George P Chrousos

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Ann N Y Acad Sci 1179:153-66. 2009
  2. ncbi Gender differences in Greek centenarians. A cross-sectional nation-wide study, examining multiple socio-demographic and personality factors and health locus of control
    Xanthi Tigani
    First Department of Pediatrics, Children s Hospital Aghia Sofia, School of Medicine, University of Athens, Thivon and Papadiamantopoulou Str, GR 115 27, Athens, Greece
    BMC Geriatr 11:87. 2011
  3. ncbi Post-SARS sickness syndrome manifestations and endocrinopathy: how, why, and so what?
    George P Chrousos
    Athens University, Athens, Greece and National Institutes of Health, Bethesda, MD, USA
    Clin Endocrinol (Oxf) 63:363-5. 2005
  4. ncbi Effects of mometasone furoate dry powder inhaler and beclomethasone dipropionate hydrofluoroalkane and chlorofluorocarbon on the hypothalamic-pituitary-adrenal axis in asthmatic subjects
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Agia Sophia Children s Hospital, 11527 Athens, Greece
    Chest 128:70-7. 2005
  5. ncbi Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension
    Polyxeni Nicolaidou
    First Pediatric Department, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Pediatr Int 45:35-8. 2003
  6. ncbi Basal and cosyntropin-stimulated plasma cortisol concentrations, as measured by high-performance liquid chromatography, in children aged 5 months to younger than 6 years
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    J Clin Endocrinol Metab 92:2125-9. 2007
  7. ncbi Stress and sex versus immunity and inflammation
    George P Chrousos
    First Department of Pediatrics, Children s Hospital Aghia Sophia, University of Athens, Athens, Greece
    Sci Signal 3:pe36. 2010
  8. ncbi Stress and disorders of the stress system
    George P Chrousos
    Aghia Sophia Children s Hospital, University of Athens, Greece
    Nat Rev Endocrinol 5:374-81. 2009
  9. ncbi Intracellular glucocorticoid signaling: a formerly simple system turns stochastic
    George P Chrousos
    Department of Pediatrics, University of Athens, Athens 115 27, Greece
    Sci STKE 2005:pe48. 2005
  10. ncbi HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr MSC 1109, Building 10, Clinical Research Center, Room 1 3140, Bethesda, MD 20892 1109, USA
    Diabetes 54:23-31. 2005

Detail Information

Publications119 found, 100 shown here

  1. ncbi Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Ann N Y Acad Sci 1179:153-66. 2009
    ....
  2. ncbi Gender differences in Greek centenarians. A cross-sectional nation-wide study, examining multiple socio-demographic and personality factors and health locus of control
    Xanthi Tigani
    First Department of Pediatrics, Children s Hospital Aghia Sofia, School of Medicine, University of Athens, Thivon and Papadiamantopoulou Str, GR 115 27, Athens, Greece
    BMC Geriatr 11:87. 2011
    ..Although, there are several studies examining different biomedical factors as determinants of longevity in centenarians, little is known about gender differences with respect to personality traits and health locus of control...
  3. ncbi Post-SARS sickness syndrome manifestations and endocrinopathy: how, why, and so what?
    George P Chrousos
    Athens University, Athens, Greece and National Institutes of Health, Bethesda, MD, USA
    Clin Endocrinol (Oxf) 63:363-5. 2005
  4. ncbi Effects of mometasone furoate dry powder inhaler and beclomethasone dipropionate hydrofluoroalkane and chlorofluorocarbon on the hypothalamic-pituitary-adrenal axis in asthmatic subjects
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Agia Sophia Children s Hospital, 11527 Athens, Greece
    Chest 128:70-7. 2005
    ..The effect of MF-DPI, 400 microg qd, on the HPA axis was compared to that of beclomethasone dipropionate (BDP) using hydrofluoroalkane (HFA) and chlorofluorocarbon (CFC) propellants via metered-dose inhalers (MDIs) twice daily...
  5. ncbi Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension
    Polyxeni Nicolaidou
    First Pediatric Department, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Pediatr Int 45:35-8. 2003
    ..The aim of the present study was to investigate whether the levels of plasma ET-1 are elevated in children with APSGN. Furthermore, we examined the association between plasma ET-1 levels and blood pressure levels in the same children...
  6. ncbi Basal and cosyntropin-stimulated plasma cortisol concentrations, as measured by high-performance liquid chromatography, in children aged 5 months to younger than 6 years
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    J Clin Endocrinol Metab 92:2125-9. 2007
    ..Measurement of pretreatment cortisol concentrations is necessary to assess effects on adrenal function...
  7. ncbi Stress and sex versus immunity and inflammation
    George P Chrousos
    First Department of Pediatrics, Children s Hospital Aghia Sophia, University of Athens, Athens, Greece
    Sci Signal 3:pe36. 2010
    ....
  8. ncbi Stress and disorders of the stress system
    George P Chrousos
    Aghia Sophia Children s Hospital, University of Athens, Greece
    Nat Rev Endocrinol 5:374-81. 2009
    ..By contrast, excessive or inadequate basal activity and responsiveness of this system might impair development, growth and body composition, and lead to a host of behavioral and somatic pathological conditions...
  9. ncbi Intracellular glucocorticoid signaling: a formerly simple system turns stochastic
    George P Chrousos
    Department of Pediatrics, University of Athens, Athens 115 27, Greece
    Sci STKE 2005:pe48. 2005
    ..The presence of multiple GR monomers and dimers in different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic...
  10. ncbi HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr MSC 1109, Building 10, Clinical Research Center, Room 1 3140, Bethesda, MD 20892 1109, USA
    Diabetes 54:23-31. 2005
    ..Vpr thus may contribute to the tissue-selective insulin resistance often observed in HIV-1-infected individuals...
  11. ncbi Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:1939-49. 2004
    ....
  12. ncbi Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization
    Sophia D Sakka
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Aghia Sophia Children s Hospital, Athens University Medical School, Athens, Greece
    Fertil Steril 94:1693-9. 2010
    ..To investigate the metabolic profile, traditional adipokines, and indices of insulin resistance and low-grade inflammation in children born as a result of IVF compared with spontaneously conceived controls...
  13. ncbi Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiat
    Takamasa Ichijo
    Section on Pediatric Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Mol Cell Endocrinol 283:19-31. 2008
    ....
  14. ncbi Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident
    Panagiota Pervanidou
    First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Psychoneuroendocrinology 32:991-9. 2007
    ....
  15. ncbi Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 1109, USA
    Biochem Biophys Res Commun 381:671-5. 2009
    ..Our results indicate that GRbeta has intrinsic, GRalpha-independent, gene-specific transcriptional activity, in addition to its previously reported dominant negative effect on GRalpha-induced transactivation of GRE-driven promoters...
  16. ncbi AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK
    Nancy Nader
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Mol Endocrinol 24:1748-64. 2010
    ..Because increased action of glucocorticoids is associated with the development of metabolic disorders, activation of AMPK could be a promising target for developing pharmacological interventions to these pathologies...
  17. ncbi G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus
    Tomoshige Kino
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:885-96. 2005
    ..We conclude that the Gbetagamma complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters...
  18. ncbi Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
    Tomoshige Kino
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Sci Signal 3:ra8. 2010
    ..We conclude that Gas5 is a "riborepressor" of the GR, influencing cell survival and metabolic activities during starvation by modulating the transcriptional activity of the GR...
  19. ncbi Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:25651-6. 2003
    ..Conversely, through its 14-3-3 protein interactions, GRalpha may influence these processes...
  20. ncbi Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress
    Tomoshige Kino
    Reproductive Biology and Medicine Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Mol Endocrinol 21:1552-68. 2007
    ..Thus, CDK5 exerts some of its biological activities in neuronal cells through the GR, dynamically modulating GR transcriptional activity in a target promoter-dependent fashion...
  21. ncbi Stress dose of hydrocortisone is not beneficial in patients with classic congenital adrenal hyperplasia undergoing short-term, high-intensity exercise
    Martina Weise
    Developmental Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:3679-84. 2004
    ....
  22. ncbi A favorable metabolic and antiatherogenic profile in carriers of CYP21A2 gene mutations supports the theory of a survival advantage in this population
    Sarantis Livadas
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Horm Res 72:337-43. 2009
    ..The very high carrier frequency of 21-hydroxylase deficiency worldwide has been postulated as indicating a survival advantage. The 'mediators' of such an effect remain speculative...
  23. ncbi A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
    Evangelia Charmandari
    Section on Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 92:3986-90. 2007
    ....
  24. ncbi Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance
    Evangelia Charmandari
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20895, USA
    J Clin Endocrinol Metab 91:1535-43. 2006
    ....
  25. ncbi Exercise and the stress system
    George Mastorakos
    Endocrine Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens, Greece
    Hormones (Athens) 4:73-89. 2005
    ..The mechanisms involved in the pathogenesis of the above disorders are discussed in this review...
  26. ncbi L-carnitine: A nutritional modulator of glucocorticoid receptor functions
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    FASEB J 17:1553-5. 2003
    ....
  27. ncbi The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 9D42, Bethesda, Maryland 20892 1583, USA
    Mol Endocrinol 19:52-64. 2005
    ..These findings suggest that participation of hGRbeta in the formation of a coactivator complex renders this complex ineffective...
  28. ncbi Beta-sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells
    Stella Loizou
    Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
    Mol Nutr Food Res 54:551-8. 2010
    ..This study extends existing data regarding the cardioprotective effect of beta-sitosterol and provides new insights into understanding the molecular mechanism underlying the beneficial effect of beta-sitosterol on endothelial function...
  29. ncbi Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy
    Shashi Shrivastav
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease NIH, 10 Center Drive MSC 1268, Bethesda, MD 20892 1268, USA
    Mol Endocrinol 22:234-47. 2008
    ..Vpr may alter sensitivity to insulin and thereby contribute to the development of lipodystrophy and insulin resistance observed in HIV-1-infected patients...
  30. ncbi Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Virol 76:9724-34. 2002
    ..These results indicate that Vpr activates transcription by acting as an adapter linking transcription components and coactivators...
  31. ncbi Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD 20892 1109, USA
    Mol Med 10:80-8. 2004
    ....
  32. ncbi HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection
    Marco Mirani
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:6361-8. 2002
    ..Through this effect, Vpr may contribute to the suppression of innate and cellular immunities of HIV-1-infected individuals and AIDS patients...
  33. ncbi Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:153-67. 2004
    ....
  34. ncbi Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: when children are not just "small adults"
    Christina Kanaka-Gantenbein
    First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes, Athens University Medical School, Athens, Greece
    Clin Chem 54:1176-82. 2008
    ....
  35. ncbi Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor
    Tomoshige Kino
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Mol Endocrinol 24:941-52. 2010
    ....
  36. ncbi Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man
    Evangelia Charmandari
    First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    PLoS ONE 6:e25612. 2011
    ..In this manuscript, we studied the effect of CLOCK-mediated GR acetylation on the sensitivity of peripheral tissues to glucocorticoids in humans...
  37. ncbi Elevated levels of growth-related hormones in autism and autism spectrum disorder
    James L Mills
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health DHHS, Bethesda, MD 20892, USA
    Clin Endocrinol (Oxf) 67:230-7. 2007
    ..We investigated whether children with autism were taller and heavier, and whether they had higher levels of growth-related hormones than control children did...
  38. ncbi Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  39. ncbi The human glucocorticoid receptor: molecular basis of biologic function
    Nicolas C Nicolaides
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, 11527, Athens, Greece
    Steroids 75:1-12. 2010
    ..This review summarizes the basic aspects of the structure and actions of the human (h) GR, and the molecular basis of its biologic functions...
  40. ncbi Tissue glucocorticoid resistance/hypersensitivity syndromes
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Steroid Biochem Mol Biol 85:457-67. 2003
    ....
  41. ncbi Intramuscular administration of ACTH1-24 vs. 24-hour blood sampling in the assessment of adrenocortical function
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA
    Hormones (Athens) 4:96-100. 2005
    ..In conclusion, we confirmed that i.m. administration of ACTH1-24, followed by a single blood sampling at 60 min for cortisol measurement represents a valid, convenient and cost- effective screening test of adrenal function...
  42. ncbi FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive, MSC 1109, Bethesda, MD 20892 1109, USA
    J Steroid Biochem Mol Biol 92:357-63. 2004
    ..Thus, FLASH differentially suppresses steroid hormone receptor-induced transcriptional activity by interfering with their association with SRC2/N-CoA2 and SRC3/N-CoA3 but not with SRC1/N-CoA1...
  43. ncbi Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation
    Maria G Pavlatou
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Eur J Clin Invest 41:652-8. 2011
    ..In this study, we examined the effects of candesartan, an angiotensin receptror blocker, in the chronic low-grade inflammation observed in DM 2...
  44. ncbi Interactions of the circadian CLOCK system and the HPA axis
    Nancy Nader
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 21:277-86. 2010
    ..In this review, we summarize the mutual physiologic interactions between the circadian CLOCK system and the HPA axis, and discuss their clinical implications...
  45. ncbi Endocrinologic and psychologic evaluation of 21-hydroxylase deficiency carriers and matched normal subjects: evidence for physical and/or psychologic vulnerability to stress
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, The Warren Grant Magnuson Clinical Center, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:2228-36. 2004
    ..These changes might predict mild predisposition of these subjects to physical and psychologic pathology, suggesting that larger studies are necessary...
  46. ncbi Plasma proteomic analysis in obese and overweight prepubertal children
    Zoi Galata
    Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Eur J Clin Invest 41:1275-83. 2011
    ..Proteomics is a large-scale analysis of proteins, which provides, information on protein expression levels, post-translational modifications, subcellular localization and interactions...
  47. ncbi Elevated coagulation and inflammatory markers in adolescents with a history of premature adrenarche
    Sarantis Livadas
    First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece
    Metabolism 58:576-81. 2009
    ..Adolescent girls with a history of premature adrenarche display metabolic deviations usually encountered in subjects with PCOS and metabolic syndrome, such as subclinical inflammation and fibrinolytic abnormalities...
  48. ncbi Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Methods Mol Biol 590:33-60. 2009
    ....
  49. ncbi Fatty acids derived from royal jelly are modulators of estrogen receptor functions
    Paraskevi Moutsatsou
    Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
    PLoS ONE 5:e15594. 2010
    ....
  50. ncbi Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 2:ra5. 2009
    ..Our results indicate that Brx integrates the responses of immune cells to osmotic stress and inflammation by elevating intracellular osmolarity and stimulating the production of cytokines...
  51. ncbi Inverse association of leptin levels with renal cell carcinoma: results from a case-control study
    Themistoklis N Spyridopoulos
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece
    Hormones (Athens) 8:39-46. 2009
    ..Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk...
  52. ncbi Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:72-85. 2004
    ..It appears that glucocorticoids exert their intermediary effects partly via physical interaction with COUP-TFII...
  53. ncbi Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Biol Chem 278:3023-9. 2003
    ..These findings indicate that FLASH participates in TNF alpha-induced blockade of GR transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa B...
  54. ncbi Familial/sporadic glucocorticoid resistance syndrome and hypertension
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:101-11. 2002
    ..These results suggest that the pathologic mechanisms of glucocorticoid resistance is quite broad, and this is reflected in the wide variability of the clinical picture in patients with the syndrome...
  55. ncbi Ikaros transcription factors: flying between stress and inflammation
    George P Chrousos
    First Department of Pediatrics, University of Athens, Athens, Greece
    J Clin Invest 115:844-8. 2005
    ..These results indicate that Ikaros is an ontogenetic and phylogenetic integrator of the stress and immune systems and that abnormalities in its function may produce endocrine and/or immune pathologies...
  56. ncbi A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension
    Evangelia Charmandari
    Division of Endocrinology, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece
    J Clin Endocrinol Metab 97:E1532-9. 2012
    ....
  57. ncbi Chios mastic gum extract and isolated phytosterol tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells
    Stella Loizou
    Department of Biological Chemistry, Medical School, University of Athens, and Second Department of Cardiology, University General Hospital, 75 Mikras Asias Str, Goudi, Athens, Attiki 11527, Greece
    Exp Biol Med (Maywood) 234:553-61. 2009
    ....
  58. ncbi The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications
    Takamasa Ichijo
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:42067-77. 2005
    ....
  59. ncbi Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome
    Deborah P Merke
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1932, USA
    J Clin Endocrinol Metab 90:2531-6. 2005
    ..Despite rapid reversibility of cerebral atrophy, children experience a significant decline in cognitive function 1 yr after correction of hypercortisolism...
  60. ncbi The hypothalamic-pituitary-adrenal axis in asthmatic children
    Kostas N Priftis
    Department of Allergy Pneumonology, Penteli Children s Hospital, Athens, Greece
    Trends Endocrinol Metab 19:32-8. 2008
    ..Adrenal suppression of some asthmatic patients on maintenance ICS seems to be a separate phenomenon, possibly constitutionally or genetically determined...
  61. ncbi Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, 11527 Athens, Greece
    Stress 10:213-9. 2007
    ....
  62. ncbi Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence
    George P Chrousos
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neuroimmunomodulation 16:272-83. 2009
    ..We review the most common endocrinologic investigations used in the evaluation of the HPA axis integrity and function...
  63. ncbi The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Mail Stop Code 1583, Building 10, Room 9D42, Bethesda, MD 20892 1583, USA
    Mol Endocrinol 18:820-33. 2004
    ..These interactions influence the transcription of both COUP-TFII- and GRalpha-responsive target genes, seem to be promoter specific, and can be in either a positive or negative direction...
  64. ncbi Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm
    Alejandro R Ayala
    Pediatric Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:5729-37. 2004
    ..Taken together, these findings suggest that CRHR-1 antagonists may be a valid treatment for stress-related disorders...
  65. ncbi Screening for congenital hypothyroidism: the significance of threshold limit in false-negative results
    Chryssanthi Mengreli
    Department of Biochemical Laboratories, Institute of Child Health, Aghia Sophia Children s Hospital, 11527 Goudi, Athens, Greece
    J Clin Endocrinol Metab 95:4283-90. 2010
    ..In our neonatal program, a number of infants with congenital hypothyroidism (CH) had escaped diagnosis, when a spot RIA-TSH value of 20 mU/liter whole blood was used as a cutoff point...
  66. ncbi Increased glucocorticoid receptor Beta expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype
    Pia J Hauk
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 27:361-7. 2002
    ..Furthermore, in such cells GCRalpha is complexed with GCRbeta. Such heterodimer formation may account for the reduced effectiveness of GC action in cells overexpressing GCRbeta...
  67. ncbi Gender dimorphic associations between N-terminal pro-brain natriuretic peptide, body mass index and blood pressure in children and adolescents
    Panagiota Pervanidou
    First Department of Pediatrics, Childhood Obesity Clinic, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece ppervanid med uoa gr
    Horm Res Paediatr 73:341-8. 2010
    ..Conclusions: Longitudinal studies are needed to define the role of NT-proBNP as a screening biomarker in obese children, particularly males, to determine their risk for developing arterial hypertension...
  68. ncbi The natural history of neuroendocrine changes in pediatric posttraumatic stress disorder (PTSD) after motor vehicle accidents: progressive divergence of noradrenaline and cortisol concentrations over time
    Panagiota Pervanidou
    First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Biol Psychiatry 62:1095-102. 2007
    ..This was a prospective and longitudinal study of neuroendocrine physiology in children with PTSD following a motor vehicle accident (MVA)...
  69. ncbi A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators
    Alessandra Vottero
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, MSC 1583, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 87:2658-67. 2002
    ..The mutant receptor has an ineffective AF-2 domain, which leads to an abnormal interaction with p160 coactivators and a distinct nuclear distribution of both...
  70. ncbi Clinical review: Constitutional advancement of growth, a.k.a. early growth acceleration, predicts early puberty and childhood obesity
    Anastasios Papadimitriou
    Third Department of Pediatrics, University of Athens School of Medicine, Attikon University Hospital, Athens, Greece
    J Clin Endocrinol Metab 95:4535-41. 2010
    ..For a child to be considered as presenting CAG, other conditions that lead to early growth acceleration, like genetic tall stature, infant overfeeding, and intrauterine growth restraint, have to be excluded...
  71. ncbi Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls: evidence for catecholamine-mediated ghrelin regulation
    Kleopatra H Schulpis
    Institute of Child Health, Athens, Greece
    J Clin Endocrinol Metab 89:3983-7. 2004
    ....
  72. ncbi The efficacy and safety of gonadotropin-releasing hormone analog treatment in childhood and adolescence: a single center, long-term follow-up study
    Maria Alexandra Magiakou
    Division of Endocrinology, Athens University Medical School, Aghia Sophia Children s Hospital, 11527 Athens, Greece
    J Clin Endocrinol Metab 95:109-17. 2010
    ..The objective of the study was to evaluate the long-term effect of GnRH analog (GnRHa) treatment on final height (FH), body mass index (BMI), body composition, bone mineral density (BMD), and ovarian function...
  73. ncbi Neuroendocrinology of post-traumatic stress disorder
    Panagiota Pervanidou
    Developmental and Behavioral Pediatrics Unit, First Department of Pediatrics, Athens University Medical School, Agia Sophia Children s Hospital, Goudi, Athens, Greece
    Prog Brain Res 182:149-60. 2010
    ..Chronically disturbed hormones in PTSD may contribute to brain changes and further emotional and behavior symptoms and disorders, as well as to an increased cardiometabolic risk...
  74. ncbi Euthyroid hyperthyrotropinemia in children born after in vitro fertilization
    Sophia D Sakka
    First Department of Obstetrics and Gynaecology, Division of Endocrinology, Metabolism, Athens University Medical School, Athens, Greece
    J Clin Endocrinol Metab 94:1338-41. 2009
    ..Although classic in vitro fertilization (IVF) started almost 30 yr ago, few long-term systematic prospective studies of children conceived with assisted reproduction have been performed...
  75. ncbi Parental stress affects the emotions and behaviour of children up to adolescence: a Greek prospective, longitudinal study
    Chryssa Bakoula
    First Department of Paediatrics, University of Athens, Aghia Sofia Children s Hospital, Athens, Greece
    Stress 12:486-98. 2009
    ..The adverse effects of parental stress and poor care-giving practices on child's psychopathology need to be recognised and improved...
  76. ncbi Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: preliminary results
    Maria G Pavlatou
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Stress 11:62-72. 2008
    ..91 +/- 0.16 vs. 0.70 +/- 0.15, P = 0.027) and depression scores (0.96 +/- 0.15 vs. 0.71 +/- 0.10, P = 0.026). We suggest that candesartan resets the HPA axis of patients with DM type 2 and improves their affect...
  77. ncbi Hypertension in Cushing's syndrome
    Maria Alexandra Magiakou
    Unit of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Agia Sophia Children s Hospital, 11527 Goudi, Athens, Greece
    Best Pract Res Clin Endocrinol Metab 20:467-82. 2006
    ..The various pathogenetic mechanisms that have been proposed for the development of glucocorticoid-induced hypertension in Cushing's syndrome and its management are discussed...
  78. ncbi Assessment of metabolic profile in a clinical setting
    Panagiota Pervanidou
    First Department of Pediatrics, Division of Endocrinology, Diabetes and Metabolism, University of Athens, Aghia Sophia Children s Hospital, Athens, Greece
    Curr Opin Clin Nutr Metab Care 9:589-95. 2006
    ..There are several definitions of the metabolic syndrome, all aiming at including as many persons at risk as possible. The assessment and, hence, the identification of such persons in a clinical setting is of utmost importance...
  79. ncbi Vitamin D receptor polymorphisms in hypocalcemic vitamin D-resistant rickets carriers
    Polyxeni Nicolaidou
    Third Department of Pediatrics, University General Hospital Attikon, Athens University Medical School, Chaidari, Greece
    Horm Res 67:179-83. 2007
    ....
  80. ncbi Hypoxemic resuscitation from hemorrhagic shock prevents lung injury and attenuates oxidative response and IL-8 overexpression
    Emmanuel E Douzinas
    Third Department of Critical Care Medicine, University of Athens Medical School, Evgenidio Hospital, Athens 115 28, Greece
    Free Radic Biol Med 50:245-53. 2011
    ..We conclude that hypoxemic resuscitation from hemorrhagic shock ameliorates lung injury and reduces oxygen radical generation and lung IL-8 expression...
  81. ncbi Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Clinical Research Center, Rm 1E 3140, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Cell Mol Life Sci 66:3435-48. 2009
    ..In this review, we discuss the functions of GRbeta, its mechanisms of action, and its pathologic implications...
  82. ncbi Endocrine-related causes and consequences of intrauterine growth retardation
    Christina Kanaka-Gantenbein
    Department of Pediatric Endocrinology, 1st Department of Pediatrics, Agia Sofia Children s Hospital, Medical School, University of Athens, Tymfristou 52 15234 Halandri, Athens, Greece
    Ann N Y Acad Sci 997:150-7. 2003
    ....
  83. ncbi Effects of child- and adolescent-onset endogenous Cushing syndrome on bone mass, body composition, and growth: a 7-year prospective study into young adulthood
    Gary M Leong
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    J Bone Miner Res 22:110-8. 2007
    ..In 14 children followed for 3-7 years into young adulthood after cure of CS, whereas bone mass largely recovered, persisting increases in total body and visceral fat suggests an increase risk of the metabolic syndrome...
  84. ncbi Low adiponectin levels are associated with renal cell carcinoma: a case-control study
    Themistoklis N Spyridopoulos
    Department of Hygiene and Epidemiology, Athens University Medical School, Goudi, Athens, Greece
    Int J Cancer 120:1573-8. 2007
    ..Prospective studies as well as studies exploring underlying mechanisms are needed to fully explore the role of adiponectin in predicting future risk of RCC in humans...
  85. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
    ....
  86. ncbi Glucose dysregulation in obese children: predictive, risk, and potential protective factors
    Paraskevi Xekouki
    Endocrine Unit, Department of Pediatrics, Athens University School of Medicine, Aghia Sophia Children s Hospital, Thivon and Levadias, 115 27, Athens, Greece
    Obesity (Silver Spring) 15:860-9. 2007
    ....
  87. ncbi Glucocorticoids and their actions: an introduction
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1583, USA
    Ann N Y Acad Sci 1024:1-8. 2004
  88. ncbi Stress, visceral obesity, and metabolic complications
    Ioannis Kyrou
    Endocrinology, Metabolism and Diabetes Unit, Evgenidion Hospital, Athens University Medical School, Athens, 115 28, Greece
    Ann N Y Acad Sci 1083:77-110. 2006
    ....
  89. ncbi Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    Jerome Galon
    Lymphocyte Cell Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 16:61-71. 2002
    ..Considering the broad and continuously renewed interest in glucocorticoid therapy, the profiles we describe here will be useful in designing more specific and efficient treatment strategies...
  90. ncbi Parental involvement does not augment the effectiveness of an intense behavioral program for the treatment of childhood obesity
    Eirini Bathrellou
    Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
    Hormones (Athens) 9:171-5. 2010
    ..To evaluate the effectiveness of active parental involvement in a lifestyle intervention for the management of childhood obesity...
  91. ncbi Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 87:2114-20. 2002
    ....
  92. ncbi Metabolic syndrome manifestations in classic congenital adrenal hyperplasia: do they predispose to atherosclerotic cardiovascular disease and secondary polycystic ovary syndrome?
    Evangelia Charmandari
    Section on Pediatric Endocrinology, Reproductive and Molecular Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1083:37-53. 2006
    ..Nonpharmacologic and pharmacologic interventions targeting obesity and/or insulin resistance may offer an improved outcome in terms of cardiovascular morbidity...
  93. ncbi Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:168-81. 2004
    ..The present review focuses on the mechanisms of GR action and the clinical manifestations and molecular mechanisms of familial/sporadic glucocorticoid resistance...
  94. ncbi Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
    ..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
  95. ncbi Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou tou Efessiou Street, Athens, Greece
    J Clin Endocrinol Metab 93:1563-72. 2008
    ..We review the clinical aspects, molecular mechanisms, and implications of this disorder...
  96. ncbi Nuclear factor-kappaB- and glucocorticoid receptor alpha- mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to glu
    G Umberto Meduri
    Memphis Lung Research Program, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, USA
    Neuroimmunomodulation 12:321-38. 2005
    ..The findings provide a rationale for the use of prolonged GC treatment in early ARDS...
  97. ncbi Divergent endocrine abnormalities in melancholic and atypical depression: clinical and pathophysiologic implications
    Philip W Gold
    Clinical Endocrinology Branch, Intramural Research Program, National Institute of Mental Health, Bathesda, MD 20892, USA
    Endocrinol Metab Clin North Am 31:37-62, vi. 2002
    ..Subdividing patients with major depression into meaningful biologic subgroups will facilitate the elucidation of the mechanisms that underlie the central and peripheral manifestations of major depressive illness...
  98. ncbi A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
    Evangelia Charmandari
    Department of Pediatric Endocrinology, Great Ormond Street Hospital for Children, 9th Floor, Southwood Building, Great Ormond Street, London, United Kingdom WC1N 3JH
    J Clin Endocrinol Metab 90:3696-705. 2005
    ..We conclude that the carboxyl terminus of the ligand-binding domain of hGRalpha is extremely important in conferring transactivational activity by altering multiple functions of this composite transcription factor...
  99. ncbi Predictors of endothelial dysfunction in young women with polycystic ovary syndrome
    Maria Kravariti
    F.R.C.P, Department of Endocrinology, University of Ioannina, Panepistimiou Avenue, 45 110 Ioannina, Greece
    J Clin Endocrinol Metab 90:5088-95. 2005
    ..e. early 20s), and largely independent of obesity. This suggests that women with PCOS are at increased risk for early onset cardiovascular disease and may gain particular benefit from measures to improve endothelial function...
  100. ncbi Glucocorticoid action networks--an introduction to systems biology
    George P Chrousos
    J Clin Endocrinol Metab 89:563-4. 2004
  101. ncbi Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 88:2087-95. 2003
    ....