Evanthia Diamanti-Kandarakis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi request reprint Selective modulation of postmenopausal women: cutting the Gordian knot of hormone replacement therapy with breast carcinoma
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, 11527 Athens, Greece
    Cancer 97:12-20. 2003
  2. doi request reprint Metformin in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Third Department of Medicine, Endocrine Unit, Medical School University of Athens, Sotiria General Hospital, Greece
    Ann N Y Acad Sci 1205:192-8. 2010
  3. doi request reprint Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications
    Evanthia Diamanti-Kandarakis
    University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Expert Rev Mol Med 10:e3. 2008
  4. ncbi request reprint Role of obesity and adiposity in polycystic ovary syndrome
    E Diamanti-Kandarakis
    1st Department of Internal Medicine, Athens University Medical School, Athens, Greece
    Int J Obes (Lond) 31:S8-13; discussion S31-2. 2007
  5. ncbi request reprint Early onset adiposity: a pathway to polycystic ovary syndrome in adolescents?
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, Athens University School of Medicine, Athens, Greece
    Hormones (Athens) 6:210-7. 2007
  6. doi request reprint Androgens associated with advanced glycation end-products in postmenopausal women
    Evanthia Diamanti-Kandarakis
    Third Department of Internal Medicine, Sotiria General Hospital, Medical School, University of Athens, Athens, Greece
    Menopause 17:1182-7. 2010
  7. ncbi request reprint Pathophysiology and types of dyslipidemia in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR 11527 Athens, Greece
    Trends Endocrinol Metab 18:280-5. 2007
  8. ncbi request reprint Metabolic syndrome: a contemporary fuel excess syndrome and its specific impact in women
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, University of Athens, Greece
    Ann Endocrinol (Paris) 68:299-303. 2007
  9. ncbi request reprint Polycystic ovarian syndrome: the commonest cause of hyperandrogenemia in women as a risk factor for metabolic syndrome
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Laiko General Hospital, University of Athens Medical School, Athens, Greece
    Minerva Endocrinol 32:35-47. 2007
  10. ncbi request reprint Indices of low-grade inflammation in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, University of Athens, GR 115 27, Athens, Greece
    Ann N Y Acad Sci 1092:175-86. 2006

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Selective modulation of postmenopausal women: cutting the Gordian knot of hormone replacement therapy with breast carcinoma
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, 11527 Athens, Greece
    Cancer 97:12-20. 2003
    ..Identifying effective alternative medications that are not associated with breast carcinoma or that even may prevent its development would be a major advance...
  2. doi request reprint Metformin in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Third Department of Medicine, Endocrine Unit, Medical School University of Athens, Sotiria General Hospital, Greece
    Ann N Y Acad Sci 1205:192-8. 2010
    ..The use of metformin in pregnant women with PCOS is another of its positive features. Overall, available data supports the therapeutic usefulness of metformin on cardiometabolic risk and reproduction assistance in PCOS women...
  3. doi request reprint Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications
    Evanthia Diamanti-Kandarakis
    University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Expert Rev Mol Med 10:e3. 2008
    ..The putative interdependence between reproductive and metabolic aspects of PCOS, and therapeutic implications for the management of PCOS, are also discussed...
  4. ncbi request reprint Role of obesity and adiposity in polycystic ovary syndrome
    E Diamanti-Kandarakis
    1st Department of Internal Medicine, Athens University Medical School, Athens, Greece
    Int J Obes (Lond) 31:S8-13; discussion S31-2. 2007
    ..It has been shown that weight loss improves the metabolic and reproductive abnormalities that characterise the syndrome...
  5. ncbi request reprint Early onset adiposity: a pathway to polycystic ovary syndrome in adolescents?
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, Athens University School of Medicine, Athens, Greece
    Hormones (Athens) 6:210-7. 2007
    ..The interaction of adiposity with genetic traits as well as with prenatal environmental factors may further aggravate the metabolic and endocrine abnormalities, which become more pronounced in adolescence...
  6. doi request reprint Androgens associated with advanced glycation end-products in postmenopausal women
    Evanthia Diamanti-Kandarakis
    Third Department of Internal Medicine, Sotiria General Hospital, Medical School, University of Athens, Athens, Greece
    Menopause 17:1182-7. 2010
    ..Advanced glycation end-products (AGEs) are well-recognized atherogenic molecules. Therefore, we investigated the association of postmenopausal sex steroid and metabolic status with serum AGE levels...
  7. ncbi request reprint Pathophysiology and types of dyslipidemia in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR 11527 Athens, Greece
    Trends Endocrinol Metab 18:280-5. 2007
    ..Here, we review the types and pathophysiology of dyslipidemia associated with PCOS and its related conditions...
  8. ncbi request reprint Metabolic syndrome: a contemporary fuel excess syndrome and its specific impact in women
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, University of Athens, Greece
    Ann Endocrinol (Paris) 68:299-303. 2007
  9. ncbi request reprint Polycystic ovarian syndrome: the commonest cause of hyperandrogenemia in women as a risk factor for metabolic syndrome
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Laiko General Hospital, University of Athens Medical School, Athens, Greece
    Minerva Endocrinol 32:35-47. 2007
    ..Hyperandrogenemia, the predominant endocrine hallmark of PCOS, has also been implicated as a contributing factor to the suggested interrelationship...
  10. ncbi request reprint Indices of low-grade inflammation in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, University of Athens, GR 115 27, Athens, Greece
    Ann N Y Acad Sci 1092:175-86. 2006
    ..However, it remains to be assessed with long-term studies whether the early presence of markers of chronic inflammation in young women with this syndrome has clinical significance...
  11. ncbi request reprint Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, University of Athens Medical School, 75, M Asias str, 11527, Athens, Greece
    Histochem Cell Biol 127:581-9. 2007
    ....
  12. ncbi request reprint Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Laiko Hospital, Medical School, University of Athens, Endocrine Section, First Department of Medicine, Athens, Greece
    Clin Endocrinol (Oxf) 66:103-9. 2007
    ..Short-term administration of orlistat has been shown to reduce the postmeal increase in serum AGE levels in women with PCOS and in controls...
  13. doi request reprint Brown tumor of the fibula: unusual presentation of an uncommon manifestation. Report of a case and review of the literature
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Laiko General Hospital, University of Athens Medical School, 1 A Zefyrou str, Athens 145 78, Greece
    Endocrine 32:345-9. 2007
    ..This case illustrates the need for continuous vigilance of any physician, regardless of his specialty or his position in medical services structures...
  14. doi request reprint Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS)
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, Endocrine Section, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Clin Endocrinol (Oxf) 69:634-41. 2008
    ....
  15. doi request reprint Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS)
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, University of Athens Medical School, 17 Ag Thoma, Goudi 11527, Athens, Greece
    J Steroid Biochem Mol Biol 109:242-6. 2008
    ..This review will be focused on insulin's action on the ovary and other target tissues, describing the intracellular signaling pathways implicated in steroidogenesis and their defects in women with PCOS...
  16. doi request reprint Serum concentrations of carboxylated osteocalcin are increased and associated with several components of the polycystic ovarian syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi, 115 27, Athens, Greece
    J Bone Miner Metab 29:201-6. 2011
    ..However, the pathophysiological mechanisms and moreover the possible clinical implications require further investigation...
  17. doi request reprint The impact of endocrine disruptors on endocrine targets
    E Diamanti-Kandarakis
    Endocrine Section, Third Department of Internal Medicine, Sotiria Hospital, University of Athens Medical School, Athens, Greece
    Horm Metab Res 42:543-52. 2010
    ..This article reviews the evidence linking endocrine disrupting chemicals to a broad spectrum of clinical perturbations from reproduction and thyroid to metabolic regulation...
  18. doi request reprint PCOS in adolescents
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi, 115 27, Athens, Greece
    Best Pract Res Clin Obstet Gynaecol 24:173-83. 2010
    ..The clinical implications of PCOS diagnosis in adolescents remain unclear. Experts in the field still ponder whether PCOS should be managed at such a young age with a view to hindering the long-term sequelae of the syndrome...
  19. doi request reprint Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Eur J Endocrinol 162:193-212. 2010
    ..Even if many of these actions are individually modest, they seem to be collectively sufficient to confer therapeutic benefits not only in cardiometabolic aspects but also in reproductive aspects of PCOS...
  20. ncbi request reprint The acute effect of Orlistat on dietary glycotoxins in diabetics and healthy women
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Minerva Endocrinol 34:97-104. 2009
    ..Exogenous AGEs, namely glycotoxins, are present in certain foods and are absorbed from the gastrointestinal tract. Experimental data suggest that lifestyle interventions reducing their content in diet have beneficial effect...
  21. doi request reprint The effect of pharmaceutical intervention on lipid profile in polycystic ovary syndrome
    E Diamanti-Kandarakis
    Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Obes Rev 10:431-41. 2009
    ..Because dyslipidemia may contribute to long-term cardiometabolic and reproductive sequelae in PCOS, it should be considered as an additional therapeutic target when these patients are assigned to appropriate pharmaceutical treatment...
  22. doi request reprint Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Laiko General Hospital, Athens, Greece
    Kidney Blood Press Res 32:24-31. 2009
    ..Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenemia and insulin resistance. Hyperreninemia is observed in insulin resistance and hyperandrogenemic states...
  23. doi request reprint Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi 115 27, Athens, Greece
    Eur J Endocrinol 160:847-53. 2009
    ..Design Cross-sectional study...
  24. ncbi request reprint Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Laiko General Hospital, University of Athens Medical School, Athens 14578, Greece
    J Endocrinol Invest 31:950-5. 2008
    ..A more sensitive marker of circulating RBP4 is free plasma RBP4 expressed by RBP4 to transthyretin (TTR) ratio, since in circulation RBP4 is bound to TTR...
  25. ncbi request reprint Does polycystic ovary syndrome start in childhood?
    Evanthia Diamanti-Kandarakis
    Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Pediatr Endocrinol Rev 5:904-11. 2008
    ..The clinical picture of PCOS becomes manifest in the peripubertal period, unfolds as patients enter later stages of life and may change over time...
  26. ncbi request reprint Effect of metformin administration on plasma advanced glycation end product levels in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, University of Athens Medical School, 17562 Athens, Greece
    Metabolism 56:129-34. 2007
    ..Future studies are required to confirm the need of therapeutic intervention for short-term abnormalities and for prevention of long-term sequelae characterizing this syndrome...
  27. ncbi request reprint The influence of obesity on hyperandrogenism and infertility in the female
    E Diamanti-Kandarakis
    Endocrine Section, 1st Department of Internal Medicine, Laiko General Hospital, Athens University, Athens, Greece
    Obes Rev 2:231-8. 2001
    ..These have been considered as some of the links in the sequence of events of the disrupted ovulatory process. The mechanisms of these actions and their influence on female reproductive function are discussed below...
  28. ncbi request reprint Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece
    Hum Reprod 21:1426-31. 2006
    ....
  29. ncbi request reprint Obesity and gonadal function of women
    Evanthia Diamanti-Kandarakis
    First Dept of Medical School in the University of Athens, Greece
    Pediatr Endocrinol Rev 1:465-70. 2004
    ..The impact of obesity in these mechanisms and their influence on female reproductive function are discussed in this article...
  30. ncbi request reprint Erythropoietin abuse and erythropoietin gene doping: detection strategies in the genomic era
    Evanthia Diamanti-Kandarakis
    Department of Medicine, Endocrine Section, Medical School, University of Athens, Athens, Greece
    Sports Med 35:831-40. 2005
    ....
  31. ncbi request reprint Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, University of Athens Medical School, Athens, Greece
    Hum Reprod Update 11:631-43. 2005
    ....
  32. ncbi request reprint The prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels
    Evanthia Diamanti-Kandarakis
    Endocrine Section of First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, 17 Aghiou Thoma Str, Athens 115 27, Greece
    Eur J Endocrinol 150:793-8. 2004
    ..To investigate the prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovary syndrome (PCOS) and its functional significance...
  33. ncbi request reprint Metformin administration improves endothelial function in women with polycystic ovary syndrome
    E Diamanti-Kandarakis
    Laiko Hospital, Medical School, University of Athens, Endocrine Section, First Department of Medicine, Athens, Greece
    Eur J Endocrinol 152:749-56. 2005
    ....
  34. ncbi request reprint Presence of metabolic risk factors in non-obese PCOS sisters: evidence of heritability of insulin resistance
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Laiko General Hospital, Athens, Greece
    J Endocrinol Invest 27:931-6. 2004
    ..No difference of insulin resistance indices was detected between the PCOS and their sisters. This finding provides additional evidence that there is a hereditary trait regarding insulin resistance in the PCOS families...
  35. ncbi request reprint Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Aretaieion Hospital, University of Athens Medical School, Athens, Greece
    Clin Endocrinol (Oxf) 62:37-43. 2005
    ..Elevated concentrations of advanced glycation end-products (AGE), which exert their effects through interaction with specific receptors (RAGE), have been implicated in the cellular and tissue damage during atherosclerotic processes...
  36. ncbi request reprint Hormone replacement therapy and risk of malignancy
    Evanthia Diamanti-Kandarakis
    1st Department of Medicine, Laiko Hospital, University of Athens Medical School, Athens, Greece
    Curr Opin Obstet Gynecol 16:73-8. 2004
    ..The safety of hormone replacement therapy, an estrogen-progestin combination which has been sympathetic to and supportive of disturbing menopausal symptoms of women, is seriously challenged...
  37. ncbi request reprint Failure of mathematical indices to accurately assess insulin resistance in lean, overweight, or obese women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section of the First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Athens 115 27, Greece
    J Clin Endocrinol Metab 89:1273-6. 2004
    ..We conclude that mathematical indices should be applied with caution in different insulin-resistant populations and should not be considered a priori equivalent to the euglycemic clamp technique...
  38. ncbi request reprint Conservative management of gynecologic diseases: insulin sensitizing agents in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    University of Athens Medical School, 1A Zefyrou Ekali, 145 78 Athens, Greece
    Ann N Y Acad Sci 997:322-9. 2003
    ..Finally, insulin sensitizers should be considered by all subspecialists who aim at a comprehensive management of patients with PCOS...
  39. ncbi request reprint Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Athens 14578, Greece
    Metabolism 55:494-500. 2006
    ..In conclusion, this study demonstrated the beneficial effect of orlistat on the absorption of food glycotoxins...
  40. ncbi request reprint Polycystic ovary syndrome: the influence of environmental and genetic factors
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Athens University Medical School, Athens, Greece
    Hormones (Athens) 5:17-34. 2006
    ..Currently, PCOS is considered a polygenic trait that might result from the interaction of susceptible and protective genomic variants and environmental factors, during either prenatal or postnatal life...
  41. ncbi request reprint Molecular mechanisms of insulin resistance in polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR 11527 Athens, Greece
    Trends Mol Med 12:324-32. 2006
    ..Investigators are still searching for clues to understand the cause of this enigmatic syndrome, despite great advances in molecular medicine and genetics...
  42. ncbi request reprint Hyperandrogenemia: pathophysiology and its role in ovulatory dysfunction in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Internal Medicine, Laiko Hospital, Athens University School of Medicine, Athens, Greece
    Pediatr Endocrinol Rev 3:198-204. 2006
    ..The early diagnosis and management of hyperandrogenemia in women has been proved to be essential for their health and fertility...
  43. ncbi request reprint Stress in women: metabolic syndrome and polycystic ovary syndrome
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Greece
    Ann N Y Acad Sci 1083:54-62. 2006
    ..This results in specific endocrinological and metabolic disorders which are shared by women with PCOS and women with MBS...
  44. ncbi request reprint Inflammatory and endothelial markers in women with polycystic ovary syndrome
    E Diamanti-Kandarakis
    National and Kapodistrian University of Athens, Greece
    Eur J Clin Invest 36:691-7. 2006
    ..The purpose of the study was to investigate the coexistence of active inflammation markers and endothelial dysfunction in young women with PCOS, and their relationship with metabolic and hormonal abnormalities of the syndrome...
  45. ncbi request reprint Accumulation of dietary glycotoxins in the reproductive system of normal female rats
    Evanthia Diamanti-Kandarakis
    First Department of Internal Medicine, Endocrine Section, Medical School, University of Athens, Athens, Greece
    J Mol Med (Berl) 85:1413-20. 2007
    ....
  46. doi request reprint Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats
    Antonios Chatzigeorgiou
    Department of Experimental Physiology, University of Athens Medical School, Athens, Greece
    J Endocrinol 218:331-7. 2013
    ..Decreased monocytic expression of scavenger receptors such as RAGE and SR-A may result in a higher deposition of AGEs in peripheral endocrine tissues, thus promoting endocrine-related abnormalities and diseases. ..
  47. ncbi request reprint Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): a prospective study of 634 women with PCOS
    Evanthia Diamanti-Kandarakis
    Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece
    Clin Endocrinol (Oxf) 67:735-42. 2007
    ..The phenotypic spectrum of PCOS has been broadened but the prevalence and clinical significance of PCOS phenotypes continue to challenge the scientific community...
  48. ncbi request reprint In overweight/obese but not in normal-weight women, polycystic ovary syndrome is associated with elevated liver enzymes compared to controls
    Frangiskos Economou
    Endocrine Section, First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Greece
    Hormones (Athens) 8:199-206. 2009
    ..To investigate liver enzymes in a cohort of women with Polycystic Ovary Syndrome (PCOS) and controls divided according to body mass index (BMI) and their association with features of the syndrome...
  49. doi request reprint Anxiety is associated with hormonal and metabolic profile in women with polycystic ovarian syndrome
    Sarantis Livadas
    Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Clin Endocrinol (Oxf) 75:698-703. 2011
    ..Increased prevalence of psychological morbidities, including anxiety, depression and eating disorders, has been reported in women with polycystic ovary syndrome (PCOS) in comparison with normal ovulating, nonhyperandrogenemic women...
  50. ncbi request reprint Endothelial function and arterial stiffness in sickle-thalassemia patients
    Athanasios Aessopos
    First Department of Internal Medicine, University of Athens Medical School, Laiko Hospital, 17 Aghiou Thoma St, Athens 115 27, Greece
    Atherosclerosis 191:427-32. 2007
    ..We sought to investigate aortic elastic properties and endothelial function in sickle-thalassemia, which combines molecular and clinical features of the above conditions...
  51. ncbi request reprint Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome
    Dimitrios Panidis
    Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Fertil Steril 85:1778-83. 2006
    ....
  52. doi request reprint Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?
    Panagiotis Christopoulos
    Division of Pediatric Adolescent Gynecology and Reconstructive Surgery, 2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Athens, Greece
    Gynecol Endocrinol 26:698-703. 2010
    ..The present study was undertaken to determine whether IRS-1 Gly972Arg and IRS-2 Gly1057Asp influence hormonal and metabolic characteristics in Greek patients with polycystic ovary syndrome (PCOS) and controls...
  53. ncbi request reprint Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome
    George Mastorakos
    Endocrine Unit, Athens University School of Medicine, Aretaieion Hospital, Athens, Greece
    Fertil Steril 85:420-7. 2006
    ..To compare the effects of combined oral contraceptives (OCs) containing cyproterone acetate or desogestrel on insulin sensitivity in adolescents with polycystic ovary syndrome (PCOS)...
  54. doi request reprint Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, Laiko General Hospital, University of Athens, 11527 Athens, Greece
    Eur J Endocrinol 158:525-31. 2008
    ..Since the instability of atherosclerotic plaque is a key factor in the clinical manifestations of cardiovascular disease, molecules challenging the plaque stability should be investigated...
  55. ncbi request reprint The knowledge of osteoporosis risk factors in a Greek female population
    Krystallenia I Alexandraki
    Department of Endocrinology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Maturitas 59:38-45. 2008
    ..Aim of the study was to assess female population knowledge about osteoporosis risk factors and to identify the risk factors of the studied population...
  56. doi request reprint Liver failure due to antithyroid drugs: report of a case and literature review
    Sarantis Livadas
    First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece
    Endocrine 38:24-8. 2010
    ..This case along with a concise literature review is presented aiming to increase the awareness of endocrinologists of possible fatal complications from the everyday use of common agents such as antithyroid drugs...
  57. ncbi request reprint Early microvascular and macrovascular dysfunction is not accompanied by structural arterial injury in polycystic ovary syndrome
    Krystallenia Alexandraki
    Division of Endocrinology, First Department of Medicine, Laiko Hospital
    Hormones (Athens) 5:126-36. 2006
    ..The aim of the present study was a global assessment of abnormalities in the arterial bed of young women with PCOS by non-invasive, reproducible methods...
  58. ncbi request reprint Phenotypes and enviromental factors: their influence in PCOS
    Evanthia Diamanti-Kandarakis
    The Third Department of Internal Medicine, Medical School, University of Athens, Sotiria General Hospital, Mesogion Avenue 152, Athens 11527, Greece
    Curr Pharm Des 18:270-82. 2012
    ..AGEs and BPA may act as endocrine disruptors in the pathogenesis of the syndrome. PCOS appears to mirror the harmful influence of the modern environment on the reproductive and metabolic balance of inherently predisposed individuals...
  59. doi request reprint Role of androgen excess on metabolic aberrations and cardiovascular risk in women with polycystic ovary syndrome
    Charikleia D Christakou
    Endocrine Unit, First Department of Medicine, Medical Scool, University of Athens, Greece
    Womens Health (Lond Engl) 4:583-94. 2008
    ....
  60. doi request reprint The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome
    Sarantis Livadas
    First Department of Medicine, Endocrine Section, University of Athens Medical School, Athens, Greece
    Fertil Steril 94:242-6. 2010
    ....
  61. ncbi request reprint A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, University of Athens, GR 17548 Athens, Greece
    J Clin Endocrinol Metab 88:1927-32. 2003
  62. ncbi request reprint Exercise and the stress system
    George Mastorakos
    Endocrine Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens, Greece
    Hormones (Athens) 4:73-89. 2005
    ..These consequences include amenorrhea, infertility, eating disorders, osteoporosis, coronary heart disease and euthyroid "sick" syndrome. The mechanisms involved in the pathogenesis of the above disorders are discussed in this review...
  63. doi request reprint Cytokine secretion in long-standing diabetes mellitus type 1 and 2: associations with low-grade systemic inflammation
    Krystallenia I Alexandraki
    Laboratory of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    J Clin Immunol 28:314-21. 2008
    ..In conclusion, patients with DM have evidence of low-grade inflammation and abnormal PBMC function that could be related to long-term sequelae, the accelerated atherosclerotic process, and the susceptibility to infections...
  64. doi request reprint Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue
    Katerina K Papachroni
    Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
    J Cell Mol Med 14:2460-9. 2010
    ..These findings suggest that deposition of excess collagen in PCO tissue that induces cystogenesis may, in part, be due to AGE-mediated stimulation of LOX activity...
  65. ncbi request reprint The pluripotential effects of hypolipidemic treatment for polycystic ovary syndrome (PCOS): dyslipidemia, cardiovascular risk factors and beyond
    Frangiskos Economou
    Third Department of Medicine, Endocrine Unit, Medical School, University of Athens, Sotiria General Hospital, Athens, Greece
    Curr Pharm Des 17:908-21. 2011
    ....
  66. ncbi request reprint The role of genes and environment in the etiology of PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Athens, Greece
    Endocrine 30:19-26. 2006
    ..However, the responsible gene at chromosome 19p13.3 remains to be identified. To date, no gene has been identified that causes or contributes substantially to the development of a PCOS phenotype...
  67. doi request reprint Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS
    Eleni Kandaraki
    Department of Medicine, Huddersfield Royal Infirmary Hospital, West Yorkshire HD3 3EA, United Kingdom
    J Clin Endocrinol Metab 96:E480-4. 2011
    ..In experimental animals, neonatal exposure to BPA results in a polycystic ovary-like syndrome (PCOS) in adulthood. A bidirectional interaction between androgens and BPA levels has been disclosed...
  68. ncbi request reprint Insulin resistance in PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School University of Athens, Greece
    Endocrine 30:13-7. 2006
    ..Today our knowledge about PCOS appears to have broader health implications and to have profoundly altered our view of the gravity of this condition...
  69. ncbi request reprint Plasma B-type natriuretic peptide concentration in beta-thalassaemia patients
    Athanasios Aessopos
    Cardiac Outpatient Clinic for Hemoglobinopathies, First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, Greece
    Eur J Heart Fail 9:537-41. 2007
    ..Whether BNP is also useful in the evaluation and management of thalassaemia heart disease remains to be determined...
  70. pmc Endocrine-disrupting chemicals: an Endocrine Society scientific statement
    Evanthia Diamanti-Kandarakis
    Endocrine Section of First Department of Medicine, Laiko Hospital, Medical School University of Athens, 11527 Athens, Greece
    Endocr Rev 30:293-342. 2009
    ....