Concurrent administration of liposomal doxorubicin improves the survival of patients with invasive bladder cancer undergoing hypofractionated accelerated radiotherapy (HypoARC)
    Marianthi Panteliadou
    Department of Radiotherapy Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Med Oncol 28:1356-62. 2011
    ....
  42. ncbi request reprint Ultrasound submucosal inferior nasal turbinate reduction technique: histological study of wound healing in a sheep model
    Christina Nousia
    Dept of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Rhinology 48:169-73. 2010
    ....
  43. doi request reprint The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Gynecol Oncol 110:216-21. 2008
    ..In this study, we investigated the numbers of FOXP3(+) Tregs in the normal and malignat endometrium and examined potential links with tumor angiogenesis...
  44. ncbi request reprint C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Lung Cancer 53:257-62. 2006
    ..In this study, we investigated whether polymorphisms of the HIF-1alpha gene may account for the patterns of HIF-1alpha protein expression in non-small cell lung carcinomas (NSCLC) and the expression of HIF-1alpha down-stream proteins...
  45. ncbi request reprint Assessment of highly angiogenic and disseminated in the peripheral blood disease in breast cancer patients predicts for resistance to adjuvant chemotherapy and early relapse
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Cancer 108:620-7. 2004
    ..The simultaneous presence of high MVD and CK19-positive cells in the blood of patients with early breast is linked with poor prognosis, which cannot be improved with standard chemotherapy regimens...
  46. ncbi request reprint Thymidine phosphorylase expression in gallbladder adenocarcinomas
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Department of Pathology, Democritus University of Thrace, Greece
    Int J Surg Pathol 10:181-8. 2002
    ..TP is associated with an aggressive phenotype apparently because of its anglogenic activity. Therapeutic strategies targeting TP may be of value in patients overexpressing this enzyme...
  47. ncbi request reprint Interferon regulatory factor-1 (IRF-1) suppression and derepression during endometrial tumorigenesis and cancer progression
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Cytokine 26:164-8. 2004
    ..However, derepression of IRF-1 may occur in a subset of tumors, and this event is associated with TP up-regulation and aggressive tumor behavior...
  48. ncbi request reprint Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Democritus University of Thrace, 68100, Alexandroupolis, Greece
    Cancer Chemother Pharmacol 53:8-14. 2004
    ....
  49. doi request reprint Treatment of invasive bladder cancer with conformal hypofractionated accelerated radiotherapy and amifostine (HypoARC)
    Marianthi Panteliadou
    Department of Radiotherapy and Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Urol Oncol 30:813-20. 2012
    ..We suggest that accelerated hypofractionation (HypoARC) may be more effective, as it targets both tumors with increased clonogenic activity and tumors with low radio-sensitivity...
  50. doi request reprint Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1
    Efthimios Sivridis
    Department of Pathology, University of Thrace Medical School, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Melanoma Res 21:188-95. 2011
    ..Atg6/beclin 1 was proved to be capable of deciphering the prognosis in cutaneous malignant melanoma, but the matter requires further investigation...
  51. pmc Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma
    Michael I Koukourakis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece targ her forthnet gr
    Neoplasia 7:1-6. 2005
    ..This means that stroma may use lactic acid produced by tumor cells, preventing the creation of an intolerable intratumoral acidic environment at the same time...
  52. ncbi request reprint BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer
    Alexandra Giatromanolaki
    Departments of Pathology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 10:5566-71. 2004
    ..009). High BNIP3 expression was a major independent factor for overall survival. Thus, high expression of a hypoxia regulated proapoptotic pathway was associated with a selection of an aggressive phenotype in vivo...
  53. ncbi request reprint Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Departments of Pathology, Internal Medicine, and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Semin Oncol 29:14-21. 2002
    ..In contrast, the abundance of IAP expression in normal tissues, stromal and vascular, ensures an intense hydrolysis of WR-2721 and rapid intracellular accumulation of WR-1065...
  54. doi request reprint Immunohistological study of wound healing after submucosal radiofrequency tissue ablation of inferior nasal turbinate in a sheep model
    Haralampos Gouveris
    Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Rhinol Allergy 25:131-6. 2011
    ..This study was designed to examine tissue expression of fibronectin, collagen III, CD68, and matrix metalloproteinase (MMP) 9 in the INT (ventral) after RTA in sheep...
  55. ncbi request reprint Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    J Clin Oncol 24:727-35. 2006
    ....
  56. doi request reprint Effect of VEGF on angiogenesis in pedicle penile skin flaps: an experimental study of urethral reconstruction in rabbits
    Elefteria Efstathiou
    Alexandroupolis University Hospital, Laboratory of Experimental Surgery and Surgical Research, Alexandroupolis, Greece
    Eur J Pediatr Surg 22:460-4. 2012
    ....
  57. doi request reprint Amifostine-related fever-rash during fractionated radiotherapy: diagnostic and predictive role of C-reactive protein
    Michael I Koukourakis
    Department of Radiotherapy Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Clin Oncol 34:281-5. 2011
    ..Fever/rash is a side-effect of amifostine that demands immediate interruption of the drug. Here, we focus on the role of C-reactive protein (CRP) as a putative marker linked with amifostine fever/rash...
  58. doi request reprint Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    J Clin Pathol 63:867-72. 2010
    ....
  59. doi request reprint Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Cytokine 53:370-5. 2011
    ..Yet, its role in benign breast/gynecological conditions is less clear...
  60. ncbi request reprint Erythropoietin receptors in endometrial carcinoma as related to HIF1{alpha} and VEGF expression
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Greece
    In Vivo 23:699-703. 2009
    ..07). It is concluded that EpoR are common constituents of endometrial adenocarcinomas and are related to tumor aggressiveness, although this is probably a result of their involvement in an active HIF pathway...
  61. ncbi request reprint VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Lung Cancer 46:293-8. 2004
    ..The large variation in angiogenicity between tumors of similar histologic morphology emerges as a consequence of the 'parental' VEGF gene ability to produce VEGF...
  62. ncbi request reprint Phosphorylated KDR expression in endometrial cancer cells relates to HIF1alpha/VEGF pathway and unfavourable prognosis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Mod Pathol 19:701-7. 2006
    ..The unfavourable prognosis that VEGF confers to endometrial adenocarcinomas could be attributed to its angiogenic activity, but also to a direct effect on cancer cells through an autocrine VEGF/KDR loop...
  63. pmc Angiogenic factor expression in hepatic cirrhosis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, P O Box 12, 68100 Alexandroupolis, Greece
    Mediators Inflamm 2007:67187. 2007
    ..The immunohistochemical findings suggest that angiogenic factors and factors promoting oxidative stress (i.e., TP) produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis...
  64. doi request reprint Phosphorylated pVEGFR2/KDR receptor expression in uveal melanomas: relation with HIF2α and survival
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Clin Exp Metastasis 29:11-7. 2012
    ..As pVEGFR2/KDR expression was significantly related with poor prognosis, inhibitors of this receptor may improve the clinical outcome of patients with pVEGFR2/KDR overexpressing uveal melanomas...
  65. ncbi request reprint Differential assessment of angiogenic activity and of vascular survival ability (VSA) in breast cancer
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Exp Metastasis 19:673-9. 2002
    ..Elucidation of the pathways may provide additional targets for antiangiogenic therapy...
  66. ncbi request reprint Hypoxia-inducible factor-2 alpha (HIF-2 alpha) induces angiogenesis in breast carcinomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Appl Immunohistochem Mol Morphol 14:78-82. 2006
    ..The authors conclude that HIF-2alpha overexpression, a common event in infiltrating ductal carcinomas of the breast, is related to high metastatic potential via increased angiogenic and c-erbB-2 activity...
  67. ncbi request reprint Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Mod Pathol 19:9-16. 2006
    ..This study provides evidence on pathways to be investigated to elucidate the interplay between FOXP1, ER-alpha and HIF-1alpha in hormone dependent cancers...
  68. ncbi request reprint Hypofractionated accelerated radiotherapy with cytoprotection combined with trastuzumab, liposomal doxorubicine, and docetaxel in c-erbB-2-positive breast cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Clin Oncol 28:495-500. 2005
    ..Despite the experimental evidence of its radiosensitizing properties, trastuzumab has never been used in combination with radiotherapy for the treatment of patients with locally advanced disease...
  69. doi request reprint Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
    Alexandra Giatromanolaki
    Departments of Pathology, Radiotherapy Oncology, Pneumology and Thoracic Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer Lett 262:87-93. 2008
    ..High lactate dehydrogenase LDH5 expression was noted in cases with high HIF/PHD phenotype. The value of such a classification in defining different metabolic phenotypes of NSCLC deserves further evaluation...
  70. ncbi request reprint Hypoxia and activated VEGF/receptor pathway in multiple myeloma
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, P O Box 12, Alexandroupolis 68100, Greece
    Anticancer Res 30:2831-6. 2010
    ..Intensified angiogenic pathways are associated with poor prognosis and resistance of multiple myeloma (MM) cells to therapy. The links of the VEGF pathway with the hypoxia inducible factor (HIF) expression in MM are herein investigated...
  71. ncbi request reprint Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Hematol Oncol 26:219-24. 2008
    ....
  72. doi request reprint Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
    Michael I Koukourakis
    Department of Radiotherapy, Democritus University of Thrace, Alexandroupolis, Greece
    Oncology 77:285-92. 2009
    ..We assessed the expression and the prognostic role of lactate dehydrogenase 5 (LDH5, the major LDH isoenzyme involved in anaerobic glycolysis) in patients with squamous cell head and neck cancer (SCHNC)...
  73. ncbi request reprint The HIF-2alpha/VEGF pathway activation in cutaneous capillary haemangiomas
    Alexandra Giatromanolaki
    Department of Pathology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Pathology 37:149-51. 2005
    ..To investigate the pathogenesis of capillary haemangiomas, a common form of vascular malformation...
  74. doi request reprint Recurrence of HCV infection in a sustained responder after chemotherapy for non-Hodgkin's lymphoma: successful retreatment
    K Thomopoulos
    University of Patras Medical School, Parodos Kimothois 6, Department of Internal Medicine, Division of Gastroenterology, University Hospital of Patras, Patras, Greece
    Am J Med Sci 336:73-6. 2008
    ..This case suggests that recurrence of HCV infection in a sustained responder may be probable after immunosuppressive therapy. Prevention is currently impossible but retreatment may be successful...
  75. ncbi request reprint Mucocele of the appendix: a report of five cases
    M Pitiakoudis
    2nd Department of Surgery, Medical School Democritus University of Thrace, 6 Ioakeim Kaviri Street, 68100 Alexandroupolis, Greece
    Tech Coloproctol 8:109-12. 2004
    ..Mucocele is often associated with concomitant colon cancer, thus patients with this tumor should be systematically checked for other colonic lesions...
  76. ncbi request reprint Paired comparison between water and nutrient drink tests in healthy volunteers
    Vasileios Papadopoulos
    First Department of Internal Medicine, Democritus University of Thrace, Greece
    Arq Gastroenterol 46:304-10. 2009
    ..However, their use in everyday clinical practice is still limited as standardization still lacks...
  77. ncbi request reprint Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect?
    Stavros Giaglis
    First Division of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Dig Dis Sci 51:687-92. 2006
    ..Larger, longitudinal studies are needed to confirm these initial findings...
  78. ncbi request reprint Impact of Helicobacter pylori infection on histological changes in non-erosive reflux disease
    Anthie Gatopoulou
    Gastroenterologist, Lecturer in Internal Medicine, Chrisostomou Smirnis 8, 68100 Alexandroupolis, Greece
    World J Gastroenterol 10:1180-2. 2004
    ..The aim of this study therefore was to prospectively evaluate the histological findings and the impact of H pylori infection on a group of symptomatic patients with NERD...
  79. ncbi request reprint Coagulation, platelets, and acute pancreatitis
    Anna Kakafika
    Department of Clinical Biochemistry, Royal Free Hospital, Royal Free and University College School of Medicine, London, UK
    Pancreas 34:15-20. 2007
    ..Furthermore, we discuss the prognostic value and the potential therapeutic implications of platelet activation and other hemostatic variables...
  80. ncbi request reprint Eplerenone relieves spironolactone-induced painful gynaecomastia in patients with decompensated hepatitis B-related cirrhosis
    Konstantinos Mimidis
    Scand J Gastroenterol 42:1516-7. 2007