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Genomes and GenesSpecies | Haralampos J MilionisSummaryCountry: Greece Publications
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Treating to target patients with primary hyperlipidaemia: comparison of the effects of ATOrvastatin and ROSuvastatin (the ATOROS study)Haralampos J Milionis
Department of Internal Medicine School of Medicine, University of Ioannina, Greece
Curr Med Res Opin 22:1123-31. 2006....- Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjectsHaralampos J Milionis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Stroke 36:1372-6. 2005..Metabolic syndrome (MetSyn) represents a constellation of lipid and nonlipid risk factors for cardiovascular disease and is a recognized target for increased behavioral therapy... 
Effects of rosuvastatin combined with olmesartan, irbesartan, or telmisartan on indices of glucose metabolism in Greek adults with impaired fasting glucose, hypertension, and mixed hyperlipidemia: a 24-week, randomized, open-label, prospective studyChristos V Rizos
Department of Internal Medicine, University Hospital and School of Medicine, University of Ioannina, Ioannina, Greece
Clin Ther 32:492-505. 2010..Among the ARBs, telmisartan is a partial activator of PPARgamma, irbesartan is a weak partial activator, and olmesartan has no effect on PPARgamma activation...- Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjectsMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
J Stroke Cerebrovasc Dis 19:497-502. 2010..02; 95% CI=1.16-7.83; P=.02). Our findings support elevated apoB/apoA1 ratio as an independent predictor of ischemic stroke in individuals over age 70... - Dose-dependent effect of rosuvastatin treatment on HDL-subfraction phenotype in patients with primary hyperlipidemiaMichael S Kostapanos
Department of Internal Medicine, University of Ioannina, Ioannina, Greece
J Cardiovasc Pharmacol Ther 14:5-13. 2009..0% in the RSV20 group, P = .01). Rosuvastatin treatment increases the high-density lipoprotein cholesterol by increasing the cholesterol mass only of the larger high-density lipoprotein particles in a dose-dependent manner... - A 12-week, prospective, open-label analysis of the effect of rosuvastatin on triglyceride-rich lipoprotein metabolism in patients with primary dyslipidemiaMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Clin Ther 29:1403-14. 2007..Although the effect of statins on lowering low-density lipoprotein cholesterol (LDL-C) has been extensively studied, their hypotriglyceridemic capacity is not fully understood... - Hypertriglyceridaemic waist phenotype criteria and prevalent metabolic triad in womenIrene F Gazi
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Diabetes Metab Res Rev 24:223-30. 2008.... - Starting with rosuvastatin in primary hyperlipidemia--Is there more than lipid lowering?Haralampos J Milionis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Angiology 56:585-92. 2005.... - Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemiaMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
Eur J Pharmacol 590:327-32. 2008..Baseline triglyceride levels as well as baseline HOMA-index were found to be the major predictors of this beneficial action of rosuvastatin... - Effect of rosuvastatin treatment on plasma visfatin levels in patients with primary hyperlipidemiaMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
Eur J Pharmacol 578:249-52. 2008..1+/-2.1 versus 15.5+/-2.0 ng/ml, P=0.03). This effect correlated with baseline visfatin levels (r=0.51, P<0.01) and was independent of any lipid-lowering actions of rosuvastatin... - Serum lipoprotein(a) levels and apolipoprotein(a) isoform size and risk for first-ever acute ischaemic nonembolic stroke in elderly individualsHaralampos J Milionis
Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
Atherosclerosis 187:170-6. 2006..015]. Our study suggests that determination of Lp(a) levels and Apo(a) isoform size may be important in identifying elderly individuals at risk of ischaemic stroke independently of other risk factors and concurrent metabolic derangements... - Dose-dependent effect of rosuvastatin treatment on urinary protein excretionMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, Greece
J Cardiovasc Pharmacol Ther 12:292-7. 2007..These findings indicate that rosuvastatin treatment increases the urinary excretion of alpha1-microglobulin urinary excretion in a dose-dependent manner without adversely affecting renal function... - Adherence to the mediterranean diet in relation to ischemic stroke nonfatal events in nonhypercholesterolemic and hypercholesterolemic participants: results of a case/case-control studyChristina Maria Kastorini
School of Medicine, University of Ioannina, Ioannina, Greece
Angiology 63:509-15. 2012..81-0.99). The present work highlights the cardioprotective benefits from the adoption of the Mediterranean diet, by showing its beneficial effect regarding ischemic stroke development, regardless of the presence of hypercholesterolemia... - An overview of the extra-lipid effects of rosuvastatinMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
J Cardiovasc Pharmacol Ther 13:157-74. 2008..Whether the established "pleiotropy" and/or lipid-lowering efficacy of rosuvastatin may translate into reduced morbidity and mortality remains to be shown in ongoing clinical outcome trials... - Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndromeHaralampos J Milionis
Department of Internal Medicine, Outpatient Hypertension Clinic, School of Medicine, University of Ioannina, Ioannina, Greece
J Renin Angiotensin Aldosterone Syst 8:181-9. 2007..To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS)... - Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemiaHaralampos J Milionis
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Am Heart J 148:635-40. 2004..CONCLUSIONS: Atorvastatin (but not simvastatin) significantly lowered serum uric acid levels. This result may be in favor of a preferable choice of atorvastatin for the treatment of hyperlipidemic patients presenting with hyperuricemia... - Postoperative levels of cardiac troponin versus CK-MB and high-sensitivity C-reactive protein for the prediction of 1-year cardiovascular outcome in patients undergoing vascular surgeryGeorge N Kouvelos
Departments of Surgery Vascular Surgery Unit, University of Ioannina, Greece
Coron Artery Dis 22:428-34. 2011.... - Association of Helicobacter pylori infection with cardiovascular disease--is it just a myth?Dimitrios K Christodoulou
Department of Internal Medicine, Medical School of Ioannina, University of Ioannina, Greece
Eur J Intern Med 22:191-4. 2011..To test the hypothesis that Helicobacter pylori infection is associated with a higher rate of documented cardiovascular disease (CVD) in subjects undergoing elective upper gastrointestinal endoscopy... - Statin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgeryAthanasios Papathanasiou
Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece
Coron Artery Dis 19:619-25. 2008..In an observational study, we evaluated the association between postoperative statin therapy and long-term mortality among patients undergoing a first-ever coronary artery bypass grafting (CABG) surgery... - Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemiaMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Am J Cardiovasc Drugs 10:11-28. 2010..Practitioners of all medical practices should be alert when rosuvastatin is prescribed concomitantly with agents that may increase the risk of rosuvastatin-associated toxicity... - Metabolic syndrome and risk of acute coronary syndromes in patients younger than 45 years of ageHaralampos J Milionis
Department of Internal Medicine, School of Medicine, University of Ioannina, Greece
Coron Artery Dis 18:247-52. 2007..We investigated the association of the metabolic syndrome with acute coronary syndrome in adults aged 45 years or younger... - Treatment of hyperlipidaemia with fenofibrate and related fibratesTheodosios Filippatos
University of Ioannina, School of Medicine, Department of Internal Medicine, 451 10 Ioannina, Greece
Expert Opin Investig Drugs 17:1599-614. 2008..Fenofibrate is the most widely used fibrate. Its efficacy and tolerability in the treatment of hypertriglyceridaemia and combined hyperlipidaemia have been demonstrated in several clinical trials... - The mediating effect of the Mediterranean diet on the role of discretionary and hidden salt intake regarding non-fatal acute coronary syndrome or stroke events: case/case-control studyChristina Maria Kastorini
School of Medicine, University of Ioannina, Ioannina, Greece
Atherosclerosis 225:187-93. 2012..The aim of the present work was to evaluate the association between salt and salty food consumption on the development of an acute coronary syndrome (ACS) or ischemic stroke, under the context of adherence to the Mediterranean diet... - Do statins beneficially or adversely affect glucose homeostasis?Michael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
Curr Vasc Pharmacol 8:612-31. 2010..Comparison trials suggest a potential preferable effect of the hydrophilic statins pravastatin, rosuvastatin and pitavastatin as compared to lipophilic components of the class, including atorvastatin and simvastatin... 
Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acidElisavet Moutzouri
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Vasc Health Risk Manag 6:525-39. 2010....- Effects of rosuvastatin with or without ezetimibe on clinical outcomes in patients undergoing elective vascular surgery: results of a pilot studyGeorge N Kouvelos
Department of Surgery Vascular Surgery Unit, School of Medicine, University of Ioannina, Ioannina, Greece
J Cardiovasc Pharmacol Ther 18:5-12. 2013..This was a prospective randomized, open-label study to investigate the effect of lipid-lowering treatment by statin monotherapy or intensified by combining statin with ezetimibe on a 12-month prognosis after vascular surgery... - The role of C-reactive protein in atherosclerotic cardiovascular disease: an overviewEleni S Nakou
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Curr Vasc Pharmacol 6:258-70. 2008..We review the literature concerning the mechanisms by which CRP may influence the development of cardiovascular disease and discuss the findings of clinical studies assessing the association between CRP and cardiovascular disease... - The relative value of metabolic syndrome and cardiovascular risk score estimates in premature acute coronary syndromesKallirroi Kalantzi
Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece
Am Heart J 155:534-40. 2008..To compare the relative value of metabolic syndrome (MetS) and cardiovascular risk score estimates in patients with acute coronary syndromes (ACS) aged <45 years... - Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemiaMichael S Kostapanos
Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
J Clin Pharmacol 46:1337-43. 2006..05) indicating that statin-related proteinuria involves low-molecular-weight proteins and is of proximal tubular origin... - Current role of statins in the treatment of essential hypertensionMichael S Kostapanos
University of Ioannina, School of Medicine, Department of Internal Medicine, 451 10 Ioannina, Greece
Expert Opin Pharmacother 11:2635-50. 2010..Statins are known to enhance cardiovascular protection beyond their lipid-lowering capacity... - Risk factors for first-ever acute ischemic non-embolic stroke in elderly individualsHaralampos J Milionis
Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
Int J Cardiol 99:269-75. 2005..CONCLUSION: Ischemic non-embolic stroke in the elderly is associated with dyslipidemia and several predictor metabolic factors, which could be substantially modified by lifestyle changes and therapeutic intervention... - Management of the elderly patient with hyperlipidaemia: recent concernsKallirroi I Kalantzi
Department of Internal Medicine, Medical School, University of Ioannina, Greece
Hellenic J Cardiol 47:93-9. 2006 - Endocrine disorders: causes of hyponatremia not to neglectGeorge Liamis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Ann Med 43:179-87. 2011..This review focuses on clinical and pathophysiological aspects of hyponatremia due to endocrine disorders... - Alterations in electrolyte equilibrium in patients with acute leukemiaTheodosios D Filippatos
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Eur J Haematol 75:449-60. 2005..Clinicians should be vigilant for early detection and appropriate management of these disorders before the initiation of chemotherapy regimens as well as during treatment... - Clopidogrel vs. aspirin treatment on admission improves 5-year survival after a first-ever acute ischemic stroke. data from the Athens Stroke Outcome ProjectHaralampos J Milionis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannnina, Greece
Arch Med Res 42:443-50. 2011..We undertook this study to compare the impact of aspirin vs. clopidogrel treatment on 5-year survival of patients experiencing a first-ever acute ischemic noncardioembolic stroke... - Lipid lowering therapy in the elderly: is there a benefit?Kallirroi J Kalantzi
Department of Cardiology, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
Curr Pharm Des 12:3945-60. 2006..Further, prospective randomised trials are required to guide physicians towards an effective management of older individuals at increased atherosclerotic risk... - Adherence to the Mediterranean diet in relation to acute coronary syndrome or stroke nonfatal events: a comparative analysis of a case/case-control studyChristina Maria Kastorini
School of Medicine, University of Ioannina, Greece
Am Heart J 162:717-24. 2011..The aim of the present work was to comparatively evaluate the association between adherence to the Mediterranean diet and the development of an acute coronary syndrome (ACS) or ischemic stroke... - Comparative effects of atorvastatin, simvastatin, and fenofibrate on serum homocysteine levels in patients with primary hyperlipidemiaHaralampos J Milionis
Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
J Clin Pharmacol 43:825-30. 2003..In contrast to fenofibrate, therapeutic dosages of atorvastatin and simvastatin have a neutral effect on serum homocysteine levels, which is in favor of their "cardioprotective" properties... - Hyponatremia in patients with infectious diseasesGeorge Liamis
Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
J Infect 63:327-35. 2011..Inadvertent administration of fluids may worsen hyponatremia and prolong morbidity... - Pharmacologically-induced metabolic acidosis: a reviewGeorge Liamis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Drug Saf 33:371-91. 2010..In all cases of drug-related metabolic acidosis, discontinuation of the culprit medications and avoidance of readministration is advised... - Therapeutic management of hyperglycaemic hyperosmolar syndromeHaralampos J Milionis
Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
Expert Opin Pharmacother 6:1841-9. 2005..This review provides an outline of the diagnostic approach of patients with manifestations of hyperglycaemic hyperosmolar syndrome and discusses the contemporary therapeutic recommendations... - Thyroid substitution therapy induces high-density lipoprotein-associated platelet-activating factor-acetylhydrolase in patients with subclinical hypothyroidism: a potential antiatherogenic effectHaralampos J Milionis
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
Thyroid 15:455-60. 2005..Levothyroxine induces a significant increase in HDL-PAF-AH activity. This action may represent a potential antiatherogenic effect of thyroid replacement therapy... - A review of drug-induced hypocalcemiaGeorge Liamis
Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
J Bone Miner Metab 27:635-42. 2009..Herein, we review pertinent clinical information on the incidence of hypocalcemia associated with specific drug treatment and discuss the underlying pathophysiological mechanisms... - Effects of atorvastatin on red-blood cell Na(+)/Li(+) countertransport in hyperlipidemic patients with and without hypertensionMaria S Kosmidou
Department of Internal Medicine, Aristotle University, AHEPA Hospital, Thessaloniki, Greece
Am J Hypertens 21:303-9. 2008..To explore the effect of short-term cholesterol-lowering treatment with atorvastatin on erythrocyte sodium-lithium countertransport (Na(+)/Li(+) CT) activity... - Reply to Al-Shaer, is atorvastatin more appropriate to use in combination with niacin than simvastatin in patients with the metabolic syndrome? (Am Heart J 2005;149:e17.)Haralampos J Milionis
Am Heart J 150:e7. 2005 - Analysis of antihypertensive effects of statinsHaralampos J Milionis
Department of Clinical Biochemistry, Vascular Disease Prevention Clinics, Royal Free Hospital, Pond Street, London NW3 2QG, UK
Curr Hypertens Rep 9:175-83. 2007..Whether the effect of statins on BP is accompanied by an additional decrease in clinical outcomes needs to be investigated in long-term, large-scale trials... - Lipid abnormalities and cardiovascular risk in the elderlyHaralampos J Milionis
Curr Med Res Opin 24:653-7. 2008..There is evidence supporting the use of statins in the elderly. It is also likely that these drugs are under-used in this population...