Evanthia Diamanti Kandarakis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, University of Athens, GR 17548 Athens, Greece
    J Clin Endocrinol Metab 88:1927-32. 2003
  2. ncbi Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Laiko Hospital, Medical School, University of Athens, Endocrine Section, First Department of Medicine, Athens, Greece
    Clin Endocrinol (Oxf) 66:103-9. 2007
  3. ncbi Accumulation of dietary glycotoxins in the reproductive system of normal female rats
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Medical School, University of Athens, Athens, Greece
    J Mol Med (Berl) 85:1413-20. 2007
  4. ncbi The knowledge of osteoporosis risk factors in a Greek female population
    Krystallenia I Alexandraki
    Department of Endocrinology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Maturitas 59:38-45. 2008
  5. ncbi Cardiovascular risk factors in adult patients with multisystem Langerhans-cell histiocytosis: evidence of glucose metabolism abnormalities
    K I Alexandraki
    Department of Endocrinology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Themistokleous 19 str, Amaroussion, Athens, Greece
    QJM 101:31-40. 2008
  6. ncbi Corticomedullary mixed adrenal tumor: case report and literature review
    Krystallenia I Alexandraki
    Division of Endocrinology, Department of Pathophysiology, Laiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athen, Greece
    Endocr J 56:817-24. 2009
  7. doi Role of androgen excess on metabolic aberrations and cardiovascular risk in women with polycystic ovary syndrome
    Charikleia D Christakou
    Endocrine Unit, First Department of Medicine, Medical Scool, University of Athens, Greece
    Womens Health (Lond Engl) 4:583-94. 2008
  8. doi Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, Laiko General Hospital, University of Athens, 11527 Athens, Greece
    Eur J Endocrinol 158:525-31. 2008
  9. ncbi Molecular mechanisms of insulin resistance in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR 11527 Athens, Greece
    Trends Mol Med 12:324-32. 2006
  10. ncbi Hyperandrogenemia: pathophysiology and its role in ovulatory dysfunction in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Laiko Hospital, Athens University School of Medicine, Athens, Greece
    Pediatr Endocrinol Rev 3:198-204. 2006

Collaborators

Detail Information

Publications46

  1. ncbi A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, University of Athens, GR 17548 Athens, Greece
    J Clin Endocrinol Metab 88:1927-32. 2003
  2. ncbi Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Laiko Hospital, Medical School, University of Athens, Endocrine Section, First Department of Medicine, Athens, Greece
    Clin Endocrinol (Oxf) 66:103-9. 2007
    ..Short-term administration of orlistat has been shown to reduce the postmeal increase in serum AGE levels in women with PCOS and in controls...
  3. ncbi Accumulation of dietary glycotoxins in the reproductive system of normal female rats
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Medical School, University of Athens, Athens, Greece
    J Mol Med (Berl) 85:1413-20. 2007
    ....
  4. ncbi The knowledge of osteoporosis risk factors in a Greek female population
    Krystallenia I Alexandraki
    Department of Endocrinology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Maturitas 59:38-45. 2008
    ..Aim of the study was to assess female population knowledge about osteoporosis risk factors and to identify the risk factors of the studied population...
  5. ncbi Cardiovascular risk factors in adult patients with multisystem Langerhans-cell histiocytosis: evidence of glucose metabolism abnormalities
    K I Alexandraki
    Department of Endocrinology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Themistokleous 19 str, Amaroussion, Athens, Greece
    QJM 101:31-40. 2008
    ..Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and it may also induce hypopituitarism, conditions associated with an increased risk of cardiovascular diseases...
  6. ncbi Corticomedullary mixed adrenal tumor: case report and literature review
    Krystallenia I Alexandraki
    Division of Endocrinology, Department of Pathophysiology, Laiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athen, Greece
    Endocr J 56:817-24. 2009
    ..The previously reported reappearance of this tumor in the contralateral adrenal gland emphasizes the need for prolonged follow-up...
  7. doi Role of androgen excess on metabolic aberrations and cardiovascular risk in women with polycystic ovary syndrome
    Charikleia D Christakou
    Endocrine Unit, First Department of Medicine, Medical Scool, University of Athens, Greece
    Womens Health (Lond Engl) 4:583-94. 2008
    ....
  8. doi Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, Laiko General Hospital, University of Athens, 11527 Athens, Greece
    Eur J Endocrinol 158:525-31. 2008
    ..Since the instability of atherosclerotic plaque is a key factor in the clinical manifestations of cardiovascular disease, molecules challenging the plaque stability should be investigated...
  9. ncbi Molecular mechanisms of insulin resistance in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR 11527 Athens, Greece
    Trends Mol Med 12:324-32. 2006
    ..Investigators are still searching for clues to understand the cause of this enigmatic syndrome, despite great advances in molecular medicine and genetics...
  10. ncbi Hyperandrogenemia: pathophysiology and its role in ovulatory dysfunction in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Laiko Hospital, Athens University School of Medicine, Athens, Greece
    Pediatr Endocrinol Rev 3:198-204. 2006
    ..The early diagnosis and management of hyperandrogenemia in women has been proved to be essential for their health and fertility...
  11. ncbi Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Athens 14578, Greece
    Metabolism 55:494-500. 2006
    ..In conclusion, this study demonstrated the beneficial effect of orlistat on the absorption of food glycotoxins...
  12. ncbi Polycystic ovary syndrome: the influence of environmental and genetic factors
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Athens University Medical School, Athens, Greece
    Hormones (Athens) 5:17-34. 2006
    ..Currently, PCOS is considered a polygenic trait that might result from the interaction of susceptible and protective genomic variants and environmental factors, during either prenatal or postnatal life...
  13. doi Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications
    Evanthia Diamanti-Kandarakis
    University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Expert Rev Mol Med 10:e3. 2008
    ..The putative interdependence between reproductive and metabolic aspects of PCOS, and therapeutic implications for the management of PCOS, are also discussed...
  14. ncbi Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Aretaieion Hospital, University of Athens Medical School, Athens, Greece
    Clin Endocrinol (Oxf) 62:37-43. 2005
    ..Elevated concentrations of advanced glycation end-products (AGE), which exert their effects through interaction with specific receptors (RAGE), have been implicated in the cellular and tissue damage during atherosclerotic processes...
  15. ncbi Pathophysiology and types of dyslipidemia in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR 11527 Athens, Greece
    Trends Endocrinol Metab 18:280-5. 2007
    ..Here, we review the types and pathophysiology of dyslipidemia associated with PCOS and its related conditions...
  16. doi Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Laiko General Hospital, Athens, Greece
    Kidney Blood Press Res 32:24-31. 2009
    ..Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenemia and insulin resistance. Hyperreninemia is observed in insulin resistance and hyperandrogenemic states...
  17. ncbi Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): a prospective study of 634 women with PCOS
    Evanthia Diamanti-Kandarakis
    Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Clin Endocrinol (Oxf) 67:735-42. 2007
    ..The phenotypic spectrum of PCOS has been broadened but the prevalence and clinical significance of PCOS phenotypes continue to challenge the scientific community...
  18. doi Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS)
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Clin Endocrinol (Oxf) 69:634-41. 2008
    ....
  19. ncbi Stress in women: metabolic syndrome and polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Greece
    Ann N Y Acad Sci 1083:54-62. 2006
    ..This results in specific endocrinological and metabolic disorders which are shared by women with PCOS and women with MBS...
  20. ncbi Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome
    George Mastorakos
    Endocrine Unit, Athens University School of Medicine, Aretaieion Hospital, Athens, Greece
    Fertil Steril 85:420-7. 2006
    ..To compare the effects of combined oral contraceptives (OCs) containing cyproterone acetate or desogestrel on insulin sensitivity in adolescents with polycystic ovary syndrome (PCOS)...
  21. ncbi Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece
    Hum Reprod 21:1426-31. 2006
    ....
  22. ncbi Does polycystic ovary syndrome start in childhood?
    Evanthia Diamanti-Kandarakis
    Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Pediatr Endocrinol Rev 5:904-11. 2008
    ..The clinical picture of PCOS becomes manifest in the peripubertal period, unfolds as patients enter later stages of life and may change over time...
  23. ncbi The prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels
    Evanthia Diamanti-Kandarakis
    Endocrine Section of First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, 17 Aghiou Thoma Str, Athens 115 27, Greece
    Eur J Endocrinol 150:793-8. 2004
    ..To investigate the prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovary syndrome (PCOS) and its functional significance...
  24. ncbi Failure of mathematical indices to accurately assess insulin resistance in lean, overweight, or obese women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section of the First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Athens 115 27, Greece
    J Clin Endocrinol Metab 89:1273-6. 2004
    ..We conclude that mathematical indices should be applied with caution in different insulin-resistant populations and should not be considered a priori equivalent to the euglycemic clamp technique...
  25. ncbi Early onset adiposity: a pathway to polycystic ovary syndrome in adolescents?
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, Athens University School of Medicine, Athens, Greece
    Hormones (Athens) 6:210-7. 2007
    ..The interaction of adiposity with genetic traits as well as with prenatal environmental factors may further aggravate the metabolic and endocrine abnormalities, which become more pronounced in adolescence...
  26. doi Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Eur J Endocrinol 162:193-212. 2010
    ..Even if many of these actions are individually modest, they seem to be collectively sufficient to confer therapeutic benefits not only in cardiometabolic aspects but also in reproductive aspects of PCOS...
  27. doi PCOS in adolescents
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi, 115 27, Athens, Greece
    Best Pract Res Clin Obstet Gynaecol 24:173-83. 2010
    ..The clinical implications of PCOS diagnosis in adolescents remain unclear. Experts in the field still ponder whether PCOS should be managed at such a young age with a view to hindering the long-term sequelae of the syndrome...
  28. doi Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS)
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, University of Athens Medical School, 17 Ag Thoma, Goudi 11527, Athens, Greece
    J Steroid Biochem Mol Biol 109:242-6. 2008
    ..This review will be focused on insulin's action on the ovary and other target tissues, describing the intracellular signaling pathways implicated in steroidogenesis and their defects in women with PCOS...
  29. ncbi Indices of low-grade inflammation in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, University of Athens, GR 115 27, Athens, Greece
    Ann N Y Acad Sci 1092:175-86. 2006
    ..However, it remains to be assessed with long-term studies whether the early presence of markers of chronic inflammation in young women with this syndrome has clinical significance...
  30. ncbi Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, University of Athens Medical School, Athens, Greece
    Hum Reprod Update 11:631-43. 2005
    ....
  31. ncbi Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, University of Athens Medical School, 75, M Asias str, 11527, Athens, Greece
    Histochem Cell Biol 127:581-9. 2007
    ....
  32. ncbi Plasma B-type natriuretic peptide concentration in beta-thalassaemia patients
    Athanasios Aessopos
    Cardiac Outpatient Clinic for Hemoglobinopathies, First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, Greece
    Eur J Heart Fail 9:537-41. 2007
    ..Whether BNP is also useful in the evaluation and management of thalassaemia heart disease remains to be determined...
  33. doi Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Eur J Endocrinol 160:847-53. 2009
    ..Design Cross-sectional study...
  34. doi The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome
    Sarantis Livadas
    First Department of Medicine, Endocrine Section, University of Athens Medical School, Athens, Greece
    Fertil Steril 94:242-6. 2010
    ....
  35. pmc Endocrine-disrupting chemicals: an Endocrine Society scientific statement
    Evanthia Diamanti-Kandarakis
    Endocrine Section of First Department of Medicine, Laiko Hospital, Medical School University of Athens, 11527 Athens, Greece
    Endocr Rev 30:293-342. 2009
    ....
  36. ncbi In overweight/obese but not in normal-weight women, polycystic ovary syndrome is associated with elevated liver enzymes compared to controls
    Frangiskos Economou
    Endocrine Section, First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Greece
    Hormones (Athens) 8:199-206. 2009
    ..To investigate liver enzymes in a cohort of women with Polycystic Ovary Syndrome (PCOS) and controls divided according to body mass index (BMI) and their association with features of the syndrome...
  37. doi Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?
    Panagiotis Christopoulos
    Division of Pediatric Adolescent Gynecology and Reconstructive Surgery, 2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Athens, Greece
    Gynecol Endocrinol 26:698-703. 2010
    ..The present study was undertaken to determine whether IRS-1 Gly972Arg and IRS-2 Gly1057Asp influence hormonal and metabolic characteristics in Greek patients with polycystic ovary syndrome (PCOS) and controls...
  38. ncbi Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome
    Jean Patrice Baillargeon
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Diabetes Care 29:300-5. 2006
    ..We hypothesize that a deficiency in D-chiro-inositol (DCI) and/or a DCI-containing IPG (DCI-IPG) may contribute to insulin resistance in humans...
  39. ncbi Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome
    Dimitrios Panidis
    Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Fertil Steril 85:1778-83. 2006
    ....
  40. ncbi Conservative management of gynecologic diseases: insulin sensitizing agents in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    University of Athens Medical School, 1A Zefyrou Ekali, 145 78 Athens, Greece
    Ann N Y Acad Sci 997:322-9. 2003
    ..Finally, insulin sensitizers should be considered by all subspecialists who aim at a comprehensive management of patients with PCOS...
  41. ncbi Insulin resistance in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School University of Athens, Greece
    Endocrine 30:13-7. 2006
    ..Today our knowledge about PCOS appears to have broader health implications and to have profoundly altered our view of the gravity of this condition...
  42. ncbi The role of genes and environment in the etiology of PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Athens, Greece
    Endocrine 30:19-26. 2006
    ..However, the responsible gene at chromosome 19p13.3 remains to be identified. To date, no gene has been identified that causes or contributes substantially to the development of a PCOS phenotype...
  43. ncbi Effect of metformin administration on plasma advanced glycation end product levels in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, University of Athens Medical School, 17562 Athens, Greece
    Metabolism 56:129-34. 2007
    ..Future studies are required to confirm the need of therapeutic intervention for short-term abnormalities and for prevention of long-term sequelae characterizing this syndrome...
  44. ncbi Efficacy of octreotide-LAR in dieting women with abdominal obesity and polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 90:3854-62. 2005
    ..Somatostatin reduces LH, GH, and insulin, and somatostatin receptors are present at the ovarian level; somatostatin analogs are thus potential candidates for treatment of the polycystic ovary syndrome (PCOS)...
  45. pmc Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism
    Jean Patrice Baillargeon
    Department of Medicine, Universite Sherbrooke, Sherbrooke, Canada J1H 5N4
    Hum Reprod 23:1439-46. 2008
    ....
  46. ncbi Early microvascular and macrovascular dysfunction is not accompanied by structural arterial injury in polycystic ovary syndrome
    Krystallenia Alexandraki
    Division of Endocrinology, First Department of Medicine, Laiko Hospital
    Hormones (Athens) 5:126-36. 2006
    ..The aim of the present study was a global assessment of abnormalities in the arterial bed of young women with PCOS by non-invasive, reproducible methods...