I Dimopoulou

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. pmc Inhaled activated protein C protects mice from ventilator-induced lung injury
    Nikolaos A Maniatis
    2nd Dept, of Critical Care, Attikon Hospital, National and Kapodistrian University of Athens Medical School, Rimini 1, Haidari, Greece
    Crit Care 14:R70. 2010
  2. pmc Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
    Charalambos Gogos
    1st Department of Internal Medicine, University of Patras, Medical School, 26504 Rio, Greece
    Crit Care 14:R96. 2010
  3. pmc TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen
    Thekla Poukoulidou
    4th Department of Internal Medicine, University of Athens, Medical School, Attikon General Hospital, 1 Rimini Str, 12462 Athens, Greece
    BMC Infect Dis 11:309. 2011
  4. pmc Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay
    Iraklis Tsangaris
    The 2nd Critical Care Department, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, 12462, Athens, Greece
    BMC Infect Dis 9:213. 2009
  5. pmc Predicting ICU survival: a meta-level approach
    Lefteris G Gortzis
    Telemedicine Unit, School of Medicine, University of Patras, Patras, Greece
    BMC Health Serv Res 8:157. 2008
  6. doi request reprint Kinetics of adipose tissue microdialysis-derived metabolites in critically ill septic patients: associations with sepsis severity and clinical outcome
    Ioanna Dimopoulou
    Second Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
    Shock 35:343-8. 2011
  7. ncbi request reprint High incidence of neuroendocrine dysfunction in long-term survivors of aneurysmal subarachnoid hemorrhage
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    Stroke 35:2884-9. 2004
  8. ncbi request reprint Pulmonary toxicity from novel antineoplastic agents
    I Dimopoulou
    Second Department of Critical Care Medicine, Attikon University Hospital, Athens, Greece
    Ann Oncol 17:372-9. 2006
  9. ncbi request reprint Endocrine alterations in critically ill patients with stroke during the early recovery period
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
    Neurocrit Care 3:224-9. 2005
  10. ncbi request reprint Pituitary-adrenal responses to human corticotropin-releasing hormone in critically ill patients
    Ioanna Dimopoulou
    Pesmazoglou 2 Street, 14561, Kifissia, Athens, Greece
    Intensive Care Med 33:454-9. 2007

Collaborators

Detail Information

Publications48

  1. pmc Inhaled activated protein C protects mice from ventilator-induced lung injury
    Nikolaos A Maniatis
    2nd Dept, of Critical Care, Attikon Hospital, National and Kapodistrian University of Athens Medical School, Rimini 1, Haidari, Greece
    Crit Care 14:R70. 2010
    ..We also assessed the effects of APC on the activation status of Extracellular- Regulated Kinase 1/2 (ERK) pathway, which has been shown to be involved in regulating pulmonary responses to mechanical stretch...
  2. pmc Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
    Charalambos Gogos
    1st Department of Internal Medicine, University of Patras, Medical School, 26504 Rio, Greece
    Crit Care 14:R96. 2010
    ..Although major changes of the immune system have been described in sepsis, it has never been studied whether these may differ in relation to the type of underlying infection or not. This was studied for the first time...
  3. pmc TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen
    Thekla Poukoulidou
    4th Department of Internal Medicine, University of Athens, Medical School, Attikon General Hospital, 1 Rimini Str, 12462 Athens, Greece
    BMC Infect Dis 11:309. 2011
    ..Current knowledge on the exact ligand causing expression of TREM-1 on neutrophils and monocytes is limited. The present study aimed at the role of underlying infection and of the causative pathogen in the expression of TREM-1 in sepsis...
  4. pmc Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay
    Iraklis Tsangaris
    The 2nd Critical Care Department, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, 12462, Athens, Greece
    BMC Infect Dis 9:213. 2009
    ..Procalcitonin (PCT) has been proposed as a diagnostic and prognostic sepsis marker, but has never been validated in febrile patients with prolonged ICU stay...
  5. pmc Predicting ICU survival: a meta-level approach
    Lefteris G Gortzis
    Telemedicine Unit, School of Medicine, University of Patras, Patras, Greece
    BMC Health Serv Res 8:157. 2008
    ..The objective of the present study was twofold: to propose a prototype meta-level predicting approach concerning Intensive Care Unit (ICU) survival and to evaluate the effectiveness of typical mining models in this context...
  6. doi request reprint Kinetics of adipose tissue microdialysis-derived metabolites in critically ill septic patients: associations with sepsis severity and clinical outcome
    Ioanna Dimopoulou
    Second Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
    Shock 35:343-8. 2011
    ..Elevated tissue lactate, pyruvate, and glycerol levels are related to poor clinical outcome, with the latter constituting an independent predictor...
  7. ncbi request reprint High incidence of neuroendocrine dysfunction in long-term survivors of aneurysmal subarachnoid hemorrhage
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    Stroke 35:2884-9. 2004
    ..To investigate the incidence, pattern, and magnitude of neuroendocrine changes in long-term survivors of aneurysmal subarachnoid hemorrhage (SAH)...
  8. ncbi request reprint Pulmonary toxicity from novel antineoplastic agents
    I Dimopoulou
    Second Department of Critical Care Medicine, Attikon University Hospital, Athens, Greece
    Ann Oncol 17:372-9. 2006
    ..The pulmonary side-effects induced by novel antineoplastic agents have not been well characterized...
  9. ncbi request reprint Endocrine alterations in critically ill patients with stroke during the early recovery period
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
    Neurocrit Care 3:224-9. 2005
    ..Endocrine abnormalities in critically ill patients with stroke during the early recovery period have not been well characterized...
  10. ncbi request reprint Pituitary-adrenal responses to human corticotropin-releasing hormone in critically ill patients
    Ioanna Dimopoulou
    Pesmazoglou 2 Street, 14561, Kifissia, Athens, Greece
    Intensive Care Med 33:454-9. 2007
    ..To investigate the pattern of pituitary-adrenal responses to human corticotropin-releasing hormone (hCRH) in critically ill patients and to examine the relation between responses and clinical outcome...
  11. ncbi request reprint A prospective study on adrenal cortex responses and outcome prediction in acute critical illness: results from a large cohort of 203 mixed ICU patients
    Ioanna Dimopoulou
    Attikon Hospital, Medical School, Second Department of Critical Care Medicine, University of Athens, 2 Pesmazoglou Street, 14561 Athens, Greece
    Intensive Care Med 33:2116-21. 2007
    ..To assess whether adrenal cortex hormones predict ICU mortality in acute, mixed, critically ill patients...
  12. doi request reprint Plasma pro- and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patients
    Ioanna Dimopoulou
    Second Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, 2 Pesmazoglou Street, 14 561 Kifissia, Athens, Greece
    Cytokine 41:263-7. 2008
    ..To determine the inter-relationships between cytokine levels and physiological scores in predicting outcome in unselected, critically ill patients...
  13. ncbi request reprint A prospective study on lung toxicity in patients treated with gemcitabine and carboplatin: clinical, radiological and functional assessment
    I Dimopoulou
    Department of Pulmonary and Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Ann Oncol 15:1250-5. 2004
    ..However, a prospective evaluation of cancer patients treated with gemcitabine-based chemotherapy without neoplastic involvement of the thorax and without administration of radiotherapy has not been performed...
  14. ncbi request reprint The low-dose corticotropin stimulation test in acute traumatic and non-traumatic brain injury: incidence of hypo-responsiveness and relationship to outcome
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 10675 Athens, Greece
    Intensive Care Med 30:1216-9. 2004
    ..To investigate adrenal responses to the low-dose corticotropin (ACTH) stimulation test in acute traumatic or non-traumatic brain injury (BI) and to assess its value in predicting outcome...
  15. ncbi request reprint Adrenal function in non-septic long-stay critically ill patients: evaluation with the low-dose (1 micro g) corticotropin stimulation test
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, Greece
    Intensive Care Med 28:1168-71. 2002
    ..To investigate the adrenal function in non-septic, long-stay critically ill patients...
  16. ncbi request reprint A prospective study of pulmonary function in patients treated with paclitaxel and carboplatin
    Ioanna Dimopoulou
    Department of Pulmonary and Critical Care, Evangelismos Hospital, Medical School, Athens, Greece
    Cancer 94:452-8. 2002
    ..Adverse effects of paclitaxel and carboplatin have been well described; however, pulmonary toxicity after patients receive this regimen has not been investigated extensively...
  17. ncbi request reprint Protein S-100b serum levels in trauma-induced brain death
    I Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, Medical and Nursing School, National and Kapodistrian University of Athens, Greece
    Neurology 60:947-51. 2003
    ....
  18. ncbi request reprint High prevalence of decreased cortisol reserve in brain-dead potential organ donors
    Ioanna Dimopoulou
    Departments of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Crit Care Med 31:1113-7. 2003
    ..To investigate the adrenocortical function in brain-dead patients, potential organ donors...
  19. ncbi request reprint Prediction of prolonged ventilatory support in blunt thoracic trauma patients
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Intensive Care Med 29:1101-5. 2003
    ..To identify predictors of prolonged (>7 days) mechanical ventilation (MV) in patients with blunt thoracic trauma...
  20. ncbi request reprint Relationship of thyroid function to post-traumatic S-100b serum levels in survivors of severe head injury: preliminary results
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 45 47 Ipsilandou Street, 106 75 Athens, Greece
    Intensive Care Med 30:298-301. 2004
    ..To assess thyroid function abnormalities in survivors of severe head trauma and to examine their relationship with indices of brain injury severity...
  21. ncbi request reprint Functional status and quality of life in long-term survivors of cardiac arrest after cardiac surgery
    I Dimopoulou
    Intensive Care Unit, Onassis Cardiac Surgery Center, Athens, Greece
    Crit Care Med 29:1408-11. 2001
    ..To assess long-term survival, functional status, and quality of life in patients who experienced cardiac arrest after cardiac surgery...
  22. ncbi request reprint Endocrine abnormalities in critical care patients with moderate-to-severe head trauma: incidence, pattern and predisposing factors
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    Intensive Care Med 30:1051-7. 2004
    ..To investigate the incidence and type of endocrine abnormalities in critical care patients with traumatic brain injury (TBI) and to examine their relationships to possible predisposing factors...
  23. ncbi request reprint Effects of severity of chronic obstructive pulmonary disease on thyroid function
    I Dimopoulou
    Department of Pulmonary and Critical Care Medicine, Evangelismos General Hospital, Athens, Greece
    Metabolism 50:1397-401. 2001
    ..It is concluded that in stable COPD, severity of disease through hypoxemia is important in determining the peripheral metabolism of thyroid hormones. Whether this constitutes an adaptation is not known...
  24. ncbi request reprint Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators
    Stylianos E Orfanos
    Second Department of Critical Care, Attikon University Hospital, University of Athens Medical School, 1 Rimini Street, Haidari, Athens 124 62, Greece
    Crit Care Med 35:199-206. 2007
    ....
  25. ncbi request reprint Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels
    Ioanna Dimopoulou
    Department of Clinical Care Medicine, Evangelismos Hospital, Athens, Greece
    Crit Care Med 32:404-8. 2004
    ....
  26. doi request reprint Association of left ventricular diastolic dysfunction with elevated NT-pro-BNP in general intensive care unit patients with preserved ejection fraction: a complementary role of tissue Doppler imaging parameters and NT-pro-BNP levels for adverse outcome
    Ignatios Ikonomidis
    Second Department of Cardiology, Attikon Hospital, Medical School, University of Athens, Athens, Greece
    Shock 33:141-8. 2010
    ..01). In ICU patients with preserved EF, LV diastolic dysfunction and sepsis determine NT-pro-BNP levels. Tissue Doppler imaging markers and NT-pro-BNP have a complementary value for in-hospital mortality...
  27. ncbi request reprint Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications
    S Tsagarakis
    Department of Endocrinology, Athens Polyclinic, Athens, Greece
    Pituitary 8:251-4. 2005
    ..Therefore, assessment of the integrity of ADH secretion, hypothalamic-pituitary adrenal (HPA) axis and thyroid axis is crucial to ensure survival and optimal rehabilitation of TBI patients...
  28. ncbi request reprint Failure of tigecycline to treat severe Clostridium difficile infection
    P Kopterides
    2nd Critical Care Department, Attiko University Hospital, School ofMedicine, University ofAthens, Athens, Greece
    Anaesth Intensive Care 38:755-8. 2010
    ..Even though tigecycline looks promising for the treatment of Clostridium difficile infection, we urge caution against its indiscriminate use for off label indications...
  29. ncbi request reprint Pituitary-adrenal responses following major abdominal surgery
    Ioanna Dimopoulou
    2nd Department of Critical Care Medicine, Attikon Hospital, Athens University School of Medicine, Athens, Greece
    Hormones (Athens) 7:237-42. 2008
    ..Perioperative pituitary-adrenal responses after major abdominal surgery have not been well characterized. The aim of the present study was to further clarify perioperative pituitary-adrenal responses...
  30. ncbi request reprint Thyroid function changes and cytokine alterations following major surgery
    Ioannis Ilias
    Department of Endocrinology, Elena Venizelou Hospital, Athens, Greece
    Neuroimmunomodulation 14:243-7. 2007
    ..Significant negative correlations were noted among TNF-alpha, IL-6 and IL-8 against T(3) and FT(4). Cytokines are responsible, at least in part, for NTI following major operations...
  31. doi request reprint Prognostic importance of increased plasma amino-terminal pro-brain natriuretic peptide levels in a large noncardiac, general intensive care unit population
    Anastasia Kotanidou
    First Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Shock 31:342-7. 2009
    ..Elevated admission NT-pro-BNP represents an independent predictor for poor ICU outcome in the presence of clinical severity scores...
  32. doi request reprint Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes
    I Dimopoulou
    2nd Department of Critical Care Medicine, University of Athens, Greece
    Inflamm Res 58:127-32. 2009
    ..To describe the concentrations of sTREM-1 in patients with sepsis and to explore the effects of their serum on the expression of TREM-1 on U937 monocytes...
  33. ncbi request reprint The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis
    A Tsantes
    Attikon University General Hospital, Medical School, University of Athens, Athens 12462, Greece
    Minerva Anestesiol 76:787-94. 2010
    ..Our primary aim was to measure plasma homocysteine levels in mechanically ventilated patients with severe sepsis/septic shock and to assess the association of these levels with relevant clinical outcomes...
  34. ncbi request reprint Pattern of breathing during progressive exercise in chronic heart failure
    I Dimopoulou
    Intensive Care Unit and Pulmonary Function Laboratory, Onassis Cardiac Surgery Center, Athens, Greece
    Int J Cardiol 81:117-21; discussion 121-2. 2001
    ..In conclusion, patients with CHF adopt variable breathing patterns during exercise; specific patterns are associated with greater impairment in functional capacity...
  35. ncbi request reprint Health-related quality of life and disability in survivors of multiple trauma one year after intensive care unit discharge
    Ioanna Dimopoulou
    Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Am J Phys Med Rehabil 83:171-6. 2004
    ..To evaluate health-related quality of life and disability in multiple-trauma patients requiring intensive care unit management...
  36. ncbi request reprint Hypothalamic-pituitary dysfunction in critically ill patients with traumatic and nontraumatic brain injury
    Ioanna Dimopoulou
    Second Department of Critical Care Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Greece
    Intensive Care Med 31:1020-8. 2005
    ..A significant number of studies have shown that critically ill patients with brain injury (BI) frequently exhibit abnormal pituitary hormonal responses during the immediate postinjury period...
  37. doi request reprint Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysis
    Ilias I Siempos
    Critical Care Department, Attikon University Hospital, Athens, Greece
    Crit Care Med 37:2283-9. 2009
    ..There is controversy on whether catheter-related bloodstream infections (CR-BSI) affect the mortality of critically ill patients...
  38. ncbi request reprint Tumour necrosis factor-alpha (TNFalpha) and interleukin-10 are crucial mediators in post-operative systemic inflammatory response and determine the occurrence of complications after major abdominal surgery
    Ioanna Dimopoulou
    2nd Department of Critical Care Medicine, Attikon Hospital, University of Athens, Medical School, Greece
    Cytokine 37:55-61. 2007
    ..The course of serum cytokine levels in patients with postoperative systemic inflammatory response syndrome (SIRS) after major abdominal surgery remains currently unclear...
  39. doi request reprint Ex-vivo effect of dexamethasone on cytokine production from whole blood of septic patients: correlation with disease severity
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Cytokine 49:89-94. 2010
    ....
  40. doi request reprint Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes
    Hariklia Kranidioti
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Immunol Lett 125:65-71. 2009
    ..It seems that a circulating factor may exist in the serum of patients with septic shock that stimulates gene expression and subsequent release of Ang-2 from monocytes. TLR4 and TNFalpha modulate release of Ang-2...
  41. doi request reprint The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS
    Iraklis Tsangaris
    2nd Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
    Thromb Res 123:832-6. 2009
    ..The objective of the study was to evaluate the effect of this polymorphism on the outcome of critically ill patients with ALI/ARDS...
  42. doi request reprint The effect of four hemostatic gene polymorphisms on the outcome of septic critically ill patients
    Argirios E Tsantes
    Laboratory of Haematology and Blood Bank Unit, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, Athens, Greece
    Blood Coagul Fibrinolysis 21:175-81. 2010
    ..Our data suggest that the importance of these hemostatic polymorphisms as predictors of the prognosis of sepsis in critically ill patients is probably very small...
  43. ncbi request reprint Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unit
    Ioannis Ilias
    Department of Endocrinology, Elena Venizelou Hospital, and Athens University School of Medicine, Greece
    Hormones (Athens) 6:218-26. 2007
    ..To evaluate whether tentative prognostic models for intensive care unit survival of multiple trauma patients could be improved by including endocrine parameters...
  44. ncbi request reprint Thyroid hormone levels improve the prediction of mortality among patients admitted to the intensive care unit
    Ioanna Dimopoulou
    Intensive Care Med 32:616. 2006
  45. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  46. ncbi request reprint Reproducibility of the corticotropin stimulation test in septic shock
    Ioanna Dimopoulou
    Anesth Analg 103:1056-7; author reply 1057. 2006
  47. ncbi request reprint Association between adrenal insufficiency and ventilator weaning
    Ioanna Dimopoulou
    Am J Respir Crit Care Med 173:934; author reply 934-5. 2006
  48. ncbi request reprint Comment on "Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest" by Pene et al
    Ioanna Dimopoulou
    Intensive Care Med 31:1139; author reply 1140. 2005