Asterios Karagiannis

Summary

Affiliation: Aristotle University of Thessaloniki
Country: Greece

Publications

  1. ncbi request reprint Statins and renal function
    Moses Elisaf
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Angiology 53:493-502. 2002
  2. ncbi request reprint Editorial: aliskiren/amlodipine single-pill combinations: more evidence in favour of combination formulations for the treatment of hypertension
    Niki Katsiki
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital 44, Tsimiski str, Thessaloniki, 54623, Greece
    Curr Vasc Pharmacol 10:745-7. 2012
  3. ncbi request reprint Should atenolol still be recommended as first-line therapy for primary hypertension?
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Hellenic J Cardiol 47:298-307. 2006
  4. doi request reprint Treatment of primary aldosteronism: Where are we now?
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, 44, Tsimiski str, Thessaloniki, 54623, Greece
    Rev Endocr Metab Disord 12:15-20. 2011
  5. ncbi request reprint The unilateral measurement of blood pressure may mask the diagnosis or delay the effective treatment of hypertension
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Angiology 56:565-9. 2005
  6. ncbi request reprint Lack of an association between angiotensin converting enzyme gene polymorphism and peripheral arterial occlusive disease
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Surgical Clinic, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Vasc Med 9:189-92. 2004
  7. ncbi request reprint Gonadal dysfunction in systemic diseases
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Division of Endocrinology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Eur J Endocrinol 152:501-13. 2005
  8. ncbi request reprint Lack of an association between angiotensin-converting enzyme gene insertion/deletion polymorphism and ischaemic stroke
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur Neurol 51:148-52. 2004
  9. doi request reprint Long-term impact of multifactorial treatment on new-onset diabetes and related cardiovascular events in metabolic syndrome: a post hoc ATTEMPT analysis
    Vassilios G Athyros
    Department of Internal Medicine, Second Propedeutic Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Angiology 63:358-66. 2012
  10. ncbi request reprint Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, Aristotelean University, Hippocration Hospital, Thessaloniki, Greece
    Angiology 58:689-97. 2007

Collaborators

Detail Information

Publications138 found, 100 shown here

  1. ncbi request reprint Statins and renal function
    Moses Elisaf
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Angiology 53:493-502. 2002
    ..Which is the statin of choice? This question is relevant because impaired renal function can interfere with statin pharmacokinetics. Furthermore, other drugs administered to these patients may cause serious interactions with statins...
  2. ncbi request reprint Editorial: aliskiren/amlodipine single-pill combinations: more evidence in favour of combination formulations for the treatment of hypertension
    Niki Katsiki
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital 44, Tsimiski str, Thessaloniki, 54623, Greece
    Curr Vasc Pharmacol 10:745-7. 2012
    ..1] and Glorioso et al. [2] report the efficacy and tolerability of aliskiren/amlodipine single-pill combinations (SPCs) in patients with inadequate blood pressure (BP) response to amlodipine or aliskiren monotherapy, respectively...
  3. ncbi request reprint Should atenolol still be recommended as first-line therapy for primary hypertension?
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Hellenic J Cardiol 47:298-307. 2006
  4. doi request reprint Treatment of primary aldosteronism: Where are we now?
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, 44, Tsimiski str, Thessaloniki, 54623, Greece
    Rev Endocr Metab Disord 12:15-20. 2011
    ..On the other hand, surgery in patients considered to have bilateral PA may contribute to better blood pressure control. In this review, established and novel strategies for the management of different types of PA are discussed...
  5. ncbi request reprint The unilateral measurement of blood pressure may mask the diagnosis or delay the effective treatment of hypertension
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Angiology 56:565-9. 2005
    ..It is thus recommended that BP should be simultaneously measured in both arms at the initial consultation and the higher of the 2 readings should be used to guide further management decisions...
  6. ncbi request reprint Lack of an association between angiotensin converting enzyme gene polymorphism and peripheral arterial occlusive disease
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Surgical Clinic, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Vasc Med 9:189-92. 2004
    ..418-1.377). These results indicate an absence of association between DD genotype and PAOD. Further evaluation in a larger population study is required to examine the possibility of an increased risk of PAOD in DD homozygotes...
  7. ncbi request reprint Gonadal dysfunction in systemic diseases
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Division of Endocrinology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Eur J Endocrinol 152:501-13. 2005
    ..In this brief review, the most common disturbances seen in the main systemic diseases will be discussed...
  8. ncbi request reprint Lack of an association between angiotensin-converting enzyme gene insertion/deletion polymorphism and ischaemic stroke
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur Neurol 51:148-52. 2004
    ..The angiotensin I-converting enzyme (ACE) gene is a candidate gene for atherosclerotic-related diseases. In the present study, the association between the polymorphism of the ACE gene and ischaemic stroke was investigated...
  9. doi request reprint Long-term impact of multifactorial treatment on new-onset diabetes and related cardiovascular events in metabolic syndrome: a post hoc ATTEMPT analysis
    Vassilios G Athyros
    Department of Internal Medicine, Second Propedeutic Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Angiology 63:358-66. 2012
    ..Our findings suggest that treating the characteristics of MetS is achievable and beneficial. New-onset diabetes incidence and CVD events were negligible and not different from what is expected in the general population...
  10. ncbi request reprint Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, Aristotelean University, Hippocration Hospital, Thessaloniki, Greece
    Angiology 58:689-97. 2007
    ..Heavy drinking was associated with an increase in the prevalence of all of these disease states. Advice on alcohol consumption should probably mainly aim at reducing heavy drinking...
  11. doi request reprint Effects of statin treatment in men and women with stable coronary heart disease: a subgroup analysis of the GREACE Study
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, Second Propedeutic Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 24:1593-9. 2008
    ..Reducing low-density lipoprotein cholesterol (LDL-C) levels to National Cholesterol Expert Panel (NCEP) goal is recommended. However, sex-specific effects may influence benefit...
  12. doi request reprint Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Lancet 376:1916-22. 2010
    ..We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) study population...
  13. doi request reprint Effectiveness of ezetimibe alone or in combination with twice a week Atorvastatin (10 mg) for statin intolerant high-risk patients
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Am J Cardiol 101:483-5. 2008
    ..In conclusion, the combination of ezetimibe plus atorvastatin 10 mg twice a week might be a therapeutic option for high-risk patients intolerant to daily statin monotherapy...
  14. doi request reprint Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 26:713-9. 2010
    ..The JIS definition was compared with three previous definitions to assess their ability to predict cardiovascular disease (CVD) risk...
  15. doi request reprint Role of antihypertensive drugs in arterial 'de-stiffening' and central pulsatile hemodynamics
    Charalambos Koumaras
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Am J Cardiovasc Drugs 12:143-56. 2012
    ..Identifying the pharmacologic interventions that can improve arterial stiffness ('de-stiffening' treatment) is a promising field of research...
  16. ncbi request reprint Assessing the treatment effect in metabolic syndrome without perceptible diabetes (ATTEMPT): a prospective-randomized study in middle aged men and women
    Vassilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Curr Vasc Pharmacol 9:647-57. 2011
    ..To assess the reduction in estimated cardiovascular disease (e-CVD) risk after multifactorial treatment for 6 months and follow this change during the next 3-years...
  17. doi request reprint Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism
    Asterios Karagiannis
    Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece
    Expert Opin Pharmacother 9:509-15. 2008
    ..It was concluded that eplerenone was as effective as spironolactone in reducing BP in patients with IHA. The risk of mild hyperkalaemia was similar with both drugs...
  18. doi request reprint Association between the changes in renal function and serum uric acid levels during multifactorial intervention and clinical outcome in patients with metabolic syndrome. A post hoc analysis of the ATTEMPT study
    Vassilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Curr Med Res Opin 27:1659-68. 2011
    ..To assess the effects of long-term multifactorial intervention on renal function and serum uric acid (SUA) levels and their association with estimated cardiovascular disease (eCVD) risk and actual CVD events...
  19. ncbi request reprint Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: a subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluati
    Vasilios G Athyros
    FASA, FRSH, Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    Nephrol Dial Transplant 22:118-27. 2007
    ..Metabolic syndrome (MetS) is associated with increased risk for both vascular and chronic kidney disease. Whether statins ameliorate these risks is not established...
  20. ncbi request reprint Atorvastatin decreases triacylglycerol-associated risk of vascular events in coronary heart disease patients
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Lipids 42:999-1009. 2007
    ..Statin (mainly atorvastatin)-induced decrease in TAG levels was related to a significant reduction in subsequent CVD events. This benefit was more pronounced in CHD MetS (+) patients...
  21. ncbi request reprint Editorial: should chronic kidney disease be considered as a coronary heart disease equivalent?
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Curr Vasc Pharmacol 10:374-7. 2012
    ..Furthermore, CKD is included in recent international guidelines as a population at high CVD risk. The aim should be to effectively reduce CVD risk as well as progression of CKD...
  22. doi request reprint Medical treatment as an alternative to adrenalectomy in patients with aldosterone-producing adenomas
    Asterios Karagiannis
    Department of Internal Medicine, Medical School, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Endocr Relat Cancer 15:693-700. 2008
    ..In this review, we focus on the medical approach for the management of APA in cases where surgical excision of the adrenal is not possible...
  23. doi request reprint Impact of managing atherogenic dyslipidemia on cardiovascular outcome across different stages of diabetic nephropathy
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, Medical School, Thessaloniki, Greece
    Expert Opin Pharmacother 11:723-30. 2010
    ..In contrast, statins do not seem to decrease events in patients with advanced decline in kidney function...
  24. doi request reprint 11beta-Hydroxysteroid dehydrogenase type 1 inhibitors: novel agents for the treatment of metabolic syndrome and obesity-related disorders?
    Panagiotis Anagnostis
    Department of Endocrinology, Hippokration Hospital, 49 Konstantinoupoleos Str, Thessaloniki, 54 642, Greece
    Metabolism 62:21-33. 2013
    ..This review considers the significance of the 11β-HSD1 inhibition in the treatment of several features of MetS and provides current data about the development of 11β-HSD1 inhibitors, as new agents for this purpose...
  25. doi request reprint Should raising high-density lipoprotein cholesterol be a matter of debate?
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    J Cardiovasc Med (Hagerstown) 13:254-9. 2012
    ..Furthermore, 'dysfunctional' HDL may be present in conditions such as diabetes or acute coronary syndromes. Efforts should focus on improving HDL particle functionality in addition to a numerical increase in HDL-C levels...
  26. ncbi request reprint Non-alcoholic fatty liver disease in type 2 diabetes: pathogenesis and treatment options
    Konstantinos Tziomalos
    First Propedeutic Department of Internal Medicine, AHEPA Hospital, Thessaloniki, Greece
    Curr Vasc Pharmacol 10:162-72. 2012
    ..Accordingly, prevention of obesity and T2DM is of paramount importance for the reduction of the prevalence of NAFLD and of its associated cardiovascular and liver-related complications...
  27. ncbi request reprint Atherosclerotic renal artery stenosis: an update on diagnosis and management
    Eirini Stavrinou
    Department of Nephrology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Curr Vasc Pharmacol 9:465-70. 2011
    ..In this review, we discuss the current data in the field of diagnosis and management of patients with ARAS...
  28. ncbi request reprint High density lipoprotein cholesterol and statin trials
    Anna Kakafika
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Curr Med Chem 15:2265-70. 2008
    ..Whether a statin that beyond its LDL-C lowering effect also raises HDL-C has additional benefits in the prevention of vascular events remains to be established...
  29. doi request reprint Do we need to consider inflammatory markers when we treat atherosclerotic disease?
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Atherosclerosis 200:1-12. 2008
    ..However, this concept requires proof in appropriately designed trials that include clinically relevant end points...
  30. ncbi request reprint Prevalence of vascular disease in metabolic syndrome using three proposed definitions
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, 2nd Prop Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Int J Cardiol 117:204-10. 2007
    ..There are a number of definitions available for the diagnosis of the metabolic syndrome (MetS). The MetS-associated increase in cardiovascular disease (CVD) risk may depend on the definition used...
  31. doi request reprint Aggressive statin treatment, very low serum cholesterol levels and haemorrhagic stroke: is there an association?
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
    Curr Opin Cardiol 25:406-10. 2010
    ..To assess the potential association between haemorrhagic stroke and achieving very low serum cholesterol levels with aggressive statin treatment...
  32. ncbi request reprint Pleiotropic effects of statins--clinical evidence
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, HippocrationHospital, Thessaloniki, Greece
    Curr Pharm Des 15:479-89. 2009
    ....
  33. ncbi request reprint The role of ankle brachial index and carotid intima-media thickness in vascular risk stratification
    Konstantinos Tziomalos
    First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece
    Curr Opin Cardiol 25:394-8. 2010
    ..To summarize recent findings on the role of ankle brachial index (ABI) and carotid intima-media thickness (cIMT) in vascular risk stratification...
  34. ncbi request reprint The effect of antihypertensive agents on insulin sensitivity, lipids and haemostasis
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Curr Vasc Pharmacol 8:792-803. 2010
    ..This review discusses the differential effects of antihypertensive drugs on insulin sensitivity, lipids and haemostasis and considers their association with vascular risk...
  35. ncbi request reprint The role of renin-angiotensin system inhibition in the treatment of hypertension in metabolic syndrome: are all the angiotensin receptor blockers equal?
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Expert Opin Ther Targets 11:191-205. 2007
    ..There are differences among ARBs. Among them is the uricosuric effect of losartan. Furthermore, telmisartan may function as a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma)...
  36. ncbi request reprint Atenolol: differences in mode of action compared with other antihypertensives. An opportunity to identify features that influence outcome?
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Curr Pharm Des 13:229-39. 2007
    ..This knowledge may help design drugs that are not only more effective in achieving blood pressure targets but that also markedly decrease vascular events...
  37. pmc IMproving the imPlemEntation of cuRrent guidelines for the mAnagement of major coronary hearT disease rIsk factors by multifactorial interVEntion. The IMPERATIVE renal analysis
    Vasilios G Athyros
    2 Propedeutic Department of Internal Medicine, Aristotelian University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Arch Med Sci 7:984-92. 2011
    ..The aim of the study was to prospectively assess these effects...
  38. pmc Safety and impact on cardiovascular events of long-term multifactorial treatment in patients with metabolic syndrome and abnormal liver function tests: a post hoc analysis of the randomised ATTEMPT study
    Vassilios G Athyros
    2 Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Arch Med Sci 7:796-805. 2011
    ..We assessed the long-term effects of multifactorial intervention on LFTs and their association with cardiovascular disease (CVD) events in patients with MetS without diabetes mellitus or CVD...
  39. ncbi request reprint Do we need a statin-nicotinic acid-aspirin mini-polypill to treat combined hyperlipidaemia?
    Vasilios G Athyros
    Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Thessaloniki, Greece
    Expert Opin Pharmacother 8:2267-77. 2007
    ..However, the effective dose of aspirin may need to be at least 160 mg/day. This triple combination might improve patient compliance when compared with the three drugs administered separately...
  40. ncbi request reprint Identifying and attaining LDL-C goals: mission accomplished? Next target: new therapeutic options to raise HDL-C levels
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Curr Drug Targets 8:483-8. 2007
    ..HDL-C strategies, in combination with effective statins, are a new drug target aimed at a further reduction in CVD morbidity and mortality compared with statin monotherapy...
  41. ncbi request reprint Adrenal incidentaloma: a diagnostic challenge
    Panagiotis Anagnostis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Hormones (Athens) 8:163-84. 2009
    ..The present review considers the prevalence, pathology and natural history of AIs. We also discuss the reliability of available screening methods and localization techniques and consider optimal management and follow-up strategies...
  42. doi request reprint Cardiorenal anemia syndrome: do erythropoietin and iron therapy have a place in the treatment of heart failure?
    Efstathios D Pagourelias
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Angiology 60:74-81. 2009
    ..Nevertheless, more studies are needed and certain issues should be resolved, particularly the optimal hemoglobin level, before EPO can become part of the treatment of patients with CHF...
  43. doi request reprint Atorvastatin: safety and tolerability
    Vasilios G Athyros
    Aristotle University of Thessaloniki, Hippokration Hospital, Medical School, Second Propedeutic Department of Internal Medicine, 15 Marmara St, Thessaloniki 551 32, Greece
    Expert Opin Drug Saf 9:667-74. 2010
    ..Therefore, the safety and tolerability of atorvastatin is of paramount importance...
  44. ncbi request reprint Should adipokines be considered in the choice of the treatment of obesity-related health problems?
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
    Curr Drug Targets 11:122-35. 2010
    ..Moreover, it summarises treatment options for the normalisation of adipokine levels, which might confer an additional clinical benefit in the effort to prevent or treat obesity-related T2DM and CVD...
  45. doi request reprint Seasonal variation in the occurrence of stroke in Northern Greece: a 10 year study in 8204 patients
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Neurol Res 32:326-31. 2010
    ..The effect of seasonal variation on the occurrence of stroke remains controversial. The objective of this study was to determine whether there is a seasonal variation in the occurrence of stroke in Northern Greece...
  46. pmc Is there an additional benefit from coronary revascularization in diabetic patients with acute coronary syndromes or stable angina who are already on optimal medical treatment?
    Vasilios G Athyros
    2 Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Arch Med Sci 7:1067-75. 2011
    ..Treatment of vascular risk factors is a key option in terms of improving CVD outcomes in diabetic patients with CHD. The choice between medical therapy and revascularization warrants further assessment...
  47. ncbi request reprint Pheochromocytoma: an update on genetics and management
    Asterios Karagiannis
    Division of Endocrinology, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
    Endocr Relat Cancer 14:935-56. 2007
    ..Furthermore, it emphasizes the need for genetic testing in cases with apparently sporadic PHEOs...
  48. ncbi request reprint Serum uric acid as an independent predictor of early death after acute stroke
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Circ J 71:1120-7. 2007
    ..The prognostic significance of uric acid (UA) levels in acute stroke is unclear, so the objective of this study was to determine the association between levels of serum UA (SUA) and mortality in acute stroke...
  49. ncbi request reprint Endocrine hypertension: diagnosis and management of a complex clinical entity
    Panagiotis Anagnostis
    Endocrinology Clinic, Hippokration Hospital, Thessaloniki, Greece
    Curr Vasc Pharmacol 8:646-60. 2010
    ..In addition, it is important to differentiate benign from malignant tumors. The present review provides an update on the pathophysiology and clinical presentation of EH. We also discuss the diagnostic work-ups and therapeutic strategies...
  50. ncbi request reprint Vitamin D and cardiovascular disease: a novel agent for reducing cardiovascular risk?
    Panagiotis Anagnostis
    Endocrinology Clinic, Hippokration Hospital, Thessaloniki, Greece
    Curr Vasc Pharmacol 8:720-30. 2010
    ..This review considers current data regarding the role of vitamin D deficiency in the development of CVD and addresses the effect of supplementation on cardiovascular outcomes...
  51. ncbi request reprint Statins for the prevention of first or recurrent stroke
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Curr Vasc Pharmacol 6:124-33. 2008
    ..Thus, statins may be beneficial to both the heart and the brain...
  52. doi request reprint Statin loading in patients undergoing percutaneous coronary intervention for acute coronary syndromes: a new pleiotropic effect?
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 26:839-42. 2010
    ..This editorial discusses the results of statin loading trials and comments on the possible mechanisms involved...
  53. ncbi request reprint Disturbances of phosphate metabolism: another feature of metabolic syndrome
    Rigas Kalaitzidis
    Department of Nephrology, Medical School, University of Ioannina, Greece
    Am J Kidney Dis 45:851-8. 2005
    ..The aim of our study is to confirm the presence of hypophosphatemia in patients with metabolic syndrome, as well as investigate mechanisms that may underlie the disturbances in phosphate metabolism in this patient group...
  54. doi request reprint Efficacy of various "classic" echocardiographic and laboratory indices in distinguishing the "gray zone" between athlete's heart and hypertrophic cardiomyopathy: a pilot study
    Efstathios D Pagourelias
    Third Cardiology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Echocardiography 30:131-9. 2013
    ..Differentiation of adaptive LVH versus HCM in a gray zone population could be facilitated by recognition of certain features referring to LV dimensions, diastolic function, and BNP...
  55. ncbi request reprint Ezetimibe therapy for dyslipidemia: an update
    Niki Katsiki
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Curr Pharm Des 19:3107-14. 2013
    ..The use of ezetimibe either as monotherapy or as add-on therapy in daily clinical practice is also discussed...
  56. ncbi request reprint Omega-3 fatty acids: how can they be used in secondary prevention?
    Konstantinos Tziomalos
    Second Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, 63 Solonos Street, Thessaloniki, 54248, Greece
    Curr Atheroscler Rep 10:510-7. 2008
    ..Increased intake of EPA and DHA represents a valuable tool for vascular disease prevention and should be recommended in all patients with CHD...
  57. doi request reprint Blood pressure levels constitute the most important determinant of the metabolic syndrome in a Mediterranean population: a discrimination analysis
    Theodoros Chimonas
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Metab Syndr Relat Disord 8:523-9. 2010
    ..The aim of the study was to evaluate the relative importance of the determinants of the metabolic syndrome in a sample with metabolic syndrome from the Greek population...
  58. ncbi request reprint Targeting vascular risk in patients with metabolic syndrome but without diabetes
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, Aristotelian University, 55132 Thessaloniki, Greece
    Metabolism 54:1065-74. 2005
    ..Atorvastatin and combination treatment were more effective than fenofibrate alone in reducing CRP levels...
  59. ncbi request reprint Dyslipidemia as a risk factor for ischemic stroke
    Konstantinos Tziomalos
    Department of Clinical Biochemistry Vascular Prevention Clinic, Royal Free Campus, University College London Medical School, University College London UCL, London, UK
    Curr Top Med Chem 9:1291-7. 2009
    ..Nevertheless, more trials are required to identify which patients with stroke but without CHD will benefit more from statin treatment...
  60. ncbi request reprint Prevalence of atherosclerotic vascular disease among subjects with the metabolic syndrome with or without diabetes mellitus: the METS-GREECE Multicentre Study
    Vasilios G Athyros
    Atherosclerosis Unit, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 20:1691-1701. 2004
    ....
  61. ncbi request reprint The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study
    Evangelos Rizos
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    J Cardiovasc Pharmacol Ther 8:127-34. 2003
    ..Finally, the addition of pravastatin could further correct the well-established predictors of cardiovascular events...
  62. ncbi request reprint The prevalence of the metabolic syndrome using the National Cholesterol Educational Program and International Diabetes Federation definitions
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, 2nd Prop Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 21:1157-9. 2005
    ....
  63. ncbi request reprint Effect of atorvastatin on high density lipoprotein cholesterol and its relationship with coronary events: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study
    Vasilios G Athyros
    Atherosclerosis Unit, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 20:627-37. 2004
    ....
  64. ncbi request reprint Statins and renal function in patients with diabetes mellitus
    Vasilios G Athyros
    Atherosclerosis Unit, Second Propedeutic Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 19:615-7. 2003
    ..Lipid lowering trials need to consider that changes in renal function may occur. Renal and ischaemic heart disease may progress in parallel and statins may be beneficial to both organs...
  65. ncbi request reprint The inhibitory potency of clopidogrel on ADP-induced platelet activation is not attenuated when it is co-administered with atorvastatin (20 mg/day) for 5 weeks in patients with acute coronary syndromes
    John V Mitsios
    Laboratory of Biochemistry, Department of Chemistry, Medical School, University of Ioannina, 45110 Ioannina, Greece
    Platelets 16:287-92. 2005
    ..In conclusion, atorvastatin, even at a dose of 20 mg/day does not affect the antiplatelet efficacy of clopidogrel when co-administered for 5 weeks in ACS patients...
  66. ncbi request reprint Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study
    Vasilios G Athyros
    Atherosclerosis Unit, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Am J Kidney Dis 43:589-99. 2004
    ..Here, we report the time course of SUA levels in usual-care patients undertreated for their dyslipidemia (12% were administered statins) in comparison to structured-care patients treated with atorvastatin in the vast majority (98%)...
  67. ncbi request reprint Awareness, treatment and control of the metabolic syndrome and its components: a multicentre Greek study
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, 2nd Prop Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Hellenic J Cardiol 46:380-6. 2005
    ..There are no data concerning the degree of awareness, treatment and control of the metabolic syndrome (MetS) and its components or associated vascular risk in the general population...
  68. ncbi request reprint The effects of the addition of micronised fenofibrate on uric acid metabolism in patients receiving indapamide
    Apostolos Achimastos
    Department of Internal Medicine, Medical School, University of Athens, Greece
    Curr Med Res Opin 18:59-63. 2002
    ..In contrast, micronised fenofibrate can significantly decrease serum uric acid levels. However, there are no data on the effect of combination therapy of indapamide with micronised fenofibrate on uric acid metabolism...
  69. ncbi request reprint Effect of statins and aspirin alone and in combination on clinical outcome in dyslipidaemic patients with coronary heart disease. A subgroup analysis of the GREACE study
    Vasilios G Athyros
    Atherosclerosis Unit, Aristotelian University, Hippocration Hospital, 49 Konstantinoupoleos St, Thessaloniki, 546 42, Greece
    Platelets 16:65-71. 2005
    ..Aggressive statin use in the absence of ASA also substantially reduced cardiovascular events. Treatment with ASA in the absence of statin use reduced clinical events in comparison to patients not treated with either drug...
  70. doi request reprint Statins and nonalcoholic fatty liver disease: a bright future?
    Vasilios G Athyros
    Aristotle University of Thessaloniki, Hippokration Hospital, Medical School, Second Propedeutic Department of Internal Medicine, Thessaloniki, Greece
    Expert Opin Investig Drugs 22:1089-93. 2013
    ..However, large randomized clinical trials are needed to verify these findings. ..
  71. ncbi request reprint Colesevelam: a new and improved bile acid sequestrant?
    Konstantinos Tziomalos
    First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
    Curr Pharm Des 19:3115-23. 2013
    ..Therefore, colesevelam seems to be a useful tool for the management of high-risk patients who cannot achieve LDL-C targets with monotherapy with a potent statin...
  72. doi request reprint Hyperuricaemia: more than just a cause of gout?
    Niki Katsiki
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    J Cardiovasc Med (Hagerstown) 14:397-402. 2013
    ..Several drugs that reduce CV risk also decrease SUA levels, further improving vascular risk. Therefore, selecting SUA-lowering drugs to treat high-risk patients may prove beneficial in terms of reducing CV risk...
  73. ncbi request reprint Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study
    Vasilios G Athyros
    Atherosclerosis and Metabolic Syndrome Units, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece
    Curr Med Res Opin 22:873-83. 2006
    ..Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome (MetS). There is no established treatment for NAFLD...
  74. ncbi request reprint Stage of chronic kidney disease and severity of coronary heart disease manifestation
    Vasilios G Athyros
    Aristotle University of Thessaloniki, Hippocration Hospital, Medical School, 2nd Propedeutic Department of Internal Medicine, Thessaloniki, Greece
    Expert Opin Pharmacother 13:457-60. 2012
    ..Thus, statin treatment in early CKD, a condition considered to be a CHD equivalent by several guidelines, is likely to minimize the risk for CHD events...
  75. pmc Dyslipidaemia of obesity, metabolic syndrome and type 2 diabetes mellitus: the case for residual risk reduction after statin treatment
    Vasilios G Athyros
    Second Propedeutic Department of Internal Medicine, Aristotle University, Hippocration Hospital, Thessaloniki, Greece
    Open Cardiovasc Med J 5:24-34. 2011
    ....
  76. ncbi request reprint Statin-based treatment for cardiovascular risk and non-alcoholic fatty liver disease. Killing two birds with one stone?
    Vasilios G Athyros
    Ann Med 43:167-71. 2011
    ..These findings suggest that with statins we are able to get two birds with one stone...
  77. doi request reprint Carbon dioxide balneotherapy and cardiovascular disease
    Efstathios D Pagourelias
    First Cardiology Department, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece
    Int J Biometeorol 55:657-63. 2011
    ....
  78. ncbi request reprint The hypertriglyceridemic waist phenotype is a predictor of elevated levels of small, dense LDL cholesterol
    Irene F Gazi
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Lipids 41:647-54. 2006
    ..The HTGW phenotype, compared with the MetSyn criteria, can provide an easy and inexpensive tool to monitor patients characterized by an adverse lipid and lipoprotein profile...
  79. ncbi request reprint Effects of fibrates on serum metabolic parameters
    Moses Elisaf
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Curr Med Res Opin 18:269-76. 2002
    ..The fibrates are generally well-tolerated drugs with few side-effects. The most important side-effect is myositis, which is observed in patients with impaired renal function or when statins are given concomitantly...
  80. doi request reprint Efficacy and safety of ezetimibe plus orlistat or rimonabant in statin-intolerant nondiabetic overweight/obese patients with dyslipidemia
    Matilda Florentin
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 14:274-82. 2009
    ..To compare the effects of ezetimibe plus orlistat or rimonabant on anthropometric and lipid parameters in nondiabetic statin-intolerant overweight/obese patients with dyslipidemia...
  81. ncbi request reprint Effect of barnidipine on blood pressure and serum metabolic parameters in patients with essential hypertension: a pilot study
    Athanasia Spirou
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    J Cardiovasc Pharmacol Ther 11:256-61. 2006
    ..Barnidipine should be mainly considered as an antihypertensive agent with neutral effects on most of the studied metabolic parameters in hypertensive patients. Any antioxidant effect of barnidipine needs further investigation...
  82. ncbi request reprint Effect of fenofibrate on serum inflammatory markers in patients with high triglyceride values
    Vasilis Tsimihodimos
    Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
    J Cardiovasc Pharmacol Ther 9:27-33. 2004
    ..In this context, a number of inflammatory markers have been studied for their ability to predict future cardiovascular events in asymptomatic individuals or patients with established atherosclerotic disease...
  83. ncbi request reprint Vascular endothelial growth factor and nitric oxide serum levels in arterial hypertension
    Timoleon Vyzantiadis
    Second Propedeutic Department of Internal Medicine, Aristotelion University of Thessaloniki, Greece
    Clin Exp Hypertens 28:603-9. 2006
    ..The significant decrease of serum VEGF and NO in arterial hypertension and the existence of a correlation between the two substances in healthy subjects that did not exist in the hypertensive patients are findings that need evaluation...
  84. ncbi request reprint Effect of pioglitazone on heart function and N-terminal pro-brain natriuretic peptide levels of patients with type 2 diabetes
    Christos Sambanis
    Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    Acta Diabetol 45:23-30. 2008
    ..Pioglitazone does not affect heart function and even though it increases NT-proBNP, this appears to represent a reaction to volume overload...
  85. doi request reprint Unusual manifestation of diarrhea-associated haemolytic uraemic syndrome in an adult
    Panagiotis Anagnostis
    Second Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
    Ren Fail 30:331-4. 2008
    ..She was treated only with fresh frozen plasma transfusions and hemodialysis, and despite the long duration of anuria (22 days), the patient showed subsequent improvement over days until full recovery one month later...
  86. ncbi request reprint Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia
    George Miltiadous
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Pharmacogenet Genomics 15:219-25. 2005
    ..Specifically, patients with a class V mutation exhibit higher percentage decrease in LDL-C and apoB levels after statin therapy compared to patients sharing class II mutations...
  87. doi request reprint Effects of rimonabant, as monotherapy and in combination with fenofibrate or ezetimibe, on plasma adipokine levels: a pilot study
    Matilda Florentin
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Angiology 61:365-71. 2010
    ..047). Treatment with rimonabant may improve adipokine levels in overweight/obese patients with dyslipidemia. The addition of fenofibrate or ezetimibe may reinforce this effect...
  88. ncbi request reprint Effect of atorvastatin on the concentration, relative distribution, and chemical composition of lipoprotein subfractions in patients with dyslipidemias of type IIA and IIB
    Vasilis Tsimihodimos
    Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
    J Cardiovasc Pharmacol 42:304-10. 2003
    ..Thus, the percentage mass distribution of LDL particles remained unaffected. These results suggest that the effect of atorvastatin on LDL subfractions is affected by the underlying genetic defect...
  89. doi request reprint Cardiovascular risk factors and estimated 10-year risk of fatal cardiovascular events using various equations in Greeks with metabolic syndrome
    Theodoros Chimonas
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Angiology 61:49-57. 2010
    ..This might justify local risk engine evaluation in event-based studies. (Clinical-Trials.gov ID: NCT00416741)...
  90. ncbi request reprint Hypertriglyceridaemic waist phenotype criteria and prevalent metabolic triad in women
    Irene F Gazi
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Diabetes Metab Res Rev 24:223-30. 2008
    ....
  91. pmc Implementation of guidelines for the management of arterial hypertension. The impulsion study
    Asterios Karagiannis
    Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
    Open Cardiovasc Med J 3:26-34. 2009
    ..Further work is needed to establish if the improvement observed is sustained. [ClinicalTrials.gov NCT00416611]...
  92. ncbi request reprint The effect of fluvastatin on plasma fibrinogen levels
    Evagelos Rizos
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Curr Med Res Opin 18:154-5. 2002
    ..We conclude that fluvastatin can significantly decrease plasma fibrinogen levels. However, more studies using fluvastatin and other drugs of this class are necessary to clarify this issue...
  93. ncbi request reprint Effect of ciprofibrate on C-reactive protein and fibrinogen levels
    Evagelos Rizos
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Angiology 53:273-7. 2002
    ..A favorable effect on CRP and fibrinogen levels may increase the clinical efficacy of statins and fibrates...
  94. ncbi request reprint Uric acid homeostasis in the evaluation of diuretic-induced hyponatremia
    George Liamis
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    J Investig Med 55:36-44. 2007
    ..Here we attempt to illuminate the pathophysiology of diuretic-induced hyponatremia by focusing on uric acid homeostasis. Additionally, we analyze the epidemiology and clinical characteristics of the disorder...
  95. ncbi request reprint Differential effect of hypolipidemic drugs on lipoprotein-associated phospholipase A2
    Vasilios G Saougos
    Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece
    Arterioscler Thromb Vasc Biol 27:2236-43. 2007
    ..We investigated the effect of 3 hypolipidemic drugs that exert their action through different mechanisms on plasma and lipoprotein-associated Lp-PLA2 activity and mass...
  96. ncbi request reprint Effect of ciprofibrate on lipoproteins, fibrinogen, renal function, and hepatic enzymes
    Evangelos Rizos
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    J Cardiovasc Pharmacol Ther 7:219-26. 2002
    ..The aim of this study is to answer this question...
  97. doi request reprint Effect of HMG-CoA reductase inhibitors on vascular cell apoptosis: beneficial or detrimental?
    Niki Katsiki
    1st Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 1 Stilponos Kyriakidi Street, 546 36, Thessaloniki, Greece
    Atherosclerosis 211:9-14. 2010
    ..Current data support the initiation of statin treatment early enough to inhibit both the formation of atherosclerotic plaques (primary prevention) and in-stent restenosis (secondary prevention)...
  98. ncbi request reprint Rhabdomyolysis-related renal tubular damage studied by proton nuclear magnetic resonance spectroscopy of urine
    Eleni Bairaktari
    Laboratory of Biochemistry, University Hospital, University of Ioannina, Medical School, 455 00 Ioannina, Greece
    Clin Chem 48:1106-9. 2002
  99. ncbi request reprint Compositional lipoprotein changes and low-density lipoprotein susceptibility to oxidation in chronic renal failure patients with heavy proteinuria
    Sonia Athena Karabina
    Department of Chemistry, Laboratory of Biochemistry, Medical School, University of Ioannina, Ioannina, Greece
    Nephron Clin Pract 95:c77-83. 2003
    ..In this report, we focused on lipoprotein changes observed in uremic patients with proteinuria as well as on the susceptibility of low-density lipoprotein (LDL) of these patients to oxidative modification in vitro...
  100. ncbi request reprint Benign migratory glossitis or geographic tongue: an enigmatic oral lesion
    Dimitrios Assimakopoulos
    Department of Otorhinolaryngology, Medical School, University of Ioannina, Ioannina, Greece
    Am J Med 113:751-5. 2002
    ..The disorder is characterized by exacerbations and remissions. In most cases, patients do not require treatment other than reassurance about the benign nature of the disorder...
  101. ncbi request reprint Multiple metabolic abnormalities in a patient with the syndrome of inappropriate antidiuresis
    Evangelos Rizos
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Nephron 91:339-40. 2002
    ..These abnormalities could be partly due to the extracellular volume expansion and were corrected with the water restriction-induced increase in serum sodium levels...