Charalambos Antoniades

Summary

Affiliation: Thriasio General Hospital
Country: Greece

Publications

  1. ncbi Platelet activation in atherogenesis associated with low-grade inflammation
    Charalambos Antoniades
    Department of Cardiology, University of Athens Medical School, Ileias 8, Gerakas Attikis, 153 44, Athens, Greece
    Inflamm Allergy Drug Targets 9:334-45. 2010
  2. doi Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ilias, Gerakas Attikis, Athens, Greece
    Eur Heart J 30:6-15. 2009
  3. doi Role of asymmetrical dimethylarginine in inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ileias 8, Gerakas Attikis 153 44, Athens, Greece
    Hypertension 58:93-8. 2011
  4. doi The CD40/CD40 ligand system: linking inflammation with atherothrombosis
    Charalambos Antoniades
    1st Department of Cardiology, University of Athens Medical School, Athens, Greece
    J Am Coll Cardiol 54:669-77. 2009
  5. doi Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
  6. ncbi Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
  7. ncbi Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
  8. doi The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
  9. doi Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada, Athens, Greece
    Clin Nutr 27:594-600. 2008
  10. ncbi Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006

Collaborators

Detail Information

Publications68

  1. ncbi Platelet activation in atherogenesis associated with low-grade inflammation
    Charalambos Antoniades
    Department of Cardiology, University of Athens Medical School, Ileias 8, Gerakas Attikis, 153 44, Athens, Greece
    Inflamm Allergy Drug Targets 9:334-45. 2010
    ..The design of new therapeutic strategies targeting platelets and their impact in atherosclerosis-related low-grade inflammation are in the center of current cardiovascular research...
  2. doi Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ilias, Gerakas Attikis, Athens, Greece
    Eur Heart J 30:6-15. 2009
    ..Finally, we provide clinical recommendations regarding the therapeutic strategies targeting homocysteine in the general population...
  3. doi Role of asymmetrical dimethylarginine in inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ileias 8, Gerakas Attikis 153 44, Athens, Greece
    Hypertension 58:93-8. 2011
    ..001). Systemic, low-grade inflammation leads to increased ADMA that may induce endothelial dysfunction. This study demonstrated that ADMA may be a link between inflammation and endothelial dysfunction in humans...
  4. doi The CD40/CD40 ligand system: linking inflammation with atherothrombosis
    Charalambos Antoniades
    1st Department of Cardiology, University of Athens Medical School, Athens, Greece
    J Am Coll Cardiol 54:669-77. 2009
    ....
  5. doi Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
    ..However, it is unknown whether these abnormalities present in FH children and contribute to their vascular dysfunction...
  6. ncbi Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
    ..Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity and abnormal inflammatory response...
  7. ncbi Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
    ..We also examined the role of endothelin-1 (ET-1) in the development of endothelial dysfunction in these two conditions...
  8. doi The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
    ..We examined the impact of acute homocysteinemia on endothelial function in hypertensive patients and healthy individuals, and the potential role of ET-1...
  9. doi Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada, Athens, Greece
    Clin Nutr 27:594-600. 2008
    ..We compared the acute effects of several alcoholic beverages on endothelial function, inflammatory process and thrombosis/fibrinolysis system in young adults...
  10. ncbi Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006
    ..Homocystinemia is a metabolic abnormality associated with endothelial dysfunction and increased cardiovascular disease risk. The underlying mechanisms of these effects, however, are obscure...
  11. doi Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study
    Stella Brili
    First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 51:742-9. 2008
    ..The purpose of this study was to evaluate the effect of ramipril on endothelial function and inflammatory process in a group of normotensive subjects with successfully repaired coarctation of the aorta (SCR)...
  12. ncbi Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, A Cardiology Department, Greece
    Eur J Heart Fail 7:1126-32. 2005
    ..Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and/or advanced atherosclerosis...
  13. doi Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 24:936-42. 2011
    ..However, the mechanisms regulating ADMA synthesis in hypertension are unclear...
  14. ncbi Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response
    Charalambos Antoniades
    Department of Cardiology, Athens University Medical School, Athens, Greece
    Am J Cardiol 94:1181-4. 2004
    ..01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system...
  15. ncbi Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals
    Gerasimos Siasos
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 126:394-9. 2008
    ..Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function...
  16. doi The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance
    Gerasimos Siasos
    Department of Biological Chemistry, Athens University Medical School, Athens, Greece
    Am J Hypertens 22:586-92. 2009
    ..We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking...
  17. ncbi Effects of lipid profile on forearm hyperemic response in young subjects
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 47:152-7. 2006
    ..In the present study we examined the effect of lipid profile on forearm vasodilatory response to reactive hyperemia, an index of endothelial function, in a cohort of young, low-risk adults...
  18. doi Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
    ..We examined the effect of combined therapy with atorvastatin and metformin on glucose-induced variations of inflammatory molecules in patients with newly diagnosed diabetes mellitus type 2 (DM)...
  19. doi Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Clin Ther 32:1720-8. 2010
    ..Endothelium-dependent dilation (EDD) measured by gauge-strain plethysmography in the forearm is considered to be a reliable marker of endothelial function in forearm resistance vessels...
  20. doi Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens, Medical School, Athens, Greece
    Int J Cardiol 136:258-62. 2009
    ..We searched for clinical determinants of oxidative stress status, endothelial function and inflammatory process in patients with chronic atrial fibrillation...
  21. ncbi Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 46:1101-9. 2005
    ....
  22. ncbi Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
    ....
  23. doi Association of arterial stiffness with the angiotensin-converting enzyme gene polymorphism in healthy individuals
    Ioanna Dima
    Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 21:1354-8. 2008
    ..However, the relationship between ACE polymorphism, arterial stiffness, and wave reflections in healthy, low-risk population has not been defined yet...
  24. ncbi Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
    ..These findings indicate that atorvastatin may improve forearm vasodilatory response to reactive hyperemia and depress inflammatory process in patients with heart failure and normal baseline cholesterol levels...
  25. doi Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 134:238-43. 2009
    ..In the present study we evaluated the impact of antidepressive medication on the expression of proinflammatory cytokines and acute phase response proteins, in patients with HF and major depression...
  26. ncbi Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
    Constadina Aggeli
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, Greece
    Int J Cardiol 105:80-4. 2005
    ..We examined endothelial function and serum levels of inflammatory mediators in transfusion-dependent patients with beta-thalassemia major...
  27. ncbi Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 106:333-7. 2006
    ..We assessed the effects of short-term atorvastatin treatment on thrombotic/fibrinolysis markers in normocholesterolemic in patients with unstable angina...
  28. ncbi Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors
    Charalambos Antoniades
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Int J Cardiol 107:95-100. 2006
    ....
  29. ncbi Novel therapies targeting vascular endothelium
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Endothelium 13:411-21. 2006
    ..Although there are a variety of strategies to improve NO bioavailability in human endothelium, it is still unclear whether they have any direct benefit at a clinical level...
  30. ncbi The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 109:48-52. 2006
    ..In this study we assessed the effects of low-dose atorvastatin treatment, on inflammatory process in patients admitted for unstable angina with low cholesterol level...
  31. ncbi Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Top Med Chem 12:1214-21. 2012
    ..This review discusses pharmacological approaches to MMP inhibition...
  32. ncbi Pathophysiology of atherosclerosis: the role of inflammation
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4089-110. 2011
    ..The main drug categories that have been proved to ameliorate the inflammatory state in atherosclerosis are angiotensin converting enzyme inhibitors/angiotensin receptors blockers, statins, and antioxidants...
  33. ncbi Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Herz 28:628-38. 2003
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  34. doi Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering
    Panagiota Gounari
    1st Cardiology Department, Athens University Medical School, Vasilissis Sofias 114, 115 28, Athens, Greece
    Int J Cardiol 142:87-91. 2010
    ..However, its effect in patients with HF is not well studied. Therefore, in the present study we compared the effect of short-term treatment with rosuvastatin or ezetimibe on endothelial function in patients with HF...
  35. doi Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 23:237-42. 2010
    ..We examined the impact of A1675G on the risk and the severity of coronary artery disease (CAD), and the expression of proatherogenic inflammatory molecules in hypertensive patients...
  36. doi Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases
    Dimitris Tousoulis
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 201:236-47. 2008
    ....
  37. doi Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers
    Dimitris Tousoulis
    Hippokration Hospital, Athens University Medical School, Athens, Greece
    Br J Nutr 103:43-9. 2010
    ..However, all types of oils did not affect inflammatory process and systemic oxidative stress, suggesting that their effect on endothelial function may not be mediated by free radicals bioavailability...
  38. ncbi Novel therapeutic strategies targeting vascular redox in human atherosclerosis
    Alexis S Antonopoulos
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Recent Pat Cardiovasc Drug Discov 4:76-87. 2009
    ....
  39. doi Selective serotonin reuptake inhibitors modify the effect of beta-blockers on long-term survival of patients with end-stage heart failure and major depression
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    J Card Fail 14:456-64. 2008
    ..We examined the impact of MD on long-term survival of patients with end-stage severe HF. We also evaluated the interaction between antidepressive medication and beta-blockers on the clinical outcome of these patients...
  40. ncbi Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 115:203-7. 2007
    ..However, the underlying mechanisms of the acute coronary syndromes are still obscure. We evaluated the differences of inflammatory and thrombotic markers, at the acute phase of unstable angina (UA) and acute myocardial infarction (AMI)...
  41. ncbi Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Athens Greece
    Curr Drug Metab 10:95-103. 2009
    ..In this review article we provide a pharmacokinetic approach for the use of levosimendan in cardiovascular system by discussing its metabolism and mainly the pharmacology of its active metabolites in humans...
  42. ncbi Matrix metalloproteinases in acute coronary syndromes: current perspectives
    Anna Maria Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1192-205. 2012
    ....
  43. doi Correlation of ST-segment "hump sign" during exercise testing with impaired diastolic function of the left ventricle
    Andreas P Michaelides
    A Department of Cardiology, University of Athens, Hippokration Hospital, Athens, Greece
    J Electrocardiol 43:167-72. 2010
    ..The appearance of a discrete upward deflection of the ST segment, termed the ST hump sign during exercise testing has been associated with resting hypertension and exaggerated blood pressure response to exercise...
  44. doi Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 145:438-43. 2010
    ..In the present study, we sought to compare the effects of statins and xanthine oxidase inhibitors on circulating levels of MMPs and TIMPs in patients with chronic HF...
  45. ncbi Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
    Athanasios Trikas
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Eur J Heart Fail 8:804-9. 2006
    ..The calcium sensitizer levosimendan improves myocardial contractility in patients with heart failure, although its effects on inflammation and apoptosis are unknown...
  46. ncbi Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66. 2006
    ....
  47. ncbi Levosimendan: beyond its simple inotropic effect in heart failure
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Pharmacol Ther 114:184-97. 2007
    ....
  48. doi Novel methodology for the detection of exercise-induced myocardial wall motion abnormalities by surface electrocardiogram during exercise test
    Andreas P Michaelides
    1st Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    J Electrocardiol 44:377-82. 2011
    ..We investigated whether ischemia-induced wall motion abnormalities during exercise test modify electrical vector variation...
  49. ncbi Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective
    Dimitris Tousoulis
    Athens University Medical School, S Karagiorga 69, Glifada, 16675 Athens, Greece
    Nat Clin Pract Cardiovasc Med 4:274-83. 2007
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis...
  50. ncbi Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1
    Aggeliki Nikolopoulou
    Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 130:246-50. 2008
    ....
  51. doi Fibrinogen and cardiovascular disease: genetics and biomarkers
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Blood Rev 25:239-45. 2011
    ....
  52. ncbi The oxidative stress menace to coronary vasculature: any place for antioxidants?
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675, Glifada, Athens, Greece
    Curr Pharm Des 15:3078-90. 2009
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  53. doi Duration of treadmill exercise testing combined with QRS score predicts adverse cardiac outcome at long-term follow-up
    Andreas P Michaelides
    First Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Coron Artery Dis 20:337-42. 2009
    ..We evaluated the prognostic value of a new index (M score, Michaelides score) incorporating TET duration and QRS score values in a simple index...
  54. ncbi Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease
    Dimitris Tousoulis
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Diabetes Care 26:2749-53. 2003
    ....
  55. ncbi Alpha-1 microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients
    Gregory P Vyssoulis
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration General Hospital, Athens, Greece
    Am J Hypertens 20:1016-21. 2007
    ..In the present study we examined the ability of urinary A1M excretion to reflect the overall inflammatory status in patients with newly diagnosed essential hypertension and normal renal function...
  56. doi Right-sided chest leads in exercise testing for detection of coronary restenosis
    Andreas P Michaelides
    Exercise Laboratory, 1st University Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Clin Cardiol 33:236-40. 2010
    ..The incorporation of right-sided chest leads (V(3)R through V(5)R) into standard exercise testing has been reported to improve its diagnostic utility...
  57. ncbi Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Thromb Haemost 89:990-5. 2003
    ..In conclusion, combined administration of vitamin C and vitamin E at high dosages, improved endothelial function and decreased plasma levels of PAI-1, vWF and PAI-1/tPA ratio in chronic smokers...
  58. doi Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675 Glifada, Athens, Greece
    Trends Mol Med 14:441-9. 2008
    ..Here, we review the progress of candidate gene studies and genome-wide association studies in identifying the genetic bases of complex cardiovascular diseases such as acute coronary syndromes...
  59. ncbi The failure of immunomodulation therapy in heart failure: does the statins "paradigm" prove the rule?
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:114-21. 2010
    ..Thus, more large scale clinical trials are required to evaluate the impact of statins on immune imbalance and its restoration in patients with CHF...
  60. doi Role of depression in heart failure--choosing the right antidepressive treatment
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 140:12-8. 2010
    ..Even though certain conclusions cannot be drawn yet, evidence suggests that the use of selective serotonin reuptake inhibitors may have a beneficial effect on clinical outcome of heart failure patients...
  61. ncbi L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?
    Gerasimos Siasos
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga 69, Glifada, 16 675, Athens, Greece
    Int J Cardiol 116:300-8. 2007
    ..In conclusion, L-arginine administration may be useful in patients with premature atherosclerosis...
  62. ncbi Matrix metallopropteinases in heart failure
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1181-91. 2012
    ....
  63. ncbi Homocysteine: a risk factor for coronary artery disease?
    Kyriakoula Marinou
    University Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 46:59-67. 2005
  64. ncbi New biochemical markers in acute coronary syndromes
    Dimitris Tousoulis
    Athens University Medical School, Cardiology Department, Hippokration Hospital, Athens, Greece
    Curr Med Chem 15:1288-96. 2008
    ..In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS...
  65. doi Biomarkers of premature atherosclerosis
    Anna Maria Kampoli
    Athens University Medical School, 1 st Cardiology Department, Hippokration Hospital, Athens, Greece
    Trends Mol Med 15:323-32. 2009
    ..Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis...
  66. pmc Assessing inflammatory status in cardiovascular disease
    Dimitris Tousoulis
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Heart 93:1001-7. 2007
  67. doi Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings
    Andreas P Michaelides
    First Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    Ann Noninvasive Electrocardiol 13:364-70. 2008
    ..In a model of sequential exercise testings, we investigated the reproducibility of HRR and the association between HRR modification and myocardial adaptation to ischemia...
  68. ncbi Evidence for association between endothelial nitric oxide synthase gene polymorphism (G894T) and inflammatory markers: the ATTICA study
    Christine Chrysohoou
    First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    Am Heart J 148:733-8. 2004
    ..We evaluated the effect of the point mutation of guanine to thymine at nucleotide position 894 (G894T) of the endothelial nitric oxide synthase (eNOS) gene on inflammatory and oxidative stress markers...