Leonidas Stefanis

Summary

Affiliation: Foundation for Biomedical Research
Country: Greece

Publications

  1. pmc α-Synuclein in Parkinson's disease
    Leonidas Stefanis
    Laboratory of Neurodegenerative Diseases, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Athens 11527, Greece
    Cold Spring Harb Perspect Med 2:a009399. 2012
  2. doi Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Brain 136:2130-46. 2013
  3. doi Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    Katerina Melachroinou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurobiol Aging 34:2853-65. 2013
  4. pmc Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells
    Georgia Dermentzaki
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 8:e60674. 2013
  5. doi Decreased levels of alpha-synuclein in cerebrospinal fluid of patients with clinically isolated syndrome and multiple sclerosis
    Roubina Ch Antonelou
    Second Department of Neurology, Hospital Attikon, University of Athens Medical School, Haidari, Greece
    J Neurochem 134:748-55. 2015
  6. doi α-Synuclein and protein degradation systems: a reciprocal relationship
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, 4 Soranou Efesiou Street, Athens 11527, Greece
    Mol Neurobiol 47:537-51. 2013
  7. doi Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Hum Mol Genet 21:874-89. 2012

Collaborators

Detail Information

Publications7

  1. pmc α-Synuclein in Parkinson's disease
    Leonidas Stefanis
    Laboratory of Neurodegenerative Diseases, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Athens 11527, Greece
    Cold Spring Harb Perspect Med 2:a009399. 2012
    ....
  2. doi Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Brain 136:2130-46. 2013
    ....
  3. doi Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    Katerina Melachroinou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neurobiol Aging 34:2853-65. 2013
    ..Therefore, manipulating Ca2+ signaling pathways might represent a potential therapeutic strategy for Parkinson's disease...
  4. pmc Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells
    Georgia Dermentzaki
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS ONE 8:e60674. 2013
    ..We further observed no significant impairment of the lysosomal degradation machinery. These findings suggest that additional interaction pathways together with aberrant GCase and ASYN must govern this complex relation between GD and PD...
  5. doi Decreased levels of alpha-synuclein in cerebrospinal fluid of patients with clinically isolated syndrome and multiple sclerosis
    Roubina Ch Antonelou
    Second Department of Neurology, Hospital Attikon, University of Athens Medical School, Haidari, Greece
    J Neurochem 134:748-55. 2015
    ..We find a similar magnitude of decreased alpha-synuclein compared to a control group in all such MS spectrum conditions; such a decrease may reflect an underlying early neurodegenerative disease process...
  6. doi α-Synuclein and protein degradation systems: a reciprocal relationship
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens BRFAA, 4 Soranou Efesiou Street, Athens 11527, Greece
    Mol Neurobiol 47:537-51. 2013
    ..Identifying the factors that regulate alpha-synuclein association to cellular proteolytic pathways may represent potential targets for therapeutic interventions in PD and related synucleinopathies...
  7. doi Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
    Maria Xilouri
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Hum Mol Genet 21:874-89. 2012
    ....