D Kardassis

Summary

Affiliation: Institute of Molecular Biology and Biotechnology
Country: Greece

Publications

  1. ncbi request reprint c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School, Institute of Molecular Biology, Foundation of Research and Technology of Hellas, Heraklion GR 71110, Crete, Greece
    J Biol Chem 274:29572-81. 1999
  2. ncbi request reprint Metabolism of HDL and its Regulation
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School, Heraklion 71003 Greece
    Curr Med Chem 21:2864-80. 2014
  3. pmc Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein
    Vassiliki Prokova
    Department of Basic Sciences, University of Crete Medical School Heraklion 71003, Greece
    Nucleic Acids Res 33:3708-21. 2005
  4. pmc Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance
    Ilias Stagakis
    Rheumatology, Clinical Immunology and Allergy, University of Crete, Medical School, Voutes 1, Heraklion, 71003, Greece
    Arthritis Res Ther 14:R141. 2012
  5. pmc Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids
    Dimitris Kardassis
    Department of Basic Sciences, School of Health Sciences, Faculty of Medicine, University of Crete, PO Box 1393, 71500 Heraklion, Greece
    Biochem J 372:291-304. 2003
  6. ncbi request reprint Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein
    G Koutsodontis
    Department of Basic Sciences, University of Crete Medical School, Heraklion GR-71110, Greece
    J Biol Chem 276:29116-25. 2001
  7. ncbi request reprint SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, F O R T H, Heraklion GR 71110, Crete, Greece
    J Biol Chem 275:41405-14. 2000
  8. ncbi request reprint Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition
    E Papadimitriou
    Department of Biochemistry, University of Crete Medical School, Heraklion, Crete, Greece
    Oncogene 31:2862-75. 2012
  9. ncbi request reprint Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
    K Pardali
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    J Biol Chem 275:29244-56. 2000
  10. ncbi request reprint Transcriptional regulation of the human apolipoprotein genes
    V I Zannis
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Departments of Medicine and Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 239, USA
    Front Biosci 6:D456-504. 2001

Collaborators

  • A Moustakas
  • Vassilis Zannis
  • E Papadimitriou
  • Ilias Stagakis
  • Vassiliki Prokova
  • George Bertsias
  • Stylianos Karvounaris
  • Dimitrios T Boumpas
  • Dimitra Virla
  • Melina Kavousanaki
  • Amalia Raptopoulou
  • C Vorvis
  • Prodromos I Sidiropoulos
  • D Iliopoulos
  • C Stournaras
  • G Koutsodontis
  • E Vasilaki
  • K Pardali
  • Sofia Mavridou
  • Paraskevi Papakosta
  • I Tentes
  • P Papakosta
  • P ten Dijke
  • A Kurisaki
  • A Moren

Detail Information

Publications10

  1. ncbi request reprint c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School, Institute of Molecular Biology, Foundation of Research and Technology of Hellas, Heraklion GR 71110, Crete, Greece
    J Biol Chem 274:29572-81. 1999
    ..In conclusion, our data support a mechanism of superactivation of Sp1 by c-Jun, which is based on physical and functional interactions between these two transcription factors on the human p21 and possibly other Sp1-dependent promoters...
  2. ncbi request reprint Metabolism of HDL and its Regulation
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School, Heraklion 71003 Greece
    Curr Med Chem 21:2864-80. 2014
    ....
  3. pmc Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein
    Vassiliki Prokova
    Department of Basic Sciences, University of Crete Medical School Heraklion 71003, Greece
    Nucleic Acids Res 33:3708-21. 2005
    ..Our data support an essential role of the previously uncharacterized middle region of Smad3 for nuclear functions, such as transcriptional activation and interaction with coactivators...
  4. pmc Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance
    Ilias Stagakis
    Rheumatology, Clinical Immunology and Allergy, University of Crete, Medical School, Voutes 1, Heraklion, 71003, Greece
    Arthritis Res Ther 14:R141. 2012
    ..We examined whether anti-TNF therapy improves insulin resistance in RA patients and assessed changes in the insulin signaling cascade...
  5. pmc Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids
    Dimitris Kardassis
    Department of Basic Sciences, School of Health Sciences, Faculty of Medicine, University of Crete, PO Box 1393, 71500 Heraklion, Greece
    Biochem J 372:291-304. 2003
    ....
  6. ncbi request reprint Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein
    G Koutsodontis
    Department of Basic Sciences, University of Crete Medical School, Heraklion GR-71110, Greece
    J Biol Chem 276:29116-25. 2001
    ..In conclusion, Sp1 must play a critical role in regulating important biological processes controlled by p53 via p21 gene activation such as DNA repair, cell growth, differentiation, and apoptosis...
  7. ncbi request reprint SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, F O R T H, Heraklion GR 71110, Crete, Greece
    J Biol Chem 275:41405-14. 2000
    ....
  8. ncbi request reprint Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition
    E Papadimitriou
    Department of Biochemistry, University of Crete Medical School, Heraklion, Crete, Greece
    Oncogene 31:2862-75. 2012
    ..Our results emphasize the importance of Net1 isoform2 in the short- and long-term TGF-β-mediated regulation of EMT...
  9. ncbi request reprint Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
    K Pardali
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    J Biol Chem 275:29244-56. 2000
    ..In conclusion, Smad proteins play important roles in regulation of the p21 gene by TGF-beta, and the functional cooperation of Smad proteins with Sp1 involves the physical interaction of these two types of transcription factors...
  10. ncbi request reprint Transcriptional regulation of the human apolipoprotein genes
    V I Zannis
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Departments of Medicine and Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 239, USA
    Front Biosci 6:D456-504. 2001
    ..Understanding the transcriptional regulatory mechanism of the apolipoprotein genes may allow, in the long run, selective increase of anti-atherogenic lipoproteins and thus reduce the risk of cardiovascular disease...