Alexandra Giatromanolaki

Summary

Affiliation: Democritus University of Thrace
Country: Greece

Publications

  1. pmc Pulmonary mucus gland adenomas: are they always of endobronchial localization?
    Georgia Karpathiou
    Department of Pathology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    Case Rep Pathol 2013:239173. 2013
  2. doi request reprint Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece Electronic address
    Urol Oncol 32:39.e11-8. 2014
  3. pmc Acute appendicitis in preschoolers: a study of two different populations of children
    Stefanos Gardikis
    Department of Pediatric Surgery, Alexandoupolis University Hospital, Democritus University of Thrace School of Medicine, Alexandroupolis 68100, Greece
    Ital J Pediatr 37:35. 2011
  4. doi request reprint Autophagy and hypoxia in colonic adenomas related to aggressive features
    A Giatromanolaki
    Department of Pathology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Colorectal Dis 15:e223-30. 2013
  5. doi request reprint Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, University General Hospital of Alexandroupolis, Alexandroupolis 68100, Greece
    Hematol Oncol Stem Cell Ther 6:20-5. 2013
  6. doi request reprint High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Gynecol Oncol 123:147-51. 2011
  7. doi request reprint Autophagy patterns and prognosis in uveal melanomas
    Alexandra N Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Mod Pathol 24:1036-45. 2011
  8. ncbi request reprint The CD44+/CD24- phenotype relates to 'triple-negative' state and unfavorable prognosis in breast cancer patients
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Med Oncol 28:745-52. 2011
  9. doi request reprint Phosphorylated pVEGFR2/KDR receptor expression in uveal melanomas: relation with HIF2α and survival
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Clin Exp Metastasis 29:11-7. 2012
  10. ncbi request reprint c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
    Alexandra Giatromanolaki
    Department of Pathology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 10:7972-7. 2004

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. pmc Pulmonary mucus gland adenomas: are they always of endobronchial localization?
    Georgia Karpathiou
    Department of Pathology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    Case Rep Pathol 2013:239173. 2013
    ..We report a TTF-1 negative mucus gland adenoma, arising into the medial bronchopulmonary segment, lacking any relation to a bronchus...
  2. doi request reprint Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece Electronic address
    Urol Oncol 32:39.e11-8. 2014
    ..Up-regulation of autophagy provides an important survival mechanism to normal and malignant cells residing in a hypoxic and unfavorable nutritional environment. Yet, its role in the biology of prostate cancer remains poorly understood...
  3. pmc Acute appendicitis in preschoolers: a study of two different populations of children
    Stefanos Gardikis
    Department of Pediatric Surgery, Alexandoupolis University Hospital, Democritus University of Thrace School of Medicine, Alexandroupolis 68100, Greece
    Ital J Pediatr 37:35. 2011
    ..To assess the incidence and the risk factors implicated in acute appendicitis in preschoolers in our region...
  4. doi request reprint Autophagy and hypoxia in colonic adenomas related to aggressive features
    A Giatromanolaki
    Department of Pathology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Colorectal Dis 15:e223-30. 2013
    ..The study investigated whether autophagic activity and hypoxia parallel the adenoma-carcinoma sequence...
  5. doi request reprint Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, University General Hospital of Alexandroupolis, Alexandroupolis 68100, Greece
    Hematol Oncol Stem Cell Ther 6:20-5. 2013
    ..Autophagy is a self-degradation mechanism induced under stress conditions in all eukaryotic cells. Its activity in human lymphomas has not been studied as yet...
  6. doi request reprint High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Gynecol Oncol 123:147-51. 2011
    ....
  7. doi request reprint Autophagy patterns and prognosis in uveal melanomas
    Alexandra N Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Mod Pathol 24:1036-45. 2011
    ..There is a strong association between extensive BECN1 overexpression and early metastases/poor prognosis, and between underexpression of this protein and late metastases/better prognosis...
  8. ncbi request reprint The CD44+/CD24- phenotype relates to 'triple-negative' state and unfavorable prognosis in breast cancer patients
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Med Oncol 28:745-52. 2011
    ..The strong association between the CD44(-)/CD24(-) phenotype and prognosis requires further investigation...
  9. doi request reprint Phosphorylated pVEGFR2/KDR receptor expression in uveal melanomas: relation with HIF2α and survival
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Clin Exp Metastasis 29:11-7. 2012
    ..As pVEGFR2/KDR expression was significantly related with poor prognosis, inhibitors of this receptor may improve the clinical outcome of patients with pVEGFR2/KDR overexpressing uveal melanomas...
  10. ncbi request reprint c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
    Alexandra Giatromanolaki
    Department of Pathology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 10:7972-7. 2004
    ....
  11. ncbi request reprint Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer Sci 97:582-8. 2006
    ..Identification of specific patterns of the hypoxia molecular cascade activated in cancer cells might help in developing specific therapeutic policies...
  12. doi request reprint Bevacizumab, capecitabine, amifostine, and preoperative hypofractionated accelerated radiotherapy (HypoArc) for rectal cancer: a Phase II study
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 80:492-8. 2011
    ..We assessed the feasibility and efficacy of preoperative radiochemotherapy combined with bevacizumab in patients with rectal cancer...
  13. ncbi request reprint Hypoxia inducible factor (HIf1alpha and HIF2alpha) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Int J Radiat Biol 84:47-52. 2008
    ..We investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and carbonic anhydrase CA9) in HNC resistance to accelerated and hypofractionated radiotherapy...
  14. ncbi request reprint DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer
    Alexandra Giatromanolaki
    Departments of Pathology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    J Pathol 200:222-8. 2003
    ..It is suggested that loss of DEC1 expression is an early event in the development of lung cancer, while DEC1 gene expression occurs in a subset of tumours and parallels the overexpression of other hypoxia-regulated proteins...
  15. doi request reprint Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Leuk Lymphoma 49:2181-6. 2008
    ..It is concluded that LDH5 is highly upregulated in B-cell non-Hodgkin lymphomas and is in direct relation to HIFs expression. LDH5 expression is linked with activated VEGFR2/KDR expression in both lymphoid lesions...
  16. pmc Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Arthritis Res Ther 5:R193-201. 2003
    ..The activation of the HIF-alpha pathway occurs in both RA and OA, although for unrelated reasons...
  17. ncbi request reprint Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer 95:1055-63. 2002
    ....
  18. ncbi request reprint Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
    Alexandra Giatromanolaki
    Departments of Pathology, Dermatology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Melanoma Res 13:493-501. 2003
    ..HIF2alpha, VEGF and, to a lesser extent, VD are important prognostic factors in these cutaneous tumours...
  19. ncbi request reprint Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace Medical School, 68100 Alexandroupolis, Greece
    Clin Exp Metastasis 22:25-30. 2005
    ..It is concluded that a high LDH5 content in tumor cells is directly related to an up-regulated HIF pathway and is linked with an aggressive phenotype in colorectal adenocarcinomas...
  20. ncbi request reprint Intramyocardial injection of low-dose basic fibroblast growth factor or vascular endothelial growth factor induces angiogenesis in the infarcted rabbit myocardium
    Ioannis Bougioukas
    Department of Cardiothoracic Surgery, School of Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68 100 Alexandroupolis, Greece
    Cardiovasc Pathol 16:63-8. 2007
    ....
  21. ncbi request reprint The effect of trastuzumab/docatexel combination on breast cancer angiogenesis: dichotomus effect predictable by the HIFI alpha/VEGF pre-treatment status?
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Surgery and Pathology, Democritus University of Thrace, Medical School, Alexandroupolis 68100, Greece
    Anticancer Res 23:1673-80. 2003
    ..Adjustment of the chemotherapy regimen accordingly would prove of clinical importance...
  22. ncbi request reprint Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 59:67-71. 2004
    ..Furthermore, the ability of tumors to upregulate hypoxia-regulated molecular pathways may affect radiosensitivity by mechanisms independent of the traditional concept of "oxygen effect."..
  23. ncbi request reprint Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients
    Michael I Koukourakis
    Department of Radiotherapy, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Cancer Res 63:5376-80. 2003
    ....
  24. ncbi request reprint Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, PO Box 12, Alexandroupolis 68100, Greece
    Cancer Res 66:632-7. 2006
    ..Tumors survive and grow because they are capable of organizing the regional fibroblasts and endothelial cells into a harmoniously collaborating metabolic domain...
  25. ncbi request reprint Oxygen and glucose consumption in gastrointestinal adenocarcinomas: correlation with markers of hypoxia, acidity and anaerobic glycolysis
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace Medical School, Dragana, Alexandroupolis, Greece
    Cancer Sci 97:1056-60. 2006
    ..These in vivo data confirm the importance of HIFs and their downstream regulated genes in tumor metabolism, particularly in glycolysis and carbon dioxide buffering...
  26. doi request reprint c-erbB-2 and the "triple-state" in early breast carcinomas
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, P O Box 12, Alexandroupolis, 68100, Greece
    Med Oncol 27:578-84. 2010
    ..Elucidation of these pathways may determine subgroups of patients with tumors requiring different targeted agents...
  27. ncbi request reprint The angiogenetic effect of intramuscular administration of b-FGF and a-FGF on cardiac muscle: the influence of exercise on muscle angiogenesis
    Anna Efthimiadou
    Departments of Physiology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    J Sports Sci 24:849-54. 2006
    ..In conclusion, both the intramuscular administration of b-FGF and exercise increased significantly angiogenesis in the heart in contrast to the intramuscular administration of a-FGF, which was ineffective...
  28. doi request reprint Postmastectomy hypofractionated and accelerated radiation therapy with (and without) subcutaneous amifostine cytoprotection
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 85:e7-13. 2013
    ..More aggressive radiation therapy schemes may, however, be necessary in specific subgroups, provided they are safely administered. We report the tolerance and efficacy of a highly accelerated and hypofractionated regimen (HypoARC)...
  29. ncbi request reprint Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group
    Michael I Koukourakis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    J Clin Oncol 24:4301-8. 2006
    ..Several studies have shown that serum LDH may be an ominous prognostic marker in malignant tumors. The clinical significance of tissue LDH-5, however, remains largely unexplored...
  30. ncbi request reprint Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Medical School, PO Box 12, Alexandroupolis 68100, Greece, and John Radcliffe Hospital, Oxford, UK
    Gynecol Oncol 103:912-8. 2006
    ..In this study, the expression of LDH-5 was assessed in the normal and malignant endometrium. Its role in prognosis and tumor angiogenesis and hypoxia was also examined...
  31. doi request reprint Concurrent liposomal cisplatin (Lipoplatin), 5-fluorouracil and radiotherapy for the treatment of locally advanced gastric cancer: a phase I/II study
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Pathology and Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 78:150-5. 2010
    ..We investigated the feasibility of the combination of 5-fluorouracil/lecovorin-based radio-chemotherapy with the administration of high weekly dose of a liposomal platinum formulation (Lipoplatin)...
  32. ncbi request reprint Long-term angiogenic activity of free grafts and pedicle flap in a rabbit urethroplasty model
    George Vaos
    Department of Pediatric Surgery, Alexandroupolis University Hospital, Democritus University of Thrace School of Medicine, 68100, Alexandroupolis, Greece
    World J Urol 31:919-24. 2013
    ..We studied the late angiogenic activity of free grafts and a pedicle flap in a rabbit urethroplasty model to determine whether angiogenic activity plays a role in late outcomes of urethral reconstruction in rabbits...
  33. ncbi request reprint Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Anticancer Res 28:3035-40. 2008
    ..This is a report on the feasibility and efficacy of hypofractionated accelerated radiotherapy combined with amifostine cytoprotection (hypoARC) and capecitabine in the treatment of rectal adenocarcinoma...
  34. pmc The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Cancer Biol Ther 13:1284-9. 2012
    ..These findings support and extend our previous studies on energy recycling between the aerobic stroma and the anaerobic cancer cells within the framework of Warburg effect...
  35. doi request reprint Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas
    Georgia Karpathiou
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    APMIS 121:592-604. 2013
    ..Furthermore, we showed important correlations between glucolysis and autophagy, guiding new pathways in future lung carcinoma research...
  36. ncbi request reprint Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma
    Michael I Koukourakis
    Department of Radiotherapy and Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer Biol Ther 6:1476-9. 2007
    ..The development of agents exploiting such cancer specific metabolic pathways may prove of importance in the treatment of lung cancer...
  37. ncbi request reprint Postoperative accelerated radiotherapy with cytoprotection followed by three-dimensional conformal boost in patients with early endometrial/cervical cancer
    Michael I Koukourakis
    Department of Radiotherapy and Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Tumori 95:455-60. 2009
    ..Adjuvant external beam radiotherapy is highly recommended for uterine carcinomas invading beyond the inner half of the myometrium or cervical stage IIa carcinomas. The addition of a booster intracavitary dose is widely used...
  38. doi request reprint Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab
    Michael I Koukourakis
    Departments of Pathology, and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 15:7069-76. 2009
    ..Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in patients with metastatic colorectal cancer...
  39. ncbi request reprint Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Departments of Pathology, Internal Medicine, and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Semin Oncol 29:14-21. 2002
    ..In contrast, the abundance of IAP expression in normal tissues, stromal and vascular, ensures an intense hydrolysis of WR-2721 and rapid intracellular accumulation of WR-1065...
  40. doi request reprint Concurrent administration of liposomal doxorubicin improves the survival of patients with invasive bladder cancer undergoing hypofractionated accelerated radiotherapy (HypoARC)
    Marianthi Panteliadou
    Department of Radiotherapy Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, P O Box 12, 68100, Alexandroupolis, Greece
    Med Oncol 28:1356-62. 2011
    ....
  41. doi request reprint Effect of VEGF on angiogenesis in pedicle penile skin flaps: an experimental study of urethral reconstruction in rabbits
    Elefteria Efstathiou
    Alexandroupolis University Hospital, Laboratory of Experimental Surgery and Surgical Research, Alexandroupolis, Greece
    Eur J Pediatr Surg 22:460-4. 2012
    ....
  42. ncbi request reprint Ultrasound submucosal inferior nasal turbinate reduction technique: histological study of wound healing in a sheep model
    Christina Nousia
    Dept of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Rhinology 48:169-73. 2010
    ....
  43. ncbi request reprint Phosphorylated KDR expression in endometrial cancer cells relates to HIF1alpha/VEGF pathway and unfavourable prognosis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Mod Pathol 19:701-7. 2006
    ..The unfavourable prognosis that VEGF confers to endometrial adenocarcinomas could be attributed to its angiogenic activity, but also to a direct effect on cancer cells through an autocrine VEGF/KDR loop...
  44. ncbi request reprint C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Lung Cancer 53:257-62. 2006
    ..In this study, we investigated whether polymorphisms of the HIF-1alpha gene may account for the patterns of HIF-1alpha protein expression in non-small cell lung carcinomas (NSCLC) and the expression of HIF-1alpha down-stream proteins...
  45. ncbi request reprint Thymidine phosphorylase expression in gallbladder adenocarcinomas
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Department of Pathology, Democritus University of Thrace, Greece
    Int J Surg Pathol 10:181-8. 2002
    ..TP is associated with an aggressive phenotype apparently because of its anglogenic activity. Therapeutic strategies targeting TP may be of value in patients overexpressing this enzyme...
  46. ncbi request reprint Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Democritus University of Thrace, 68100, Alexandroupolis, Greece
    Cancer Chemother Pharmacol 53:8-14. 2004
    ....
  47. ncbi request reprint Assessment of highly angiogenic and disseminated in the peripheral blood disease in breast cancer patients predicts for resistance to adjuvant chemotherapy and early relapse
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Cancer 108:620-7. 2004
    ..The simultaneous presence of high MVD and CK19-positive cells in the blood of patients with early breast is linked with poor prognosis, which cannot be improved with standard chemotherapy regimens...
  48. ncbi request reprint BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer
    Alexandra Giatromanolaki
    Departments of Pathology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Cancer Res 10:5566-71. 2004
    ..009). High BNIP3 expression was a major independent factor for overall survival. Thus, high expression of a hypoxia regulated proapoptotic pathway was associated with a selection of an aggressive phenotype in vivo...
  49. doi request reprint Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1
    Efthimios Sivridis
    Department of Pathology, University of Thrace Medical School, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Melanoma Res 21:188-95. 2011
    ..Atg6/beclin 1 was proved to be capable of deciphering the prognosis in cutaneous malignant melanoma, but the matter requires further investigation...
  50. doi request reprint The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Gynecol Oncol 110:216-21. 2008
    ..In this study, we investigated the numbers of FOXP3(+) Tregs in the normal and malignat endometrium and examined potential links with tumor angiogenesis...
  51. ncbi request reprint Interferon regulatory factor-1 (IRF-1) suppression and derepression during endometrial tumorigenesis and cancer progression
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Cytokine 26:164-8. 2004
    ..However, derepression of IRF-1 may occur in a subset of tumors, and this event is associated with TP up-regulation and aggressive tumor behavior...
  52. doi request reprint Treatment of invasive bladder cancer with conformal hypofractionated accelerated radiotherapy and amifostine (HypoARC)
    Marianthi Panteliadou
    Department of Radiotherapy and Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
    Urol Oncol 30:813-20. 2012
    ..We suggest that accelerated hypofractionation (HypoARC) may be more effective, as it targets both tumors with increased clonogenic activity and tumors with low radio-sensitivity...
  53. ncbi request reprint Narrow amifostine dose windows define radioprotection outcome, following fractionated whole-body irradiation of mice
    Christos E Zois
    Department of Radiotherapy Oncology, Democritus University of Thrace Medical Shool, University General Hospital of Alexandroupolis, Alexandroupolis 68100, Greece
    In Vivo 25:191-6. 2011
    ..Amifostine is an important broad spectrum cytoprotective agent approved for protection during fractionated radiotherapy. The daily dose of amifostine used, however, is arbitrarily chosen and low compared to the actual tolerable dose...
  54. ncbi request reprint Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    J Clin Oncol 24:727-35. 2006
    ....
  55. pmc Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma
    Michael I Koukourakis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece targ her forthnet gr
    Neoplasia 7:1-6. 2005
    ..This means that stroma may use lactic acid produced by tumor cells, preventing the creation of an intolerable intratumoral acidic environment at the same time...
  56. doi request reprint Immunohistological study of wound healing after submucosal radiofrequency tissue ablation of inferior nasal turbinate in a sheep model
    Haralampos Gouveris
    Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Rhinol Allergy 25:131-6. 2011
    ..This study was designed to examine tissue expression of fibronectin, collagen III, CD68, and matrix metalloproteinase (MMP) 9 in the INT (ventral) after RTA in sheep...
  57. pmc Angiogenic factor expression in hepatic cirrhosis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, P O Box 12, 68100 Alexandroupolis, Greece
    Mediators Inflamm 2007:67187. 2007
    ..The immunohistochemical findings suggest that angiogenic factors and factors promoting oxidative stress (i.e., TP) produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis...
  58. ncbi request reprint Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Hematol Oncol 26:219-24. 2008
    ....
  59. doi request reprint Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Cytokine 53:370-5. 2011
    ..Yet, its role in benign breast/gynecological conditions is less clear...
  60. doi request reprint Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    J Clin Pathol 63:867-72. 2010
    ....
  61. ncbi request reprint VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Lung Cancer 46:293-8. 2004
    ..The large variation in angiogenicity between tumors of similar histologic morphology emerges as a consequence of the 'parental' VEGF gene ability to produce VEGF...
  62. doi request reprint Amifostine-related fever-rash during fractionated radiotherapy: diagnostic and predictive role of C-reactive protein
    Michael I Koukourakis
    Department of Radiotherapy Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Clin Oncol 34:281-5. 2011
    ..Fever/rash is a side-effect of amifostine that demands immediate interruption of the drug. Here, we focus on the role of C-reactive protein (CRP) as a putative marker linked with amifostine fever/rash...
  63. ncbi request reprint Erythropoietin receptors in endometrial carcinoma as related to HIF1{alpha} and VEGF expression
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Greece
    In Vivo 23:699-703. 2009
    ..07). It is concluded that EpoR are common constituents of endometrial adenocarcinomas and are related to tumor aggressiveness, although this is probably a result of their involvement in an active HIF pathway...
  64. ncbi request reprint Hypoxia-inducible factor-2 alpha (HIF-2 alpha) induces angiogenesis in breast carcinomas
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Appl Immunohistochem Mol Morphol 14:78-82. 2006
    ..The authors conclude that HIF-2alpha overexpression, a common event in infiltrating ductal carcinomas of the breast, is related to high metastatic potential via increased angiogenic and c-erbB-2 activity...
  65. ncbi request reprint Hypofractionated accelerated radiotherapy with cytoprotection combined with trastuzumab, liposomal doxorubicine, and docetaxel in c-erbB-2-positive breast cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Clin Oncol 28:495-500. 2005
    ..Despite the experimental evidence of its radiosensitizing properties, trastuzumab has never been used in combination with radiotherapy for the treatment of patients with locally advanced disease...
  66. ncbi request reprint Inclusion of vasculature-related variables in the Dukes staging system of colon cancer
    Michael I Koukourakis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece, and Department of Pathology, John Radcliffe Hospital, UK
    Clin Cancer Res 11:8653-60. 2005
    ..Improvement of the Dukes stage predictive accuracy is necessary to better assign patients for adjuvant therapies, especially nowadays when antiangiogenic agents are being incorporated in the clinical practice...
  67. ncbi request reprint Differential assessment of angiogenic activity and of vascular survival ability (VSA) in breast cancer
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Exp Metastasis 19:673-9. 2002
    ..Elucidation of the pathways may provide additional targets for antiangiogenic therapy...
  68. ncbi request reprint Hypoxia and activated VEGF/receptor pathway in multiple myeloma
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, P O Box 12, Alexandroupolis 68100, Greece
    Anticancer Res 30:2831-6. 2010
    ..Intensified angiogenic pathways are associated with poor prognosis and resistance of multiple myeloma (MM) cells to therapy. The links of the VEGF pathway with the hypoxia inducible factor (HIF) expression in MM are herein investigated...
  69. ncbi request reprint Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Mod Pathol 19:9-16. 2006
    ..This study provides evidence on pathways to be investigated to elucidate the interplay between FOXP1, ER-alpha and HIF-1alpha in hormone dependent cancers...
  70. ncbi request reprint The HIF-2alpha/VEGF pathway activation in cutaneous capillary haemangiomas
    Alexandra Giatromanolaki
    Department of Pathology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Pathology 37:149-51. 2005
    ..To investigate the pathogenesis of capillary haemangiomas, a common form of vascular malformation...
  71. doi request reprint Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
    Alexandra Giatromanolaki
    Departments of Pathology, Radiotherapy Oncology, Pneumology and Thoracic Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    Cancer Lett 262:87-93. 2008
    ..High lactate dehydrogenase LDH5 expression was noted in cases with high HIF/PHD phenotype. The value of such a classification in defining different metabolic phenotypes of NSCLC deserves further evaluation...
  72. doi request reprint Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
    Michael I Koukourakis
    Department of Radiotherapy, Democritus University of Thrace, Alexandroupolis, Greece
    Oncology 77:285-92. 2009
    ..We assessed the expression and the prognostic role of lactate dehydrogenase 5 (LDH5, the major LDH isoenzyme involved in anaerobic glycolysis) in patients with squamous cell head and neck cancer (SCHNC)...
  73. ncbi request reprint Angiogenesis relates to estrogen receptor negativity, c-erbB-2 overexpression and early relapse in node-negative ductal carcinoma of the breast
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Pathology and Surgery, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Surg Pathol 11:29-34. 2003
    ..It is concluded that high intratumoral angiogenic activity is linked with early relapse in node-negative breast cancer...
  74. ncbi request reprint Autophagy in endometrial carcinomas and prognostic relevance of 'stone-like' structures (SLS): what is destined for the atypical endometrial hyperplasia?
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Autophagy 7:74-82. 2011
    ....
  75. ncbi request reprint The significance of p53 and bcl-2 overexpression and other prognostic factors in transitional cell carcinoma of the bladder
    Stavros Touloupidis
    Department of Urology, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
    Int Urol Nephrol 38:231-6. 2006
    ..Only sex seems to significantly affect the statistics of the risk of death (p<0.05). Women had quadruple risk of death compared to men...
  76. ncbi request reprint Hypofractionated and accelerated radiotherapy with subcutaneous amifostine cytoprotection as short adjuvant regimen after breast-conserving surgery: interim report
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 74:1173-80. 2009
    ..We evaluated the efficacy and toxicity of a hypofractionated and highly accelerated radiotherapy regimen supported with cytoprotection provided by amifostine in breast cancer patients treated with breast-conserving surgery...
  77. ncbi request reprint Platelet endothelial cell adhesion molecule-1 and angiogenic factor expression in idiopathic membranous nephropathy
    Efthimios Sivridis
    Departments of Pathology and Nephrology, Democritus University of Thrace, Alexandroupolis, Greece
    Am J Kidney Dis 41:360-5. 2003
    ..Idiopathic membranous nephropathy (IMN), a principal disease of glomerular capillaries, was investigated for some aspects of glomerular capillary injury and repair (angiogenesis)...
  78. ncbi request reprint Tumour angiogenesis: vascular growth and survival
    Alexandra Giatromanolaki
    Department of Pathology, Democritus Inoversity of Thrace, Alexandroupolis, Greece
    APMIS 112:431-40. 2004
    ..It is expected that this scheme will prove useful in the field of chemoradiotherapy and anti-angiogenic treatment...
  79. ncbi request reprint "Stromatogenesis" and tumor progression
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Surg Pathol 12:1-9. 2004
    ..It appears that the process is neither neoplastic nor reactive, but rather is a, hereto unexplained, phenomenon of host's complicity in tumor progression...
  80. ncbi request reprint Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 53:1192-202. 2002
    ..Their putative role as markers of clinically relevant hypoxia and, therefore, as predictors of response to chemoradiotherapy is herein examined...
  81. ncbi request reprint Node-related factors and survival in node-positive breast carcinomas
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace Medical School, P O Box 128, Alexandroupolis 68100, Greece
    Breast 15:382-9. 2006
    ..Intranodal necrosis and extranodal tumor emboli should be considered, in parallel with the number of +LNs, in subsequent treatment design...
  82. ncbi request reprint Angiogenesis in colorectal cancer: prognostic and therapeutic implications
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Am J Clin Oncol 29:408-17. 2006
    ..It is expected that, in addition to adjuvant chemotherapy and radiotherapy, agents blocking the stimulatory effect of VEGF on endothelial cells would prove beneficial to the patient...
  83. ncbi request reprint Metastatic cancer cells from c-erbB-2 negative primary breast cancer maintain the original c-erbB-2/HIF1alpha phenotype
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis 68100, Greece
    Cancer Biol Ther 6:153-5. 2007
    ....
  84. doi request reprint Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases
    Michael I Koukourakis
    Departments of Radiotherapy Oncology, Obstetrics Gynaecology, Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Gynecol Obstet Invest 67:162-8. 2009
    ..In cancer patients, serum total lactate dehydrogenase (LDH) levels are often increased, and the gene for one of its isoenzymes, LDHA, is up-regulated. These features have been linked to poor prognosis in several studies...
  85. pmc LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Am J Pathol 176:2477-89. 2010
    ..It is concluded that autophagy can be readily recognized in breast carcinomas by light microscopy, after immunohistochemical staining with LC3A, but the significance of the various patterns expressed would need further evaluation...
  86. ncbi request reprint The vascular network of tumours--what is it not for?
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    J Pathol 201:173-80. 2003
    ....
  87. doi request reprint Light-chain 3A autophagic activity and prognostic significance in non-small cell lung carcinomas
    Georgia Karpathiou
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Chest 140:127-34. 2011
    ..Despite evaluation of various prognostic factors, the role of autophagy, a self-degradative process involved in the turnover of cytoplasmic material, remains unexplored in lung malignancy...
  88. doi request reprint Carotid body tumor in a 13-year-old child: Case report and review of the literature
    George S Georgiadis
    Department of Vascular Surgery, Demokritos University Hospital, Alexandroupolis, Greece
    J Vasc Surg 47:874-880. 2008
    ..Furthermore, no inheritance pattern between family members was confirmed. A clinical update on CBTs in childhood a propos of this case report is undertaken...
  89. ncbi request reprint The "stone-like" pattern of autophagy in human epithelial tumors and tumor-like lesions: an approach to the clinical outcome
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Autophagy 6:830-3. 2010
    ..It is concluded that immunohistochemical staining for LC3A is a suitable method for detecting autophagy in human tissues by light microscopy, but the significance of the various patterns described needs further evaluation...
  90. ncbi request reprint The angiogenetic effect of intramuscular administration of VEGF on muscle. The influence of exercise on angiogenesis
    Anna Efthimiadou
    Department of Physiology, School of Medicine, Democritus University of Thrace, Alexandroupolis 681 00, Greece
    In Vivo 18:825-9. 2004
    ..We evaluated the angiogenetic effects of vascular endothelial growth factor (VEGF) on rat heart and gastrocnemius muscles when this was administered intramuscularly and compared them to those obtained from rats, which exercised daily...
  91. doi request reprint The endometrial hyperplasias revisited
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Virchows Arch 453:223-31. 2008
    ..The EIN concept was challenged of not being independently tested and received with great enthusiasm by some scholars and relative skepticism by others...
  92. doi request reprint Primary pleural lymphoma: plaque-like thickening of the pleura
    Anastasia Oikonomou
    Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
    Jpn J Radiol 28:62-5. 2010
    ..The authors suggest that physicians should be aware of this rare location of primary pleural lymphoma manifested by plaque-like thickening of the pleura but not accompanied by mediastinal lymphadenopathy...
  93. ncbi request reprint Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    J Pathol 196:416-22. 2002
    ..TP is not an effective contributor to the angiogenic process, but is associated with aggressive histological features. The two factors, when co-expressed, play a co-operative role in the induction of angiogenesis...
  94. pmc Total and caspase-cleaved cytokeratin 18 in chronic cholecystitis: a prospective study
    Constantinos Simopoulos
    2nd Department of Surgery, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    BMC Gastroenterol 8:14. 2008
    ..Cell death mode has been studied in cancer, autoimmune, and neurodegenerative diseases. In this study, apoptosis and necrosis are investigated for the first time in patients with chronic calculous cholecystitis...
  95. doi request reprint Expression of 6 common antigenic markers in invasive ductal breast carcinoma: potential clinical implications
    Theodore S Lialiaris
    Department s of Genetics, Demokrition University of Thrace, Medical School, Alexandroupolis, Greece
    Appl Immunohistochem Mol Morphol 19:106-11. 2011
    ..6%) & +/-/-/+ (17.8%)]. We conclude that, in agreement with earlier reports, our findings support the diagnostic and potential prognostic value of these markers in the clinical assessment of breast cancer...
  96. doi request reprint LC3A-positive "stone-like" structures in cutaneous squamous cell carcinomas
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    Am J Dermatopathol 33:285-90. 2011
    ..These data suggest that autophagic activity in SCC, when expressed as high LC3A/SLS counts, can be regarded as an indicator of tumor aggressiveness...
  97. doi request reprint The pathogenesis of endometrial carcinomas at menopause: facts and figures
    Efthimios Sivridis
    Department of Pathology, Democritus University of Thrace Medical School, and University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    J Clin Pathol 64:553-60. 2011
    ....
  98. ncbi request reprint Comparison of angiogenic activities after urethral reconstruction using free grafts in rabbits
    Stefanos Gardikis
    Department of Paediatric Surgery, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    Eur Urol 47:417-21. 2005
    ..To determine the most suitable type of graft-free penile skin grafts or mucosal grafts from bladder or buccal regions - for urethral reconstruction in an animal model, as evaluated on the basis of angiogenic activity...
  99. ncbi request reprint Hypofractionated and accelerated radiotherapy with cytoprotection (HypoARC): a short, safe, and effective postoperative regimen for high-risk breast cancer patients
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Demokritus University of Thrace, Alexandroupolis, Greece
    Int J Radiat Oncol Biol Phys 52:144-55. 2002
    ....
  100. ncbi request reprint Differential assessment of vascular survival ability and tumor angiogenic activity in colorectal cancer
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Clin Cancer Res 8:1185-91. 2002
    ..This "vascular survival" potential can be assessed by comparatively examining the vascular density in peripheral and inner tumor areas...
  101. ncbi request reprint Lactate dehydrogenase isoenzymes 1 and 5: differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Tumour Biol 24:199-202. 2003
    ..Thus, LDH-1, another component isoenzyme made up of 4 H-polypeptide chains, favors aerobic oxidation of pyruvate by pyruvate dehydrogenase...