Haralampos J Milionis

Summary

Country: Greece

Publications

  1. ncbi request reprint Treating to target patients with primary hyperlipidaemia: comparison of the effects of ATOrvastatin and ROSuvastatin (the ATOROS study)
    Haralampos J Milionis
    Department of Internal Medicine School of Medicine, University of Ioannina, Greece
    Curr Med Res Opin 22:1123-31. 2006
  2. ncbi request reprint Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Stroke 36:1372-6. 2005
  3. doi request reprint Effects of rosuvastatin combined with olmesartan, irbesartan, or telmisartan on indices of glucose metabolism in Greek adults with impaired fasting glucose, hypertension, and mixed hyperlipidemia: a 24-week, randomized, open-label, prospective study
    Christos V Rizos
    Department of Internal Medicine, University Hospital and School of Medicine, University of Ioannina, Ioannina, Greece
    Clin Ther 32:492-505. 2010
  4. doi request reprint Dose-dependent effect of rosuvastatin treatment on HDL-subfraction phenotype in patients with primary hyperlipidemia
    Michael S Kostapanos
    Department of Internal Medicine, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 14:5-13. 2009
  5. doi request reprint Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    J Stroke Cerebrovasc Dis 19:497-502. 2010
  6. ncbi request reprint A 12-week, prospective, open-label analysis of the effect of rosuvastatin on triglyceride-rich lipoprotein metabolism in patients with primary dyslipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Clin Ther 29:1403-14. 2007
  7. ncbi request reprint Hypertriglyceridaemic waist phenotype criteria and prevalent metabolic triad in women
    Irene F Gazi
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Diabetes Metab Res Rev 24:223-30. 2008
  8. doi request reprint Effects of rosuvastatin with or without ezetimibe on clinical outcomes in patients undergoing elective vascular surgery: results of a pilot study
    George N Kouvelos
    Department of Surgery Vascular Surgery Unit, School of Medicine, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 18:5-12. 2013
  9. ncbi request reprint Starting with rosuvastatin in primary hyperlipidemia--Is there more than lipid lowering?
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Angiology 56:585-92. 2005
  10. doi request reprint Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    Eur J Pharmacol 590:327-32. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Treating to target patients with primary hyperlipidaemia: comparison of the effects of ATOrvastatin and ROSuvastatin (the ATOROS study)
    Haralampos J Milionis
    Department of Internal Medicine School of Medicine, University of Ioannina, Greece
    Curr Med Res Opin 22:1123-31. 2006
    ....
  2. ncbi request reprint Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Stroke 36:1372-6. 2005
    ..Metabolic syndrome (MetSyn) represents a constellation of lipid and nonlipid risk factors for cardiovascular disease and is a recognized target for increased behavioral therapy...
  3. doi request reprint Effects of rosuvastatin combined with olmesartan, irbesartan, or telmisartan on indices of glucose metabolism in Greek adults with impaired fasting glucose, hypertension, and mixed hyperlipidemia: a 24-week, randomized, open-label, prospective study
    Christos V Rizos
    Department of Internal Medicine, University Hospital and School of Medicine, University of Ioannina, Ioannina, Greece
    Clin Ther 32:492-505. 2010
    ..Among the ARBs, telmisartan is a partial activator of PPARgamma, irbesartan is a weak partial activator, and olmesartan has no effect on PPARgamma activation...
  4. doi request reprint Dose-dependent effect of rosuvastatin treatment on HDL-subfraction phenotype in patients with primary hyperlipidemia
    Michael S Kostapanos
    Department of Internal Medicine, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 14:5-13. 2009
    ..0% in the RSV20 group, P = .01). Rosuvastatin treatment increases the high-density lipoprotein cholesterol by increasing the cholesterol mass only of the larger high-density lipoprotein particles in a dose-dependent manner...
  5. doi request reprint Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    J Stroke Cerebrovasc Dis 19:497-502. 2010
    ..02; 95% CI=1.16-7.83; P=.02). Our findings support elevated apoB/apoA1 ratio as an independent predictor of ischemic stroke in individuals over age 70...
  6. ncbi request reprint A 12-week, prospective, open-label analysis of the effect of rosuvastatin on triglyceride-rich lipoprotein metabolism in patients with primary dyslipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Clin Ther 29:1403-14. 2007
    ..Although the effect of statins on lowering low-density lipoprotein cholesterol (LDL-C) has been extensively studied, their hypotriglyceridemic capacity is not fully understood...
  7. ncbi request reprint Hypertriglyceridaemic waist phenotype criteria and prevalent metabolic triad in women
    Irene F Gazi
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Diabetes Metab Res Rev 24:223-30. 2008
    ....
  8. doi request reprint Effects of rosuvastatin with or without ezetimibe on clinical outcomes in patients undergoing elective vascular surgery: results of a pilot study
    George N Kouvelos
    Department of Surgery Vascular Surgery Unit, School of Medicine, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 18:5-12. 2013
    ..This was a prospective randomized, open-label study to investigate the effect of lipid-lowering treatment by statin monotherapy or intensified by combining statin with ezetimibe on a  12-month  prognosis after vascular surgery...
  9. ncbi request reprint Starting with rosuvastatin in primary hyperlipidemia--Is there more than lipid lowering?
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Angiology 56:585-92. 2005
    ....
  10. doi request reprint Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    Eur J Pharmacol 590:327-32. 2008
    ..Baseline triglyceride levels as well as baseline HOMA-index were found to be the major predictors of this beneficial action of rosuvastatin...
  11. ncbi request reprint Serum lipoprotein(a) levels and apolipoprotein(a) isoform size and risk for first-ever acute ischaemic nonembolic stroke in elderly individuals
    Haralampos J Milionis
    Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    Atherosclerosis 187:170-6. 2006
    ..015]. Our study suggests that determination of Lp(a) levels and Apo(a) isoform size may be important in identifying elderly individuals at risk of ischaemic stroke independently of other risk factors and concurrent metabolic derangements...
  12. ncbi request reprint Effect of rosuvastatin treatment on plasma visfatin levels in patients with primary hyperlipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    Eur J Pharmacol 578:249-52. 2008
    ..1+/-2.1 versus 15.5+/-2.0 ng/ml, P=0.03). This effect correlated with baseline visfatin levels (r=0.51, P<0.01) and was independent of any lipid-lowering actions of rosuvastatin...
  13. ncbi request reprint Dose-dependent effect of rosuvastatin treatment on urinary protein excretion
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Greece
    J Cardiovasc Pharmacol Ther 12:292-7. 2007
    ..These findings indicate that rosuvastatin treatment increases the urinary excretion of alpha1-microglobulin urinary excretion in a dose-dependent manner without adversely affecting renal function...
  14. doi request reprint Adherence to the mediterranean diet in relation to ischemic stroke nonfatal events in nonhypercholesterolemic and hypercholesterolemic participants: results of a case/case-control study
    Christina Maria Kastorini
    School of Medicine, University of Ioannina, Ioannina, Greece
    Angiology 63:509-15. 2012
    ..81-0.99). The present work highlights the cardioprotective benefits from the adoption of the Mediterranean diet, by showing its beneficial effect regarding ischemic stroke development, regardless of the presence of hypercholesterolemia...
  15. doi request reprint An overview of the extra-lipid effects of rosuvastatin
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 13:157-74. 2008
    ..Whether the established "pleiotropy" and/or lipid-lowering efficacy of rosuvastatin may translate into reduced morbidity and mortality remains to be shown in ongoing clinical outcome trials...
  16. doi request reprint The mediating effect of the Mediterranean diet on the role of discretionary and hidden salt intake regarding non-fatal acute coronary syndrome or stroke events: case/case-control study
    Christina Maria Kastorini
    School of Medicine, University of Ioannina, Ioannina, Greece
    Atherosclerosis 225:187-93. 2012
    ..The aim of the present work was to evaluate the association between salt and salty food consumption on the development of an acute coronary syndrome (ACS) or ischemic stroke, under the context of adherence to the Mediterranean diet...
  17. ncbi request reprint Metabolic syndrome and risk of acute coronary syndromes in patients younger than 45 years of age
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Greece
    Coron Artery Dis 18:247-52. 2007
    ..We investigated the association of the metabolic syndrome with acute coronary syndrome in adults aged 45 years or younger...
  18. ncbi request reprint Treatment of hyperlipidaemia with fenofibrate and related fibrates
    Theodosios Filippatos
    University of Ioannina, School of Medicine, Department of Internal Medicine, 451 10 Ioannina, Greece
    Expert Opin Investig Drugs 17:1599-614. 2008
    ..Fenofibrate is the most widely used fibrate. Its efficacy and tolerability in the treatment of hypertriglyceridaemia and combined hyperlipidaemia have been demonstrated in several clinical trials...
  19. doi request reprint Statin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgery
    Athanasios Papathanasiou
    Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Coron Artery Dis 19:619-25. 2008
    ..In an observational study, we evaluated the association between postoperative statin therapy and long-term mortality among patients undergoing a first-ever coronary artery bypass grafting (CABG) surgery...
  20. ncbi request reprint Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia
    Haralampos J Milionis
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Am Heart J 148:635-40. 2004
    ..In addition to fenofibrate, there is some evidence that atorvastatin may have a hypouricemic action, but the underlying mechanisms remain speculative...
  21. doi request reprint Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome
    Haralampos J Milionis
    Department of Internal Medicine, Outpatient Hypertension Clinic, School of Medicine, University of Ioannina, Ioannina, Greece
    J Renin Angiotensin Aldosterone Syst 8:181-9. 2007
    ..To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS)...
  22. doi request reprint Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Cardiovasc Drugs 10:11-28. 2010
    ..Practitioners of all medical practices should be alert when rosuvastatin is prescribed concomitantly with agents that may increase the risk of rosuvastatin-associated toxicity...
  23. doi request reprint Postoperative levels of cardiac troponin versus CK-MB and high-sensitivity C-reactive protein for the prediction of 1-year cardiovascular outcome in patients undergoing vascular surgery
    George N Kouvelos
    Departments of Surgery Vascular Surgery Unit, University of Ioannina, Greece
    Coron Artery Dis 22:428-34. 2011
    ....
  24. doi request reprint Association of Helicobacter pylori infection with cardiovascular disease--is it just a myth?
    Dimitrios K Christodoulou
    Department of Internal Medicine, Medical School of Ioannina, University of Ioannina, Greece
    Eur J Intern Med 22:191-4. 2011
    ..To test the hypothesis that Helicobacter pylori infection is associated with a higher rate of documented cardiovascular disease (CVD) in subjects undergoing elective upper gastrointestinal endoscopy...
  25. doi request reprint Comparative analysis of cardiovascular disease risk factors influencing nonfatal acute coronary syndrome and ischemic stroke
    Christina Maria Kastorini
    School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Cardiol 112:349-54. 2013
    ..In conclusion, similarities of the risk factors regarding ACS and ischemic stroke facilitate simultaneous primary prevention measures...
  26. pmc Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid
    Elisavet Moutzouri
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Vasc Health Risk Manag 6:525-39. 2010
    ....
  27. ncbi request reprint Do statins beneficially or adversely affect glucose homeostasis?
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
    Curr Vasc Pharmacol 8:612-31. 2010
    ..Comparison trials suggest a potential preferable effect of the hydrophilic statins pravastatin, rosuvastatin and pitavastatin as compared to lipophilic components of the class, including atorvastatin and simvastatin...
  28. ncbi request reprint The role of C-reactive protein in atherosclerotic cardiovascular disease: an overview
    Eleni S Nakou
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Curr Vasc Pharmacol 6:258-70. 2008
    ..We review the literature concerning the mechanisms by which CRP may influence the development of cardiovascular disease and discuss the findings of clinical studies assessing the association between CRP and cardiovascular disease...
  29. doi request reprint The relative value of metabolic syndrome and cardiovascular risk score estimates in premature acute coronary syndromes
    Kallirroi Kalantzi
    Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am Heart J 155:534-40. 2008
    ..To compare the relative value of metabolic syndrome (MetS) and cardiovascular risk score estimates in patients with acute coronary syndromes (ACS) aged <45 years...
  30. ncbi request reprint Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia
    Michael S Kostapanos
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    J Clin Pharmacol 46:1337-43. 2006
    ..05) indicating that statin-related proteinuria involves low-molecular-weight proteins and is of proximal tubular origin...
  31. doi request reprint Current role of statins in the treatment of essential hypertension
    Michael S Kostapanos
    University of Ioannina, School of Medicine, Department of Internal Medicine, 451 10 Ioannina, Greece
    Expert Opin Pharmacother 11:2635-50. 2010
    ..Statins are known to enhance cardiovascular protection beyond their lipid-lowering capacity...
  32. ncbi request reprint Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals
    Haralampos J Milionis
    Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    Int J Cardiol 99:269-75. 2005
    ..Stroke is a leading cause of mortality and subsequent serious long-term physical and mental disability among survivors. In the elderly, ischemic stroke accounts for more than 80% of all strokes...
  33. doi request reprint Endocrine disorders: causes of hyponatremia not to neglect
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Ann Med 43:179-87. 2011
    ..This review focuses on clinical and pathophysiological aspects of hyponatremia due to endocrine disorders...
  34. ncbi request reprint Alterations in electrolyte equilibrium in patients with acute leukemia
    Theodosios D Filippatos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Eur J Haematol 75:449-60. 2005
    ..The literature dealing with AL-related electrolyte abnormalities and their interactions in leukemic patients was reviewed...
  35. doi request reprint Clopidogrel vs. aspirin treatment on admission improves 5-year survival after a first-ever acute ischemic stroke. data from the Athens Stroke Outcome Project
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannnina, Greece
    Arch Med Res 42:443-50. 2011
    ..We undertook this study to compare the impact of aspirin vs. clopidogrel treatment on 5-year survival of patients experiencing a first-ever acute ischemic noncardioembolic stroke...
  36. doi request reprint Adherence to the Mediterranean diet in relation to acute coronary syndrome or stroke nonfatal events: a comparative analysis of a case/case-control study
    Christina Maria Kastorini
    School of Medicine, University of Ioannina, Greece
    Am Heart J 162:717-24. 2011
    ..The aim of the present work was to comparatively evaluate the association between adherence to the Mediterranean diet and the development of an acute coronary syndrome (ACS) or ischemic stroke...
  37. ncbi request reprint Management of the elderly patient with hyperlipidaemia: recent concerns
    Kallirroi I Kalantzi
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Hellenic J Cardiol 47:93-9. 2006
  38. ncbi request reprint Lipid lowering therapy in the elderly: is there a benefit?
    Kallirroi J Kalantzi
    Department of Cardiology, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    Curr Pharm Des 12:3945-60. 2006
    ..Further, prospective randomised trials are required to guide physicians towards an effective management of older individuals at increased atherosclerotic risk...
  39. doi request reprint Hyponatremia in patients with infectious diseases
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    J Infect 63:327-35. 2011
    ..Inadvertent administration of fluids may worsen hyponatremia and prolong morbidity...
  40. doi request reprint Pharmacologically-induced metabolic acidosis: a review
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Drug Saf 33:371-91. 2010
    ..In all cases of drug-related metabolic acidosis, discontinuation of the culprit medications and avoidance of readministration is advised...
  41. ncbi request reprint Comparative effects of atorvastatin, simvastatin, and fenofibrate on serum homocysteine levels in patients with primary hyperlipidemia
    Haralampos J Milionis
    Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    J Clin Pharmacol 43:825-30. 2003
    ..In contrast to fenofibrate, therapeutic dosages of atorvastatin and simvastatin have a neutral effect on serum homocysteine levels, which is in favor of their "cardioprotective" properties...
  42. ncbi request reprint Thyroid substitution therapy induces high-density lipoprotein-associated platelet-activating factor-acetylhydrolase in patients with subclinical hypothyroidism: a potential antiatherogenic effect
    Haralampos J Milionis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Thyroid 15:455-60. 2005
    ..Plasma paraoxonase 1 (PON1) is an esterase exclusively associated with HDL...
  43. doi request reprint A review of drug-induced hypocalcemia
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    J Bone Miner Metab 27:635-42. 2009
    ..Herein, we review pertinent clinical information on the incidence of hypocalcemia associated with specific drug treatment and discuss the underlying pathophysiological mechanisms...
  44. ncbi request reprint Therapeutic management of hyperglycaemic hyperosmolar syndrome
    Haralampos J Milionis
    Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    Expert Opin Pharmacother 6:1841-9. 2005
    ..This review provides an outline of the diagnostic approach of patients with manifestations of hyperglycaemic hyperosmolar syndrome and discusses the contemporary therapeutic recommendations...
  45. doi request reprint Effects of atorvastatin on red-blood cell Na(+)/Li(+) countertransport in hyperlipidemic patients with and without hypertension
    Maria S Kosmidou
    Department of Internal Medicine, Aristotle University, AHEPA Hospital, Thessaloniki, Greece
    Am J Hypertens 21:303-9. 2008
    ..To explore the effect of short-term cholesterol-lowering treatment with atorvastatin on erythrocyte sodium-lithium countertransport (Na(+)/Li(+) CT) activity...
  46. ncbi request reprint Reply to Al-Shaer, is atorvastatin more appropriate to use in combination with niacin than simvastatin in patients with the metabolic syndrome? (Am Heart J 2005;149:e17.)
    Haralampos J Milionis
    Am Heart J 150:e7. 2005
  47. ncbi request reprint Analysis of antihypertensive effects of statins
    Haralampos J Milionis
    Department of Clinical Biochemistry, Vascular Disease Prevention Clinics, Royal Free Hospital, Pond Street, London NW3 2QG, UK
    Curr Hypertens Rep 9:175-83. 2007
    ..Whether the effect of statins on BP is accompanied by an additional decrease in clinical outcomes needs to be investigated in long-term, large-scale trials...
  48. doi request reprint Lipid abnormalities and cardiovascular risk in the elderly
    Haralampos J Milionis
    Curr Med Res Opin 24:653-7. 2008
    ..There is evidence supporting the use of statins in the elderly. It is also likely that these drugs are under-used in this population...