Neena Goyal

Summary

Publications

  1. doi request reprint Novel approaches for the identification of inhibitors of leishmanial dipeptidylcarboxypeptidase
    Neena Goyal
    CSIR Central Drug Research Institute, Division of Biochemistry, Chattar Manzil Palace, PO Box 173, Lucknow 226001 UP, India
    Expert Opin Drug Discov 8:1127-34. 2013
  2. ncbi request reprint Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovani
    Neena Goyal
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Mol Biochem Parasitol 145:147-57. 2006
  3. pmc Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance
    - Ashutosh
    Division of Biochemistry, Central Drug Research Institute, Council of Scientific and Industrial Research, Chattar Manzil Palace, Lucknow, India
    Antimicrob Agents Chemother 56:518-25. 2012
  4. ncbi request reprint Characterization of natural antimony resistance in Leishmania donovani isolates
    Mukul K Mittal
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Am J Trop Med Hyg 76:681-8. 2007
  5. doi request reprint Synthesis and biological evaluation of new [1,2,4]triazino[5,6-b]indol-3-ylthio-1,3,5-triazines and [1,2,4]triazino[5,6-b]indol-3-ylthio-pyrimidines against Leishmania donovani
    Leena Gupta
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, MG Road, Lucknow 226001, U P, India
    Eur J Med Chem 45:2359-65. 2010
  6. doi request reprint Development of luciferase expressing Leishmania donovani axenic amastigotes as primary model for in vitro screening of antileishmanial compounds
    - Ravinder
    Division of Biochemistry, CSIR Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, UP, India
    Curr Microbiol 65:696-700. 2012
  7. doi request reprint Characterization of dipeptidylcarboxypeptidase of Leishmania donovani: a molecular model for structure based design of antileishmanials
    Mirza Saqib Baig
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India
    J Comput Aided Mol Des 24:77-87. 2010
  8. doi request reprint Identification of novel inhibitors of dipeptidylcarboxypeptidase of Leishmania donovani via ligand-based virtual screening and biological evaluation
    Sonali Gangwar
    Division of Biochemistry, CSIR Central Drug Research Institute, Council of Scientific and Industrial Research, Chattar Manzil Palace, PO Box 173, Lucknow 22600, India
    Chem Biol Drug Des 79:149-56. 2012
  9. doi request reprint Leishmania donovani trypanothione reductase: role of urea and guanidine hydrochloride in modulation of functional and structural properties
    Smita Rai
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India
    Biochim Biophys Acta 1794:1474-84. 2009
  10. ncbi request reprint Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives
    Susmita Pandey
    Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India
    Eur J Med Chem 42:669-74. 2007

Collaborators

Detail Information

Publications19

  1. doi request reprint Novel approaches for the identification of inhibitors of leishmanial dipeptidylcarboxypeptidase
    Neena Goyal
    CSIR Central Drug Research Institute, Division of Biochemistry, Chattar Manzil Palace, PO Box 173, Lucknow 226001 UP, India
    Expert Opin Drug Discov 8:1127-34. 2013
    ..Leishmanial dipeptidylcarboxypeptidase (LDCP), an angiotensin converting enzyme (ACE) related metallopeptidase, has been recently identified as a novel drug target for antileishmanial chemotherapy...
  2. ncbi request reprint Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovani
    Neena Goyal
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Mol Biochem Parasitol 145:147-57. 2006
    ..Further, identification of LdDCP now provides an opportunity to investigate Leishmania peptidases for their potential as drug and vaccine targets...
  3. pmc Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance
    - Ashutosh
    Division of Biochemistry, Central Drug Research Institute, Council of Scientific and Industrial Research, Chattar Manzil Palace, Lucknow, India
    Antimicrob Agents Chemother 56:518-25. 2012
    ..Our results demonstrate that downregulation of LdMAPK1 may be in part correlated with antimony drug resistance in Indian VL isolates...
  4. ncbi request reprint Characterization of natural antimony resistance in Leishmania donovani isolates
    Mukul K Mittal
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Am J Trop Med Hyg 76:681-8. 2007
    ..These results suggest the possible role of thiols and MRPA in antimony resistance in field isolates...
  5. doi request reprint Synthesis and biological evaluation of new [1,2,4]triazino[5,6-b]indol-3-ylthio-1,3,5-triazines and [1,2,4]triazino[5,6-b]indol-3-ylthio-pyrimidines against Leishmania donovani
    Leena Gupta
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, MG Road, Lucknow 226001, U P, India
    Eur J Med Chem 45:2359-65. 2010
    ..I.=56.61) as compared to that of standard drugs pentamidine and sodium stibogluconate (SSG), respectively...
  6. doi request reprint Development of luciferase expressing Leishmania donovani axenic amastigotes as primary model for in vitro screening of antileishmanial compounds
    - Ravinder
    Division of Biochemistry, CSIR Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, UP, India
    Curr Microbiol 65:696-700. 2012
    ..8-fold) and also to the test compounds. Hence, the developed luciferase expressing axenic amastigotes make an ideal choice for high throughput drug screening for antileishmanial compounds...
  7. doi request reprint Characterization of dipeptidylcarboxypeptidase of Leishmania donovani: a molecular model for structure based design of antileishmanials
    Mirza Saqib Baig
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India
    J Comput Aided Mol Des 24:77-87. 2010
    ..These differences could be exploited for designing selective inhibitor of LdDCP thereby antileishmanial compounds either by denovo drug design or virtual screening of small molecule databases...
  8. doi request reprint Identification of novel inhibitors of dipeptidylcarboxypeptidase of Leishmania donovani via ligand-based virtual screening and biological evaluation
    Sonali Gangwar
    Division of Biochemistry, CSIR Central Drug Research Institute, Council of Scientific and Industrial Research, Chattar Manzil Palace, PO Box 173, Lucknow 22600, India
    Chem Biol Drug Des 79:149-56. 2012
    ..Identification of these novel and chemically diverse inhibitors should provide leads to be optimized into candidates to treat these protozoan infections...
  9. doi request reprint Leishmania donovani trypanothione reductase: role of urea and guanidine hydrochloride in modulation of functional and structural properties
    Smita Rai
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India
    Biochim Biophys Acta 1794:1474-84. 2009
    ..The results obtained from this study provide intriguing insight into the possible mechanism/s of modulation of structure, function and stability of LdTR induced by the cationic, guanidine hydrochloride and the neutral denaturant, urea...
  10. ncbi request reprint Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives
    Susmita Pandey
    Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India
    Eur J Med Chem 42:669-74. 2007
    ..Some of the compounds such as 3a, 3b, 4i and 4j displayed good antileishmanial profile...
  11. doi request reprint Cloning, characterization and sub-cellular localization of gamma subunit of T-complex protein-1 (chaperonin) from Leishmania donovani
    - Bhaskar
    Division of Biochemistry, CSIR Central Drug Research Institute, Chattar Manzil Palace, PO Box 173, Lucknow, India
    Biochem Biophys Res Commun 429:70-4. 2012
    ..Co-localization of LdTCP1γ with actin suggests that, this gene may have a role in maintaining the structural dynamics of cytoskeleton of parasite...
  12. ncbi request reprint Molecular mechanisms of antimony resistance in Leishmania
    Shyam Sundar
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, UP India
    J Med Microbiol 56:143-53. 2007
    ..Unravelling the molecular mechanisms of clinical resistance could allow the prevention and circumvention of resistance, as well as rational drug design for the treatment of drug-resistant Leishmania...
  13. ncbi request reprint Modulation of estrogen action during preimplantation period and in immature estradiol-primed rat uterus by anti-implantation agent, ormeloxifene
    Anila Dwivedi
    Divisions of Endocrinology and Biochemistry, Central Drug Research Institute, Lucknow 226001, India
    Contraception 71:458-64. 2005
    ..Moreover, it causes indirect anti-progestational effects in the uterus by virtue of its anti-estrogenic profile rather than by blocking the PRs...
  14. pmc Role of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovani
    Smita Rai
    Division of Biochemistry, CSIR Central Drug Research Institute, Lucknow, India
    PLoS ONE 8:e74862. 2013
    ..donovani field isolates by analyzing the functionality of efflux pump(s) and expression profiles of known genes involved in transport and thiol based redox metabolism...
  15. ncbi request reprint Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents
    Naresh Sunduru
    Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India
    Bioorg Med Chem 14:7706-15. 2006
    ..Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 microg/mL...
  16. ncbi request reprint Synthesis of chromenochalcones and evaluation of their in vitro antileishmanial activity
    Tadigoppula Narender
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem 13:6543-50. 2005
    ..The most potent compound in this series was compound 9 with a pyridine ring-A, which showed 99% inhibition of promastigotes at 10 microg/ml, 82% at 0.25 microg/ml and 96% at 10 microg/ml concentration against amastigotes...
  17. pmc Use of Leishmania donovani field isolates expressing the luciferase reporter gene in in vitro drug screening
    - Ashutosh
    Division of Biochemistry, Central Drug Research Institute, Chatter Manzil Palace, M G Road, Lucknow 226 001 UP, India
    Antimicrob Agents Chemother 49:3776-83. 2005
    ..The system is in routine use at the Central Drug Research Institute, Lucknow, India, for high-throughput screening of newly synthesized compounds...
  18. ncbi request reprint Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli
    Mukul K Mittal
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Protein Expr Purif 40:279-86. 2005
    ..The expressed protein was inhibited by known TR inhibitors as well as by SbIII, the known antileishmanial compound. This is the first report of large-scale production of any leishmanial TR in E. coli...
  19. ncbi request reprint The application of gene expression microarray technology to kinetoplastid research
    Robert C Duncan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER, FDA, Bethesda, MD, USA
    Curr Mol Med 4:611-21. 2004
    ....