Manuel B Graeber

Summary

Publications

  1. doi request reprint Multiple mechanisms of microglia: a gatekeeper's contribution to pain states
    Manuel B Graeber
    Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Exp Neurol 234:255-61. 2012
  2. doi request reprint Role of microglia in CNS inflammation
    Manuel B Graeber
    Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, NSW 2050, Australia
    FEBS Lett 585:3798-805. 2011
  3. pmc Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation
    Linda B Moran
    University Department of Neuropathology, Imperial College, University of London, Hammersmith Hospitals Trust, London, UK
    Neurogenetics 9:1-13. 2008
  4. pmc Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies
    Linda B Moran
    Imperial College London and Hammersmith Hospitals Trust, University Department of Neuropathology, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Acta Neuropathol 115:471-8. 2008
  5. doi request reprint Microglia: biology and pathology
    Manuel B Graeber
    Division of Neuropathology, Department of Pathology and Clinical Laboratory Medicine, Faculty of Medicine, Neurosciences Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
    Acta Neuropathol 119:89-105. 2010
  6. doi request reprint Biomarkers for Parkinson's disease
    Manuel B Graeber
    The Athenaeum, Pall Mall, London SW1Y 5ER, UK
    Exp Neurol 216:249-53. 2009
  7. doi request reprint Changing face of microglia
    Manuel B Graeber
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
    Science 330:783-8. 2010
  8. ncbi request reprint Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo
    James E Harris
    Department of Infectious Diseases and Immunity, Imperial College, Du Cane Road, London, United Kingdom
    J Immunol 178:1199-207. 2007
  9. ncbi request reprint Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
    Emilie Croisier
    University Department of Neuropathology, Imperial College London and Hammersmith Hospitals Trust, Charing Cross Campus, Fulham Palace Road, London, UK
    Acta Neuropathol 112:517-30. 2006
  10. ncbi request reprint Microglia in gemistocytic astrocytomas
    Fatemeh Geranmayeh
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience and Mental Health, Hammersmith Hospitals Trust, London, England
    Neurosurgery 60:159-66; discussion 166. 2007

Collaborators

Detail Information

Publications22

  1. doi request reprint Multiple mechanisms of microglia: a gatekeeper's contribution to pain states
    Manuel B Graeber
    Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Exp Neurol 234:255-61. 2012
    ....
  2. doi request reprint Role of microglia in CNS inflammation
    Manuel B Graeber
    Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, NSW 2050, Australia
    FEBS Lett 585:3798-805. 2011
    ..In addition, we recommend abandoning the terms "microglial inflammation" and "inflamed microglia" because of the lack of a clear concept behind them...
  3. pmc Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation
    Linda B Moran
    University Department of Neuropathology, Imperial College, University of London, Hammersmith Hospitals Trust, London, UK
    Neurogenetics 9:1-13. 2008
    ..The need for systematic human tissue banking, following the highest possible professional and ethical standard to enable sustainability, becomes evident...
  4. pmc Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies
    Linda B Moran
    Imperial College London and Hammersmith Hospitals Trust, University Department of Neuropathology, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Acta Neuropathol 115:471-8. 2008
    ....
  5. doi request reprint Microglia: biology and pathology
    Manuel B Graeber
    Division of Neuropathology, Department of Pathology and Clinical Laboratory Medicine, Faculty of Medicine, Neurosciences Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
    Acta Neuropathol 119:89-105. 2010
    ..This review provides an analysis of the latest developments in the microglia field...
  6. doi request reprint Biomarkers for Parkinson's disease
    Manuel B Graeber
    The Athenaeum, Pall Mall, London SW1Y 5ER, UK
    Exp Neurol 216:249-53. 2009
    ..This mini-review aims to provide a broader perspective on PD functional genomics and seeks to illustrate in a systems biological context why the findings by Hoepken and colleagues are of clinical significance...
  7. doi request reprint Changing face of microglia
    Manuel B Graeber
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
    Science 330:783-8. 2010
    ..Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored...
  8. ncbi request reprint Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo
    James E Harris
    Department of Infectious Diseases and Immunity, Imperial College, Du Cane Road, London, United Kingdom
    J Immunol 178:1199-207. 2007
    ..Astrocytes may contribute to a matrix degrading environment within the CNS and subsequent morbidity and mortality...
  9. ncbi request reprint Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
    Emilie Croisier
    University Department of Neuropathology, Imperial College London and Hammersmith Hospitals Trust, Charing Cross Campus, Fulham Palace Road, London, UK
    Acta Neuropathol 112:517-30. 2006
    ..Examples from the spectrum of alpha-synucleinopathies are presented...
  10. ncbi request reprint Microglia in gemistocytic astrocytomas
    Fatemeh Geranmayeh
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience and Mental Health, Hammersmith Hospitals Trust, London, England
    Neurosurgery 60:159-66; discussion 166. 2007
    ..Microglial cells, a feature of this astrocytoma variant, are of increasing interest in the context of glioma growth...
  11. ncbi request reprint The microglial gene regulatory network activated by interferon-gamma
    Linda B Moran
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience, and Hammersmith Hospitals Trust, London, UK
    J Neuroimmunol 183:1-6. 2007
    ..In addition, genes of similar function that are differentially regulated are less likely to be false positives than single unrelated genes...
  12. ncbi request reprint Mitochondria in activated microglia in vitro
    Richard B Banati
    School of Medical Radiation Sciences, and Ramaciotti Centre for Brain Imaging Brain Mind Research Institute, University of Sydney, East Street PO Box 170, Lidcombe NSW 1825, Australia
    J Neurocytol 33:535-41. 2004
    ....
  13. doi request reprint Up-regulation of metallothionein gene expression in parkinsonian astrocytes
    Gregory J Michael
    Centre for Neuroscience and Trauma, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, UK
    Neurogenetics 12:295-305. 2011
    ..However, it is possible that astrocytes are themselves affected by the disease process which may explain their comparatively modest and previously overlooked response...
  14. doi request reprint Striatal beta-amyloid deposition in Parkinson disease with dementia
    Michail E Kalaitzakis
    University Department of Neuropathology, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospitals Trust, London, UK
    J Neuropathol Exp Neurol 67:155-61. 2008
    ..Striatal Abeta deposition was type-independent of Alzheimer disease changes in the cortex and was minimal in nondemented PD cases. We conclude that Abeta deposition in the striatum strongly correlates with dementia in PD...
  15. doi request reprint Development of ramified microglia from early macrophages in the zebrafish optic tectum
    Adam J Svahn
    Brain and Mind Research Institute, Sydney Medical School, University of Sydney, 100 Mallett St, Camperdown, New South Wales 2050, Australia
    Dev Neurobiol 73:60-71. 2013
    ..Thus, the development of zebrafish microglia and their cellular interactions was studied in the intact developing brain in real time and at cellular resolution...
  16. pmc The molecular profile of microglia under the influence of glioma
    Wei Li
    Brain Tumor Research Laboratories, The Brain and Mind Research Institute, University of Sydney, 94 Mallett St, Camperdown, Sydney, NSW 2050, Australia
    Neuro Oncol 14:958-78. 2012
    ..The ability of microglia precursors to cross the blood-brain barrier makes them an attractive target for the development of novel cell-based treatments of malignant glioma...
  17. ncbi request reprint Microglia in brain tumors
    Manuel B Graeber
    Department of Neuropathology, Faculty of Medicine, Imperial College, London, United Kingdom
    Glia 40:252-9. 2002
    ..g., interferon-gamma) will benefit patients with brain tumors could prove fatally wrong. Therapeutic recruitment of microglia to treat such diffusely infiltrative brain tumors as astrocytic gliomas must be considered premature...
  18. ncbi request reprint Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts
    Manuel B Graeber
    Department of Neuropathology, Faculty of Medicine, Imperial College, London, United Kingdom
    Brain Pathol 12:385-90. 2002
    ..Importantly, a number of new cell death forms have been described in the literature and there is good reason to pay attention to these emerging concepts as they may provide a rationale for the development of disease-specific therapies...
  19. ncbi request reprint Bone marrow-derived microglia in pilocytic astrocytoma
    Wafa AlShakweer
    Division of Neuropathology, Department of Pathology and Clinical Laboratory Medicine, Faculty of Medicine, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
    Front Biosci (Elite Ed) 3:371-9. 2011
    ..Importantly, our results also confirm that microglia/macrophage infiltration per se is not associated with malignant glioma behaviour...
  20. ncbi request reprint IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis
    James E Harris
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College, Du Cane Rd, London, W12 0NN, UK
    FASEB J 21:356-65. 2007
    ..In summary, synergy between IL-1beta and STAT-3 dependent IFNgamma signaling is key in control of up-regulation of MMP-9 activity in CNS-TB and may be a significant mechanism of brain tissue destruction...
  21. ncbi request reprint The facial nerve axotomy model
    Linda B Moran
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Brain Res Brain Res Rev 44:154-78. 2004
    ..The medical implications of these findings are significant. Also, the facial nerve system of rats and mice has become the best studied and most widely used test system for the evaluation of neurotrophic factors...
  22. ncbi request reprint Dementia with Lewy bodies: disease concept and genetics
    Manuel B Graeber
    Department of Neuropathology, Division of Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Neurogenetics 4:157-62. 2003
    ..The literature on genetic findings in this complex disease is critically discussed...