Affiliation: University of Patras
- Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathwayDionysios Chartoumpekis
Department of Internal Medicine, School of Medicine, University of Patras, 26500 Patras, Greece
Biochem Biophys Res Commun 396:463-6. 2010..We show for the first time that simvastatin lowers reactive oxygen species (ROS) by activating Nrf2 through the PI3K/Akt pathway...
- Simvastatin activates Keap1/Nrf2 signaling in rat liverIoannis G Habeos
Department of Internal Medicine, School of Medicine, University of Patras, 26500, Patras, Greece
J Mol Med (Berl) 86:1279-85. 2008..In conclusion, activation of Keap1/Nrf2 signaling pathway by simvastatin might provide effective protection of the cell from the deleterious effects of oxidative stress...
- Fibrocalculous pancreatic diabetes in patient residing in the Mediterranean regionIoannis Habeos
Division of Endocrinology and Diabetes, Department of Internal Medicine, Patras University Medical School, Greece
Hormones (Athens) 5:64-6. 2006..This case accords with the criteria for fibrocalculous pancreatic diabetes with the unique feature of the patient having been born in Greece and being a resident of Greece...