Maria Xilouri

Summary

Affiliation: Foundation for Biomedical Research
Country: Greece

Publications

  1. doi request reprint Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Brain 136:2130-46. 2013
  2. doi request reprint α-Synuclein and protein degradation systems: a reciprocal relationship
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, 4 Soranou Efesiou Street, Athens 11527, Greece
    Mol Neurobiol 47:537-51. 2013
  3. doi request reprint Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Hum Mol Genet 21:874-89. 2012
  4. ncbi request reprint Autophagy in the central nervous system: implications for neurodegenerative disorders
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of Academy of Athens BRFAA 4, Soranou Efesiou Street, Athens 11527, Greece
    CNS Neurol Disord Drug Targets 9:701-19. 2010
  5. doi request reprint Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    Kostas Vekrellis
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou, Athens, Greece
    J Neurochem 109:1348-62. 2009
  6. doi request reprint Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    Katerina Melachroinou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurobiol Aging 34:2853-65. 2013
  7. pmc Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 4:e5515. 2009
  8. ncbi request reprint alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Autophagy 4:917-9. 2008
  9. pmc Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells
    Georgia Dermentzaki
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 8:e60674. 2013
  10. pmc Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008

Collaborators

Detail Information

Publications13

  1. doi request reprint Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Brain 136:2130-46. 2013
    ....
  2. doi request reprint α-Synuclein and protein degradation systems: a reciprocal relationship
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, 4 Soranou Efesiou Street, Athens 11527, Greece
    Mol Neurobiol 47:537-51. 2013
    ..Identifying the factors that regulate alpha-synuclein association to cellular proteolytic pathways may represent potential targets for therapeutic interventions in PD and related synucleinopathies...
  3. doi request reprint Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Hum Mol Genet 21:874-89. 2012
    ....
  4. ncbi request reprint Autophagy in the central nervous system: implications for neurodegenerative disorders
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of Academy of Athens BRFAA 4, Soranou Efesiou Street, Athens 11527, Greece
    CNS Neurol Disord Drug Targets 9:701-19. 2010
    ..In this review we summarize the current knowledge regarding the role of autophagy-lysosomal pathway in the central nervous system and discuss the implication of autophagy dysregulation in human neurological diseases and animal models...
  5. doi request reprint Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    Kostas Vekrellis
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou, Athens, Greece
    J Neurochem 109:1348-62. 2009
    ..This novel inducible cell model system may prove valuable in the deciphering of WT ASYN-induced pathogenic effects and in the assessment and screening of potential therapeutic strategies...
  6. doi request reprint Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    Katerina Melachroinou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurobiol Aging 34:2853-65. 2013
    ..Therefore, manipulating Ca2+ signaling pathways might represent a potential therapeutic strategy for Parkinson's disease...
  7. pmc Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 4:e5515. 2009
    ..We have investigated presently the effects of WT or mutant ASYN on the lysosomal pathways of CMA and macroautophagy in neuronal cells and assessed their impact on ASYN-mediated toxicity...
  8. ncbi request reprint alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Autophagy 4:917-9. 2008
    ..It is hypothesized that impairment of either of these two pathways, or of more general lysosomal function, may be an initiating factor in alpha-synuclein accumulation and sporadic PD pathogenesis...
  9. pmc Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells
    Georgia Dermentzaki
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 8:e60674. 2013
    ..We further observed no significant impairment of the lysosomal degradation machinery. These findings suggest that additional interaction pathways together with aberrant GCase and ASYN must govern this complex relation between GD and PD...
  10. pmc Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008
    ..These results indicate that CMA and macroautophagy are important pathways for WT ASYN degradation in neurons and underline the importance of CMA as degradation machinery in the nervous system...
  11. doi request reprint Pathological roles of α-synuclein in neurological disorders
    Kostas Vekrellis
    Biomedical Research Foundation of Academy of Athens, Athens, Greece
    Lancet Neurol 10:1015-25. 2011
    ..Consequently, factors that regulate the levels, post-translational modifications, specific aberrant cellular effects, or secretion of α-synuclein might be targets for therapy...
  12. doi request reprint Autophagic pathways in Parkinson disease and related disorders
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Expert Rev Mol Med 13:e8. 2011
    ..This wealth of new data suggests that both autophagic pathways are potential targets for therapeutic intervention in PD and other related neurodegenerative conditions...
  13. ncbi request reprint Induction of Akt by endogenous neurosteroids and calcium sequestration in P19 derived neurons
    Maria Xilouri
    Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimiopolis, 15784, Athens, Greece
    Neurotox Res 13:209-19. 2008
    ..These results suggest that neurosteroids are able to act as survival factors on P19-N neurons, promoting the activation of the PI3-K/Akt pathway through a calcium-entry dependent mechanism...