Affiliation: Aristotle University of Thessaloniki
Angelopoulou K, Karagiannis G. The canine kallikrein-related peptidases 9 and 10: structural characterization and expression in mammary cancer. Mamm Genome. 2009;20:758-67 pubmed publisher
..Overall, this is the first study that experimentally characterizes canine KLK9 and KLK10 and demonstrates their expression in normal and malignant tissues. ..
Karagiannis G, Afaloniati H, Karamanavi E, Poutahidis T, Angelopoulou K. BMP pathway suppression is an early event in inflammation-driven colon neoplasmatogenesis of uPA-deficient mice. Tumour Biol. 2016;37:2243-55 pubmed publisher
..These findings propose that BMP pathway suppression in colon cancer could be associated with very early stages of the preneoplasia-to-neoplasia sequence of events. ..
Angelopoulou K, Karagiannis G. Identification, Molecular Characterization and Alternative Splicing of Three Novel Members of the Canine Kallikrein (Klk)-related Peptidase Family. Anticancer Res. 2015;35:2715-23 pubmed
..Our data lay sufficient groundwork for validation studies and await further incorporation into genetic/evolutionary studies with translational impact. ..
Afaloniati H, Karagiannis G, Hardas A, Poutahidis T, Angelopoulou K. Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators. Exp Cell Res. 2017;361:257-264 pubmed publisher
..These findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis...
Angelopoulou K, Zavlaris M, Papaioannou N, Vlemmas I. Canis familiaris telomerase reverse transcriptase undergoes alternative splicing. Mamm Genome. 2008;19:647-53 pubmed publisher
..This is the first identification of alternative splicing events within dogTERT. The results presented here may provide the basis for more thorough studies on the regulation of telomerase activity in canine normal and cancer cells. ..
Angelopoulou K, Prassas I, Yousef G. The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer. Gene. 2009;446:68-74 pubmed publisher
..These findings may form the basis for the establishment of comparative studies investigating KLK functions in health and disease using the dog as a model...
Angelopoulou K, Karagiannis G. Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer. Mamm Genome. 2010;21:516-24 pubmed publisher
..Moreover, a parallel expression of the studied canine KLKs was observed, which suggested a possible participation of the encoded enzymes in interrelated proteolytic cascades taking place in the mammary gland...