Research Topics
| Alexandros DrososSummaryAffiliation: University of Ioannina Country: Greece Publications
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Detail Information
Publications
Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2Evangelia S Lourida
Department of Chemistry, Laboratory of Biochemistry, University of Ioannina, 45110 Ioannina, Greece
Arthritis Res Ther 9:R19. 2007....- Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment--a prospective, controlled studyAthanasios N Georgiadis
Department of Internal Medicine, Medical School, University of Ioannina, 45110 Greece
Arthritis Res Ther 8:R82. 2006..Thus, early immuno-intervention to control disease activity may reduce the risk of the atherosclerotic process and cardiovascular events in ERA patients... 
Sinus histocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in a patient with primary Sjogren's syndromeA A Drosos
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Scand J Rheumatol 33:119-22. 2004..In this report, we describe a patient with primary SS, and excessive lymphadenopathy and splenomegaly who developed Rosai-Dorfman disease, and we discuss the possible aetiopathophysiological mechanism linking these two entities...- Epidemiology of rheumatoid arthritisA A Drosos
Rheumatology Clinic, Department of Internal Medical School, University of Ioannina, 45110, Ioannina, Greece
Autoimmun Rev 3:S20-2. 2004 - Methotrexate intolerance in elderly patients with rheumatoid arthritis: what are the alternatives?Alexandros Drosos
Section of Rheumatology, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Drugs Aging 20:723-36. 2003..Experience and familiarity with the currently available agents, and knowledge of the nature of the disease are necessary in order to make better therapeutic decisions... - Persistent clinical response of infliximab treatment, over a 4-year period in ankylosing spondylitisAliki I Venetsanopoulou
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Rheumatol Int 27:935-9. 2007..Infliximab was effective, safe, and well tolerated in patients with AS. The clinical response was maintained for a period of 4 years and over, with infliximab survival of 77.9%... 
The usefulness of magnetic resonance imaging of the hand and wrist in very early rheumatoid arthritisParaskevi E Kosta
Department of Clinical Imaging and Radiology Medical School, University of Ioannina, 45110, Ioannina, Greece
Arthritis Res Ther 13:R84. 2011..Magnetic resonance imaging (MRI) was used to study the hand and wrist in very early rheumatoid arthritis (RA), and the results were compared with early and established disease...- Ear involvement in systemic lupus erythematosus patients: a comparative studyIoannis Kastanioudakis
ENT Department, Medical School, University of Ioannina, Greece
J Laryngol Otol 116:103-7. 2002..This is a lower percentage of ear involvement in SLE than that reported by other investigators. The mechanism of ear damage remains unknown. Thus, additional prospective studies are needed to elucidate its pathogenesis... - Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapyAlexandros A Drosos
Section of Rheumatology, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Drugs 62:891-907. 2002..Many studies conclude that these compounds are very useful in the treatment of chronic synovitis and therefore are very promising for RA treatment... - Seropositive rheumatoid arthritis associated with Crohn's diseaseA N Georgiadis
Division of Rheumatology, Medical School, University of Ioannina, 45110 Ioannina, Greece
Clin Exp Rheumatol 21:363-5. 2003..In the present study we report a patient with long-standing seropositive rheumatoid arthritis, who developed Crohn's disease. We discuss the possible pathophysiologic mechanisms and their associations between these two entities... 
Heterotopic ossification in systemic sclerosisV G Botzoris
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Scand J Rheumatol 38:317-9. 2009..However, differential diagnosis from other causes of extraskeletal ossification, such as tumours or tumour-like conditions, is required...- Epidemiology of ankylosing spondylitis in Northwest Greece, 1983-2002Y Alamanos
Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Greece
Rheumatology (Oxford) 43:615-8. 2004..CONCLUSION: The incidence and prevalence of AS in the area studied were significantly lower than in other white populations and higher than in the Japanese population... - Does cigarette smoking influence disease expression, activity and severity in early rheumatoid arthritis patients?N G Papadopoulos
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Clin Exp Rheumatol 23:861-6. 2005..To investigate the association of cigarette smoking with clinical expression, disease activity and severity in a cohort of Greek patients with early rheumatoid arthritis (RA)... - Rheumatoid arthritis and B-cell chronic lymphocytic leukemiaP V Voulgari
Rheumatology Clinic, Department of Internal Medicine, University of Ioannina Medical School, Greece
Clin Exp Rheumatol 20:63-5. 2002..We discuss the incidence of B-CLL among the RA population and the possible interaction of the pathogenetic mechanisms of these two entities... - Magnetic resonance imaging findings of the cervical spine in patients with rheumatoid arthritis. A cross-sectional studyA K Zikou
Department of Radiology, Medical School, University of Ioannina, Ioannina, Greece
Clin Exp Rheumatol 23:665-70. 2005..However, in patients with active erosive peripheral disease it is very probable to also have some changes in CS. These may be clinically important and in such cases, MR may offer valuable information... - Induction of psoriatic skin lesions in a patient with rheumatoid arthritis treated with rituximabT E Markatseli
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Clin Exp Rheumatol 27:996-8. 2009..However, further studies are needed in order to identify the underlying mechanism, as well as the risk factors associated with rituximab-induced psoriatic skin lesions... - Immune-mediated skin lesions in patients treated with anti-tumour necrosis factor alpha inhibitorsS A Exarchou
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Scand J Rheumatol 38:328-31. 2009..To describe immune-mediated skin lesion (IMSL) development in patients during anti-tumour necrosis factor (TNF) therapy... - Clinical course and outcome of early rheumatoid arthritisI A Papadopoulos
Department of Internal Medicine, Medical School, University of Ioannina, Greece
Rheumatol Int 20:205-10. 2001..In contrast, the seronegative group had less severe radiological findings and greater functional ability at the end of the study. In Greek patients with early RA, rheumatoid factor seems to be a predictor of more severe disease activity... - Early rheumatoid arthritis: does gender influence disease expression?P V Voulgari
Division of Rheumatology, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Clin Exp Rheumatol 22:165-70. 2004..To investigate whether gender is an independent factor associated with disease expression in early rheumatoid arthritis (RA) patients... - Prognostic factors of radiological damage in rheumatoid arthritis: a 10-year retrospective studyTheodora E Markatseli
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
J Rheumatol 38:44-52. 2011..to describe the longterm clinical and radiological outcomes in rheumatoid arthritis (RA) in a cohort in northwestern Greece; and to investigate predictive factors of radiological damage at the 10-year followup in patients with RA... - Granuloma annulare induced by anti-tumour necrosis factor therapyP V Voulgari
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Ann Rheum Dis 67:567-70. 2008..To describe granuloma annulare (GA) skin lesion development in patients during anti-tumour necrosis factor (TNF) therapy... - Evidence-based recommendations for the management of ankylosing spondylitis: results of the Hellenic working group of the 3E Initiative in RheumatologyA Raptopoulou
Department of Internal Medicine, Division of Rheumatology, Clinical Immunology and Allergy, University of Crete, Medical School, Heraklion, Greece
Clin Exp Rheumatol 26:784-92. 2008.... - Efficacy and safety of switching from infliximab to adalimumab: a comparative controlled studyS N Nikas
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
Ann Rheum Dis 65:257-60. 2006..CONCLUSION: Adalimumab is a well tolerated and effective treatment for patients with RA, even when infliximab has been discontinued... - Psychological distress and personality traits in early rheumatoid arthritis: A preliminary surveyT N Hyphantis
Department of Psychiatry, Medical School, University of Ioannina, 45110 Ioannina, Greece
Rheumatol Int 26:828-36. 2006.... - Epidemiology of primary Sjögren's syndrome in north-west Greece, 1982-2003Y Alamanos
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
Rheumatology (Oxford) 45:187-91. 2006..Mortality rates did not differ significantly between pSS patients and the general population... - Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibilityA Chatzikyriakidou
Genetics Unit, Department of Obstetrics and Gynaecology, Medical School, University of Ioannina, Ioannina, Greece
Scand J Rheumatol 38:1-5. 2009..The GC receptor (GR) has two isoforms. In the present study, we explored the role of GR-alpha polymorphisms rs33388, rs33389, and Bcl I, and the GR-beta variant rs6198 in RA susceptibility... - Infliximab treatment in combination with cyclosporin A in patients with severe refractory rheumatoid arthritisT I Temekonidis
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Ann Rheum Dis 61:822-5. 2002..It seems that CsA may be an alternative disease modifying drug to be used in combination with infliximab in patients with refractory RA who cannot tolerate MTX... - Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literatureP V Voulgari
Rheumatology Clinic, Department of Internal Medicine, Medical Bchool, University of Ioannina, Ioannina, Greece
Lupus 11:722-9. 2002..Thus, we conclude that gender influences the clinical expresion of the disease independently of age, while both gender and age do not affect the overall damage score... - Outcome of pregnancy in a patient with relapsing polychondritis and pyoderma gangrenosumG D Tsanadis
University Hospital of Ioannina, Ioannina, Greece
Clin Rheumatol 21:538. 2002 - Prognostic factors for erosive rheumatoid arthritisT E Markatseli
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Clin Exp Rheumatol 28:114-23. 2010..In the present review, the predictive role of demographic, clinical, laboratory, imaging, immunological and genetic characteristics of RA patients is discussed... - Laryngeal involvement in rheumatoid arthritisP V Voulgari
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
Rheumatol Int 25:321-5. 2005..In this report we describe two patients with RA and laryngeal involvement, mostly rheumatoid nodule formation, with a review of the literature... - The role of psychological distress and personality variables in the disablement process in rheumatoid arthritisM Bai
Consultation Liaison Psychiatry Unit, Department of Psychiatry, Medical School, University of Ioannina, Ioannina, Greece
Scand J Rheumatol 38:419-30. 2009..To test whether psychological distress and personality variables mediate or moderate physical health-related quality of life (HRQOL) in rheumatoid arthritis (RA) patients... - Infliximab treatment in ankylosing spondylitis: an observational studyS N Nikas
Rheumatology Clinic, Department of Internal Medicine, University of Ioannina Medical School, 45110 Ioannina, Greece
Ann Rheum Dis 64:940-2. 2005..Treatment was well tolerated and adverse events were mild; 3 patients discontinued the study. CONCLUSION: Infliximab was effective, safe, and well tolerated in patients with AS... - Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitisD N Kiortsis
Laboratory of Physiology, Medical School, University of Ioannina, 45110 Ioannina, Greece
Ann Rheum Dis 64:765-6. 2005..01 for both). CONCLUSIONS: The results suggest that infliximab treatment may have beneficial effects on insulin sensitivity in the most insulin resistant patients with RA and AS... - Subclinical atherosclerosis in scleroderma patientsN Tsifetaki
Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece
Scand J Rheumatol 39:326-9. 2010..To investigate subclinical atherosclerosis in patients with systemic sclerosis (SSc)... - Urticaria and angiedema-like skin reactions in a patient treated with adalimumabS N Nikas
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece
Clin Rheumatol 26:787-8. 2007..These reactions were followed by hypotension. The patient was treated appropriately and after 2 h, the rashes and the edema disappeared and the patient gradually recovered completely. Adalimumab was discontinued... - Sustained clinical response and high infliximab survival in psoriatic arthritis patients: a 3-year long-term studyParaskevi V Voulgari
Assistant Professor of Rheumatology, Rheumatology Clinic, Department of Internal Medicine Medical School, University of Ioannina, Ioannina, Greece
Semin Arthritis Rheum 37:293-8. 2008..To investigate the efficacy, toxicity, and survival of infliximab in patients with psoriatic arthritis (PsA)... - Early treatment reduces the cardiovascular risk factors in newly diagnosed rheumatoid arthritis patientsAthanasios N Georgiadis
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Semin Arthritis Rheum 38:13-9. 2008..To investigate subclinical atherosclerosis and the effect of treatment in patients with early rheumatoid arthritis (RA)... - Persistent clinical response of infliximab therapy in patients with refractory rheumatoid arthritis, over a 3-year periodParaskevi V Voulgari
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Curr Clin Pharmacol 1:103-8. 2006..The clinical response of infliximab was persistent over a 3-year period and was associated with the concomitant use of MTX. This clinical improvement was also associated with the reduction of inflammatory disease tissue damage... - Effects of infliximab treatment on lipoprotein profile in patients with rheumatoid arthritis and ankylosing spondylitisDimitrios N Kiortsis
Department of Internal Medicine, and the Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece
J Rheumatol 33:921-3. 2006..To investigate the longterm effects of the anti-tumor necrosis factor (TNF) therapy infliximab, a drug known to reduce disease activity in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS)... - Shared epitopes and rheumatoid arthritis: disease associations in Greece and meta-analysis of Mediterranean European populationsJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology and the Division of Rheumatology, University of Ioannina School of Medicine, Ioannina, Greece
Semin Arthritis Rheum 31:361-70. 2002..The immunogenetic associations of RA susceptibility are consistent, but their strength may depend on the SE prevalence in different ethnic groups... - Adalimumab for rheumatoid arthritisParaskevi V Voulgari
University of Ioannina Medical School, Rheumatology Clinic, Department of Internal Medicine, 45110 Ioannina, Greece
Expert Opin Biol Ther 6:1349-60. 2006..In addition, the radiographic progression of structural joint damage was significantly inhibited by adalimumab and improved quality of life. This review summarises the recent available data... - Infliximab in refractory psoriatic arthritis with severe psoriasis: a 2-year experienceParaskevi V Voulgari
Ann Rheum Dis 66:270-1. 2007 - Visceral leishmaniasis resembling systemic lupus erythematosusMichalis Voulgarelis
Medical School, National University of Athens, Athens, Greece
Clin Rheumatol 22:452-5. 2003..Leishmaniasis should be taken into consideration in the differential diagnosis of autoimmune disorders... - Epidemiology of adult rheumatoid arthritisYannis Alamanos
Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece
Autoimmun Rev 4:130-6. 2005..Most of these factors are likely to be associated with both disease occurrence and severity... - Epidemiology of systemic sclerosis in northwest Greece 1981 to 2002Yannis Alamanos
Medical School, University of Ioannina, Greece
Semin Arthritis Rheum 34:714-20. 2005..The survival rates were similar to those reported by other studies... - Infliximab therapy in established rheumatoid arthritis: an observational studyParaskevi V Voulgari
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
Am J Med 118:515-20. 2005..After the third year of therapy, 59% of patients continued to be treated with infliximab. The concomitant use of methotrexate was associated with the continuation of infliximab therapy... - Epidemiology of systemic lupus erythematosus in northwest Greece 1982-2001Yannis Alamanos
Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece
J Rheumatol 30:731-5. 2003..The 5 year survival rate was 96.8% and the 10 year survival rate was 90.3%. CONCLUSION: We found a relatively low frequency of SLE in northwest Greece. Age at diagnosis was younger than expected... - Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with infliximabMaria I Argyropoulou
Department of Radiology Medical School, University of Ioannina, Ioannina, Greece
Joint Bone Spine 72:557-61. 2005..Magnetic resonance imaging assessment of the volume of the enhancing inflammatory tissue may represent an additional tool for the investigation of joint disease activity and responsiveness to treatment... - Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic reviewYannis Alamanos
Department of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece
Semin Arthritis Rheum 36:182-8. 2006..However, the relatively small number of studies for most areas of the world and the lack of incidence studies for the developing countries limits the understanding of worldwide RA epidemiology... - Epidemiology of psoriatic arthritis in northwest Greece, 1982-2001Yannis Alamanos
Department of Hygiene and Epidemiology, University of Ioannina Medical School, 451 10 Ioannina, Greece
J Rheumatol 30:2641-4. 2003..CONCLUSION: The incidence and prevalence of PsA in Northwest Greece was roughly half that reported in studies from the US and Northern Europe. This frequency tended to increase in the last decade... - Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with adalimumabAnastasia K Zikou
Department of Radiology and the Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Greece
J Rheumatol 33:219-23. 2006..MRI assessment of the VEIT may represent an additional tool for investigation of joint disease activity and responsiveness to treatment... - Radiological cervical spine involvement in patients with rheumatoid arthritis: a cross sectional studyAnastasia K Zikou
Department of Radiology, Medical School, University of Ioannina, Ioannina, Greece
J Rheumatol 32:801-6. 2005..6%. CONCLUSION: Cervical spine radiological involvement is a frequent finding in our patients with RA, but the severity of the disease is rather mild, possibly related to the ethnic background... - Epidemiology of rheumatic diseases in GreeceYannis Alamanos
J Rheumatol 31:1669-70; author reply 1670-1. 2004 - Exacerbation of tuberculosis enteritis after treatment with infliximabEvagelos N Liberopoulos
Am J Med 113:615. 2002 - Disease modifying antirheumatic drugs in early rheumatoid arthritis: a longterm observational studyNikolaos G Papadopoulos
Department of Internal Medicine, Medical School, University of Ioannina, Greece
J Rheumatol 29:261-6. 2002..CONCLUSION: It appears that MTX has the longest survival time, with CSA following in second place. The main reasons for discontinuation of treatment were drug inefficacy, followed by adverse drug reactions... - Early rheumatoid arthritis patients: relationship of ageIoannis A Papadopoulos
Division of Rheumatology, Department of Internal Medicine, Medical School, University of Ioannina, 45 110 Ioannina, Greece
Rheumatol Int 23:70-4. 2003..However, at the end of the study, no differences were seen concerning radiological changes and functional ability. It seems that age at disease onset does not influence the clinical course and outcome of early RA patients... - Transcription regulatory polymorphism -43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapyAnthoula Chatzikyriakidou
Genetics Unit, Department of Obstetrics and Gynaecology, Medical School, University of Ioannina, 45110 Ioannina, Greece
Rheumatol Int 27:1057-61. 2007..Therefore, the present genotypic-phenotypic association study of a functional polymorphism revealed the need of a complex genotypic analysis in order to predict patient response to folate antagonists' therapy... - The impact of psychological functioning upon systemic sclerosis patients' quality of lifeThomas N Hyphantis
Department of Psychiatry, Medical School, University of Ioannina, Ioannina, Greece
Semin Arthritis Rheum 37:81-92. 2007.... - Gingival hyperplasia associated with cyclosporin AParaskevi V Voulgari
Department of Internal Medicine, Medical School, University of Ioannina, Greece
J Rheumatol 29:2466. 2002 - SCIO-469 Scios IncSpyros N Nikas
University of Ioannina Medical School, Department of Internal Medicine, Division of Rheumatology, Ioannina 45110, Greece
Curr Opin Investig Drugs 5:1205-12. 2004..By July 2004, SCIO-469 was in phase lib clinical trials for rheumatoid arthritis... - Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international studyTuulikki Sokka
Jyvaskyla Central Hospital, Jyvaskyla, Finland
Arthritis Rheum 59:42-50. 2008..We studied the prevalence of physical activity and associations with demographic and disease-related variables in patients with RA from 21 countries...