Research Topics
Species | Natalia PapadopoulouSummaryAffiliation: Institute of Molecular Biology and Biotechnology Country: Greece Publications
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Detail Information
Publications
Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivoShuchen Gu
Department of Physiology, University of Tubingen, Germany
Mol Cancer 8:114. 2009..Membrane androgen receptors (mAR) have been implicated in the regulation of cell growth, motility and apoptosis in prostate and breast cancer. Here we analyzed mAR expression and function in colon cancer...
Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cellsNatalia Papadopoulou
Department of Biochemistry, University of Crete Medical School, Heraklion, Greece
Mol Cancer 7:88. 2008....
Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cellsNatalia Papadopoulou
Department of Biochemistry, University of Crete Medical School, GR 71110 Heraklion, Greece
Exp Cell Res 314:3162-74. 2008..Our findings suggest that Rho small GTPases are major membrane androgen receptor effectors controlling actin reorganization and apoptosis in prostate cancer cells...
Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impactNatalia Papadopoulou
Department of Biochemistry, University of Crete Medical School, Heraklion, Greece
IUBMB Life 61:56-61. 2009..Finally, we assess the clinical impact of the reported mAR-induced apoptotic regression of prostate cancer cells both in vitro and in vivo and discuss the potential role of mAR as a novel therapeutic target...
