Panos Bitsios

Summary

Affiliation: University of Crete
Country: Greece

Publications

  1. ncbi Relationship of prepulse inhibition of the startle reflex to attentional and executive mechanisms in man
    Panos Bitsios
    Department of Psychiatry and Behavioural Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Int J Psychophysiol 55:229-41. 2005
  2. doi Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia
    Panos Bitsios
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, PO Box 2208, University of Crete, Heraklion 71003, Crete, Greece
    Pharmacogenomics 12:559-66. 2011
  3. doi The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Bipolar Disord 13:250-9. 2011
  4. ncbi Pupil miosis within 5 minutes in darkness is a valid and sensitive quantitative measure of alertness: application in daytime sleepiness associated with sleep apnea
    Panos Bitsios
    Dept of Psychiatry and Behavioural Sciences, Medical School PO BOX 2208, University of Crete, Heraklion 71003, Crete, Greece
    Sleep 29:1482-8. 2006
  5. ncbi Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males
    Panos Bitsios
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Heraklion, Greece
    Neuropsychologia 44:2494-9. 2006
  6. ncbi The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values
    Panos Bitsios
    Department of Psychiatry and Behavioural Sciences, Faculty of Medicine, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 182:144-52. 2005
  7. doi Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
    Neuropsychopharmacology 33:3058-68. 2008
  8. ncbi The 5-min pupillary alertness test is sensitive to modafinil: a placebo controlled study in patients with sleep apnea
    Alexandra Nikolaou
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, P O Box 2208, Heraklion 71003, Crete, Greece
    Psychopharmacology (Berl) 196:167-75. 2008
  9. doi Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers
    Vassilis Koudas
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 205:1-9. 2009
  10. doi Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Neuropsychologia 47:1654-9. 2009

Collaborators

Detail Information

Publications36

  1. ncbi Relationship of prepulse inhibition of the startle reflex to attentional and executive mechanisms in man
    Panos Bitsios
    Department of Psychiatry and Behavioural Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Int J Psychophysiol 55:229-41. 2005
    ..Overall PPI performance was correlated to performance indices of planning ability and there was a trend level correlation with scores in selective but not sustained attention tests. These preliminary results merit further investigation...
  2. doi Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia
    Panos Bitsios
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, PO Box 2208, University of Crete, Heraklion 71003, Crete, Greece
    Pharmacogenomics 12:559-66. 2011
    ..It will soon be understood if tolcapone represents one of the first hypothesis-driven, biology-based, genotype-specific, targeted treatments of cognitive and negative symptoms of schizophrenia...
  3. doi The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Bipolar Disord 13:250-9. 2011
    ..The aim of this study was to examine the phenotypic consequences of the risk CACNA1C and ANK3 alleles in a large homogeneous cohort of healthy young males...
  4. ncbi Pupil miosis within 5 minutes in darkness is a valid and sensitive quantitative measure of alertness: application in daytime sleepiness associated with sleep apnea
    Panos Bitsios
    Dept of Psychiatry and Behavioural Sciences, Medical School PO BOX 2208, University of Crete, Heraklion 71003, Crete, Greece
    Sleep 29:1482-8. 2006
    ..In this preliminary study, we tested the validity of the gradual pupillary miosis during 5 minutes in darkness, as a quantitative physiologic index of the arousal state of the brain...
  5. ncbi Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males
    Panos Bitsios
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Heraklion, Greece
    Neuropsychologia 44:2494-9. 2006
    ..Our findings suggest that greater PPI is associated with superior abilities in strategy formation and execution times. We suggest that this is due to more efficient early information processing...
  6. ncbi The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values
    Panos Bitsios
    Department of Psychiatry and Behavioural Sciences, Faculty of Medicine, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 182:144-52. 2005
    ..This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA agonist-induced PPI disruption in humans...
  7. doi Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
    Neuropsychopharmacology 33:3058-68. 2008
    ..These results suggest that early information processing and working memory may both depend on PFC DA signaling, and that they may both relate to PFC DA levels according to an inverted U-shaped curve function...
  8. ncbi The 5-min pupillary alertness test is sensitive to modafinil: a placebo controlled study in patients with sleep apnea
    Alexandra Nikolaou
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, P O Box 2208, Heraklion 71003, Crete, Greece
    Psychopharmacology (Berl) 196:167-75. 2008
    ..The extent of pupillary miosis during 5 min in darkness is a simple, recently introduced alertness test which may become useful in the clinical assessment of normal and pathological sleepiness...
  9. doi Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers
    Vassilis Koudas
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 205:1-9. 2009
    ..The human pupil may be a suitable physiological test system for the assessment of excessive daytime sleepiness (EDS), but pupillometric assessment could be confounded by medication for comorbid hypertension and mood disorders...
  10. doi Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Neuropsychologia 47:1654-9. 2009
    ..The proposed role of the NS phenotype in human evolution and in disorders of impulsivity is discussed under the light of the present findings...
  11. doi Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Greece
    Biol Psychiatry 66:997-1004. 2009
    ..Here, we explored the effects of the synonymous COMT rs4818 C/G polymorphism and tolcapone on PPI and working memory...
  12. doi Cognitive and emotional processing associated with the Season of Birth and dopamine D4 receptor gene
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Neuropsychologia 48:3926-33. 2010
    ..SOB should be included in future studies of risky behaviors and behavioral genetic studies of the dopamine system...
  13. ncbi Disruption of prepulse inhibition of the startle reflex by the preferential D(3) agonist ropinirole in healthy males
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 194:289-95. 2007
    ..Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects...
  14. ncbi Parametric exploration of the fear-inhibited light reflex
    Eugenia Hourdaki
    Department of Psychiatry and Behavioural Sciences, University of Crete, Heraklion, Crete, Greece
    Psychophysiology 42:447-55. 2005
    ....
  15. ncbi Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion 71003, Greece
    Psychophysiology 47:659-68. 2010
    ..Low startle and blunted startle reactivity may represent trait deficits in remitted BD patients and their relatives, possibly associated with attentional deficits and adaptive down-regulation of emotion...
  16. doi The dopamine D(3) receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflex
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
    Biol Psychiatry 64:235-40. 2008
    ..The Ser9Gly polymorphism is a common variant of the DRD(3) gene and determines the gain of function of the D(3) receptor. This is the first study to examine the influence of the DRD(3) Ser9Gly polymorphism on human PPI...
  17. pmc The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Neuropsychopharmacology 36:1677-88. 2011
    ....
  18. doi Sustained attention and working memory deficits follow a familial pattern in schizophrenia
    Stella G Giakoumaki
    Department of Psychology, University of Crete, Rethymno, Greece
    Arch Clin Neuropsychol 26:687-95. 2011
    ..Reaction time and false alarm rates are suggested as additional useful endophenotypic measures that could potentially account for differences in performance in tasks that are not purported to examine the specific measures per se...
  19. doi Evidence of dysregulated affect indicated by high alexithymia in obstructive sleep apnea
    Alexandra Nikolaou
    Department of Psychiatry, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    J Sleep Res 20:92-100. 2011
    ....
  20. ncbi Cognitive and personality analysis of startle reactivity in a large cohort of healthy males
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece Department of Psychology, University of Crete, Rethymno, Crete, Greece Electronic address
    Biol Psychol 94:582-91. 2013
    ..It is possible that the "non-responsive" status may capture disease related features such as executive dysfunction. ..
  21. doi The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Biol Psychiatry 69:479-86. 2011
    ....
  22. ncbi Evidence of disrupted prepulse inhibition in unaffected siblings of bipolar disorder patients
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Crete, Greece
    Biol Psychiatry 62:1418-22. 2007
    ..To address this issue, the present study examined whether disrupted PPI is present in individuals at high risk for BD...
  23. ncbi The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing
    Stella G Giakoumaki
    Department of Psychiatry and Behavioural Sciences, Medical School, University of Crete, Heraklion 71003, Crete, Greece
    Brain Res 1078:168-70. 2006
    ..These data suggest that high-PPI status reflects greater efficiency in tasks that engage SAS...
  24. doi Antenatal and postnatal maternal mental health as determinants of infant neurodevelopment at 18 months of age in a mother-child cohort (Rhea Study) in Crete, Greece
    Katerina Koutra
    Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, Heraklion, 71003, Crete, Greece
    Soc Psychiatry Psychiatr Epidemiol 48:1335-45. 2013
    ..We examined the effect of antenatal and postnatal maternal mental health on infant neurodevelopment at age 18 months in a population-based mother-child cohort (Rhea Study) in Crete, Greece...
  25. pmc Risk factors for new onset and persistence of multi-site musculoskeletal pain in a longitudinal study of workers in Crete
    Eleni Solidaki
    Department of Social Medicine, Medical School, University of Crete, Heraklion, Greece
    Occup Environ Med 70:29-34. 2013
    ..To explore occupational and psychological risk factors for the incidence and persistence of multi-site musculoskeletal pain...
  26. doi Threat and trait anxiety affect stability of gaze fixation
    Georgia Laretzaki
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Biol Psychol 86:330-6. 2011
    ..The effects of anxiety extend to perceptual and sensorimotor processes. These results have implications for the understanding of individual differences in occulomotor planning and visually guided behavior...
  27. ncbi Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece
    Katerina Koutra
    Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003, Heraklion, Crete, Greece
    Soc Psychiatry Psychiatr Epidemiol 49:711-21. 2014
    ....
  28. doi A risk PRODH haplotype affects sensorimotor gating, memory, schizotypy, and anxiety in healthy male subjects
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Biol Psychiatry 65:1063-70. 2009
    ..We assessed the relationship between these high-risk PRODH polymorphisms and schizophrenia-related endophenotypes in a large and highly homogeneous cohort of healthy males...
  29. ncbi Planning, decision-making and the COMT rs4818 polymorphism in healthy males
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Crete, Greece
    Neuropsychologia 46:757-63. 2008
    ..While high prefrontal dopamine levels may be advantageous for non-emotional problem solving, they lead to disadvantageous choices when decision-making depends on processing of emotional feedback...
  30. ncbi The CSMD1 genome-wide associated schizophrenia risk variant rs10503253 affects general cognitive ability and executive function in healthy males
    Erasmia Koiliari
    Department of Psychiatry, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Schizophr Res 154:42-7. 2014
    ..2, has reached genome-wide support as a risk factor for schizophrenia. There is initial but inconclusive evidence for a role of this variant in aspects of cognition...
  31. doi Type 1 diabetes is associated with alexithymia in nondepressed, non-mentally ill diabetic patients: a case-control study
    Leda Chatzi
    Faculty of Medicine, Department of Social Medicine, University of Crete, Crete, Greece
    J Psychosom Res 67:307-13. 2009
    ..The central aim of this study was to examine alexithymia levels in psychiatrically uncomplicated T1D outpatients with that of nondiabetic controls...
  32. doi Dietary patterns during pregnancy and the risk of postpartum depression: the mother-child 'Rhea' cohort in Crete, Greece
    Leda Chatzi
    Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, Heraklion 71003, Crete, Greece
    Public Health Nutr 14:1663-70. 2011
    ..To identify and describe dietary patterns in a cohort of pregnant women, and investigate whether dietary patterns during pregnancy are related to postpartum depression (PPD)...
  33. pmc Work-related and psychological determinants of multisite musculoskeletal pain
    Eleni Solidaki
    Department of Social Medicine, University of Crete, Heraklion, Crete, Greece
    Scand J Work Environ Health 36:54-61. 2010
    ..We evaluated the relative importance of work-related and psychological determinants of the number of -anatomical sites affected by musculoskeletal pain in a cross-sectional survey...
  34. ncbi Effects of peripheral sympathetic blockade with dapiprazole on the fear-inhibited light reflex
    Stella G Giakoumaki
    Department of Psychiatry and Behavioural Sciences, Medical School, University of Crete, Heraklion, Crete, Greece
    J Psychopharmacol 19:139-48. 2005
    ..The different central autonomic mechanisms underlying the two pupillary responses to threat may explain the dissociation between the separate effects of threat on IPD and light reflex amplitude...
  35. pmc Assessing the burden of caregivers of patients with mental disorders: translating and validating the involvement evaluation questionnaire into Greek
    Vasiliki Sapouna
    Clinic of Social and Family Medicine, Department of Social Medicine, School of Medicine, University of Crete, P, O, Box 2208, Heraklion, 71003, Greece
    Ann Gen Psychiatry 12:3. 2013
    ..This study reports on the translation, cultural adaptation, and validation of the Involvement Evaluation Questionnaire-European Union (IEQ-EU) into the Greek language...
  36. pmc The Edinburgh Postnatal Depression Scale: translation and validation for a Greek sample
    Victoria G Vivilaki
    Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece
    BMC Public Health 9:329. 2009
    ..The purpose of this study was to validate the Greek version of EPDS along with sensitivity, specificity and predictive values...