Ralph Graeser

Summary

Publications

  1. ncbi Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
    Ralph Graeser
    ICRF Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    J Cell Sci 115:3479-90. 2002
  2. ncbi Antimetastatic effects of liposomal gemcitabine and empty liposomes in an orthotopic mouse model of pancreatic cancer
    Ralph Graeser
    ProQinase GmbH, Freiburg, Germany
    Pancreas 38:330-7. 2009
  3. ncbi Anti-metastatic effects of liposomal gemcitabine in a human orthotopic LNCaP prostate cancer xenograft model
    Peter Jantscheff
    Department of Clinical Research, Tumor Biology Center, Freiburg, Germany
    Clin Exp Metastasis 26:981-92. 2009
  4. ncbi In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B
    Khalid Abu Ajaj
    Tumor Biology Center, Breisacher Strasse 117, 79106, Freiburg, Germany
    Cancer Chemother Pharmacol 64:413-8. 2009
  5. ncbi Zosuquidar and an albumin-binding prodrug of zosuquidar reverse multidrug resistance in breast cancer cells of doxorubicin and an albumin-binding prodrug of doxorubicin
    Khalid Abu Ajaj
    Division of Macromolecular Prodrugs, Tumor Biology Center, Breisacher Strasse 117, 79106, Freiburg, Germany
    Breast Cancer Res Treat 134:117-29. 2012
  6. ncbi Non-invasive in vivo imaging of tumor-associated CD133/prominin
    Chizuko Tsurumi
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 5:e15605. 2010
  7. ncbi Generation of a conditionally transformed murine embryonic fibroblast cell line using doxycycline-dependent IGF-1R overexpression
    Ralph Graeser
    ProQinase GmbH, Tumor Biology Center, Freiburg, Germany
    J Biomol Screen 17:339-49. 2012
  8. ncbi Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP)
    Ralph Graeser
    ProQinase GmbH, Freiburg, Germany
    Int J Cancer 122:1145-54. 2008
  9. ncbi The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes
    Chizuko Tsurumi
    Max Planck Institut fuer Immunbiologie, Developmental Biology, Freiburg, Germany
    J Cell Biol 167:1037-50. 2004

Collaborators

Detail Information

Publications9

  1. ncbi Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
    Ralph Graeser
    ICRF Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    J Cell Sci 115:3479-90. 2002
    ....
  2. ncbi Antimetastatic effects of liposomal gemcitabine and empty liposomes in an orthotopic mouse model of pancreatic cancer
    Ralph Graeser
    ProQinase GmbH, Freiburg, Germany
    Pancreas 38:330-7. 2009
    ..Test the efficacy of liposomal gemcitabine (GemLip) on primary tumor and metastases using the pancreatic tumor cell line AsPC1 implanted orthotopically into nude mice...
  3. ncbi Anti-metastatic effects of liposomal gemcitabine in a human orthotopic LNCaP prostate cancer xenograft model
    Peter Jantscheff
    Department of Clinical Research, Tumor Biology Center, Freiburg, Germany
    Clin Exp Metastasis 26:981-92. 2009
    ....
  4. ncbi In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B
    Khalid Abu Ajaj
    Tumor Biology Center, Breisacher Strasse 117, 79106, Freiburg, Germany
    Cancer Chemother Pharmacol 64:413-8. 2009
    ....
  5. ncbi Zosuquidar and an albumin-binding prodrug of zosuquidar reverse multidrug resistance in breast cancer cells of doxorubicin and an albumin-binding prodrug of doxorubicin
    Khalid Abu Ajaj
    Division of Macromolecular Prodrugs, Tumor Biology Center, Breisacher Strasse 117, 79106, Freiburg, Germany
    Breast Cancer Res Treat 134:117-29. 2012
    ..Thus, a novel formulation of zosuquidar has been developed that could have the potential to improve the toxicity issues and tumor targeting properties of the original compound...
  6. ncbi Non-invasive in vivo imaging of tumor-associated CD133/prominin
    Chizuko Tsurumi
    Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 5:e15605. 2010
    ..Cancer stem cells are thought to play a pivotal role in tumor maintenance, metastasis, tumor therapy resistance and relapse. Hence, the development of methods for non-invasive in vivo detection of cancer stem cells is of great importance...
  7. ncbi Generation of a conditionally transformed murine embryonic fibroblast cell line using doxycycline-dependent IGF-1R overexpression
    Ralph Graeser
    ProQinase GmbH, Tumor Biology Center, Freiburg, Germany
    J Biomol Screen 17:339-49. 2012
    ..Besides efficacy as a read-out, phospho-AKT could be identified as a pharmacodynamic biomarker, establishing this cell line as a valuable tool for the preclinical development of IGF-1R inhibitors...
  8. ncbi Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP)
    Ralph Graeser
    ProQinase GmbH, Freiburg, Germany
    Int J Cancer 122:1145-54. 2008
    ..003) as well as a decrease of the metastatic burden in the lungs as detected in luciferase assays (-50%, SD +/- 115%, *p = 0.038)...
  9. ncbi The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes
    Chizuko Tsurumi
    Max Planck Institut fuer Immunbiologie, Developmental Biology, Freiburg, Germany
    J Cell Biol 167:1037-50. 2004
    ..Thus, SAC proteins are required for checkpoint functions in meiosis I and II, but, in contrast to frog eggs, the SAC is not required for establishing or maintaining the CSF arrest in mouse oocytes...