George Dedoussis

Summary

Affiliation: Harokopio University
Country: Greece

Publications

  1. pmc Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study
    Eirini V Theodoraki
    Department of Dietetics and Nutritional Science, Harokopio University of Athens, El Venizelou 70, 17671 Athens, Greece
    BMC Med Genet 11:28. 2010
  2. doi Does a short breastfeeding period protect from FTO-induced adiposity in children?
    George V Z Dedoussis
    Department of Dietetics and Nutrition, Harokopio University, Athens, Greece
    Int J Pediatr Obes 6:e326-35. 2011
  3. ncbi Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia
    George V Z Dedoussis
    Laboratory of Molecular Biology, Department of Dietetics and Nutrition, Harokopio University of Athens, Athens, Greece
    J Clin Lab Anal 20:98-104. 2006
  4. doi Dairy intake associates with the IGF rs680 polymorphism to height variation in periadolescent children
    G V Dedoussis
    Department of Dietetics, Nutrition, Harokopio University, Athens, Greece
    Eur J Clin Nutr 64:253-8. 2010
  5. ncbi The Pro12Ala polymorphism in PPARgamma2 gene affects lipid parameters in Greek primary school children: A case of gene-to-gender interaction
    George V Z Dedoussis
    Department of Science in Dietetics Nutrition, Harokopio University of Athens, Greece
    Am J Med Sci 333:10-5. 2007
  6. ncbi Cholesteryl ester-transfer protein (CETP) polymorphism and the association of acute coronary syndromes by obesity status in Greek subjects: the CARDIO2000-GENE study
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, Athens, Greece
    Hum Hered 63:155-61. 2007
  7. ncbi Apolipoprotein polymorphisms and familial hypercholesterolemia
    George V Z Dedoussis
    University of Athens, Laboratory of Molecular Genetics, Department of Nutrition and Dietetics, Harokopio, 70 El Venizelou Str, 17671 Kallithea Athens, Greece
    Pharmacogenomics 8:1179-89. 2007
  8. doi Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease
    G V Z Dedoussis
    Department of Science Dietetics Nutrition, Harokopio University of Athens, Athens, Greece
    Eur J Clin Invest 38:180-90. 2008
  9. pmc Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, 17671 Athens, Greece
    Exp Mol Med 40:27-34. 2008
  10. ncbi Human gene mutations. Gene symbol: SLC3A1. Disease: cystinuria
    George Dedoussis
    Harokopio University, Department of Science Dietetics Nutrition, El Venizelou, 70, 17671, Athens, Greece
    Hum Genet 122:215. 2007

Detail Information

Publications44

  1. pmc Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study
    Eirini V Theodoraki
    Department of Dietetics and Nutritional Science, Harokopio University of Athens, El Venizelou 70, 17671 Athens, Greece
    BMC Med Genet 11:28. 2010
    ..The purpose of the present study was to investigate the effect of fibrinogen A (FGA), fibrinogen B (FGB) and fibrinogen G (FGG) gene SNPs and haplotypes on susceptibility to CAD in a homogeneous Greek population...
  2. doi Does a short breastfeeding period protect from FTO-induced adiposity in children?
    George V Z Dedoussis
    Department of Dietetics and Nutrition, Harokopio University, Athens, Greece
    Int J Pediatr Obes 6:e326-35. 2011
    ..One of these loci is the fat mass and obesity associated locus (FTO). We aimed to assess whether breastfeeding mediated the known association between FTO and indices of body fatness...
  3. ncbi Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia
    George V Z Dedoussis
    Laboratory of Molecular Biology, Department of Dietetics and Nutrition, Harokopio University of Athens, Athens, Greece
    J Clin Lab Anal 20:98-104. 2006
    ..The 664A allele of the ANP polymorphism is associated with lower levels of ApoA1 and HDL-C in FH patients, but not with CAD risk. Concerning the T2238C polymorphism, no effect was found on lipid parameters or CAD incidence...
  4. doi Dairy intake associates with the IGF rs680 polymorphism to height variation in periadolescent children
    G V Dedoussis
    Department of Dietetics, Nutrition, Harokopio University, Athens, Greece
    Eur J Clin Nutr 64:253-8. 2010
    ..We evaluated the prospect of gene-to-diet interactions in a children's cohort, for the insulin-like growth factor II (IGF) rs680 polymorphism and height variation...
  5. ncbi The Pro12Ala polymorphism in PPARgamma2 gene affects lipid parameters in Greek primary school children: A case of gene-to-gender interaction
    George V Z Dedoussis
    Department of Science in Dietetics Nutrition, Harokopio University of Athens, Greece
    Am J Med Sci 333:10-5. 2007
    ..In the present study we sought to evaluate the impact of the PPAR-gamma2 Pro12Ala polymorphism on blood lipid levels of primary school children...
  6. ncbi Cholesteryl ester-transfer protein (CETP) polymorphism and the association of acute coronary syndromes by obesity status in Greek subjects: the CARDIO2000-GENE study
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, Athens, Greece
    Hum Hered 63:155-61. 2007
    ..Cholesterol ester transfer protein (CETP) regulates plasma lipid distribution. The present study aimed to investigate whether the CETP gene (Taq1B) polymorphism predisposes to Acute Coronary Syndromes (ACS) depending on obesity status...
  7. ncbi Apolipoprotein polymorphisms and familial hypercholesterolemia
    George V Z Dedoussis
    University of Athens, Laboratory of Molecular Genetics, Department of Nutrition and Dietetics, Harokopio, 70 El Venizelou Str, 17671 Kallithea Athens, Greece
    Pharmacogenomics 8:1179-89. 2007
    ..In this review, we present current information that demonstrates the impact of apolipoprotein polymorphisms on the FH phenotype...
  8. doi Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease
    G V Z Dedoussis
    Department of Science Dietetics Nutrition, Harokopio University of Athens, Athens, Greece
    Eur J Clin Invest 38:180-90. 2008
    ..Autosomal dominant polycystic kidney disease (ADPKD), which is caused by mutations in polycystins 1 (PC1) and 2 (PC2), is one of the most commonly inherited renal diseases, affecting ~1 : 1000 Caucasians...
  9. pmc Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, 17671 Athens, Greece
    Exp Mol Med 40:27-34. 2008
    ..The results suggest that SOD Ala16Val polymorphism is an age-dependent modulator of ox-LDL-C levels in middle-aged men and elderly women...
  10. ncbi Human gene mutations. Gene symbol: SLC3A1. Disease: cystinuria
    George Dedoussis
    Harokopio University, Department of Science Dietetics Nutrition, El Venizelou, 70, 17671, Athens, Greece
    Hum Genet 122:215. 2007
  11. doi Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study
    George V Dedoussis
    Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
    Clin Chem Lab Med 46:990-6. 2008
    ..The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects...
  12. doi Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and risk for pediatric obesity
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, Athens, Greece
    Clin Chem Lab Med 47:1047-50. 2009
    ..Variation in the peroxisome-proliferator-activated receptor gamma (PPARgamma) gene has been reported to alter the risk for adiposity in adults...
  13. doi Adipokine expression in adipose tissue and in peripheral blood mononuclear cells in children Correlation with BMI and fatty acid content
    George V Dedoussis
    Department of Nutrition Dietetics, Harokopio University, 70 El Venizelou St, 17671 Athens, Greece
    Clin Chim Acta 410:85-9. 2009
    ..Our aim was to study the associations between adipose tissue (AT) fatty acid content, adipokines' expression in AT and PBMCs and BMI in children...
  14. doi Expression of inflammatory molecules and associations with BMI in children
    George V Z Dedoussis
    Department of Dietetics Nutrition, Harokopio University, Athens, Greece
    Eur J Clin Invest 40:388-92. 2010
    ..Our aim was to investigate the adipokine expression in adipose tissue and peripheral blood mononuclear cells (PBMCs) in children...
  15. doi An age-dependent diet-modified effect of the PPARĪ³ Pro12Ala polymorphism in children
    George V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, 17671 Athens, Greece
    Metabolism 60:467-73. 2011
    ..We also demonstrate evidence of an age-dependent gene-diet (SFA, TF) interaction, suggesting that the type of fat intake modifies the effect of the Pro12 allele on obesity-related measures...
  16. ncbi Different genes and polymorphisms affecting high-density lipoprotein cholesterol levels in Greek familial hypercholesterolemia patients
    George V Z Dedoussis
    Laboratory of Molecular Biology, Department of Science of Dietetics Nutrition, Harokopio University of Athens, Kallithea Athens, Greece
    Genet Test 10:192-9. 2006
    ..01, p = 0.018, p = 0.04, respectively). These results suggest that HDL-C levels in FH heterozygotes may be affected by several different genetic variants...
  17. ncbi FH-Pyrgos: a novel mutation in the promoter (-45delT) of the low-density lipoprotein receptor gene associated with familial hypercholesterolemia
    G V Z Dedoussis
    Laboratory of Molecular Biology, Department of Science of Dietetics Nutrition, Harokopio University of Athens, Greece
    Clin Genet 64:414-9. 2003
    ....
  18. ncbi Inverse correlation of plasma leptin and soluble transferrin receptor levels in beta-thalassemia patients
    G V Z Dedoussis
    Department of Diet and Nutrition, Harokopio University of Athens, 70, El Venizelou str, 17671 Kallithea, Athens, Greece
    Ann Hematol 81:543-7. 2002
    ..These findings enhance previous results indicating that leptin may play some role in hematopoiesis and could associate the pathophysiology of thalassemic patients with the triggering effect of leptin in reproductive ability...
  19. ncbi Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression
    George V Z Dedoussis
    Department of Science of Dietetics Nutrition, Harokopio University, 70 El Venizelou Str, 17 671 Kallithea, Athens, Greece
    Atherosclerosis 174:293-303. 2004
    ..lentiscus triterpenes exert antioxidant/antiatherogenic effect. Additionally, our results provide strong evidence of the resin's antiatherogenic effect; therefore it is credited with beneficial health aspects...
  20. ncbi FH clinical phenotype in Greek patients with LDL-R defective vs. negative mutations
    G V Z Dedoussis
    Laboratory of Molecular Biology, Department of Science of Dietetics Nutrition, Harokopio University of Athens, Athens, Greece
    Eur J Clin Invest 34:402-9. 2004
    ..Familial hypercholesterolaemia (FH) is caused by mutations in the low-density lipoprotein receptor gene and the gene encoding apolipoprotein B-100, affecting one in 500 individuals...
  21. ncbi The IL-6 gene G-174C polymorphism related to health indices in Greek primary school children
    George V Z Dedoussis
    Laboratory of Molecular Genetics, Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El Venizelou Str, 17671 Kallithea Athens, Greece
    Obes Res 12:1037-41. 2004
    ..From the results of the present study, we concluded that individuals homozygous for G allele on the IL-6 gene have higher values in some parameters associated with obesity...
  22. ncbi Glutathione depletion restores the susceptibility of cisplatin-resistant chronic myelogenous leukemia cell lines to Natural Killer cell-mediated cell death via necrosis rather than apoptosis
    G V Dedoussis
    Department of Dietetics Nutrition, Harokopio University, Kallithea, Athens, Greece
    Eur J Cell Biol 80:608-14. 2001
    ..These results suggest that the GSH level affects the NK cell-mediated cell death of cisplatin-resistant K562 cells by inducing necrosis rather than apoptosis...
  23. ncbi Fetal hemoglobin expression in the compound heterozygous state for -117 (G-->A) Agamma HPFH and IVS-1 nt 110 (G-->A) beta+ thalassemia: a case study
    G V Dedoussis
    Center for Thalassemia, Unit of Prenatal Diagnosis, Laiko General Hospital, Athens, Greece
    Eur J Haematol 65:93-6. 2000
    ..He has 13% HbF with a Ggamma/Agamma ratio 32:68. Her sister is a compound heterozygote for the IVS-I-110 mutation in trans to the - 158 C-->T, with HbF levels of 3% and a Ggamma/Agamma ratio 72:28...
  24. ncbi HbF production in beta thalassaemia heterozygotes for the IVS-II-1 G-->A beta(0)-globin mutation. Implication of the haplotype and the (G)gamma-158 C-->T mutation on the HbF level
    G V Dedoussis
    Center for Thalassaemia, Laiko General Hospital, Athens, Greece
    Am J Hematol 64:151-5. 2000
    ..On the other hand the (G)gamma -158 C-->T mutation is associated with small amounts of HbF in IVSII-1 heterozygotes, when the beta-globin mutation is linked to haplotype IIIa...
  25. ncbi Endogenous interleukin 6 conveys resistance to cis-diamminedichloroplatinum-mediated apoptosis of the K562 human leukemic cell line
    G V Dedoussis
    Nursing Military Academy, Vironas, Athens, 16201, Greece
    Exp Cell Res 249:269-78. 1999
    ..The current studies show that anti-IL-6 mAb sensitized CDDP-resistant K562 cells to CDDP by induction of apoptotic death and the reduction of glutathione levels might be implicated in the enhanced cytotoxicity observed...
  26. ncbi Fetal hemoglobin expression in the compound heterozygous state for -117 (G-->A) Agamma HPFH and IVSII-745 (C-->G) beta+ thalassemia: a case study
    G V Dedoussis
    Laiko General Hospital, Center for Thalassemia, Athens, Greece
    Am J Hematol 61:139-43. 1999
    ..He presented 13.5% HbF with a Ggamma/Agamma ratio 75:25. His daughter was a compound heterozygote for the IVSII-745 mutation in trans with the -158 C-->T, while her HbF levels were 3.7% with a Ggamma/Agamma ratio 31:69...
  27. ncbi Wilson disease: high prevalence in a mountainous area of Crete
    G V Z Dedoussis
    Department of Science Dietetics Nutrition, Harokopio University of Athens, Kallithea, Greece
    Ann Hum Genet 69:268-74. 2005
    ..These findings indicate the need for health education intervention, genetic counselling and newborn screening for the Wilson disease...
  28. ncbi Health status, blood and anthropometrical indices from Greek old and nonagenarian subjects
    Stavroula Kanoni
    Laboratory of Molecular Genetics, Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El Venizelou Str, 17671, Kallithea Athens, Greece
    Biogerontology 7:329-37. 2006
    ..Blood analysis confirmed the good health status of the elderly recruited as healthy, except for the high prevalence of obesity and hypercholesterolemia...
  29. ncbi Interaction between Mediterranean diet and methylenetetrahydrofolate reductase C677T mutation on oxidized low density lipoprotein concentrations: the ATTICA study
    Christos Pitsavos
    First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    Nutr Metab Cardiovasc Dis 16:91-9. 2006
    ..We evaluated whether adoption of a Mediterranean type of diet is associated with oxidized LDL levels, as well as the role of MTHFR C677T mutation in this relationship...
  30. doi ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity
    Ioanna Ntalla
    Department of Dietetics, Nutrition, Harokopio University, 70 El Venizelou St, 17671, Athens, Greece
    Eur J Nutr 48:493-7. 2009
    ..Interactions between genetic and environmental factors have been associated with decrease in circulating adiponectin leading to obesity...
  31. ncbi Human gene mutations. Gene symbol: SLC7A9. Disease: cystinuria
    Eirini Louizou
    Harokopio University, Department of Science Dietetics Nutrition, El Venizelou, 70, 17671, Athens, Greece
    Hum Genet 122:214. 2007
  32. ncbi Human gene mutations. Gene symbol: SLC7A9. Disease: cystinuria
    Eirini Louizou
    Harokopio University, Department of Science Dietetics Nutrition, El Venizelou, 70, 17671, Athens, Greece
    Hum Genet 122:214. 2007
  33. ncbi Dietary antioxidants in preventing atherogenesis
    A C Kaliora
    Department of Science of Dietetics Nutrition, Harokopio University of Athens, Greece
    Atherosclerosis 187:1-17. 2006
    ....
  34. doi Mineral intake
    Maria G Stathopoulou
    Department of Dietetics and Nutritional Science, Harokopio University of Athens, Athens, Greece
    Prog Mol Biol Transl Sci 108:201-36. 2012
    ..Also, these elements are associated with genetic diseases and are known to interact with genetic variants in a wide range of diseases...
  35. ncbi Molecular characterization of familial hypercholesterolemia in German and Greek patients
    George V Z Dedoussis
    Department of Science Dietetics Nutrition, Harokopio University of Athens, Greece
    Hum Mutat 23:285-6. 2004
    ..Further studies in progress are trying to elucidate the responsiveness to drug therapy in association with LDLR genotype and the nutritional habits of the two FH populations...
  36. ncbi Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia
    Despoina M Choumerianou
    Laboratory of Molecular Biology, Department of Science of Dietetics Nutrition, Harokopio University of Athens, Athens, Greece
    Clin Chem Lab Med 44:799-806. 2006
    ..The clinical expression of FH is highly variable, even in patients carrying the same LDL receptor (LDLR) gene mutation. This variability may be due to environmental and other genetic factors...
  37. ncbi An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease
    George V Z Dedoussis
    Department of Dietetics and Nutrition, Harokopio University, 46 Paleon Polemiston St Glyfada, Attica 166 74, Athens, Greece
    Int J Cardiol 100:409-14. 2005
    ..In this work, we evaluated the relationship between the levels of inflammation markers and MTHFR genotype among cardiovascular disease free subjects of the ATTICA study...
  38. ncbi Familial hypercholesterolemia and response to statin therapy according to LDLR genetic background
    Despoina M Choumerianou
    Department of Science of Dietetics Nutrition, Harokopio University of Athens, Greece
    Clin Chem Lab Med 43:793-801. 2005
    ....
  39. ncbi Management of a patient with a null low-density lipoprotein receptor mutation: a case report
    Genovefa D Kolovou
    1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
    Angiology 57:729-32. 2006
    ..Furthermore, the coadministration of statins, cholestyramine, and ezetimibe during low-density lipoprotein-apheresis tends to counterbalance the postapheresis relapse in low-density lipoprotein cholesterol levels...
  40. ncbi Chios mastic treatment of patients with active Crohn's disease
    Andriana C Kaliora
    Department of Science of Dietetics Nutrition, Harokopio University of Athens, 70 El Venizelou Ave, Kallithea 17671, Athens, Greece
    World J Gastroenterol 13:748-53. 2007
    ..To evaluate the effectiveness of mastic administration on the clinical course and plasma inflammatory mediators of patients with active Crohn's disease (CD)...
  41. ncbi Natural antioxidant compounds in risk factors for CVD
    Andriana C Kaliora
    Department of Science of Dietetics Nutrition, Harokopio University of Athens, 70 El Venizelou Ave, 17671 Athens, Greece
    Pharmacol Res 56:99-109. 2007
    ..Although their clinical use not always translates into clinical benefit, data are motivating. In the future, these agents may be very important complementary treatment options for subjects with high risk for CVD...
  42. ncbi Deterioration of natural antioxidant species of vegetable edible oils during the domestic deep-frying and pan-frying of potatoes
    Nikolaos K Andrikopoulos
    Laboratory of Food Chemistry Biochemistry Physical Chemistry, Department of Science of Dietetics Nutrition, Harokopio University, 70 El Venizelou Avenue, 176 71 Kallithea, Athens, Greece
    Int J Food Sci Nutr 53:351-63. 2002
    ..The correlation of the deterioration rate of the phenolic compounds and tocopherols during frying is discussed and the nutritional aspects of the natural antioxidant intake, through the oil absorbed by the potatoes, are evaluated...
  43. ncbi Effect of phenols on natural killer (NK) cell-mediated death in the K562 human leukemic cell line
    George V Z Dedoussis
    Department of Science of Dietetics Nutrition, Harokopio University, 70 El Venizelou Street, 17671 Kallithea, Athens, Greece
    Cell Biol Int 29:884-9. 2005
    ..Gallic acid and rutin exert anticarcinogenic activity via the enhancement of K562 cell susceptibility to NK cell-mediated necrosis and apoptosis, respectively...
  44. ncbi LDL-receptor mutations in Europe
    George V Z Dedoussis
    Department of Science Dietetics Nutrition, Harokopio University of Athens, Athens, Greece
    Hum Mutat 24:443-59. 2004
    ..Herein, we focus on the published European LDLR mutation data that reflect its heterogeneity and phenotypic penetrance...