M E Falagas

Summary

Affiliation: Alfa Institute of Biomedical Sciences
Country: Greece

Publications

  1. doi request reprint Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Greece
    Clin Infect Dis 56:272-82. 2013
  2. ncbi request reprint Inhaled antibiotics in mechanically ventilated patients
    A S Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Minerva Anestesiol 80:236-44. 2014
  3. pmc Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients
    Argyris S Michalopoulos
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Greece
    Ann Intensive Care 1:30. 2011
  4. doi request reprint Aminoglycoside therapy in infectious diseases
    Panagiotis Poulikakos
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Expert Opin Pharmacother 14:1585-97. 2013
  5. pmc Reaction to the threat of influenza pandemic: the mass media and the public
    Matthew E Falagas
    Crit Care 10:408. 2006
  6. pmc Oral decontamination with chlorhexidine reduces the incidence of nosocomial pneumonia
    Ilias I Siempos
    Crit Care 11:402; author reply 402. 2007
  7. pmc Attributable mortality of Acinetobacter baumannii: no longer a controversial issue
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Crit Care 11:134. 2007
  8. pmc World Wide Web resources on control of nosocomial infections
    Ilias I Siempos
    Alfa Institute of Biomedical Sciences, Marousi, Athens, Greece
    Crit Care 11:101. 2007
  9. pmc Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Greece
    Crit Care 10:R48. 2006
  10. pmc The effect of psychosocial factors on breast cancer outcome: a systematic review
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Breast Cancer Res 9:R44. 2007

Detail Information

Publications148 found, 100 shown here

  1. doi request reprint Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Greece
    Clin Infect Dis 56:272-82. 2013
    ..Well-designed randomized controlled trials are warranted to confirm these findings before such approaches become widely used...
  2. ncbi request reprint Inhaled antibiotics in mechanically ventilated patients
    A S Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Minerva Anestesiol 80:236-44. 2014
    ..Indeed, more data are needed to establish the appropriate role of inhaled antibiotics for the treatment of VAP. ..
  3. pmc Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients
    Argyris S Michalopoulos
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Greece
    Ann Intensive Care 1:30. 2011
    ....
  4. doi request reprint Aminoglycoside therapy in infectious diseases
    Panagiotis Poulikakos
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Expert Opin Pharmacother 14:1585-97. 2013
    ..Aminoglycosides are of the oldest antibiotics. Even though representatives of the class are used in various applications, the use that has established aminoglycosides in medicine is their antimicrobial activity...
  5. pmc Reaction to the threat of influenza pandemic: the mass media and the public
    Matthew E Falagas
    Crit Care 10:408. 2006
  6. pmc Oral decontamination with chlorhexidine reduces the incidence of nosocomial pneumonia
    Ilias I Siempos
    Crit Care 11:402; author reply 402. 2007
  7. pmc Attributable mortality of Acinetobacter baumannii: no longer a controversial issue
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Crit Care 11:134. 2007
    ..baumannii as well as the implementation of infection control measures that may help us in the control of the increasing problem of A. baumannii infections...
  8. pmc World Wide Web resources on control of nosocomial infections
    Ilias I Siempos
    Alfa Institute of Biomedical Sciences, Marousi, Athens, Greece
    Crit Care 11:101. 2007
    ....
  9. pmc Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Greece
    Crit Care 10:R48. 2006
    ..There has been a continuing controversy about whether infection with Acinetobacter baumannii increases morbidity and mortality independently of the effect of other confounding factors...
  10. pmc The effect of psychosocial factors on breast cancer outcome: a systematic review
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Breast Cancer Res 9:R44. 2007
    ..We sought to review the available evidence regarding the effect of psychosocial factors on the survival of breast cancer patients...
  11. pmc Health promotion programs related to the Athens 2004 Olympic and Para Olympic games
    Elpidoforos S Soteriades
    Alfa Institute of Biomedical Sciences, Athens, Greece
    BMC Public Health 6:47. 2006
    ..Our objective was to identify and describe the population-based health-promotion programs implemented in relation to the Athens 2004 Olympic and Para Olympic Games...
  12. pmc A bibliometric analysis in the fields of preventive medicine, occupational and environmental medicine, epidemiology, and public health
    Elpidoforos S Soteriades
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    BMC Public Health 6:301. 2006
    ..In order to map the research production around the world we performed a bibliometric analysis in the above fields...
  13. pmc E-meducation.org: an open access medical education web portal
    Vangelis G Alexiou
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    BMC Med Educ 8:6. 2008
    ..We sought to provide the world medical community with a web portal that may be used as a clearinghouse providing the outlet for dissemination of high quality WWW educational products...
  14. pmc Serologic indices of hepatitis B virus infection in military recruits in Greece (2004-2005)
    Vasilios German
    Department of Internal Medicine and Infectious Diseases, 401 Army General Hospital of Athens, Greece
    BMC Infect Dis 6:163. 2006
    ..The prevalence of hepatitis B virus infection in Greece has been decreasing over the last decades. However, recent epidemiological data are lacking...
  15. pmc A bibliometric analysis of research productivity in Parasitology by different world regions during a 9-year period (1995-2003)
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    BMC Infect Dis 6:56. 2006
    ..The objective of this study was to estimate the research productivity of different world regions in the field of Parasitology...
  16. pmc Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    BMC Infect Dis 6:99. 2006
    ..Antimicrobial resistance is one of the most challenging issues in modern medicine...
  17. pmc Prevalence and predictors of tuberculin skin positivity in Hellenic Army recruits
    Vasilios German
    Medical Service of the Hellenic Army Supply and Transportation Corps Training Center, Sparta, Greece
    BMC Infect Dis 6:102. 2006
    ..In this study, we analyzed the prevalence and predictors of tuberculin skin testing positivity in Hellenic Army recruits...
  18. pmc An analysis of patient house calls in the area of Attica, Greece
    George Peppas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    BMC Health Serv Res 6:112. 2006
    ..Physicians house calls to patients have been declining in many countries of the world. The objective of this study was to describe the patterns of utilization of house call services provided by SOS doctors in the area of Attica, Greece...
  19. pmc Epidemiology of constipation in Europe and Oceania: a systematic review
    George Peppas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    BMC Gastroenterol 8:5. 2008
    ..We aimed to review the literature regarding the epidemiology of constipation in Europe and Oceania and the associated prevalence/risk factors...
  20. ncbi request reprint Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 29:630-6. 2007
    ....
  21. ncbi request reprint Sex differences in the incidence and severity of respiratory tract infections
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Greece
    Respir Med 101:1845-63. 2007
    ..The role of sex hormones in the regulation of the immune system may also contribute to the reported sex differences in the incidence and severity of the various types of RTIs, especially in adolescents and adults...
  22. doi request reprint Incidence, characteristics and outcomes of patients with severe community acquired-MRSA pneumonia
    K Z Vardakas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Greece
    Eur Respir J 34:1148-58. 2009
    ..001), shock (p = 0.001), acute respiratory distress syndrome (p = 0.001), influenza like symptoms (p = 0.008), disseminated intravascular coagulation (p = 0.042) and rash (p = 0.04) were the factors associated with death...
  23. ncbi request reprint Daptomycin for endocarditis and/or bacteraemia: a systematic review of the experimental and clinical evidence
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 60:7-19. 2007
    ..Furthermore, it is a bactericidal antibiotic, a factor that is frequently considered in the choice of treatment of patients with bacteraemia and endocarditis...
  24. ncbi request reprint Infections related to coils used for embolization of arteries: review of the published evidence
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Marousi, Greece
    J Vasc Interv Radiol 18:697-701. 2007
    ..However, the existence of the identified case reports suggests that clinicians should include coil-related infection in the differential diagnosis of patients with fever after this procedure...
  25. doi request reprint Community-acquired Stenotrophomonas maltophilia infections: a systematic review
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23, Marousi, Athens, Greece
    Eur J Clin Microbiol Infect Dis 28:719-30. 2009
    ..maltophilia infections; the majority of them refer to patients with some kind of comorbidity. Physicians should be aware that S. maltophilia infections are not restricted to hospitalized patients...
  26. ncbi request reprint Do high doses of quinolones decrease the emergence of antibacterial resistance? A systematic review of data from comparative clinical trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Marousi, Greece
    J Infect 55:97-105. 2007
    ..To evaluate whether the use of high doses of quinolones may reduce the development of antimicrobial resistance...
  27. doi request reprint Matching criteria in case-control studies on postoperative infections
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Marousi, Greece
    J Hosp Infect 69:101-13. 2008
    ..A more consistent use of matching with the specific type of surgical procedure may help in increasing the internal validity of a case-control study in this field of clinical research...
  28. doi request reprint Effect of body mass index on the outcome of infections: a systematic review
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Obes Rev 10:280-9. 2009
    ..Although not consistently reported, an association of both ends of the BMI distribution with worse outcome of infections is plausible and merits further investigation...
  29. doi request reprint Do PubMed and Google searches help medical students and young doctors reach the correct diagnosis? A pilot study
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Eur J Intern Med 20:788-90. 2009
    ..In the era of the World Wide Web we sought to examine whether the use of PubMed and Google can help physicians to improve their diagnostic skills...
  30. ncbi request reprint Guidelines and consensus statements regarding the conduction and reporting of clinical research studies
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Marousi, Greece
    Arch Intern Med 167:877-8. 2007
  31. ncbi request reprint When to include polymyxins in the empirical antibiotic regimen in critically ill patients with fever? A decision analysis approach
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Shock 27:605-9. 2007
    ..baumannii, P. aeruginosa, or K. pneumoniae) is polymyxin-only-susceptible is close to that (50%) used in our model (based on the individual hospital data)...
  32. ncbi request reprint Trends in antimicrobial resistance of Acinetobacter baumannii clinical isolates from hospitalised patients in Greece and treatment implications
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Clin Microbiol Infect 13:816-9. 2007
    ..baumannii isolates resistant to imipenem from patients hospitalised in intensive care units, medical wards and surgical wards during the study period from 0% to 91%, 8% to 71%, and 5% to 71%, respectively...
  33. doi request reprint Comparison of antibiotics with placebo for treatment of acute sinusitis: a meta-analysis of randomised controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Lancet Infect Dis 8:543-52. 2008
    ..We suggest that antibiotics should be reserved for carefully selected patients with a higher probability for bacterial disease...
  34. doi request reprint Bacterial interference for the prevention and treatment of infections
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 31:518-22. 2008
    ..Such trials should initially employ selected strains of probiotics for which there are preliminary data regarding their effectiveness and lack of common or serious toxicity...
  35. doi request reprint Short- versus long-duration antimicrobial treatment for exacerbations of chronic bronchitis: a meta-analysis
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 62:442-50. 2008
    ..The aim of this study was to evaluate the comparative effectiveness and safety of short (5 days) and long (7 or 10 days) duration antimicrobial treatment of patients with acute exacerbations of chronic bronchitis (AECB)...
  36. doi request reprint Statins for infection and sepsis: a systematic review of the clinical evidence
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 61:774-85. 2008
    ..Statins are currently used for hyperlipidaemia control and considered useful for protection from cardiovascular events. In addition, there is increasing evidence for the potential use of statins in preventing and treating infections...
  37. ncbi request reprint Clinical Microbiology and Infectious Diseases (ECCMID)--18th European Congress. Drug resistance among Gram-negative and Gram-positive bacteria
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    IDrugs 11:409-11. 2008
  38. pmc Socioeconomic status (SES) as a determinant of adherence to treatment in HIV infected patients: a systematic review of the literature
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Retrovirology 5:13. 2008
    ..Thus, we sought to perform a systematic review of the evidence regarding the association of SES with adherence to treatment of patients with HIV/AIDS...
  39. doi request reprint The top-ten in journal impact factor manipulation
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Arch Immunol Ther Exp (Warsz) 56:223-6. 2008
    ..Editors and publishers should strive for quality through fair and thoughtful selection of papers forwarded for peer review and editorial comments that enhance the quality and scientific accuracy of a manuscript...
  40. ncbi request reprint Effectiveness and safety of short-course vs long-course antibiotic therapy for group a beta hemolytic streptococcal tonsillopharyngitis: a meta-analysis of randomized trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos St, 151 23 Marousi, Athens, Greece
    Mayo Clin Proc 83:880-9. 2008
    ..To evaluate the effectiveness and safety of short-course antibiotic treatment of group A beta-hemolytic streptococcal (GAS) tonsillopharyngitis...
  41. ncbi request reprint Decreasing the incidence and impact of infections in neutropenic patients: evidence from meta-analyses of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Curr Med Res Opin 24:215-35. 2008
    ..Many interventions have been employed in order to limit the incidence of these infections or to treat them when the prophylactic measures fail...
  42. pmc Acinetobacter infections: a growing threat for critically ill patients
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Epidemiol Infect 136:1009-19. 2008
    ..The data suggest that Acinetobacter infections are a growing threat affecting a considerable proportion of critically ill patients, especially in Asia and Europe...
  43. doi request reprint A systematic review of trends in the methodological quality of randomized controlled trials in various research fields
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Marousi, Greece
    J Clin Epidemiol 62:227-31, 231.e1-9. 2009
    ..We sought to evaluate the trends in the methodological quality of randomized controlled trials in various medical fields...
  44. ncbi request reprint Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos St, 151 23 Marousi, Greece
    FASEB J 22:338-42. 2008
    ..Google Scholar, as for the Web in general, can help in the retrieval of even the most obscure information but its use is marred by inadequate, less often updated, citation information...
  45. ncbi request reprint Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 60:1124-30. 2007
    ..Thus, the emergence of infections due to carbapenem-resistant K. pneumoniae (CRKp) is a major public health concern...
  46. doi request reprint Effect of meteorological variables on the incidence of lower urinary tract infections
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23, Marousi, Athens, Greece
    Eur J Clin Microbiol Infect Dis 28:709-12. 2009
    ..The awareness of this association may facilitate preventive public health strategies. [corrected]..
  47. doi request reprint Inhaled colistin as monotherapy for multidrug-resistant gram (-) nosocomial pneumonia: a case series
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Respir Med 103:707-13. 2009
    ..Reports of patients with polymyxin-only susceptible gram-negative nosocomial pneumonia treated with inhaled, but without concurrent intravenous, colistin are rare...
  48. pmc Effectiveness and safety of short vs. long duration of antibiotic therapy for acute bacterial sinusitis: a meta-analysis of randomized trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, Marousi, Greece
    Br J Clin Pharmacol 67:161-71. 2009
    ....
  49. doi request reprint Systemic colistin use in children without cystic fibrosis: a systematic review of the literature
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 33:503.e1-503.e13. 2009
    ..The available evidence, mainly from old case series, suggests that systemic colistin is an effective and acceptably safe option for the treatment of children without CF who have MDR Gram-negative infections...
  50. ncbi request reprint Under-diagnosis of common chronic diseases: prevalence and impact on human health
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Int J Clin Pract 61:1569-79. 2007
    ..Our impression was that several common chronic diseases responsible for many DALYs are frequently under-diagnosed...
  51. doi request reprint Article and journal impact factor in various scientific fields
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Marousi, Greece
    Am J Med Sci 335:188-91. 2008
    ..with data to answer the following simple question: What proportion of publications in the various scientific fields is published in journals with impact factor above the median and mean values of the distribution of journal impact factor?..
  52. doi request reprint Fosfomycin for the treatment of infections caused by Gram-positive cocci with advanced antimicrobial drug resistance: a review of microbiological, animal and clinical studies
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 15123 Marousi, Athens, Greece
    Expert Opin Investig Drugs 18:921-44. 2009
    ..The advancing antimicrobial drug resistance in Gram-positive cocci complicates the selection of appropriate therapy. The re-evaluation of older antibiotics may prove useful in expanding relevant therapeutic options...
  53. doi request reprint Airborne hydrogen peroxide for disinfection of the hospital environment and infection control: a systematic review
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Hosp Infect 78:171-7. 2011
    ..This was associated with control of a nosocomial outbreak in two studies, eradication of persistent environmental contamination with MRSA and decrease in C. difficile infection in each of the remaining two studies...
  54. pmc Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Crit Care 10:R123. 2006
    ....
  55. ncbi request reprint Arab science in the golden age (750-1258 C.E.) and today
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos St, Marousi 15123, Greece
    FASEB J 20:1581-6. 2006
  56. doi request reprint Inadequate statistical power of published comparative cohort studies on ventilator-associated pneumonia to detect mortality differences
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA
    Clin Infect Dis 50:468-72. 2010
    ..We aimed to evaluate the power of such studies to provide clinically and statistically significant conclusions with regard to mortality differences...
  57. doi request reprint Antimicrobial susceptibility of Gram-positive non-urinary isolates to fosfomycin
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 35:497-9. 2010
    ..Fosfomycin was inactive against the 166 enterococcal isolates tested. This old antibiotic may deserve consideration for further studies and use in clinical practice, especially for S. aureus (including MRSA) infections...
  58. ncbi request reprint A bibliometric analysis of global trends of research productivity in tropical medicine
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Acta Trop 99:155-9. 2006
    ....
  59. doi request reprint Effectiveness and safety of neuraminidase inhibitors in reducing influenza complications: a meta-analysis of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 151 23 Marousi, Athens, Greece
    J Antimicrob Chemother 65:1330-46. 2010
    ..Several studies suggest that neuraminidase inhibitors (NIs) can reduce the duration of influenza symptoms. However, data regarding their effectiveness in reducing influenza complications are scarce...
  60. ncbi request reprint "Eigenlob": self-citation in biomedical journals
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    FASEB J 20:1039-42. 2006
  61. doi request reprint Tuberculosis and malignancy
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Greece
    QJM 103:461-87. 2010
    ..Surprisingly, the pathophysiological and practical implications of their co-existence have received little attention...
  62. doi request reprint Colistin therapy for microbiologically documented multidrug-resistant Gram-negative bacterial infections: a retrospective cohort study of 258 patients
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 15 123 Marousi, Athens, Greece
    Int J Antimicrob Agents 35:194-9. 2010
    ..The findings of the largest cohort study to date on i.v. colistin show that colistin is a valuable antibiotic with acceptable nephrotoxicity and considerable effectiveness that depends on the daily dosage and infection site...
  63. pmc Secular trends of blood isolates in patients from a rural area population hospitalized in a tertiary center in a small city in Greece
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    BMC Microbiol 6:41. 2006
    ..We sought to study the trends of the antimicrobial resistance of blood isolates in patients from a rural population hospitalized in a tertiary hospital in a small city in Greece...
  64. ncbi request reprint Comparison of mortality of patients with Acinetobacter baumannii bacteraemia receiving appropriate and inappropriate empirical therapy
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS Athens, Greece
    J Antimicrob Chemother 57:1251-4. 2006
    ..To evaluate the effect of inappropriate empirical antimicrobial treatment on the mortality of patients with Acinetobacter baumannii bacteraemia...
  65. doi request reprint Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Antimicrob Chemother 65:1862-77. 2010
    ..Cystitis is a common infection. The alarmingly high resistance rates exhibited by contemporary uropathogens necessitate the re-evaluation of old antibiotics...
  66. ncbi request reprint The role of aminoglycosides in combination with a beta-lactam for the treatment of bacterial endocarditis: a meta-analysis of comparative trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 57:639-47. 2006
    ..The addition of an aminoglycoside to a beta-lactam for the treatment of patients with infective endocarditis has been supported by data from laboratory and animal studies...
  67. ncbi request reprint Urinary tract infections in patients with urinary diversion
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Department of Medicine, Henry Dunant Hospital, Athens, Greece
    Am J Kidney Dis 46:1030-7. 2005
    ..In addition, symptoms from the lower urinary tract may not be prominent in this population...
  68. doi request reprint Inaccuracies in dosing drugs with teaspoons and tablespoons
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Int J Clin Pract 64:1185-9. 2010
    ..We aimed to evaluate the potential inaccuracies in administering the desired dose of drugs with teaspoons and tablespoons...
  69. ncbi request reprint Microbiologically documented nosocomial infections after coronary artery bypass surgery without cardiopulmonary bypass
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Thorac Cardiovasc Surg 132:481-90. 2006
    ..This study was undertaken to evaluate the frequency, characteristics, and risk factors of microbiologically documented nosocomial infections after off-pump coronary artery bypass grafting...
  70. doi request reprint Economic crises and mortality: a review of the literature
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Clin Pract 63:1128-35. 2009
    ..Public health authorities should be aware of this issue and consider appropriate preventive and control measures...
  71. ncbi request reprint Caspofungin for the treatment of fungal infections: a systematic review of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 29:136-43. 2007
    ..No difference in mortality was noted. Caspofungin was associated with better clinical outcomes (higher cure and fewer adverse effects) than amphotericin B in the treatment of patients with fungal infections...
  72. ncbi request reprint Morganella morganii infections in a general tertiary hospital
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23, Marousi, Athens, Greece
    Infection 34:315-21. 2006
    ..Morganella morganii is a commensal Gram-negative bacillus of the intestinal tract of humans and other mammals and reptiles. Few reports exist in the literature regarding infections caused by this organism...
  73. ncbi request reprint Systematic review: fluoroquinolones for the treatment of intra-abdominal surgical infections
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Aliment Pharmacol Ther 25:123-31. 2007
    ..Intra-abdominal infections result in substantial morbidity and mortality. Fluoroquinolones are among the various regimens that are used for the treatment of these infections...
  74. ncbi request reprint Fluoroquinolones vs beta-lactams for empirical treatment of immunocompetent patients with skin and soft tissue infections: a meta-analysis of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos St, 151 23 Marousi, Athens, Greece
    Mayo Clin Proc 81:1553-66. 2006
    ..To compare the effectiveness and safety of fluoroquinolones with beta-lactams in the treatment of patients with skin and soft tissue infections (SSTIs)...
  75. ncbi request reprint Intravenous heparin in combination with antibiotics for the treatment of deep vein septic thrombophlebitis: a systematic review
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Eur J Pharmacol 557:93-8. 2007
    ..Although data from comparative trials are required to draw definitive conclusions, the available evidence suggests that the administration of heparin should be considered early in the management of patients with septic thrombophlebitis...
  76. ncbi request reprint Streptococcus agalactiae infections in non-pregnant adults: single center experience of a growing clinical problem
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Med Sci Monit 12:CR447-51. 2006
    ..Group B beta-hemolytic streptococcus (Streptococcus agalactiae) has been traditionally considered a major pathogen in neonates and pregnant women. However, there is accumulating concern about its significance in non-pregnant adults too...
  77. pmc Seasonality of mortality: the September phenomenon in Mediterranean countries
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Department of Medicine, Henry Dunant Hospital, Athens, Greece
    CMAJ 181:484-6. 2009
    ..Seasonal increases in the mortality rate have been associated with excessively cold or hot weather. We evaluated monthly patterns of mortality in selected countries...
  78. doi request reprint Extended-spectrum beta-lactamase-producing organisms
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    J Hosp Infect 73:345-54. 2009
    ..Tigecycline and polymyxins have substantial antimicrobial activity against ESBL-producing Enterobacteriaceae, and, along with fosfomycin, merit further evaluation...
  79. ncbi request reprint Effectiveness and nephrotoxicity of intravenous colistin for treatment of patients with infections due to polymyxin-only-susceptible (POS) gram-negative bacteria
    M E Falagas
    Department of Medicine, Tufts University School of Medicine, Boston, MA, USA
    Eur J Clin Microbiol Infect Dis 25:596-9. 2006
    ..POS gram-negative pathogens represent a major threat for hospitalized patients. Colistin appears to be an effective and safe treatment, even in patients with severe underlying diseases...
  80. doi request reprint Do changes in antimicrobial resistance necessitate reconsideration of surgical antimicrobial prophylaxis strategies?
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Surg Infect (Larchmt) 10:557-62. 2009
    ..The potential need for re-evaluation of guidelines on surgical antimicrobial prophylaxis (AMP) in an era of advancing antimicrobial resistance is a matter of a considerable controversy...
  81. doi request reprint The pleiotropic effects of statins and omega-3 fatty acids against sepsis: a new perspective
    Gregory C Makris
    Alfa Institute of Biomedical Sciences AIBS, Marousi, Greece
    Expert Opin Investig Drugs 19:809-14. 2010
    ..Appropriately designed and powered clinical trials are warranted to investigate the effectiveness and safety of the combined administration of statins and OM3FA for the prevention and treatment of sepsis...
  82. ncbi request reprint Carbapenems for the treatment of immunocompetent adult patients with nosocomial pneumonia
    I I Siempos
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Eur Respir J 29:548-60. 2007
    ..In patients with Pseudomonas aeruginosa pneumonia, carbapenems are associated with worse outcomes than the comparators...
  83. doi request reprint Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a prospective evaluation
    A Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Clin Microbiol Infect 16:184-6. 2010
    ..Intravenous fosfomycin may be a beneficial and safe adjunctive treatment in the management of life-threatening ICU-acquired infections caused by carbapenem-resistant K. pneumoniae...
  84. doi request reprint Candidaemia: incidence, risk factors, characteristics and outcomes in immunocompetent critically ill patients
    K Z Vardakas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Clin Microbiol Infect 15:289-92. 2009
    ..ICU and total in-hospital mortality were 40% and 66.7%, respectively. Candidaemia-related mortality was 20%. Candidaemia treatment failure was the only variable associated with in-hospital mortality (p 0.008)...
  85. ncbi request reprint Comparison of community-acquired pneumonia due to methicillin-resistant and methicillin-susceptible Staphylococcus aureus producing the Panton-Valentine leukocidin
    K Z Vardakas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Int J Tuberc Lung Dis 13:1476-85. 2009
    ..aureus (MSSA) community-acquired pneumonia (CAP) producing the Panton-Valentine leukocidin (PVL)...
  86. ncbi request reprint Probiotics for the treatment of women with bacterial vaginosis
    M E Falagas
    Alfa Institute of Biomedical Sciences, Marousi, Greece
    Clin Microbiol Infect 13:657-64. 2007
    ..Thus, although the available results concerning the effectiveness of the administration of lactobacilli for the treatment of BV are mostly positive, it cannot yet be concluded definitively that probiotics are useful for this purpose...
  87. doi request reprint The therapeutic effect of balneotherapy: evaluation of the evidence from randomised controlled trials
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Int J Clin Pract 63:1068-84. 2009
    ..Systematic review...
  88. doi request reprint Epidemiological aspects of 2009 H1N1 influenza: the accumulating experience from the Northern Hemisphere
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, Marousi, 151 23, Athens, Greece
    Eur J Clin Microbiol Infect Dis 29:1327-47. 2010
    ..The evaluation of the currently available published evidence contributes to the clarification of the epidemiological features of pandemic 2009 A(H1N1) influenza, which is useful in terms of the individual and public health perspectives...
  89. doi request reprint Clinical practice of obtaining blood cultures from patients with a central venous catheter in place: an international survey
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Department of Medicine, Henry Dunant Hospital, Athens, Greece
    Clin Microbiol Infect 15:683-6. 2009
    ..Clinicians who, according to the survey, demonstrated that they know the diagnostic performance characteristics of cultures more often obtain one culture from the CVC and one from the PV (73.9% vs. 61.7%, p 0.037)...
  90. ncbi request reprint Psychosocial factors and susceptibility to or outcome of acute respiratory tract infections
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Int J Tuberc Lung Dis 14:141-8. 2010
    ..To perform a systematic review of the literature to assess the possible effect that psychosocial variables may have on the susceptibility and/or outcome of acute respiratory tract infections (ARTIs)...
  91. doi request reprint Comparison of the distribution of citations received by articles published in high, moderate, and low impact factor journals in clinical medicine
    M E Falagas
    Department of Medicine, Alfa Institute of Biomedical Sciences, Athens, Greece
    Intern Med J 40:587-91. 2010
    ..We sought to further investigate this issue in general and internal medicine journals...
  92. ncbi request reprint Risk factors leading to clinical failure in the treatment of intra-abdominal or skin/soft tissue infections
    M E Falagas
    Division of Infectious Diseases, New England Medical Center, Boston, Massachusetts, USA
    Eur J Clin Microbiol Infect Dis 15:913-21. 1996
    ..in its spectrum when this organism is isolated from patients with such infections...
  93. doi request reprint Probiotic bacteria and biosurfactants for nosocomial infection control: a hypothesis
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Hosp Infect 71:301-6. 2009
    ..This could potentially impede a central step in the pathogenesis of nosocomial infections...
  94. doi request reprint Antimicrobial susceptibility of multidrug-resistant Gram negative bacteria to fosfomycin
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Eur J Clin Microbiol Infect Dis 27:439-43. 2008
    ..pneumoniae and, secondly, P. aeruginosa...
  95. ncbi request reprint Risk factors for the isolation of multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa: a systematic review of the literature
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Hosp Infect 64:7-15. 2006
    ..baumannii and P. aeruginosa suggests that a separate outbreak investigation should be performed in each hospital setting. The development of innovative control strategies is needed in order to limit the spread of these pathogens...
  96. ncbi request reprint Meta-analysis: randomized controlled trials of clindamycin/aminoglycoside vs. beta-lactam monotherapy for the treatment of intra-abdominal infections
    M E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Aliment Pharmacol Ther 25:537-56. 2007
    ..To compare the effectiveness and safety of clindamycin/aminoglycoside with broad-spectrum beta-lactam monotherapy in patients with intra-abdominal infections by performing a meta-analysis of randomized controlled trials (RCTs)...
  97. ncbi request reprint Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, Athens, Marousi, 15123, Greece
    Eur J Clin Microbiol Infect Dis 25:419-25. 2006
    ....
  98. ncbi request reprint Effectiveness and nephrotoxicity of colistin monotherapy vs. colistin-meropenem combination therapy for multidrug-resistant Gram-negative bacterial infections
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Clin Microbiol Infect 12:1227-30. 2006
    ..21/57 (36.8%) deaths, p 0.007), even after adjusting for the variables for which significant differences were found...
  99. ncbi request reprint Effect of aerosolized colistin on multidrug-resistant Pseudomonas aeruginosa in bronchial secretions of patients without cystic fibrosis
    M Horianopoulou
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Chemother 17:536-8. 2005
    ..The results of this preliminary study suggest that aerosolized colistin was effective in reducing quickly the microbial counts and eliminating microbial growth of Pseudomonas aeruginosa by the sixth day of use in all studied patients...
  100. ncbi request reprint Gangrenous, hemorrhagic, bullous cellulitis associated with pseudomonas aeruginosa in a patient with Waldenström's macroglobulinemia
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, Marousi, 151 23, Athens, Greece
    Infection 35:370-3. 2007
    ..Patients with Waldenström's macroglobulinemia may manifest several types of skin lesions. We present our experience with a patient with the disease that adds to the literature on the topic...
  101. doi request reprint An analysis of trends in globalisation of origin of research published in major general medical journals
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Int J Clin Pract 62:71-5. 2008
    ..There is an ongoing discussion in the scientific community that even the leading scientific journals publish mainly research that is produced in the countries where these journals are based...