Emmanuel E Douzinas

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Hypoxemic reperfusion after 120 mins of intestinal ischemia attenuates the histopathologic and inflammatory response
    Emmanuel E Douzinas
    Department of Critical Care, University of Athens Medical School, Athens, Greece
    Crit Care Med 32:2279-83. 2004
  2. ncbi Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult
    E E Douzinas
    Department of Critical Care, Evangelismos Hospital, Athens, Greece
    Intensive Care Med 27:905-10. 2001
  3. ncbi Myocardial ischemia in intestinal postischemic shock: the effect of hypoxemic reperfusion
    Emmanuel E Douzinas
    Departmentof Critical Care, University of Athens Medical School, Greece
    Crit Care Med 31:2183-9. 2003
  4. ncbi Effect of percutaneous endoscopic gastrostomy on gastro-esophageal reflux in mechanically-ventilated patients
    Emmanuel E Douzinas
    Department of Critical Care, Evangelismos Hospital, Athens 10675, Greece
    World J Gastroenterol 12:114-8. 2006
  5. ncbi The effect of hypoxemic resuscitation from hemorrhagic shock on blood pressure restoration and on oxidative and inflammatory responses
    Emmanuel E Douzinas
    Evgenidion Hospital, 20 Papadiamantopoulou Street, Athens, Greece
    Intensive Care Med 34:1133-41. 2008
  6. ncbi The effect of hypoxemic resuscitation of hemorrhagic shock on hemodynamic stabilization and inflammatory response: a pilot study in a rat experimental model
    Emmanuel E Douzinas
    Department of Critical Care, University of Athens Medical School, Athens, Greece
    J Trauma 61:918-23. 2006
  7. ncbi Stimulation of monocytes is a pathway involved in systemic inflammatory response following haemorrhagic shock resuscitation: the effect of hypoxaemic resuscitation
    E E Douzinas
    3rd Department of Critical Care, University of Athens Medical School, Athens, Greece
    Clin Exp Immunol 150:502-8. 2007
  8. ncbi Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation
    Emmanuel E Douzinas
    3rd Department of Critical Care Medicine, University of Athens Medical School, Athens, Greece
    PLoS ONE 7:e32968. 2012
  9. ncbi Hypoxemic resuscitation from hemorrhagic shock prevents lung injury and attenuates oxidative response and IL-8 overexpression
    Emmanuel E Douzinas
    Third Department of Critical Care Medicine, University of Athens Medical School, Evgenidio Hospital, Athens 115 28, Greece
    Free Radic Biol Med 50:245-53. 2011
  10. ncbi Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients
    Emmanuel E Douzinas
    3rd Department of Critical Care, Evgenidion Hospital, University of Athens Medical School, Athens 115 28, Greece
    World J Gastroenterol 15:5455-60. 2009

Collaborators

Detail Information

Publications22

  1. ncbi Hypoxemic reperfusion after 120 mins of intestinal ischemia attenuates the histopathologic and inflammatory response
    Emmanuel E Douzinas
    Department of Critical Care, University of Athens Medical School, Athens, Greece
    Crit Care Med 32:2279-83. 2004
    ..CONCLUSIONS: Hypoxemic reperfusion represents an intervention that may attenuate the triggering of multifactorial cascade and organ tissue injury...
  2. ncbi Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult
    E E Douzinas
    Department of Critical Care, Evangelismos Hospital, Athens, Greece
    Intensive Care Med 27:905-10. 2001
    ..In the present study, we investigated the effect of hypoxaemic reperfusion on brain histopathological changes...
  3. ncbi Myocardial ischemia in intestinal postischemic shock: the effect of hypoxemic reperfusion
    Emmanuel E Douzinas
    Departmentof Critical Care, University of Athens Medical School, Greece
    Crit Care Med 31:2183-9. 2003
    ..The purpose of the current study is to clarify the pathophysiology of this type of shock and to test the hypothesis that hypoxemic compared with normoxemic reperfusion improves hemodynamics...
  4. ncbi Effect of percutaneous endoscopic gastrostomy on gastro-esophageal reflux in mechanically-ventilated patients
    Emmanuel E Douzinas
    Department of Critical Care, Evangelismos Hospital, Athens 10675, Greece
    World J Gastroenterol 12:114-8. 2006
    ..To investigate the effect of percutaneous endoscopic gastrostomy (PEG) on gastroesophageal reflux (GER) in mechanically-ventilated patients...
  5. ncbi The effect of hypoxemic resuscitation from hemorrhagic shock on blood pressure restoration and on oxidative and inflammatory responses
    Emmanuel E Douzinas
    Evgenidion Hospital, 20 Papadiamantopoulou Street, Athens, Greece
    Intensive Care Med 34:1133-41. 2008
    ..We investigated whether hypoxemic resuscitation from hemorrhagic shock prevents the late circulatory instability and attenuates the oxidative and inflammatory responses associated with the standard strategy...
  6. ncbi The effect of hypoxemic resuscitation of hemorrhagic shock on hemodynamic stabilization and inflammatory response: a pilot study in a rat experimental model
    Emmanuel E Douzinas
    Department of Critical Care, University of Athens Medical School, Athens, Greece
    J Trauma 61:918-23. 2006
    ..Resuscitation of hemorrhagic shock is associated with tissue injury. The effect of hypoxemia during resuscitation was investigated...
  7. ncbi Stimulation of monocytes is a pathway involved in systemic inflammatory response following haemorrhagic shock resuscitation: the effect of hypoxaemic resuscitation
    E E Douzinas
    3rd Department of Critical Care, University of Athens Medical School, Athens, Greece
    Clin Exp Immunol 150:502-8. 2007
    ..Lower stimulation of the p38 MAPK-mediated production of IL-1beta, IL-6 and IL-8 by monocytes may be implicated as an explanation for the benefits shown for the host when resuscitation is performed under hypoxaemic conditions...
  8. ncbi Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation
    Emmanuel E Douzinas
    3rd Department of Critical Care Medicine, University of Athens Medical School, Athens, Greece
    PLoS ONE 7:e32968. 2012
    ..Hemorrhagic shock and resuscitation is frequently associated with liver ischemia-reperfusion injury. The aim of the study was to investigate whether hypoxemic resuscitation attenuates liver injury...
  9. ncbi Hypoxemic resuscitation from hemorrhagic shock prevents lung injury and attenuates oxidative response and IL-8 overexpression
    Emmanuel E Douzinas
    Third Department of Critical Care Medicine, University of Athens Medical School, Evgenidio Hospital, Athens 115 28, Greece
    Free Radic Biol Med 50:245-53. 2011
    ..We conclude that hypoxemic resuscitation from hemorrhagic shock ameliorates lung injury and reduces oxygen radical generation and lung IL-8 expression...
  10. ncbi Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients
    Emmanuel E Douzinas
    3rd Department of Critical Care, Evgenidion Hospital, University of Athens Medical School, Athens 115 28, Greece
    World J Gastroenterol 15:5455-60. 2009
    ..To investigate factors predicting failure of percutaneous endoscopic gastrostomy (PEG) to eliminate gastroesophageal reflux (GER)...
  11. ncbi Hypoxemic resuscitation prevents pulmonary capillary endothelial dysfunction induced by normoxemic resuscitation from hemorrhagic shock
    Emmanuel E Douzinas
    3rd Department of Critical Care, Metaxa Cancer Hospital, Piraeus, Greece
    Crit Care Med 37:869-75. 2009
    ..In this study, we sought to investigate the effect of hypoxemic resuscitation on pulmonary endothelium...
  12. ncbi High concentrations of reactive oxygen species in the BAL fluid are correlated with lung injury in rabbits after hemorrhagic shock and resuscitation
    Marios Konstantinos Tasoulis
    Third Department of Critical Care Medicine, Athens University School of Medicine, Athens, Greece
    Tohoku J Exp Med 219:193-9. 2009
    ..In conclusion, ROS in the BAL fluid are good markers that predict lung injury following hemorrhagic shock and resuscitation...
  13. ncbi Administration of human protein C improves survival in an experimental model of sepsis
    Evangelos Messaris
    Laboratory of Surgical Research, First Department of Propaedeutic Surgery, Athens University Medical School, Hippokratio General Hospital, Athens, Greece
    Crit Care Med 38:209-16. 2010
    ..Study the effect of human protein C (PC) concentrate administration on organ damage and survival in septic rats...
  14. ncbi Hypoxemic resuscitation after hemorrhagic shock is accompanied by reduced serum levels of angiopoietin-2
    Emmanuel E Douzinas
    3rd Department of Critical Care, University of Athens Medical School, Greece
    Cytokine 47:82-4. 2009
    ..To investigate whether angiopoietin-2 (Ang2) and vascular endothelial growth factor (VEGF) are implicated in the hypoxemic resuscitation from hemorrhagic shock...
  15. ncbi Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections
    Alex P Betrosian
    Athens University, Evgenidion Hospital, 3rd Department of Critical Care, Greece
    Expert Opin Drug Metab Toxicol 5:1099-112. 2009
    ..baumannii infections for carbapenem-resistant strains in the nosocomial setting. Thus, ampicillin-sulbactam remains a valuable agent in the physician's armamentarium in the management of adult and pediatric infections...
  16. ncbi Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis
    Olga Livaditi
    3rd (Evgenidion Hospital, Department of Critical Care, University of Athens Medical School, 20 Papadiamantopoulou St, Athens, 115 28, Greece
    Cytokine 36:283-90. 2006
    ..Based on this single measurement it is possible to reliably assess the stage, detect the severity and predict the 28-day mortality of sepsis...
  17. ncbi Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the septic host
    Diamantis Plachouras
    Fourth Department of Internal Medicine, University of Athens Medical School, Greece
    Scand J Infect Dis 38:909-15. 2006
    ..In essence, the above results suggest that monocytes contribute to the production of sTREM-1 in the event of septic syndrome...
  18. ncbi Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency
    Emmanuel E Douzinas
    3rd Department of Critical Care, Athens University, Evgenidion Hospital, 20 Papadiamantopoulou Str, Athens, Greece
    Scand J Infect Dis 42:76-8. 2010
    ..She was successfully treated with oral atovaquone and ganciclovir. Atovaquone represents a safe alternative in severe Pneumocystis infection when trimethoprim-sulfamethoxazole (co-trimoxazole) is contraindicated...
  19. ncbi Grouping of patients with common variable immunodeficiency based on immunoglobulin biosynthesis: comparison with a classification system on CD4-naïve cells
    Olga Livaditi
    3rd Department of Critical Care, University of Athens, Medical School, Greece
    Immunol Lett 114:103-9. 2007
    ..Our proposal is that both should be used for the characterization of patients with CVID...
  20. ncbi Acute renal dysfunction in liver diseases
    Alex P Betrosian
    Third Department of Critical Care, Athens University, Evgenidion Hospital, Papadiamantopoulou 20, Athens 11528, Greece
    World J Gastroenterol 13:5552-9. 2007
    ..Continuous renal replacement therapy (CRRT) and molecular absorbent recirculating system (MARS) in selected patients may be life saving while awaiting liver transplantation...
  21. ncbi Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia
    Alex P Betrosian
    3rd Department of Critical Care, Athens University, Evgenidion Hospital, Papadiamantopoulou 20, Athens, Greece
    J Infect 56:432-6. 2008
    ..To compare the safety and efficacy of ampicillin/sulbactam (Amp/Sulb) and colistin (COL) in the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP)...
  22. ncbi The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: an experimental study
    Emmanuel E Douzinas
    3rd Department of Critical Care Medicine, University of Athens, Medical School, Greece
    BMC Physiol 8:15. 2008
    ..To evaluate whether the level of hypotension during hemorrhagic shock may influence the oxidative and inflammatory responses developed during post-ischemic resuscitation...