Gerasimos Filippatos

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Leptin serum levels in cachectic heart failure patients. Relationship with tumor necrosis factor-alpha system
    G S Filippatos
    First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    Int J Cardiol 76:117-22. 2000
  2. ncbi Chemokines and other novel inflammatory markers in hypertension: what can their plasma levels tell us?
    Gerasimos S Filippatos
    Heart Failure Hypertension Clinic, Second Department of Cardiology, Evangelismos Hospital, Athens, Greece
    Int J Cardiol 83:21-3. 2002
  3. ncbi Chemokines in cardiovascular remodeling: clinical and therapeutic implications
    Gerasimos Filippatos
    Second Department of Cardiology, Evangelismos Hospital, Athens, Greece
    Curr Mol Med 3:139-47. 2003
  4. ncbi Studies on apoptosis and fibrosis in skeletal musculature: a comparison of heart failure patients with and without cardiac cachexia
    Gerasimos S Filippatos
    Second Department of Cardiology, Evangelismos General Hospital, 28 Doukissis Plakentias street, 115 23, Athens, Greece
    Int J Cardiol 90:107-13. 2003
  5. pmc Fas induces apoptosis in human coronary artery endothelial cells in vitro
    Gerasimos Filippatos
    Second Division of Cardiology, Evangelismos General Hospital, Athens, Greece
    BMC Cell Biol 5:6. 2004
  6. doi Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study
    John T Parissis
    Second Department of Cardiology, Heart Failure Clinic, Attikon University Hospital, 15122 Maroussi, Athens, Greece
    Eur J Heart Fail 11:967-72. 2009
  7. ncbi Clinical and neurohormonal correlates and prognostic value of serum prolactin levels in patients with chronic heart failure
    John T Parissis
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attiko University Hospital, Athens, Greece
    Eur J Heart Fail 15:1122-30. 2013
  8. ncbi Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failure
    Kallirrhoe Kourea
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Atherosclerosis 199:215-21. 2008
  9. doi Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    John T Parissis
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Am Heart J 155:751.e1-7. 2008
  10. doi Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failure
    Dimitrios Farmakis
    Second Department of Cardiology and Heart Failure Unit, Attiko University Hospital, Athens, Greece
    Int J Cardiol 139:75-9. 2010

Collaborators

Detail Information

Publications44

  1. ncbi Leptin serum levels in cachectic heart failure patients. Relationship with tumor necrosis factor-alpha system
    G S Filippatos
    First Department of Cardiology, Evangelismos Hospital, Athens, Greece
    Int J Cardiol 76:117-22. 2000
    ..5, P=0.006) and in those with cachexia (r=0.52, P=0.036). Our data indicate that more prospective studies are needed to clarify the role of leptin in the pathophysiology of heart failure cachexia...
  2. ncbi Chemokines and other novel inflammatory markers in hypertension: what can their plasma levels tell us?
    Gerasimos S Filippatos
    Heart Failure Hypertension Clinic, Second Department of Cardiology, Evangelismos Hospital, Athens, Greece
    Int J Cardiol 83:21-3. 2002
  3. ncbi Chemokines in cardiovascular remodeling: clinical and therapeutic implications
    Gerasimos Filippatos
    Second Department of Cardiology, Evangelismos Hospital, Athens, Greece
    Curr Mol Med 3:139-47. 2003
    ....
  4. ncbi Studies on apoptosis and fibrosis in skeletal musculature: a comparison of heart failure patients with and without cardiac cachexia
    Gerasimos S Filippatos
    Second Department of Cardiology, Evangelismos General Hospital, 28 Doukissis Plakentias street, 115 23, Athens, Greece
    Int J Cardiol 90:107-13. 2003
    ....
  5. pmc Fas induces apoptosis in human coronary artery endothelial cells in vitro
    Gerasimos Filippatos
    Second Division of Cardiology, Evangelismos General Hospital, Athens, Greece
    BMC Cell Biol 5:6. 2004
    ....
  6. doi Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study
    John T Parissis
    Second Department of Cardiology, Heart Failure Clinic, Attikon University Hospital, 15122 Maroussi, Athens, Greece
    Eur J Heart Fail 11:967-72. 2009
    ..To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms...
  7. ncbi Clinical and neurohormonal correlates and prognostic value of serum prolactin levels in patients with chronic heart failure
    John T Parissis
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attiko University Hospital, Athens, Greece
    Eur J Heart Fail 15:1122-30. 2013
    ..We investigated the relationship of serum prolactin, an indicator of hypothalamic axis function, to neurohomonal/immune activation and depressive symptoms in CHF as well as its prognostic value...
  8. ncbi Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failure
    Kallirrhoe Kourea
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Atherosclerosis 199:215-21. 2008
    ..044). In conclusion, darbepoetin-alpha reduces circulating pro-inflammatory cytokine IL-6 and apoptotic mediator soluble Fas ligand in CHF patients with anemia, with a parallel improvement of cardiac performance and exercise capacity...
  9. doi Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    John T Parissis
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Am Heart J 155:751.e1-7. 2008
    ..We sought to investigate the effects of recombinant human erythropoietin analogue darbepoetin alpha on left (LV) and right ventricular (RV) function and neurohormonal activation in patients with CHF and anemia...
  10. doi Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failure
    Dimitrios Farmakis
    Second Department of Cardiology and Heart Failure Unit, Attiko University Hospital, Athens, Greece
    Int J Cardiol 139:75-9. 2010
    ..We sought to identify predictors of long-term response to levosimendan therapy among patients' baseline features and treatment-induced changes in acutely decompensated chronic heart failure (ADHF)...
  11. doi Usefulness of dobutamine-induced changes of the two-dimensional longitudinal deformation predict clinical and neurohumoral improvement in men after levosimendan treatment in acutely decompensated chronic heart failure
    Ioannis A Paraskevaidis
    Heart Failure Unit and Second Cardiology Department, Attikon University Hospital, Athens, Greece
    Am J Cardiol 102:1225-9. 2008
    ..In conclusion, dobutamine-induced changes in longitudinal systolic strain rate are associated with clinical and neurohumoral improvement after levosimendan treatment in patients with ADCHF...
  12. doi Effects of darbepoetin-alpha on quality of life and emotional stress in anemic patients with chronic heart failure
    Kallirrhoe Kourea
    Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Eur J Cardiovasc Prev Rehabil 15:365-9. 2008
    ..This study investigates the effects of recombinant human erythropoietin analog darbepoetin-alpha on quality of life and emotional stress, evaluated by relevant questionnaires in patients with CHF and anemia...
  13. doi Effects of functional electrical stimulation on quality of life and emotional stress in patients with chronic heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy: a randomised, placebo-controlled trial
    Apostolos Karavidas
    Cardiology Department, General Hospital G Genimmatas, Athens, Greece
    Eur J Heart Fail 10:709-13. 2008
    ..This study evaluates the impact of FES on quality of life and emotional stress in patients with moderate to severe CHF...
  14. doi Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Vasiliki Bistola
    Second Department of Cardiology and Heart Failure Unit, Attikon University Hospital, Athens, Greece
    Am J Cardiol 105:249-54. 2010
    ..01) and increased BNP (p <0.05) predicted the combined end point. In conclusion, RV TDI indexes combined with increased plasma BNP additively predict adverse cardiac outcomes in advanced CHF...
  15. ncbi Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failure
    Ignatios Ikonomidis
    Second Cardiology Department and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Eur J Heart Fail 9:1172-7. 2007
    ..Levosimendan has inotropic and vasodilatory effects. We investigated the effects of levosimendan on coronary flow and associated changes in neurohormonal activation and cardiac performance in patients with advanced heart failure...
  16. pmc Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failure
    John T Parissis
    Heart Failure Clinic, Second Department of Cardiology, Attikon University Hospital, Navarinou 13, Maroussi, 15122 Athens, Greece
    Eur J Heart Fail 11:163-9. 2009
    ..We investigated the correlation between health status and inflammation burden as well as its long-term prognostic value in CHF outpatients...
  17. ncbi Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure
    John T Parissis
    Second Department of Cardiology, Attikon University Hospital, Rimini 1, 12461 Chaidari, Athens, Greece
    Atherosclerosis 197:278-82. 2008
    ..We sought to investigate whether the calcium sensitizer levosimendan affects beneficially endothelial function and attenuates the deleterious effects of soluble adhesion molecules in patients with advanced CHF...
  18. ncbi Effects of levosimendan on quality of life and emotional stress in advanced heart failure patients
    John T Parissis
    Second Cardiology Department and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Cardiovasc Drugs Ther 21:263-8. 2007
    ..However, its effects on quality of life, emotional stress and functional capacity of patients with advanced CHF have not been properly investigated...
  19. doi Clinical and prognostic value of Duke's Activity Status Index along with plasma B-type natriuretic peptide levels in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    John T Parissis
    Heart Failure Clinic and Second Department of Cardiology, Attikon University Hospital, Athens, Greece
    Am J Cardiol 103:73-5. 2009
    ..0001). In conclusion, functional status assessment by the DASI bears prognostic value, and its combination with plasma BNP may provide quite specific risk stratification in patients with chronic HF...
  20. doi Functional electrical stimulation of peripheral muscles improves endothelial function and clinical and emotional status in heart failure patients with preserved left ventricular ejection fraction
    Apostolos Karavidas
    Department of Cardiology, Georgios Gennimatas Hospital, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Am Heart J 166:760-7. 2013
    ..We sought to investigate the effects of FES on the above parameters in patients with preserved ejection fraction (HFpEF)...
  21. ncbi Effects of levosimendan on right ventricular function in patients with advanced heart failure
    John T Parissis
    Second Cardiology Department, Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Am J Cardiol 98:1489-92. 2006
    ..05). In conclusion, levosimendan could offer further therapeutic advantages in patients with advanced heart failure by improving systolic and diastolic RV function...
  22. doi Functional electrical stimulation is more effective in severe symptomatic heart failure patients and improves their adherence to rehabilitation programs
    Apostolos Karavidas
    Cardiology Department, General Hospital G Genimmatas, Athens, Greece
    J Card Fail 16:244-9. 2010
    ..This study compares the effectiveness of FES on exercise capacity, endothelial function, neurohormonal status, and emotional stress in New York Heart Association (NYHA) III-IV versus NYHA II patients...
  23. ncbi Novel biologic mechanisms of levosimendan and its effect on the failing heart
    John T Parissis
    University of Athens and Attikon General Hospital, Heart Failure Clinic and Second Cardiology Department, Navarinou 13, 15122 Maroussi, Athens, Greece
    Expert Opin Investig Drugs 17:1143-50. 2008
    ..Levosimendan, the most well-studied calcium sensitizer in the real clinical practice, produces greater hemodynamic and symptomatic improvement in patients with acute heart failure than traditional inotropes...
  24. ncbi Carvedilol improves left atrial and left ventricular function and reserve in dilated cardiomyopathy after 1 year of treatment
    Ioannis Paraskevaidis
    Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    J Card Fail 13:108-13. 2007
    ..The aim of this study was to evaluate the effects of carvedilol therapy on left atrial (LA) function in patients with heart failure from nonischemic dilated cardiomyopathy...
  25. ncbi Effects of Levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure
    John T Parissis
    Heart Failure Unit, Attikon University Hospital, Athens, Greece
    Atherosclerosis 195:e210-5. 2007
    ..We sought to investigate if the calcium sensitizer levosimendan beneficially modulates circulating markers of oxidative and nitrosative stress thus lessening their deleterious effects in patients with advanced CHF...
  26. ncbi Levosimendan for the treatment of acute heart failure syndromes
    John T Parissis
    Second Cardiology Department, Heart Failure Clinic, Attikon Univesity Hospital, Athens, Greece
    Expert Opin Pharmacother 6:2741-51. 2005
    ..The most common adverse effects of levosimendan treatment are hypotension and headache. Overall, levosimendan represents an effective and safe option for the treatment of decompensated heart failure patients...
  27. pmc Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial
    Gerasimos Filippatos
    Athens University Hospital Attikon, Athens, Greece
    Eur J Heart Fail 15:1267-76. 2013
    ..Therapy with i.v. iron in patients with chronic heart failure (CHF) and iron deficiency (ID) improves symptoms, functional capacity, and quality of life. We sought to investigate whether these beneficial outcomes are independent of anaemia...
  28. ncbi Effective sleep apnoea treatment improves cardiac function in patients with chronic heart failure
    Spiros P Kourouklis
    1st Department of Cardiology, Korgialenio Benakio, Red Cross Hospital of Athens, Greece
    Int J Cardiol 168:157-62. 2013
    ..The impact of selection of therapy and effective apnoea alleviation on cardiac performance and reverse left ventricular remodelling (r-LVR) has not yet been evaluated...
  29. ncbi Excessive vagal response during left atrial ablation in a patient with paroxysmal atrial fibrillation
    Michalis Efremidis
    Second Department of Cardiology, Evangelismos General Hospital, Athens, Greece
    Hellenic J Cardiol 50:227-9. 2009
    ..During radiofrequency application around the left superior pulmonary vein, the patient exhibited an excessive vagal response with a sinus pause of 17 s...
  30. ncbi Plasma activity of B-type natriuretic peptide in patients with biventricular heart failure versus those with right heart failure due to chronic obstructive pulmonary disease
    Nikolaos Flessas
    aDepartment of Cardiology, Sotiria Hospital of Chest Diseases bDepartment of Cardiology, Athens University Hospital Attikon, Athens, Greece
    J Cardiovasc Med (Hagerstown) 15:476-80. 2014
    ..However, no efficient data exist regarding the differences in plasma BNP activity between patients with biventricular heart failure and those with right heart failure (RHF) due to chronic obstructive pulmonary disease (COPD)...
  31. ncbi Treating depression in coronary artery disease and chronic heart failure: what's new in using selective serotonin re-uptake inhibitors?
    Ioannis Paraskevaidis
    2nd Department of Cardiology, ATTIKON University Hospital of Athens, Athens, Greece
    Cardiovasc Hematol Agents Med Chem 10:109-15. 2012
    ..This review summarizes current experimental and clinical evidence regarding the effects of SSRIs on platelet functions, immune and neurohormonal activation, and cardiac rhythm disturbances in patients with cardiovascular disease...
  32. doi Anticoagulants, antiplatelets, and statins in heart failure
    Dimitrios Farmakis
    University of Athens Medical School, Attikon University Hospital, Athens, Greece
    Cardiol Clin 26:49-58, vi. 2008
    ..This article outlines the current knowledge regarding the use of antiplatelet and anticoagulant agents and statins in patients who have heart failure...
  33. ncbi Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure
    John T Parissis
    Second Department of Cardiology and Heart Failure Clinic, Attikon University Hospital, Athens, Greece
    Am J Cardiol 96:423-6. 2005
    ..Thus, levosimendan seems to be effective in improving left ventricular diastolic function and reducing neurohormonal activation in patients with severe heart failure...
  34. ncbi Depression in coronary artery disease: novel pathophysiologic mechanisms and therapeutic implications
    John T Parissis
    Second Department of Cardiology, Attikon University Hospital, Aftokratoros Irakliou 17, 15122 Maroussi, Athens, Greece
    Int J Cardiol 116:153-60. 2007
    ....
  35. doi Hyponatremia in heart failure
    Dimitrios Farmakis
    Second Department of Cardiology, Heart Failure Unit, Attikon University Hospital, Athens, Greece
    Heart Fail Rev 14:59-63. 2009
    ..However, it still remains to be seen whether the normalization of serum sodium with vasopressin antagonists will also lead to an improved long-term prognosis...
  36. ncbi Insights into onco-cardiology: atrial fibrillation in cancer
    Dimitrios Farmakis
    First Department of Internal Medicine, University of Athens Medical School, Athens, Greece Second Department of Cardiology, University of Athens Medical School, Athens, Greece
    J Am Coll Cardiol 63:945-53. 2014
    ....
  37. ncbi Hematopoietic colony stimulating factors in cardiovascular and pulmonary remodeling: promoters or inhibitors?
    John Parissis
    2nd Department of Cardiology, University of Athens, Atticon University Hospital, Rimini 1, 12461, Athens, Greece
    Curr Pharm Des 12:2689-99. 2006
    ..This article summarizes current knowledge about the clinical and therapeutic implications of these factors in chronic artery disease, post-infarction cardiac remodeling, chronic heart failure and in pulmonary fibrosis...
  38. ncbi Natriuretic peptides in acute coronary syndromes: prognostic value and clinical implications
    Dimitrios Farmakis
    Second Department of Cardiology, Athens University Medical School, Attikon University Hospital, Athens, Greece
    Congest Heart Fail 14:25-9. 2008
    ..In conclusion, natriuretic peptide values may improve risk stratification in ACS when used in addition to troponin levels and other prognostic markers, but more data are needed to define their role in ACS therapy...
  39. ncbi An introduction to acute heart failure syndromes: definition and classification
    Gerasimos Filippatos
    Heart Failure Unit, Department of Cardiology, Athens University Hospital Attikon, 12461, Athens, Greece
    Heart Fail Rev 12:87-90. 2007
  40. pmc Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial
    Gerasimos Filippatos
    Athens University Hospital Attikon, Athens, Greece
    Eur Heart J 35:1041-50. 2014
    ..Many AHF patients have preserved ejection fraction (HFpEF). Given the lack of evidence-based therapies in this population, we evaluated the effects of serelaxin according to EF in RELAX-AHF trial...
  41. doi Modeling and simulation of right ventricular volume measurement system during right heart catheterization
    Petros Toumpaniaris
    School of Electrical and Computers Engineering, National Technical University of Athens, Athens, Greece
    J Med Syst 36:615-20. 2012
    ..The results show that the algorithm accurately calculates the RVEDV. For the RVESV, greater deviations are observed between values calculated with our algorithm and cardiac MRI...
  42. ncbi Effect of atrial pressure increase on sinus node automaticity
    Michael Efremidis
    Second Department of Cardiology, Evangelismos General Hospital, Athens, Greece
    Heart Vessels 19:221-4. 2004
    ..Autonomic blockade had no effect on SNRT. This study demonstrates that atrial pressure increase does not significantly affect sinus node automaticity expressed by SNRT...
  43. ncbi Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) study
    Gerasimos Filippatos
    Department of Cardiology, Athens University, Athens, Greece
    J Card Fail 13:360-4. 2007
    ..The association between baseline blood urea nitrogen (BUN) and clinical outcomes in patients admitted for ADHF was evaluated in a post-hoc analysis of the ACTIV in CHF trial...
  44. ncbi Facilitating internal cardioversion of chronic atrial fibrillation with ibutilide--predictors of atrial defibrillation-threshold decrease
    Michalis Efremidis
    2nd Department of Cardiology, Evangelismos General Hospital, Athens, Greece
    Med Sci Monit 10:CR258-63. 2004
    ..The object of this study was to depict the effect of ibutilide on sinus rhythm restoration and internal atrial defibrillation threshold in patients with chronic atrial fibrillation...