Charalambos Antoniades

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
    Athanasios Trikas
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Eur J Heart Fail 8:804-9. 2006
  2. ncbi Effects of endothelial nitric oxide synthase gene polymorphisms on oxidative stress, inflammatory status, and coronary atherosclerosis: an example of a transient phenotype
    Charalambos Antoniades
    J Am Coll Cardiol 49:1226; author reply 1226-7. 2007
  3. ncbi Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study
    Stella Brili
    First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 51:742-9. 2008
  4. ncbi Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
  5. ncbi Adiponectin: from obesity to cardiovascular disease
    C Antoniades
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Obes Rev 10:269-79. 2009
  6. ncbi Levosimendan: beyond its simple inotropic effect in heart failure
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Pharmacol Ther 114:184-97. 2007
  7. ncbi Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
  8. ncbi Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
  9. ncbi The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
  10. ncbi Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006

Collaborators

Detail Information

Publications91

  1. ncbi Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
    Athanasios Trikas
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Eur J Heart Fail 8:804-9. 2006
    ..The calcium sensitizer levosimendan improves myocardial contractility in patients with heart failure, although its effects on inflammation and apoptosis are unknown...
  2. ncbi Effects of endothelial nitric oxide synthase gene polymorphisms on oxidative stress, inflammatory status, and coronary atherosclerosis: an example of a transient phenotype
    Charalambos Antoniades
    J Am Coll Cardiol 49:1226; author reply 1226-7. 2007
  3. ncbi Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study
    Stella Brili
    First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 51:742-9. 2008
    ..The purpose of this study was to evaluate the effect of ramipril on endothelial function and inflammatory process in a group of normotensive subjects with successfully repaired coarctation of the aorta (SCR)...
  4. ncbi Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
    ..Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity and abnormal inflammatory response...
  5. ncbi Adiponectin: from obesity to cardiovascular disease
    C Antoniades
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Obes Rev 10:269-79. 2009
    ..Circulating adiponectin levels should be interpreted with caution, as they may have completely different prognostic value, depending on the underlying disease state...
  6. ncbi Levosimendan: beyond its simple inotropic effect in heart failure
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Pharmacol Ther 114:184-97. 2007
    ....
  7. ncbi Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
    ..However, it is unknown whether these abnormalities present in FH children and contribute to their vascular dysfunction...
  8. ncbi Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
    ..We also examined the role of endothelin-1 (ET-1) in the development of endothelial dysfunction in these two conditions...
  9. ncbi The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
    ..We examined the impact of acute homocysteinemia on endothelial function in hypertensive patients and healthy individuals, and the potential role of ET-1...
  10. ncbi Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006
    ..However, the ADMA pathway is activated only in acute homocystinemia by mechanisms not mediated by oxidized LDL or proinflammatory stimuli...
  11. ncbi Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada, Athens, Greece
    Clin Nutr 27:594-600. 2008
    ..We compared the acute effects of several alcoholic beverages on endothelial function, inflammatory process and thrombosis/fibrinolysis system in young adults...
  12. ncbi Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, A Cardiology Department, Greece
    Eur J Heart Fail 7:1126-32. 2005
    ..Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and/or advanced atherosclerosis...
  13. ncbi Effects of lipid profile on forearm hyperemic response in young subjects
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 47:152-7. 2006
    ....
  14. ncbi Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 24:936-42. 2011
    ..However, the mechanisms regulating ADMA synthesis in hypertension are unclear...
  15. ncbi Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response
    Charalambos Antoniades
    Department of Cardiology, Athens University Medical School, Athens, Greece
    Am J Cardiol 94:1181-4. 2004
    ..01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system...
  16. ncbi The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance
    Gerasimos Siasos
    Department of Biological Chemistry, Athens University Medical School, Athens, Greece
    Am J Hypertens 22:586-92. 2009
    ..We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking...
  17. ncbi Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens, Medical School, Athens, Greece
    Int J Cardiol 136:258-62. 2009
    ..We searched for clinical determinants of oxidative stress status, endothelial function and inflammatory process in patients with chronic atrial fibrillation...
  18. ncbi Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals
    Gerasimos Siasos
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 126:394-9. 2008
    ..Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function...
  19. ncbi Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 46:1101-9. 2005
    ....
  20. ncbi Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
    ..We examined the effect of combined therapy with atorvastatin and metformin on glucose-induced variations of inflammatory molecules in patients with newly diagnosed diabetes mellitus type 2 (DM)...
  21. ncbi Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Clin Ther 32:1720-8. 2010
    ..Endothelium-dependent dilation (EDD) measured by gauge-strain plethysmography in the forearm is considered to be a reliable marker of endothelial function in forearm resistance vessels...
  22. ncbi Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease
    Dimitris Tousoulis
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Diabetes Care 26:2749-53. 2003
    ....
  23. ncbi Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
    ....
  24. ncbi Association of arterial stiffness with the angiotensin-converting enzyme gene polymorphism in healthy individuals
    Ioanna Dima
    Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 21:1354-8. 2008
    ..However, the relationship between ACE polymorphism, arterial stiffness, and wave reflections in healthy, low-risk population has not been defined yet...
  25. ncbi Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
    ..These findings indicate that atorvastatin may improve forearm vasodilatory response to reactive hyperemia and depress inflammatory process in patients with heart failure and normal baseline cholesterol levels...
  26. ncbi Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors
    Charalambos Antoniades
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Int J Cardiol 107:95-100. 2006
    ....
  27. ncbi Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
    Constadina Aggeli
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, Greece
    Int J Cardiol 105:80-4. 2005
    ..We examined endothelial function and serum levels of inflammatory mediators in transfusion-dependent patients with beta-thalassemia major...
  28. ncbi Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 134:238-43. 2009
    ..In the present study we evaluated the impact of antidepressive medication on the expression of proinflammatory cytokines and acute phase response proteins, in patients with HF and major depression...
  29. ncbi The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 109:48-52. 2006
    ..In this study we assessed the effects of low-dose atorvastatin treatment, on inflammatory process in patients admitted for unstable angina with low cholesterol level...
  30. ncbi Pathophysiology of atherosclerosis: the role of inflammation
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4089-110. 2011
    ..The main drug categories that have been proved to ameliorate the inflammatory state in atherosclerosis are angiotensin converting enzyme inhibitors/angiotensin receptors blockers, statins, and antioxidants...
  31. ncbi Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering
    Panagiota Gounari
    1st Cardiology Department, Athens University Medical School, Vasilissis Sofias 114, 115 28, Athens, Greece
    Int J Cardiol 142:87-91. 2010
    ..However, its effect in patients with HF is not well studied. Therefore, in the present study we compared the effect of short-term treatment with rosuvastatin or ezetimibe on endothelial function in patients with HF...
  32. ncbi Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 115:203-7. 2007
    ..However, the underlying mechanisms of the acute coronary syndromes are still obscure. We evaluated the differences of inflammatory and thrombotic markers, at the acute phase of unstable angina (UA) and acute myocardial infarction (AMI)...
  33. ncbi Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 106:333-7. 2006
    ..We assessed the effects of short-term atorvastatin treatment on thrombotic/fibrinolysis markers in normocholesterolemic in patients with unstable angina...
  34. ncbi Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 23:237-42. 2010
    ..We examined the impact of A1675G on the risk and the severity of coronary artery disease (CAD), and the expression of proatherogenic inflammatory molecules in hypertensive patients...
  35. ncbi Novel therapies targeting vascular endothelium
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Endothelium 13:411-21. 2006
    ..Although there are a variety of strategies to improve NO bioavailability in human endothelium, it is still unclear whether they have any direct benefit at a clinical level...
  36. ncbi Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Herz 28:628-38. 2003
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  37. ncbi Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases
    Dimitris Tousoulis
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 201:236-47. 2008
    ....
  38. ncbi Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers
    Dimitris Tousoulis
    Hippokration Hospital, Athens University Medical School, Athens, Greece
    Br J Nutr 103:43-9. 2010
    ..However, all types of oils did not affect inflammatory process and systemic oxidative stress, suggesting that their effect on endothelial function may not be mediated by free radicals bioavailability...
  39. ncbi Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Athens Greece
    Curr Drug Metab 10:95-103. 2009
    ..In this review article we provide a pharmacokinetic approach for the use of levosimendan in cardiovascular system by discussing its metabolism and mainly the pharmacology of its active metabolites in humans...
  40. ncbi Selective serotonin reuptake inhibitors modify the effect of beta-blockers on long-term survival of patients with end-stage heart failure and major depression
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    J Card Fail 14:456-64. 2008
    ..We examined the impact of MD on long-term survival of patients with end-stage severe HF. We also evaluated the interaction between antidepressive medication and beta-blockers on the clinical outcome of these patients...
  41. ncbi Role of asymmetrical dimethylarginine in inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ileias 8, Gerakas Attikis 153 44, Athens, Greece
    Hypertension 58:93-8. 2011
    ..001). Systemic, low-grade inflammation leads to increased ADMA that may induce endothelial dysfunction. This study demonstrated that ADMA may be a link between inflammation and endothelial dysfunction in humans...
  42. ncbi Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Thromb Haemost 89:990-5. 2003
    ..In conclusion, combined administration of vitamin C and vitamin E at high dosages, improved endothelial function and decreased plasma levels of PAI-1, vWF and PAI-1/tPA ratio in chronic smokers...
  43. ncbi Correlation of ST-segment "hump sign" during exercise testing with impaired diastolic function of the left ventricle
    Andreas P Michaelides
    A Department of Cardiology, University of Athens, Hippokration Hospital, Athens, Greece
    J Electrocardiol 43:167-72. 2010
    ..The appearance of a discrete upward deflection of the ST segment, termed the ST hump sign during exercise testing has been associated with resting hypertension and exaggerated blood pressure response to exercise...
  44. ncbi Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 145:438-43. 2010
    ..In the present study, we sought to compare the effects of statins and xanthine oxidase inhibitors on circulating levels of MMPs and TIMPs in patients with chronic HF...
  45. ncbi Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66. 2006
    ....
  46. ncbi L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?
    Gerasimos Siasos
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga 69, Glifada, 16 675, Athens, Greece
    Int J Cardiol 116:300-8. 2007
    ..In conclusion, L-arginine administration may be useful in patients with premature atherosclerosis...
  47. ncbi Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1
    Aggeliki Nikolopoulou
    Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 130:246-50. 2008
    ....
  48. ncbi Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy
    Costas Tentolouris
    Cardiology Units, Hippokration Hospital, Athens University Medical School, 69 S. Karagiorga, 16675 Athens, Greece
    Int J Cardiol 94:301-5. 2004
    ..A greater endothelial dysfunction was observed in patients with ischemic heart failure compared to those with dilated cardiomyopathy, implying that the underlying atherosclerosis may participate in this process...
  49. ncbi Novel methodology for the detection of exercise-induced myocardial wall motion abnormalities by surface electrocardiogram during exercise test
    Andreas P Michaelides
    1st Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    J Electrocardiol 44:377-82. 2011
    ..We investigated whether ischemia-induced wall motion abnormalities during exercise test modify electrical vector variation...
  50. ncbi Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective
    Dimitris Tousoulis
    Athens University Medical School, S Karagiorga 69, Glifada, 16675 Athens, Greece
    Nat Clin Pract Cardiovasc Med 4:274-83. 2007
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis...
  51. ncbi Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Top Med Chem 12:1214-21. 2012
    ..This review discusses pharmacological approaches to MMP inhibition...
  52. ncbi Fibrinogen and cardiovascular disease: genetics and biomarkers
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Blood Rev 25:239-45. 2011
    ....
  53. ncbi Alpha-1 microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients
    Gregory P Vyssoulis
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration General Hospital, Athens, Greece
    Am J Hypertens 20:1016-21. 2007
    ..In the present study we examined the ability of urinary A1M excretion to reflect the overall inflammatory status in patients with newly diagnosed essential hypertension and normal renal function...
  54. ncbi Duration of treadmill exercise testing combined with QRS score predicts adverse cardiac outcome at long-term follow-up
    Andreas P Michaelides
    First Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Coron Artery Dis 20:337-42. 2009
    ..We evaluated the prognostic value of a new index (M score, Michaelides score) incorporating TET duration and QRS score values in a simple index...
  55. ncbi The failure of immunomodulation therapy in heart failure: does the statins "paradigm" prove the rule?
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:114-21. 2010
    ..Thus, more large scale clinical trials are required to evaluate the impact of statins on immune imbalance and its restoration in patients with CHF...
  56. ncbi The CD40/CD40 ligand system: linking inflammation with atherothrombosis
    Charalambos Antoniades
    1st Department of Cardiology, University of Athens Medical School, Athens, Greece
    J Am Coll Cardiol 54:669-77. 2009
    ....
  57. ncbi The oxidative stress menace to coronary vasculature: any place for antioxidants?
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675, Glifada, Athens, Greece
    Curr Pharm Des 15:3078-90. 2009
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  58. ncbi Role of depression in heart failure--choosing the right antidepressive treatment
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 140:12-8. 2010
    ..Even though certain conclusions cannot be drawn yet, evidence suggests that the use of selective serotonin reuptake inhibitors may have a beneficial effect on clinical outcome of heart failure patients...
  59. ncbi Novel therapeutic strategies targeting vascular redox in human atherosclerosis
    Alexis S Antonopoulos
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Recent Pat Cardiovasc Drug Discov 4:76-87. 2009
    ....
  60. ncbi Right-sided chest leads in exercise testing for detection of coronary restenosis
    Andreas P Michaelides
    Exercise Laboratory, 1st University Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Clin Cardiol 33:236-40. 2010
    ..The incorporation of right-sided chest leads (V(3)R through V(5)R) into standard exercise testing has been reported to improve its diagnostic utility...
  61. ncbi Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675 Glifada, Athens, Greece
    Trends Mol Med 14:441-9. 2008
    ..Here, we review the progress of candidate gene studies and genome-wide association studies in identifying the genetic bases of complex cardiovascular diseases such as acute coronary syndromes...
  62. ncbi Platelet activation in atherogenesis associated with low-grade inflammation
    Charalambos Antoniades
    Department of Cardiology, University of Athens Medical School, Ileias 8, Gerakas Attikis, 153 44, Athens, Greece
    Inflamm Allergy Drug Targets 9:334-45. 2010
    ..The design of new therapeutic strategies targeting platelets and their impact in atherosclerosis-related low-grade inflammation are in the center of current cardiovascular research...
  63. ncbi Homocysteine: a risk factor for coronary artery disease?
    Kyriakoula Marinou
    University Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 46:59-67. 2005
  64. ncbi Biomarkers of premature atherosclerosis
    Anna Maria Kampoli
    Athens University Medical School, 1 st Cardiology Department, Hippokration Hospital, Athens, Greece
    Trends Mol Med 15:323-32. 2009
    ..Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis...
  65. ncbi New biochemical markers in acute coronary syndromes
    Dimitris Tousoulis
    Athens University Medical School, Cardiology Department, Hippokration Hospital, Athens, Greece
    Curr Med Chem 15:1288-96. 2008
    ..In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS...
  66. ncbi Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings
    Andreas P Michaelides
    First Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    Ann Noninvasive Electrocardiol 13:364-70. 2008
    ..In a model of sequential exercise testings, we investigated the reproducibility of HRR and the association between HRR modification and myocardial adaptation to ischemia...
  67. ncbi Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ilias, Gerakas Attikis, Athens, Greece
    Eur Heart J 30:6-15. 2009
    ..Finally, we provide clinical recommendations regarding the therapeutic strategies targeting homocysteine in the general population...
  68. ncbi Assessing inflammatory status in cardiovascular disease
    Dimitris Tousoulis
    Athens University Medical School, A' Cardiology Department, Athens, Greece
    Heart 93:1001-7. 2007
  69. ncbi Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure
    John T Parissis
    Second Department of Cardiology, Amalia Fleming Hospital, Athens, Greece
    Am J Cardiol 93:1309-12. 2004
    ..These immunomodulatory effects may lead to improvement of symptoms and echocardiographic markers of cardiac contractile performance in these patients...
  70. ncbi Levosimendan: a novel agent in heart failure
    Nikolas Koumallos
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Recent Patents Cardiovasc Drug Discov 1:185-91. 2006
    ....
  71. ncbi Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta
    Stella Brili
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Vasilissis Sofias 114, 11528 Athens, Greece
    Atherosclerosis 182:97-103. 2005
    ..These results may partly explain the high incidence of coronary artery disease in patients with repaired coarctation of the aorta...
  72. ncbi Left atrial function, cytokines and soluble apoptotic markers in mitral stenosis: effects of valvular replacement
    Athanasios Trikas
    Cardiology Department, University of Athens, Hippokration Hospital, Greece
    Int J Cardiol 99:111-5. 2005
    ..The purpose of the present study was the evaluation of the effect of mitral valve replacement on the LA function, on inflammatory process and apoptotic markers in patients with MS and HF...
  73. ncbi Potential role of endothelial progenitor cells in the pathophysiology of heart failure: clinical implications and perspectives
    Ioannis Andreou
    Athens University Medical School, A' Cardiology Department, Hippokration Hospital, S. Karagiorga 69, Glifada 16 675, Athens, Greece
    Atherosclerosis 189:247-54. 2006
    ..However, the exact role of EPCs in heart failure and their potential therapeutic implications still remain to be elucidated...
  74. ncbi L-arginine in cardiovascular disease: dream or reality?
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Vasc Med 7:203-11. 2002
    ..However, more data derived from large-scale prospective studies evaluating the effects of long-term treatment with L-arginine are needed...
  75. ncbi The impact of diabetes mellitus on coronary artery disease: new therapeutic approaches
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Curr Pharm Des 15:2037-48. 2009
    ....
  76. ncbi Evidence that non-lipid cardiovascular risk factors are associated with high prevalence of coronary artery disease in patients with heterozygous familial hypercholesterolemia or familial combined hyperlipidemia
    Ioannis Skoumas
    1st Department of Cardiology, University of Athens Medical School, Hippokration Hospital, 69 S Karagiorga, Glifada, Athens, Greece
    Int J Cardiol 121:178-83. 2007
    ..The present study evaluates the contribution of such risk factors to the development of CAD in these two dyslipidemic populations...
  77. ncbi Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease
    Dimitris Tousoulis
    Int J Cardiol 124:127-9. 2008
  78. ncbi Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting
    Bikram P Choudhary
    Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 50:1047-53. 2007
    ..Our purpose was to examine the impact of diabetes mellitus (DM) on vasoreactivity and endothelial function of radial artery (RA) grafts ex vivo...
  79. ncbi Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus
    Dimitris Tousoulis
    Heart 93:244-6. 2007
  80. ncbi Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Circulation 116:2851-9. 2007
    ..We sought to define the relationships between plasma and vascular biopterin levels in patients with coronary artery disease and to determine how BH4 levels affect endothelial function, eNOS coupling, and vascular superoxide production...
  81. ncbi Terlipressin and albumin for the hepatorenal syndrome
    Charalambos Antoniades
    Hepatology 37:946; author reply 946. 2003
  82. ncbi GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
    Charalambos Antoniades
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Am Coll Cardiol 52:158-65. 2008
    ....
  83. ncbi 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 114:1193-201. 2006
    ..CONCLUSIONS: 5-MTHF has beneficial effects on endothelial function and vascular superoxide production in human atherosclerosis, by preventing peroxynitrite-mediated BH4 oxidation and improving eNOS coupling...
  84. ncbi Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk
    Alexandra Doehring
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mutat Res 659:195-201. 2008
    ....
  85. ncbi Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study
    Benedicte Jacquemin
    Centre for Environmental Research, Municipal Institute of Medical Research, Barcelona, Spain
    J Am Coll Cardiol 52:941-52. 2008
    ..We also searched for genetic determinants affecting the responses of fibrinogen genes to proinflammatory stimulation...
  86. ncbi Smoking in Asians: it doesn't stop at vascular endothelium
    Charalambos Antoniades
    Int J Cardiol 128:151-3. 2008
    ....
  87. ncbi Statins and antioxidant vitamins: should co-administration be avoided?
    Dimitris Tousoulis
    J Am Coll Cardiol 47:1237; author reply 1237-8. 2006
  88. ncbi Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors
    Regina Ruckerl
    GSF National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 115:1072-80. 2007
    ..Numerous studies have found that ambient air pollution has been associated with cardiovascular disease exacerbation...
  89. ncbi Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease
    Cheerag Shirodaria
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Circulation 115:2262-70. 2007
    ..We compared the effects of folic acid on human vessels using pharmacological high-dose versus low-dose treatment, equivalent to dietary folate fortification...
  90. ncbi Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus
    Justin M S Lee
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Diab Vasc Dis Res 4:44-8. 2007
    ..MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy...
  91. ncbi Cold pressor test as a marker for the detection of early stage coronary atherosclerosis
    Dimitris Tousoulis
    Int J Cardiol 115:120-2. 2007