Maria G Roubelakis

Summary

Affiliation: Foundation for Biomedical Research
Country: Greece

Publications

  1. ncbi request reprint The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation
    Maria G Roubelakis
    Stem Cell Research Laboratory, National Blood Service, NHS Blood and Transplant Authority, Oxford OX3 5BG, UK
    J Cell Biochem 102:955-69. 2007
  2. pmc Human microRNA target analysis and gene ontology clustering by GOmir, a novel stand-alone application
    Maria G Roubelakis
    Cell and Gene Therapy Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, 11527, Athens, Greece
    BMC Bioinformatics 10:S20. 2009
  3. doi request reprint In vitro and in vivo properties of distinct populations of amniotic fluid mesenchymal progenitor cells
    Maria G Roubelakis
    Cell and Gene Therapy Laboratory, Centre of Basic Research, Biomedical Research Foundation, Academy of Athens BRFAA, Athens, Greece
    J Cell Mol Med 15:1896-913. 2011
  4. doi request reprint Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer
    Vasiliki Bitsika
    Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Stem Cells Dev 21:1097-111. 2012
  5. doi request reprint Therapeutic potential of a distinct population of human amniotic fluid mesenchymal stem cells and their secreted molecules in mice with acute hepatic failure
    Dimitra S Zagoura
    Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Gut 61:894-906. 2012
  6. ncbi request reprint Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells
    Maria G Roubelakis
    Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens BRF, Athens, Greece
    Stem Cells Dev 16:931-52. 2007
  7. doi request reprint Analysis of secreted proteins for the study of bladder cancer cell aggressiveness
    Manousos Makridakis
    Biotechnology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    J Proteome Res 9:3243-59. 2010
  8. doi request reprint Chromosomal and proteome analysis of a new T24-based cell line model for aggressive bladder cancer
    Manousos Makridakis
    Biotechnology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Proteomics 9:287-98. 2009
  9. doi request reprint Sox2 Suppression by miR-21 Governs Human Mesenchymal Stem Cell Properties
    Ourania Trohatou
    Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece Cell and Gene Therapy Laboratory, Center of Basic Research II, and Biotechnology Laboratory, Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece First Department of Obstetrics and Gynecology, School of Medicine, University of Athens, Athens, Greece
    Stem Cells Transl Med 3:54-68. 2014
  10. pmc Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization
    Maria G Roubelakis
    Laboratory of Biology, University of Athens, Medical School and Cell and Gene Therapy Laboratory, Centre of Basic Research, Biomedical Research Foundation, Academy of Athens BRFAA, Athens, Greece
    PLoS ONE 8:e54747. 2013

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation
    Maria G Roubelakis
    Stem Cell Research Laboratory, National Blood Service, NHS Blood and Transplant Authority, Oxford OX3 5BG, UK
    J Cell Biochem 102:955-69. 2007
    ..These studies thus provide the basis for defining the function of the mPZR isoforms in vivo, particularly with respect to their roles in regulating SHP-2-dependent cell migration during development...
  2. pmc Human microRNA target analysis and gene ontology clustering by GOmir, a novel stand-alone application
    Maria G Roubelakis
    Cell and Gene Therapy Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, 11527, Athens, Greece
    BMC Bioinformatics 10:S20. 2009
    ..Predicting or verifying mRNA targets of specific miRNAs is a difficult process of great importance...
  3. doi request reprint In vitro and in vivo properties of distinct populations of amniotic fluid mesenchymal progenitor cells
    Maria G Roubelakis
    Cell and Gene Therapy Laboratory, Centre of Basic Research, Biomedical Research Foundation, Academy of Athens BRFAA, Athens, Greece
    J Cell Mol Med 15:1896-913. 2011
    ..In addition, SS-AF-MPCs, isolated based on their colony morphology and CD90 expression, represented the only MPC population that can be expanded easily in culture and used as an efficient tool for future in vivo therapeutic applications...
  4. doi request reprint Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer
    Vasiliki Bitsika
    Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Stem Cells Dev 21:1097-111. 2012
    ..Collectively, these results document the great potential of AF-MSCs as anti-cancer vehicles, implemented by the targeting of the tumor site and further facilitated by their high proliferation rate and expansion efficiency in culture...
  5. doi request reprint Therapeutic potential of a distinct population of human amniotic fluid mesenchymal stem cells and their secreted molecules in mice with acute hepatic failure
    Dimitra S Zagoura
    Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Gut 61:894-906. 2012
    ..In previous studies, a distinct population termed human spindle-shaped MSCs were isolated and expanded from second trimester amniotic fluid (AF-MSCs) and characterised based on their phenotype, pluripotency and differentiation potential...
  6. ncbi request reprint Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells
    Maria G Roubelakis
    Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens BRF, Athens, Greece
    Stem Cells Dev 16:931-52. 2007
    ..Considering the easy access to this new cell source and the yield of expanded MSCs for stem cell research, AF may provide an excellent source of MSCs both for basic research and for potential therapeutic applications...
  7. doi request reprint Analysis of secreted proteins for the study of bladder cancer cell aggressiveness
    Manousos Makridakis
    Biotechnology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    J Proteome Res 9:3243-59. 2010
    ..The results indicate various secreted proteins with potential involvement in bladder cancer cell aggressiveness and more specifically provide initial evidence for special role of SPARC in bladder cancer cell motility and invasiveness...
  8. doi request reprint Chromosomal and proteome analysis of a new T24-based cell line model for aggressive bladder cancer
    Manousos Makridakis
    Biotechnology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Proteomics 9:287-98. 2009
    ..Collectively, our results suggest that the T24M cells reflect many known chromosomal and proteomic aberrations encountered in aggressive bladder cancers but also provide access to novel findings with potentially clinical applications...
  9. doi request reprint Sox2 Suppression by miR-21 Governs Human Mesenchymal Stem Cell Properties
    Ourania Trohatou
    Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece Cell and Gene Therapy Laboratory, Center of Basic Research II, and Biotechnology Laboratory, Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece First Department of Obstetrics and Gynecology, School of Medicine, University of Athens, Athens, Greece
    Stem Cells Transl Med 3:54-68. 2014
    ..Therefore, these findings suggest that miR-21 might specifically function by regulating Sox2 expression in human MSCs and might also act as a key molecule determining MSC proliferation and differentiation. ..
  10. pmc Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization
    Maria G Roubelakis
    Laboratory of Biology, University of Athens, Medical School and Cell and Gene Therapy Laboratory, Centre of Basic Research, Biomedical Research Foundation, Academy of Athens BRFAA, Athens, Greece
    PLoS ONE 8:e54747. 2013
    ....
  11. doi request reprint A novel function for the haemopoietic supportive murine bone marrow MS-5 mesenchymal stromal cell line in promoting human vasculogenesis and angiogenesis
    Bob Zhou
    Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Haematol 157:299-311. 2012
    ..Thus, the clonal nestin(+) MS-5 murine bone marrow stromal cell line not only promotes human haemopoiesis but also induces human vasculogenesis, with CXCL12 playing important roles in both processes...
  12. pmc Profilin 1 is a potential biomarker for bladder cancer aggressiveness
    Jérôme Zoidakis
    Biotechnology Division, Biomedical Research Foundation, Academy of Athens, Greece
    Mol Cell Proteomics 11:M111.009449. 2012
    ....
  13. ncbi request reprint Human amniotic fluid stem cells as an attractive tool for clinical applications
    Ourania Trohatou
    Laboratory of Biology, University of Athens, School of Medicine, Athens, Greece
    Curr Stem Cell Res Ther 8:125-32. 2013
    ..The major aim of this review is to summarize the advent of hAFSCs capabilities into novel therapeutic modalities and discuss their potential use in future pre-clinical and clinical studies...
  14. ncbi request reprint Fetal mesenchymal stem cells in cancer therapy
    Vasiliki Bitsika
    Biotechnology Laboratory, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens BRFAA, Athens, Greece
    Curr Stem Cell Res Ther 8:133-43. 2013
    ..This review summarizes various approaches where the tumor-homing capacity of fetal MSCs has been employed for the localized delivery of anti-tumor therapeutic agents...
  15. doi request reprint OCT4 spliced variant OCT4B1 is expressed in human colorectal cancer
    Maria Gazouli
    Laboratory of Biology, Department of Basic Medical Sciences, University of Athens School of Medicine and Cell and Gene Therapy Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Mol Carcinog 51:165-73. 2012
    ..Over-expression of OCT4B1 was found in poorly and moderately differentiated CRC tissues. In conclusion, the data imply that OCT4B1 isoform may represent a potential biomarker for the initiation, progression, and differentiation of CRC...
  16. pmc Amniotic fluid and amniotic membrane stem cells: marker discovery
    Maria G Roubelakis
    Laboratory of Biology, University of Athens School of Medicine, 115 27 Athens, Greece
    Stem Cells Int 2012:107836. 2012
    ..In this paper, we aim to summarize the recent progress in marker discovery for stem cells derived from fetal sources such as AF and AM, using novel methodologies based on transcriptomics, proteomics, or secretome analyses...
  17. pmc Antiviral Stratagems Against HIV-1 Using RNA Interference (RNAi) Technology
    Dimitrios Vlachakis
    Bioinformatics and Medical Informatics Team, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Evol Bioinform Online 9:203-13. 2013
    ....