George Kollias

Summary

Affiliation: Institute of Immunology
Country: Greece

Publications

  1. ncbi request reprint Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity
    Lena Alexopoulou
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    Eur J Immunol 36:2768-80. 2006
  2. pmc Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia
    Christina Eftychi
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    PLoS ONE 7:e31550. 2012
  3. pmc Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    Sofia Xanthoulea
    Institute of Immunology, Biomedical Sciences Research Centre Al Fleming, 34 Al Fleming St, Vari 166 72, Greece
    J Exp Med 200:367-76. 2004
  4. pmc Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    Maria Armaka
    Institute of Immunology, Biomedical Sciences Research Center BSRC Alexander Fleming, Vari 16672, Greece
    J Exp Med 205:331-7. 2008
  5. pmc Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
    Dimitris Kontoyiannis
    Institute for Immunology, Biomedical Sciences Research Center Al Fleming, Vari 166 72, Greece Division of Gastroenterology and Hepatology, University of Virginia Health Sciences Center, Charlottesville, VA 22906, USA
    J Exp Med 196:1563-74. 2002
  6. pmc Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
    Maung Maung Thwin
    Department of Anatomy, Yong Loo Lin School of Medicine, 4 Medical Drive, National University of Singapore, 117597 Singapore
    Arthritis Res Ther 11:R138. 2009
  7. ncbi request reprint TNF pathophysiology in murine models of chronic inflammation and autoimmunity
    George Kollias
    Biomedical Sciences Research Center Al Fleming, Vari, Greece
    Semin Arthritis Rheum 34:3-6. 2005
  8. ncbi request reprint Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments
    George Kollias
    Biomedical Sciences Research Centre, Institute for Immunology, Alexander Fleming, 14 16 Alexander Fleming Street, 166 72 Vari, Athens, Greece
    Cytokine Growth Factor Rev 13:315-21. 2002
  9. ncbi request reprint Animal models for arthritis: innovative tools for prevention and treatment
    George Kollias
    Biomedical Sciences Research Center Alexander Fleming, Institute of Immunology, Vari Athens, Greece
    Ann Rheum Dis 70:1357-62. 2011
  10. ncbi request reprint Modeling the function of tumor necrosis factor in immune pathophysiology
    G Kollias
    Biomedical Sciences Research Centre Alexander Fleming, Vari Athens, Greece
    Autoimmun Rev 3:S24-5. 2004

Detail Information

Publications78

  1. ncbi request reprint Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity
    Lena Alexopoulou
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    Eur J Immunol 36:2768-80. 2006
    ..These data support the hypothesis that selective targeting of soluble TNF may offer several advantages over complete blockade of TNF in the treatment of chronic inflammation and autoimmunity...
  2. pmc Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia
    Christina Eftychi
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    PLoS ONE 7:e31550. 2012
    ..These results highlight an antiinflammatory role for myeloid TAK1, which is essential for balanced innate immune responses and host survival during endotoxemia...
  3. pmc Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    Sofia Xanthoulea
    Institute of Immunology, Biomedical Sciences Research Centre Al Fleming, 34 Al Fleming St, Vari 166 72, Greece
    J Exp Med 200:367-76. 2004
    ..Assessment of p55TNFR shedding may thus be of prognostic value in infectious, inflammatory, and autoimmune diseases...
  4. pmc Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    Maria Armaka
    Institute of Immunology, Biomedical Sciences Research Center BSRC Alexander Fleming, Vari 16672, Greece
    J Exp Med 205:331-7. 2008
    ..Our results offer a novel mechanistic perspective for TNF function in gut and joint pathologies and indicate early common cellular pathways that may also explain the often observed synovial-gut axis in human disease...
  5. pmc Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
    Dimitris Kontoyiannis
    Institute for Immunology, Biomedical Sciences Research Center Al Fleming, Vari 166 72, Greece Division of Gastroenterology and Hepatology, University of Virginia Health Sciences Center, Charlottesville, VA 22906, USA
    J Exp Med 196:1563-74. 2002
    ..Our data establish the existence of redundant cellular pathways operating downstream of TNF in inflammatory bowel disease, and demonstrate the therapeutic potential of selective kinase blockade in TNF-mediated intestinal pathology...
  6. pmc Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
    Maung Maung Thwin
    Department of Anatomy, Yong Loo Lin School of Medicine, 4 Medical Drive, National University of Singapore, 117597 Singapore
    Arthritis Res Ther 11:R138. 2009
    ....
  7. ncbi request reprint TNF pathophysiology in murine models of chronic inflammation and autoimmunity
    George Kollias
    Biomedical Sciences Research Center Al Fleming, Vari, Greece
    Semin Arthritis Rheum 34:3-6. 2005
    ....
  8. ncbi request reprint Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments
    George Kollias
    Biomedical Sciences Research Centre, Institute for Immunology, Alexander Fleming, 14 16 Alexander Fleming Street, 166 72 Vari, Athens, Greece
    Cytokine Growth Factor Rev 13:315-21. 2002
    ....
  9. ncbi request reprint Animal models for arthritis: innovative tools for prevention and treatment
    George Kollias
    Biomedical Sciences Research Center Alexander Fleming, Institute of Immunology, Vari Athens, Greece
    Ann Rheum Dis 70:1357-62. 2011
    ....
  10. ncbi request reprint Modeling the function of tumor necrosis factor in immune pathophysiology
    G Kollias
    Biomedical Sciences Research Centre Alexander Fleming, Vari Athens, Greece
    Autoimmun Rev 3:S24-5. 2004
  11. ncbi request reprint Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease
    Maria Apostolaki
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    Gastroenterology 134:2025-35. 2008
    ....
  12. doi request reprint Cellular mechanisms of TNF function in models of inflammation and autoimmunity
    Maria Apostolaki
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Al Fleming Street, Vari, Greece
    Curr Dir Autoimmun 11:1-26. 2010
    ..Knowledge of the mechanisms by which TNF either initiates or contributes to disease pathology is fundamentally required for the design of safe and effective anti-TNF/TNFR therapies for human inflammatory and autoimmune disorders...
  13. pmc Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production
    Sotiria Tzima
    Biomedical Sciences Research Center Alexander Fleming, Vari 166 72, Greece
    J Exp Med 206:1167-79. 2009
    ..These results uncover a novel direct function for myeloid HO-1 in the regulation of IFN-beta production, establishing HO-1 as a critical early mediator of the innate immune response...
  14. pmc Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology
    Manolis Roulis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Proc Natl Acad Sci U S A 108:5396-401. 2011
    ..Our results argue against IEC being early and sufficient responders to chronic TNF-mediated pathogenic signals and suggest that proinflammatory aberrations leading to chronic TNF production by IEC may initiate pathology in Crohn disease...
  15. pmc Functional analysis of an arthritogenic synovial fibroblast
    Vassilis Aidinis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Arthritis Res Ther 5:R140-57. 2003
    ..Our findings support an aggressive role for the SF in the development of the disease and reinforce the perspective of a transformed-like character of the SF...
  16. ncbi request reprint HuR as a negative posttranscriptional modulator in inflammation
    Vicky Katsanou
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece
    Mol Cell 19:777-89. 2005
    ..Our data suggest that HuR acts in a pleiotropic fashion in inflammation through its functional interactions with specific mRNA subsets and negative posttranscriptional modules...
  17. ncbi request reprint FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    Panayiotis Victoratos
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, Vari 166 72, Greece
    Immunity 24:65-77. 2006
    ....
  18. doi request reprint Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer
    Kostas Nikolaou
    Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece
    Cancer Cell 21:738-50. 2012
    ..The results demonstrate that, in the liver, CYLD acts as an important regulator of hepatocyte homeostasis, protecting cells from spontaneous apoptosis by preventing uncontrolled TAK1 and JNK activation...
  19. doi request reprint Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells
    Panayiotis Victoratos
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Attica, Greece
    Immunity 30:130-42. 2009
    ..Importantly, pharmacological interference in the maintenance of FDCs ameliorated disease development, suggesting the FDC as a potential target for dampening autoimmunity...
  20. pmc Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis
    Vassilis Aidinis
    Institute of Immunology, Alexander Fleming Biomedical Sciences Research Center, Athens, Greece
    PLoS Genet 1:e48. 2005
    ....
  21. ncbi request reprint The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies
    George Kollias
    Institute for Immunology, Biomedical Sciences Research Centre, Alexander Fleming, Vari, Greece
    Curr Dir Autoimmun 5:30-50. 2002
  22. ncbi request reprint Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders
    Jan Staelens
    Unit for Molecular Genetics in the Mouse, Department of Molecular Biomedical Research, Ghent University Flanders Interuniversity Institute for Biotechnology, Zwijnaarde, Belgium
    Mamm Genome 15:537-43. 2004
    ..It is very well possible that different genes are implicated in the different models...
  23. ncbi request reprint Genetic engineering in the mouse: tuning TNF/TNFR expression
    Eleni Douni
    Institute of Immunology, Biomedical Sciences Research Center, Vari, Greece
    Methods Mol Med 98:137-70. 2004
    ....
  24. pmc Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis
    Vasiliki Koliaraki
    Institute of Immunology, Biomedical Sciences Research Centre Alexander Fleming, Vari, Attica, Greece
    J Clin Invest 122:4231-42. 2012
    ..These findings establish a mesenchyme-specific role for Tpl2 in the regulation of HGF production and suppression of epithelial tumorigenesis...
  25. doi request reprint A combined LS-SVM & MLR QSAR workflow for predicting the inhibition of CXCR3 receptor by quinazolinone analogs
    Antreas Afantitis
    Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Mol Divers 14:225-35. 2010
    ....
  26. ncbi request reprint Functional genetic and genomic analysis of modeled arthritis
    Eleni Douni
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Al Fleming Str, 16672 Vari, Greece
    Adv Exp Med Biol 602:33-42. 2007
  27. pmc Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice
    Katerina Akassoglou
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 11521, Greece
    Proc Natl Acad Sci U S A 100:709-14. 2003
    ....
  28. ncbi request reprint Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model
    Ioannis Pandis
    Biomedical Sciences Research Centre Alexander Fleming, Institute of Immunology, Vari 16672, Greece
    Ann Rheum Dis 71:1716-23. 2012
    ..To identify novel microRNA (miR) associations in synovial fibroblasts (SF), by performing miR expression profiling on cells isolated from the human tumour necrosis factor (TNF) transgenic mouse model (TghuTNF, Tg197) and patients biopsies...
  29. pmc Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo
    Dimitris Panagopoulos
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming St, Vari 16672, Greece
    J Virol 78:13253-61. 2004
    ..Consistent with these findings, LMP1CD40 but not LMP1 transgenic mice showed signs of spontaneous inflammatory reactions and the potential for autoimmunity...
  30. pmc Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis
    Kurt Redlich
    Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Am J Pathol 164:543-55. 2004
    ....
  31. pmc Osteoclasts are essential for TNF-alpha-mediated joint destruction
    Kurt Redlich
    Department of Internal Medicine III, Division of Rheumatology, University of Vienna, Vienna, Austria
    J Clin Invest 110:1419-27. 2002
    ..Therefore, in addition to the use of anti-inflammatory therapies, osteoclast inhibition could be beneficial for the treatment of rheumatoid arthritis...
  32. ncbi request reprint Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo
    Martin H Holtmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 32:3142-51. 2002
    ..Taken together with the increased expression of TNF-R2 in CD, selective targeting of TNF-R2 signaling thus emerges as a potentially novel approach to the treatment of CD...
  33. pmc Generation and characterization of p38beta (MAPK11) gene-targeted mice
    Victoria A Beardmore
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom
    Mol Cell Biol 25:10454-64. 2005
    ..Together these results suggest that p38alpha, and not p38beta, is the major p38 isoform involved in the immune response and that it would not be necessary to retain activity against p38beta during the development of p38 inhibitors...
  34. ncbi request reprint Acid-induced acute lung injury in mice is associated with P44/42 and c-Jun N-terminal kinase activation and requires the function of tumor necrosis factor α receptor I
    Nikolaos A Maniatis
    Marianthi Simou and Experimental Surgery Laboratories, of the 1 st Department of Critical Care, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
    Shock 38:381-6. 2012
    ..In conclusion, ALI induced by HCl requires TNF-α receptor I function and associates with activation of downstream proinflammatory signaling pathways p44/42 and c-Jun N-terminal kinase...
  35. ncbi request reprint Tumor necrosis factor biology in experimental and clinical arthritis
    Petros P Sfikakis
    First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Curr Opin Rheumatol 15:380-6. 2003
    ....
  36. pmc MUGEN mouse database; animal models of human immunological diseases
    V Aidinis
    B S R C Alexander Fleming, 34 Fleming Street, 16672, Vari, Greece
    Nucleic Acids Res 36:D1048-54. 2008
    ..MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying...
  37. pmc Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study
    Maung Maung Thwin
    Venom and Toxin Research Program, Department of Anatomy, National University of Singapore, Singapore
    Arthritis Res Ther 6:R282-94. 2004
    ..II suggests that the peptide may influence the prostaglandin-mediated inflammatory response in rheumatoid arthritis by limiting the bioavailability of arachidonic acid through sPLA2 inhibition...
  38. ncbi request reprint An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells
    Ioannis Chatzidakis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Vassilika Vouton, Crete, Greece
    J Immunol 178:6735-45. 2007
    ..Collectively, our results provide evidence that endogenous TNF modulates thresholds in several ligand-driven T cell responses...
  39. ncbi request reprint Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice
    Uta Schurigt
    Friedrich Schiller University, Jena, Germany
    Arthritis Rheum 58:422-34. 2008
    ....
  40. ncbi request reprint Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-alpha transgenic mice
    Silvia Hayer
    Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
    J Immunol 175:8327-36. 2005
    ..These findings suggest that overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process...
  41. ncbi request reprint Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice
    Mika Hukkanen
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki and ORTON Research Institute, Orthopaedic Hospital of the Invalid Foundation, Finland
    J Rheumatol 30:652-9. 2003
    ..We investigated the induction of iNOS together with argininosuccinate synthase (AS) and GTP cyclohydrolase I (GTPCH), 2 of the rate-limiting enzymes for high output NO generation, in the Tg197 h-TNF-alpha transgenic model of arthritis...
  42. pmc Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis
    Ioanna Nikitopoulou
    Institute of Immunology, Alexander Fleming Biomedical Sciences Research Center, 16672 Athens, Greece
    J Exp Med 209:925-33. 2012
    ....
  43. ncbi request reprint Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin
    Kurt Redlich
    University of Vienna, Vienna, Austria
    Arthritis Rheum 46:785-92. 2002
    ..To study the effects of osteoclast-targeted therapies, such as osteoprotegerin (OPG) and pamidronate, on joint inflammation and bone destruction using a tumor necrosis factor alpha (TNF alpha)-transgenic mouse model...
  44. ncbi request reprint Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy
    Wim Van Molle
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Cancer Res 67:7301-7. 2007
    ..We conclude that zinc protects against TNF in a HSP70-dependent way and that protection by zinc could be helpful in developing a safer anticancer therapy with TNF/IFNgamma...
  45. pmc Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice
    Ping Ye
    Division of Endocrinology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:712-22. 2007
    ..Our results indicate that IGF-I is capable of protecting myelin and oligodendrocytes from TNF-alpha-induced damage in vivo...
  46. doi request reprint Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: potential importance for cartilage breakdown and synovial hypertrophy
    Klaus Bobacz
    University of Vienna, Vienna, Austria
    Arthritis Rheum 58:109-18. 2008
    ....
  47. ncbi request reprint Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice
    Ping Ye
    Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 71:721-31. 2003
    ..Our data indicate that TNF-alpha alters the expression of IGF-I system proteins in vivo, and suggest that altered expression of IGF-I system proteins may in part explain TNF-alpha deleterious actions on brain growth...
  48. ncbi request reprint Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis
    Nadine Hövelmeyer
    Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
    J Immunol 175:5875-84. 2005
    ..Although only moderate reduction of lymphocyte infiltration into CNS tissue was observed, the absence of these receptors appears to confer protection from demyelination and development of clinical disease...
  49. ncbi request reprint Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption
    Jochen Zwerina
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    FASEB J 19:2011-3. 2005
    ..In summary, these data indicate that HO-1 negatively regulates osteoclastogenesis, leading to a positive net balance of bone...
  50. ncbi request reprint A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF
    Eleni Douni
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Hum Mol Genet 21:784-98. 2012
    ....
  51. ncbi request reprint TNFR2 on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE
    Niki Tsakiri
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    Eur J Immunol 42:403-12. 2012
    ....
  52. ncbi request reprint On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
    G Kollias
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunol Rev 169:175-94. 1999
    ....
  53. ncbi request reprint MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
    Armin Neininger
    Innovationskolleg Zellspezialisierung, Martin Luther Universitat Halle Wittenberg, 06120 Halle, Germany
    J Biol Chem 277:3065-8. 2002
    ....
  54. ncbi request reprint Overexpression of tumor necrosis factor causes bilateral sacroiliitis
    Kurt Redlich
    University of Vienna Vienna, Austria
    Arthritis Rheum 50:1001-5. 2004
  55. doi request reprint Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters
    Sylvie Huybers
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Inflamm Bowel Dis 14:803-11. 2008
    ..To evaluate whether these mice have a Ca(2+) handling problem, this study analyzed the Ca(2+) homeostasis in heterozygous TNF(DeltaARE) mice (TNF(DeltaARE/+)) in comparison to wildtype littermates...
  56. ncbi request reprint Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation
    Birgit Görtz
    Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    J Bone Miner Res 19:990-8. 2004
    ..Bone marrow next to arthritic lesions exhibits B-lymphocyte-rich infiltrates, which express BMPs and stimulate endosteal bone formation. Thus, bone marrow actively participates in the arthritic process...
  57. ncbi request reprint Drug-induced Brugada syndrome by noncardiac agents
    Konstantinos P Letsas
    Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, Greece
    Pacing Clin Electrophysiol 36:1570-7. 2013
    ..This review highlights the mechanisms and the noncardiac medical agents that unmask a genetic predisposition to BrS. ..
  58. ncbi request reprint A New Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis
    Vasiliki Koliaraki
    Biomedical Sciences Research Center Al Fleming, Institute of Immunology, Vari, 16672, Greece
    Adv Exp Med Biol 780:101-11. 2012
    ..This new frame of understanding HO-1 function should also be important for the future design of novel interventions differentially targeting the enzymatic versus the IRF3 modulating properties of HO-1...
  59. ncbi request reprint A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas
    Antreas Afantitis
    Biomedical Sciences Research Center Alexander Fleming, 34 Fleming Street, Vari 16672, Greece
    Eur J Med Chem 44:877-84. 2009
    ..The selected physicochemical descriptors serve as a first guideline for the design of novel and potent antagonists of CXCR3...
  60. ncbi request reprint Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  61. pmc Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Am J Pathol 153:801-13. 1998
    ....
  62. ncbi request reprint A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
    L Alexopoulou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 27:2588-92. 1997
    ..These results indicate that blocking the activities of both soluble and transmembrane TNF may be required to effectively neutralize the pathogenic potential of this cytokine in arthritis...
  63. ncbi request reprint TNF-alpha transgenic and knockout models of CNS inflammation and degeneration
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Neuroimmunol 72:137-41. 1997
    ....
  64. ncbi request reprint The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 25:1794-7. 1995
    ..Our results show that in TNF-transgenic mice the IL-1 receptor accepts the whole pathogenic load of TNF, thereby acting as a potent downstream mediator in the pathogenesis of chronic arthritis...
  65. ncbi request reprint A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice
    G Kassiotis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:912-7. 1999
    ..We conclude that TNF is sufficient to induce primary inflammatory demyelination and neurological deficits even in the absence of adaptive immunity...
  66. ncbi request reprint Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Immunol 158:438-45. 1997
    ..These results demonstrate that target cells mediating the neuroinflammatory activities of TNF localize in the vicinity of astrocytes rather than neurons...
  67. ncbi request reprint Onset and progression in inherited ALS determined by motor neurons and microglia
    Severine Boillee
    Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 312:1389-92. 2006
    ....
  68. ncbi request reprint Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance
    Hans Christian Probst
    Institute of Experimental Immunology, University of Zurich, Switzerland
    Immunity 18:713-20. 2003
    ..On the other hand, antigen presentation by activated DC primed endogenous CTL to expand and to develop protective effector function...
  69. ncbi request reprint TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis
    G Kassiotis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:774-80. 1999
    ..Taken together, these results indicate that although TNF is not required for the progression of MBP-induced EAE, it contributes positively by advancing the onset of disease...
  70. pmc Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    M Pasparakis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Exp Med 184:1397-411. 1996
    ....
  71. ncbi request reprint Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles
    M Pasparakis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, 115 21, Greece
    Cell Immunol 201:33-41. 2000
    ....
  72. ncbi request reprint Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 30:2038-47. 2000
    ....
  73. pmc Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology
    D Kontoyiannis
    Institute of Immunology, BSRC Alexander Fleming, 166 72 Vari, Greece
    EMBO J 20:3760-70. 2001
    ..This cross-talk is necessary for optimal TNF production and for the maintenance of immune homeostasis in the gut...
  74. ncbi request reprint Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness
    G Kassiotis
    Institute for Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari 166 72, Greece
    J Neuroimmunol 119:239-47. 2001
    ..Therefore, TNF shows distinct functions in linking innate responsiveness to CD4+ T cell priming and to the induction of autoimmune disease...
  75. pmc Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis
    Y Vasilopoulos
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Ann Rheum Dis 66:iii23-8. 2007
    ..Recent advances in this field of research are reviewed and discussed...
  76. ncbi request reprint Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
    Maria A Ermolaeva
    Institute for Genetics, Centre for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50674 Cologne, Germany
    Nat Immunol 9:1037-46. 2008
    ..Thus, TRADD is an essential component of TNFR1 signaling and has a critical but apparently cell type-specific function in TRIF-dependent TLR responses...
  77. ncbi request reprint Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources
    John M Hancock
    Mamm Genome 18:157-63. 2007
    ..This process is ongoing and needs to be supported by the wider mouse genetics and phenotyping communities to succeed. We invite interested parties to contact us as we develop this process further...