Research Topics
Species | I DimopoulouSummaryAffiliation: University of Athens Country: Greece Publications
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Detail Information
Publications
Inhaled activated protein C protects mice from ventilator-induced lung injuryNikolaos A Maniatis
2nd Dept, of Critical Care, Attikon Hospital, National and Kapodistrian University of Athens Medical School, Rimini 1, Haidari, Greece
Crit Care 14:R70. 2010..We also assessed the effects of APC on the activation status of Extracellular- Regulated Kinase 1/2 (ERK) pathway, which has been shown to be involved in regulating pulmonary responses to mechanical stretch...- Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infectionCharalambos Gogos
1st Department of Internal Medicine, University of Patras, Medical School, 26504 Rio, Greece
Crit Care 14:R96. 2010..Although major changes of the immune system have been described in sepsis, it has never been studied whether these may differ in relation to the type of underlying infection or not. This was studied for the first time... - TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogenThekla Poukoulidou
4th Department of Internal Medicine, University of Athens, Medical School, Attikon General Hospital, 1 Rimini Str, 12462 Athens, Greece
BMC Infect Dis 11:309. 2011..Current knowledge on the exact ligand causing expression of TREM-1 on neutrophils and monocytes is limited. The present study aimed at the role of underlying infection and of the causative pathogen in the expression of TREM-1 in sepsis... - Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stayIraklis Tsangaris
The 2nd Critical Care Department, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, 12462, Athens, Greece
BMC Infect Dis 9:213. 2009..Procalcitonin (PCT) has been proposed as a diagnostic and prognostic sepsis marker, but has never been validated in febrile patients with prolonged ICU stay... - Predicting ICU survival: a meta-level approachLefteris G Gortzis
Telemedicine Unit, School of Medicine, University of Patras, Patras, Greece
BMC Health Serv Res 8:157. 2008..The objective of the present study was twofold: to propose a prototype meta-level predicting approach concerning Intensive Care Unit (ICU) survival and to evaluate the effectiveness of typical mining models in this context... - Kinetics of adipose tissue microdialysis-derived metabolites in critically ill septic patients: associations with sepsis severity and clinical outcomeIoanna Dimopoulou
Second Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
Shock 35:343-8. 2011..Elevated tissue lactate, pyruvate, and glycerol levels are related to poor clinical outcome, with the latter constituting an independent predictor... - High incidence of neuroendocrine dysfunction in long-term survivors of aneurysmal subarachnoid hemorrhageIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Stroke 35:2884-9. 2004..To investigate the incidence, pattern, and magnitude of neuroendocrine changes in long-term survivors of aneurysmal subarachnoid hemorrhage (SAH)... - Pulmonary toxicity from novel antineoplastic agentsI Dimopoulou
Second Department of Critical Care Medicine, Attikon University Hospital, Athens, Greece
Ann Oncol 17:372-9. 2006..The pulmonary side-effects induced by novel antineoplastic agents have not been well characterized... - Endocrine alterations in critically ill patients with stroke during the early recovery periodIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
Neurocrit Care 3:224-9. 2005..Endocrine abnormalities in critically ill patients with stroke during the early recovery period have not been well characterized... - Pituitary-adrenal responses to human corticotropin-releasing hormone in critically ill patientsIoanna Dimopoulou
Pesmazoglou 2 Street, 14561, Kifissia, Athens, Greece
Intensive Care Med 33:454-9. 2007..To investigate the pattern of pituitary-adrenal responses to human corticotropin-releasing hormone (hCRH) in critically ill patients and to examine the relation between responses and clinical outcome... - A prospective study on adrenal cortex responses and outcome prediction in acute critical illness: results from a large cohort of 203 mixed ICU patientsIoanna Dimopoulou
Attikon Hospital, Medical School, Second Department of Critical Care Medicine, University of Athens, 2 Pesmazoglou Street, 14561 Athens, Greece
Intensive Care Med 33:2116-21. 2007..To assess whether adrenal cortex hormones predict ICU mortality in acute, mixed, critically ill patients... - Plasma pro- and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patientsIoanna Dimopoulou
Second Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, 2 Pesmazoglou Street, 14 561 Kifissia, Athens, Greece
Cytokine 41:263-7. 2008..To determine the inter-relationships between cytokine levels and physiological scores in predicting outcome in unselected, critically ill patients... - A prospective study on lung toxicity in patients treated with gemcitabine and carboplatin: clinical, radiological and functional assessmentI Dimopoulou
Department of Pulmonary and Critical Care Medicine, Evangelismos Hospital, Athens, Greece
Ann Oncol 15:1250-5. 2004..However, a prospective evaluation of cancer patients treated with gemcitabine-based chemotherapy without neoplastic involvement of the thorax and without administration of radiotherapy has not been performed... - The low-dose corticotropin stimulation test in acute traumatic and non-traumatic brain injury: incidence of hypo-responsiveness and relationship to outcomeIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 10675 Athens, Greece
Intensive Care Med 30:1216-9. 2004..To investigate adrenal responses to the low-dose corticotropin (ACTH) stimulation test in acute traumatic or non-traumatic brain injury (BI) and to assess its value in predicting outcome... - Adrenal function in non-septic long-stay critically ill patients: evaluation with the low-dose (1 micro g) corticotropin stimulation testIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, Greece
Intensive Care Med 28:1168-71. 2002..To investigate the adrenal function in non-septic, long-stay critically ill patients... - A prospective study of pulmonary function in patients treated with paclitaxel and carboplatinIoanna Dimopoulou
Department of Pulmonary and Critical Care, Evangelismos Hospital, Medical School, Athens, Greece
Cancer 94:452-8. 2002..Adverse effects of paclitaxel and carboplatin have been well described; however, pulmonary toxicity after patients receive this regimen has not been investigated extensively... - Protein S-100b serum levels in trauma-induced brain deathI Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical and Nursing School, National and Kapodistrian University of Athens, Greece
Neurology 60:947-51. 2003.... - High prevalence of decreased cortisol reserve in brain-dead potential organ donorsIoanna Dimopoulou
Departments of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
Crit Care Med 31:1113-7. 2003..To investigate the adrenocortical function in brain-dead patients, potential organ donors... - Prediction of prolonged ventilatory support in blunt thoracic trauma patientsIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
Intensive Care Med 29:1101-5. 2003..To identify predictors of prolonged (>7 days) mechanical ventilation (MV) in patients with blunt thoracic trauma... - Relationship of thyroid function to post-traumatic S-100b serum levels in survivors of severe head injury: preliminary resultsIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 45 47 Ipsilandou Street, 106 75 Athens, Greece
Intensive Care Med 30:298-301. 2004..To assess thyroid function abnormalities in survivors of severe head trauma and to examine their relationship with indices of brain injury severity... - Functional status and quality of life in long-term survivors of cardiac arrest after cardiac surgeryI Dimopoulou
Intensive Care Unit, Onassis Cardiac Surgery Center, Athens, Greece
Crit Care Med 29:1408-11. 2001..To assess long-term survival, functional status, and quality of life in patients who experienced cardiac arrest after cardiac surgery... - Endocrine abnormalities in critical care patients with moderate-to-severe head trauma: incidence, pattern and predisposing factorsIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Intensive Care Med 30:1051-7. 2004..To investigate the incidence and type of endocrine abnormalities in critical care patients with traumatic brain injury (TBI) and to examine their relationships to possible predisposing factors... - Effects of severity of chronic obstructive pulmonary disease on thyroid functionI Dimopoulou
Department of Pulmonary and Critical Care Medicine, Evangelismos General Hospital, Athens, Greece
Metabolism 50:1397-401. 2001..It is concluded that in stable COPD, severity of disease through hypoxemia is important in determining the peripheral metabolism of thyroid hormones. Whether this constitutes an adaptation is not known... - Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediatorsStylianos E Orfanos
Second Department of Critical Care, Attikon University Hospital, University of Athens Medical School, 1 Rimini Street, Haidari, Athens 124 62, Greece
Crit Care Med 35:199-206. 2007.... - Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levelsIoanna Dimopoulou
Department of Clinical Care Medicine, Evangelismos Hospital, Athens, Greece
Crit Care Med 32:404-8. 2004..This disorder is associated with prior vasopressor dependency and higher interleukin-6 levels... - Association of left ventricular diastolic dysfunction with elevated NT-pro-BNP in general intensive care unit patients with preserved ejection fraction: a complementary role of tissue Doppler imaging parameters and NT-pro-BNP levels for adverse outcomeIgnatios Ikonomidis
Second Department of Cardiology, Attikon Hospital, Medical School, University of Athens, Athens, Greece
Shock 33:141-8. 2010..01). In ICU patients with preserved EF, LV diastolic dysfunction and sepsis determine NT-pro-BNP levels. Tissue Doppler imaging markers and NT-pro-BNP have a complementary value for in-hospital mortality... - Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implicationsS Tsagarakis
Department of Endocrinology, Athens Polyclinic, Athens, Greece
Pituitary 8:251-4. 2005..Therefore, assessment of the integrity of ADH secretion, hypothalamic-pituitary adrenal (HPA) axis and thyroid axis is crucial to ensure survival and optimal rehabilitation of TBI patients... - Failure of tigecycline to treat severe Clostridium difficile infectionP Kopterides
2nd Critical Care Department, Attiko University Hospital, School ofMedicine, University ofAthens, Athens, Greece
Anaesth Intensive Care 38:755-8. 2010..Even though tigecycline looks promising for the treatment of Clostridium difficile infection, we urge caution against its indiscriminate use for off label indications... - Pituitary-adrenal responses following major abdominal surgeryIoanna Dimopoulou
2nd Department of Critical Care Medicine, Attikon Hospital, Athens University School of Medicine, Athens, Greece
Hormones (Athens) 7:237-42. 2008..Perioperative pituitary-adrenal responses after major abdominal surgery have not been well characterized. The aim of the present study was to further clarify perioperative pituitary-adrenal responses... - Thyroid function changes and cytokine alterations following major surgeryIoannis Ilias
Department of Endocrinology, Elena Venizelou Hospital, Athens, Greece
Neuroimmunomodulation 14:243-7. 2007..Significant negative correlations were noted among TNF-alpha, IL-6 and IL-8 against T(3) and FT(4). Cytokines are responsible, at least in part, for NTI following major operations... - Prognostic importance of increased plasma amino-terminal pro-brain natriuretic peptide levels in a large noncardiac, general intensive care unit populationAnastasia Kotanidou
First Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
Shock 31:342-7. 2009..Elevated admission NT-pro-BNP represents an independent predictor for poor ICU outcome in the presence of clinical severity scores... - Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytesI Dimopoulou
2nd Department of Critical Care Medicine, University of Athens, Greece
Inflamm Res 58:127-32. 2009..To describe the concentrations of sTREM-1 in patients with sepsis and to explore the effects of their serum on the expression of TREM-1 on U937 monocytes... - The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsisA Tsantes
Attikon University General Hospital, Medical School, University of Athens, Athens 12462, Greece
Minerva Anestesiol 76:787-94. 2010..Our primary aim was to measure plasma homocysteine levels in mechanically ventilated patients with severe sepsis/septic shock and to assess the association of these levels with relevant clinical outcomes... - Pattern of breathing during progressive exercise in chronic heart failureI Dimopoulou
Intensive Care Unit and Pulmonary Function Laboratory, Onassis Cardiac Surgery Center, Athens, Greece
Int J Cardiol 81:117-21; discussion 121-2. 2001..In conclusion, patients with CHF adopt variable breathing patterns during exercise; specific patterns are associated with greater impairment in functional capacity... - Health-related quality of life and disability in survivors of multiple trauma one year after intensive care unit dischargeIoanna Dimopoulou
Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
Am J Phys Med Rehabil 83:171-6. 2004..Global injury severity score and degree of brain trauma determine functional limitations. This information may help in organizing long-term rehabilitation of multiple-trauma patients... - Hypothalamic-pituitary dysfunction in critically ill patients with traumatic and nontraumatic brain injuryIoanna Dimopoulou
Second Department of Critical Care Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Greece
Intensive Care Med 31:1020-8. 2005..A significant number of studies have shown that critically ill patients with brain injury (BI) frequently exhibit abnormal pituitary hormonal responses during the immediate postinjury period... - Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysisIlias I Siempos
Critical Care Department, Attikon University Hospital, Athens, Greece
Crit Care Med 37:2283-9. 2009..There is controversy on whether catheter-related bloodstream infections (CR-BSI) affect the mortality of critically ill patients... - Tumour necrosis factor-alpha (TNFalpha) and interleukin-10 are crucial mediators in post-operative systemic inflammatory response and determine the occurrence of complications after major abdominal surgeryIoanna Dimopoulou
2nd Department of Critical Care Medicine, Attikon Hospital, University of Athens, Medical School, Greece
Cytokine 37:55-61. 2007..The course of serum cytokine levels in patients with postoperative systemic inflammatory response syndrome (SIRS) after major abdominal surgery remains currently unclear... - Ex-vivo effect of dexamethasone on cytokine production from whole blood of septic patients: correlation with disease severityEvangelos J Giamarellos-Bourboulis
4th Department of Internal Medicine, University of Athens, Medical School, Greece
Cytokine 49:89-94. 2010.... - Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytesHariklia Kranidioti
4th Department of Internal Medicine, University of Athens, Medical School, Greece
Immunol Lett 125:65-71. 2009..It seems that a circulating factor may exist in the serum of patients with septic shock that stimulates gene expression and subsequent release of Ang-2 from monocytes. TLR4 and TNFalpha modulate release of Ang-2... - The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDSIraklis Tsangaris
2nd Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
Thromb Res 123:832-6. 2009..The objective of the study was to evaluate the effect of this polymorphism on the outcome of critically ill patients with ALI/ARDS... - The effect of four hemostatic gene polymorphisms on the outcome of septic critically ill patientsArgirios E Tsantes
Laboratory of Haematology and Blood Bank Unit, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, Athens, Greece
Blood Coagul Fibrinolysis 21:175-81. 2010..Our data suggest that the importance of these hemostatic polymorphisms as predictors of the prognosis of sepsis in critically ill patients is probably very small... - Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unitIoannis Ilias
Department of Endocrinology, Elena Venizelou Hospital, and Athens University School of Medicine, Greece
Hormones (Athens) 6:218-26. 2007..To evaluate whether tentative prognostic models for intensive care unit survival of multiple trauma patients could be improved by including endocrine parameters... - Thyroid hormone levels improve the prediction of mortality among patients admitted to the intensive care unitIoanna Dimopoulou
Intensive Care Med 32:616. 2006 - Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care MedicinePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:1937-49. 2008..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients... - Reproducibility of the corticotropin stimulation test in septic shockIoanna Dimopoulou
Anesth Analg 103:1056-7; author reply 1057. 2006 - Association between adrenal insufficiency and ventilator weaningIoanna Dimopoulou
Am J Respir Crit Care Med 173:934; author reply 934-5. 2006 - Comment on "Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest" by Pene et alIoanna Dimopoulou
Intensive Care Med 31:1139; author reply 1140. 2005