NAP (davunetide) provides functional and structural neuroprotectionIllana Gozes
The Adams Super Center for Brain Studies, Israel
Curr Pharm Des 17:1040-4. 2011
..The interaction of these disparate yet complementary pathways is the subject of future studies toward human brain neuroprotection in the clinical scenario...
- Protection against tauopathy by the drug candidates NAP (davunetide) and D-SAL: biochemical, cellular and behavioral aspects
Natalia Shiryaev
The Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel
Curr Pharm Des 17:2603-12. 2011
..These studies associate neuroprotection in vivo and in vitro and provide a broad base for future drug development based on NAP and D-SAL against multiple neurodegenerative conditions...
NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse--a microtubule-deficient model of schizophreniaAvia Merenlender-Wagner
The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Peptides 31:1368-73. 2010
..Daily intranasal NAP treatment significantly decreased hyperactivity in the STOP+/- mice and protected visual memory...
- Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model
Anat Idan-Feldman
The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, School of Neuroscience, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Neurobiol Dis 44:327-39. 2011
..NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model...
- 3R tau expression modifies behavior in transgenic mice
Natalia Shiryaev
The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Elton Laboratory for Neuroendocrinology, and the Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
J Neurosci Res 88:2727-35. 2010
..In conclusion, 7-8-month-old tau-tg mice overexpressing nonmutated 0N3R human tau isoform demonstrated enhanced behavior in the passive avoidance test, paralleled by relative tau hypophosphorylation in the subcortical brain region...
- Addressing Alzheimer's disease tangles: from NAP to AL-108
Illana Gozes
The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Levi Edersheim Gitter Institute for Functional Brain Imaging, The Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Curr Alzheimer Res 6:455-60. 2009
..The following article reviews NAP's discovery and pharmacological characterization that has led to clinical development of a novel tangle-directed drug candidate...
Tau and caspase 3 as targets for neuroprotectionAnat Idan-Feldman
The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Elton Laboratory for Molecular Neuroendocrinology, and Department of Human Molecular Genetics and Biochemistry, Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
Int J Alzheimers Dis 2012:493670. 2012
..Our data suggest that, in this model system, caspase activation may be an upstream event to tau hyperphosphorylation, although additional studies will be required to fully elucidate the cascade of events...
- NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model
Natalia Shiryaev
The Adams Super Center for Brain Studies, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Israel
Neurobiol Dis 34:381-8. 2009
..The current studies show for the first time activity for NAP in a "pure" tauopathy model, positioning it as a promising drug candidate in multiple neurodegenerative tauopathies...
