Role of microglia in CNS inflammationManuel B Graeber
Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, NSW 2050, Australia
FEBS Lett 585:3798-805. 2011
..In addition, we recommend abandoning the terms "microglial inflammation" and "inflamed microglia" because of the lack of a clear concept behind them...
- Multiple mechanisms of microglia: a gatekeeper's contribution to pain states
Manuel B Graeber
Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Exp Neurol 234:255-61. 2012
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Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammationLinda B Moran
University Department of Neuropathology, Imperial College, University of London, Hammersmith Hospitals Trust, London, UK
Neurogenetics 9:1-13. 2008
..The need for systematic human tissue banking, following the highest possible professional and ethical standard to enable sustainability, becomes evident...
- Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies
Linda B Moran
Imperial College London and Hammersmith Hospitals Trust, University Department of Neuropathology, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
Acta Neuropathol 115:471-8. 2008
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- Microglia: biology and pathology
Manuel B Graeber
Division of Neuropathology, Department of Pathology and Clinical Laboratory Medicine, Faculty of Medicine, Neurosciences Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
Acta Neuropathol 119:89-105. 2010
..This review provides an analysis of the latest developments in the microglia field...
- Biomarkers for Parkinson's disease
Manuel B Graeber
The Athenaeum, Pall Mall, London SW1Y 5ER, UK
Exp Neurol 216:249-53. 2009
..This mini-review aims to provide a broader perspective on PD functional genomics and seeks to illustrate in a systems biological context why the findings by Hoepken and colleagues are of clinical significance...
- Changing face of microglia
Manuel B Graeber
Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
Science 330:783-8. 2010
..Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored...
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivoJames E Harris
Department of Infectious Diseases and Immunity, Imperial College, Du Cane Road, London, United Kingdom
J Immunol 178:1199-207. 2007
..Astrocytes may contribute to a matrix degrading environment within the CNS and subsequent morbidity and mortality...
- Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
Emilie Croisier
University Department of Neuropathology, Imperial College London and Hammersmith Hospitals Trust, Charing Cross Campus, Fulham Palace Road, London, UK
Acta Neuropathol (Berl) 112:517-30. 2006
..Examples from the spectrum of alpha-synucleinopathies are presented...
- Microglia in gemistocytic astrocytomas
Fatemeh Geranmayeh
University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience and Mental Health, Hammersmith Hospitals Trust, London, England
Neurosurgery 60:159-66; discussion 166. 2007
..Microglial cells, a feature of this astrocytoma variant, are of increasing interest in the context of glioma growth...
- The microglial gene regulatory network activated by interferon-gamma
Linda B Moran
University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience, and Hammersmith Hospitals Trust, London, UK
J Neuroimmunol 183:1-6. 2007
..In addition, genes of similar function that are differentially regulated are less likely to be false positives than single unrelated genes...
- Mitochondria in activated microglia in vitro
Richard B Banati
School of Medical Radiation Sciences, and Ramaciotti Centre for Brain Imaging (Brain-Mind Research Institute, University of Sydney, East Street PO Box 170, Lidcombe NSW 1825, Australia
J Neurocytol 33:535-41. 2004
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- Up-regulation of metallothionein gene expression in parkinsonian astrocytes
Gregory J Michael
Centre for Neuroscience and Trauma, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, UK
Neurogenetics 12:295-305. 2011
..However, it is possible that astrocytes are themselves affected by the disease process which may explain their comparatively modest and previously overlooked response...
- Striatal beta-amyloid deposition in Parkinson disease with dementia
Michail E Kalaitzakis
University Department of Neuropathology, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospitals Trust, London, UK
J Neuropathol Exp Neurol 67:155-61. 2008
..Striatal Abeta deposition was type-independent of Alzheimer disease changes in the cortex and was minimal in nondemented PD cases. We conclude that Abeta deposition in the striatum strongly correlates with dementia in PD...
- The molecular profile of microglia under the influence of glioma
Wei Li
Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, 94 Mallett St, Camperdown, Sydney, NSW 2050, Australia
Neuro Oncol 14:958-78. 2012
..The ability of microglia precursors to cross the blood-brain barrier makes them an attractive target for the development of novel cell-based treatments of malignant glioma...
- Microglia in brain tumors
Manuel B Graeber
Department of Neuropathology, Faculty of Medicine, Imperial College, London, United Kingdom
Glia 40:252-9. 2002
..g., interferon-gamma) will benefit patients with brain tumors could prove fatally wrong. Therapeutic recruitment of microglia to treat such diffusely infiltrative brain tumors as astrocytic gliomas must be considered premature...
- Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts
Manuel B Graeber
Department of Neuropathology, Faculty of Medicine, Imperial College, London, United Kingdom
Brain Pathol 12:385-90. 2002
..Importantly, a number of new cell death forms have been described in the literature and there is good reason to pay attention to these emerging concepts as they may provide a rationale for the development of disease-specific therapies...
- Bone marrow-derived microglia in pilocytic astrocytoma
Wafa AlShakweer
Division of Neuropathology, Department of Pathology and Clinical Laboratory Medicine, Faculty of Medicine, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
Front Biosci (Elite Ed) 3:371-9. 2011
..Importantly, our results also confirm that microglia/macrophage infiltration per se is not associated with malignant glioma behaviour...
- IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis
James E Harris
Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College, Du Cane Rd, London, W12 0NN, UK
FASEB J 21:356-65. 2007
..In summary, synergy between IL-1beta and STAT-3 dependent IFNgamma signaling is key in control of up-regulation of MMP-9 activity in CNS-TB and may be a significant mechanism of brain tissue destruction...
- The facial nerve axotomy model
Linda B Moran
Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
Brain Res Brain Res Rev 44:154-78. 2004
..The medical implications of these findings are significant. Also, the facial nerve system of rats and mice has become the best studied and most widely used test system for the evaluation of neurotrophic factors...
- Dementia with Lewy bodies: disease concept and genetics
Manuel B Graeber
Department of Neuropathology, Division of Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
Neurogenetics 4:157-62. 2003
..The literature on genetic findings in this complex disease is critically discussed...
