Kostas Vekrellis

Summary

Affiliation: Foundation for Biomedical Research
Country: Greece

Publications

  1. ncbi Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    Kostas Vekrellis
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou, Athens, Greece
    J Neurochem 109:1348-62. 2009
  2. ncbi Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurosci 30:6838-51. 2010
  3. ncbi Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Neurobiol Aging 31:953-68. 2010
  4. ncbi Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 4:e5515. 2009
  5. ncbi alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Autophagy 4:917-9. 2008
  6. ncbi Pathological roles of α-synuclein in neurological disorders
    Kostas Vekrellis
    Biomedical Research Foundation of Academy of Athens, Athens, Greece
    Lancet Neurol 10:1015-25. 2011
  7. ncbi Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies
    Kostas Vekrellis
    Center for Neurosciences, Biomedical Research Foundation of the Academy of Athens, Greece
    Expert Opin Ther Targets 16:421-32. 2012
  8. ncbi Assessment of α-synuclein secretion in mouse and human brain parenchyma
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 6:e22225. 2011
  9. ncbi Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging
    Assimina Argyriou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurosci Lett 528:205-9. 2012
  10. ncbi Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008

Collaborators

  • Maria Xilouri
  • Spiros D Garbis
  • Evangelia Emmanouilidou
  • Leonidas Stefanis
  • Assimina Argyriou
  • Tereza Vogiatzi
  • Georgia Dermentzaki
  • Eleftherios Stamboulis
  • Themistoklis Papasilekas
  • Marina Moraitou
  • Helen Michelakakis
  • Themis Papasilekas
  • Georgios Stranjalis
  • Dimitris Elenis
  • Kyriaki Gerozissis
  • Penelopi C Ioannou
  • Katerina Melachroinou
  • Maria Ntzouni
  • Theodoros Roumeliotis
  • Lukas H Margaritis

Detail Information

Publications10

  1. ncbi Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    Kostas Vekrellis
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou, Athens, Greece
    J Neurochem 109:1348-62. 2009
    ..This novel inducible cell model system may prove valuable in the deciphering of WT ASYN-induced pathogenic effects and in the assessment and screening of potential therapeutic strategies...
  2. ncbi Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurosci 30:6838-51. 2010
    ....
  3. ncbi Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Neurobiol Aging 31:953-68. 2010
    ....
  4. ncbi Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 4:e5515. 2009
    ..We have investigated presently the effects of WT or mutant ASYN on the lysosomal pathways of CMA and macroautophagy in neuronal cells and assessed their impact on ASYN-mediated toxicity...
  5. ncbi alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Autophagy 4:917-9. 2008
    ..It is hypothesized that impairment of either of these two pathways, or of more general lysosomal function, may be an initiating factor in alpha-synuclein accumulation and sporadic PD pathogenesis...
  6. ncbi Pathological roles of α-synuclein in neurological disorders
    Kostas Vekrellis
    Biomedical Research Foundation of Academy of Athens, Athens, Greece
    Lancet Neurol 10:1015-25. 2011
    ..Consequently, factors that regulate the levels, post-translational modifications, specific aberrant cellular effects, or secretion of α-synuclein might be targets for therapy...
  7. ncbi Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies
    Kostas Vekrellis
    Center for Neurosciences, Biomedical Research Foundation of the Academy of Athens, Greece
    Expert Opin Ther Targets 16:421-32. 2012
    ....
  8. ncbi Assessment of α-synuclein secretion in mouse and human brain parenchyma
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 6:e22225. 2011
    ..Our data suggest that α-synuclein is physiologically secreted by neurons in vivo. This interstitial fluid pool of the protein may have a role in the propagation of synuclein pathology and progression of Parkinson's disease...
  9. ncbi Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging
    Assimina Argyriou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurosci Lett 528:205-9. 2012
    ..Therefore, two major risk factors for PD, aging and GD status, are associated with an increased AS dimer to monomer ratio in erythrocytes. This ratio needs to be validated in further studies as a potential biomarker for PD risk...
  10. ncbi Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008
    ..These results indicate that CMA and macroautophagy are important pathways for WT ASYN degradation in neurons and underline the importance of CMA as degradation machinery in the nervous system...