Kostas Vekrellis

Summary

Affiliation: Foundation for Biomedical Research
Country: Greece

Publications

  1. pmc Assessment of α-synuclein secretion in mouse and human brain parenchyma
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 6:e22225. 2011
  2. doi request reprint Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    Kostas Vekrellis
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou, Athens, Greece
    J Neurochem 109:1348-62. 2009
  3. pmc Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurosci 30:6838-51. 2010
  4. doi request reprint Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    Katerina Melachroinou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurobiol Aging 34:2853-65. 2013
  5. doi request reprint Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Neurobiol Aging 31:953-68. 2010
  6. pmc Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 4:e5515. 2009
  7. ncbi request reprint alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Autophagy 4:917-9. 2008
  8. doi request reprint Pathological roles of α-synuclein in neurological disorders
    Kostas Vekrellis
    Biomedical Research Foundation of Academy of Athens, Athens, Greece
    Lancet Neurol 10:1015-25. 2011
  9. pmc Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008
  10. doi request reprint Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies
    Kostas Vekrellis
    Center for Neurosciences, Biomedical Research Foundation of the Academy of Athens, Greece
    Expert Opin Ther Targets 16:421-32. 2012

Collaborators

Detail Information

Publications12

  1. pmc Assessment of α-synuclein secretion in mouse and human brain parenchyma
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 6:e22225. 2011
    ..Our data suggest that α-synuclein is physiologically secreted by neurons in vivo. This interstitial fluid pool of the protein may have a role in the propagation of synuclein pathology and progression of Parkinson's disease...
  2. doi request reprint Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    Kostas Vekrellis
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou, Athens, Greece
    J Neurochem 109:1348-62. 2009
    ..This novel inducible cell model system may prove valuable in the deciphering of WT ASYN-induced pathogenic effects and in the assessment and screening of potential therapeutic strategies...
  3. pmc Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurosci 30:6838-51. 2010
    ....
  4. doi request reprint Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    Katerina Melachroinou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurobiol Aging 34:2853-65. 2013
    ..Therefore, manipulating Ca2+ signaling pathways might represent a potential therapeutic strategy for Parkinson's disease...
  5. doi request reprint Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Neurobiol Aging 31:953-68. 2010
    ....
  6. pmc Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 4:e5515. 2009
    ..We have investigated presently the effects of WT or mutant ASYN on the lysosomal pathways of CMA and macroautophagy in neuronal cells and assessed their impact on ASYN-mediated toxicity...
  7. ncbi request reprint alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Autophagy 4:917-9. 2008
    ..It is hypothesized that impairment of either of these two pathways, or of more general lysosomal function, may be an initiating factor in alpha-synuclein accumulation and sporadic PD pathogenesis...
  8. doi request reprint Pathological roles of α-synuclein in neurological disorders
    Kostas Vekrellis
    Biomedical Research Foundation of Academy of Athens, Athens, Greece
    Lancet Neurol 10:1015-25. 2011
    ..Consequently, factors that regulate the levels, post-translational modifications, specific aberrant cellular effects, or secretion of α-synuclein might be targets for therapy...
  9. pmc Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008
    ..These results indicate that CMA and macroautophagy are important pathways for WT ASYN degradation in neurons and underline the importance of CMA as degradation machinery in the nervous system...
  10. doi request reprint Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies
    Kostas Vekrellis
    Center for Neurosciences, Biomedical Research Foundation of the Academy of Athens, Greece
    Expert Opin Ther Targets 16:421-32. 2012
    ..Synuclein can also be secreted and can thus affect neuronal and glial function. Propagation of α-Synuclein pathology via neuron-to-neuron transmission and seeding may also contribute to Parkinson's disease pathogenesis...
  11. doi request reprint Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging
    Assimina Argyriou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurosci Lett 528:205-9. 2012
    ..Therefore, two major risk factors for PD, aging and GD status, are associated with an increased AS dimer to monomer ratio in erythrocytes. This ratio needs to be validated in further studies as a potential biomarker for PD risk...
  12. pmc The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease
    Elisabeth Kapaki
    National and Kapodistrian University of Athens, School of Medicine, 1st Department of Neurology, Eginition Hospital, Athens, Greece
    PLoS ONE 8:e81654. 2013
    ..8% specific for the discrimination of DLB vs. CTRL and 90% vs. AD. However, sensitivity was lower (56.2 % and 50% respectively). These findings provide evidence for a possible diagnostic role of α-syn as a surrogate biomarker for DLB...