Mukhopadhyay P, Seelan R, Greene R, Pisano M. Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells. Reprod Toxicol. 2019;86:76-85 pubmed publisher
..Ingenuity Pathway and NIH-DAVID analyses revealed cellular response pathways, biological themes, and potential upstream regulators, that may underlie altered fetal programming of arsenate exposed CNCCs. ..
WARNER D, Ding J, Mukhopadhyay P, Brock G, Smolenkova I, Seelan R, et al
. Temporal Expression of miRNAs in Laser Capture Microdissected Palate Medial Edge Epithelium from TgfÎ²3(-/-) Mouse Fetuses. Microrna. 2015;4:64-71 pubmed
..Moreover, analysis of the TgfÎ²3 knockout mouse model has enabled identification of miRNAs with altered expression that may contribute to the cleft palate phenotype. ..
Greene R, Pisano M. Palate morphogenesis: current understanding and future directions. Birth Defects Res C Embryo Today. 2010;90:133-54 pubmed publisher
Mukhopadhyay P, Seelan R, Rezzoug F, Warner D, Smolenkova I, Brock G, et al
. Determinants of orofacial clefting I: Effects of 5-Aza-2'-deoxycytidine on cellular processes and gene expression during development of the first branchial arch. Reprod Toxicol. 2017;67:85-99 pubmed publisher
..CpG methylation analysis suggested that the effects of AzaD on gene expression were likely indirect. ..
Seelan R, Mukhopadhyay P, Warner D, Smolenkova I, Pisano M, Greene R. Determinants of orofacial clefting II: Effects of 5-Aza-2'-deoxycytidine on gene methylation during development of the first branchial arch. Reprod Toxicol. 2017;67:100-110 pubmed publisher
..This may result in the dysregulation of key signaling pathways during palatogenesis, causing CP. ..
Mukhopadhyay P, Greene R, Pisano M. Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells. Reprod Toxicol. 2015;58:140-8 pubmed publisher
..Collectively, these data allow the suggestion of a potential epigenetic mechanism underlying maternal cigarette smoke exposure-induced orofacial clefting. ..