Clinical trials of single-drug therapy for the cardiac effects of hypertensionJ S Gottdiener
Georgetown University Medical Center, Washington, DC, USA
Am J Hypertens 12:12S-18S. 1999
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- Overview of stress echocardiography: uses, advantages, and limitations
J S Gottdiener
Division of Cardiology, St Francis Hospital, Roslyn, NY 11576, USA
Prog Cardiovasc Dis 43:315-34. 2001
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- Costs for heart failure with normal vs reduced ejection fraction
Lawrence Liao
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Arch Intern Med 166:112-8. 2006
..However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of elderly participants, we compared the costs and resource use of patients with HF and normal and reduced EF...
- Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study
J S Gottdiener
Division of Cardiology, Georgetown University Hospital, Washington, DC, USA
J Am Coll Cardiol 35:1628-37. 2000
..We sought to characterize the predictors of incident congestive heart failure (CHF), as determined by central adjudication, in a community-based elderly population...
- Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease
John S Gottdiener
Division of Cardiology, St Francis Hospital, 100 Port Washington Boulevard, Roslyn, NY 11516, USA
Am J Cardiol 92:687-91. 2003
..Mental stress inhibits flow-mediated vasodilation in normal subjects and those with hypercholesterolemia. The magnitude of this inhibition is associated with hostility...
- Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study
John S Gottdiener
St Francis Hospital, Roslyn, New York Mayo Clinic, Rochester, Minnesota 55905, USA
Ann Intern Med 137:631-9. 2002
..Most persons with congestive heart failure are elderly, and many elderly persons with congestive heart failure have normal left ventricular systolic function...
- Testing the test: the reliability of echocardiography in the sequential assessment of valvular regurgitation
John S Gottdiener
St Francis Hospital, Roslyn, NY 11576, USA
Am Heart J 144:115-21. 2002
..We attempted to determine the relative contributions of acquisition and reader variability as components of total test-retest variability for aortic (AR) and mitral (MR) regurgitation...
- Left atrial size in hypertensive men: influence of obesity, race and age. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents
J S Gottdiener
Cooperative Studies Program of the Medical Research Service of the Department of Veterans Affairs, Washington, D C, USA
J Am Coll Cardiol 29:651-8. 1997
..We sought to determine the relations of left atrial (LA) size to blood pressure, obesity, race, age and left ventricular (LV) mass in hypertension...
- Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents
J S Gottdiener
Division of Cardiology, Georgetown University Medical Center, Washington, DC 20007, USA
Circulation 95:2007-14. 1997
..Covariates other than drug selection, such as pretreatment LV mass, body weight, the magnitude of blood pressure reduction, race, and age may modify the response of LV mass to therapy...
- Effect of single-drug therapy on reduction of left atrial size in mild to moderate hypertension: comparison of six antihypertensive agents
J S Gottdiener
Department of Veterans Affairs Research and Development Service and the Division of Cardiology, Georgetown University Medical Center, Washington, DC, USA
Circulation 98:140-8. 1998
..Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on effects of treatment on left atrial size...
- Prevalence of valvular-regurgitation associated with dexfenfluramine three to five months after discontinuation of treatment
N J Weissman
Division of Cardiology, Georgetown University Medical Center, Washington, DC, USA
J Am Coll Cardiol 34:2088-95. 1999
..The goal of this study was to determine the prevalence of valvular regurgitation and abnormal valve morphology in patients three to five months after discontinuation of dexfenfluramine (Dexfen) therapy...
- Ventricular and myocardial function following treatment of hypertension
G P Aurigemma
Division of Cardiology, University of Massachusetts Medical School, Worcester, USA
Am J Cardiol 87:732-6. 2001
..Improvement in midwall shortening is more closely related to normalization of LV geometry than to reduction in LV mass...
- Specificity of Doppler echocardiography for the assessment of changes in valvular regurgitation: comparison of side-by-side versus serial interpretation
N J Weissman
Cardiovascular Research Institute, Washington Hospital Center, DC, USA
J Am Coll Cardiol 37:1614-21. 2001
..We sought to determine the specificity of two different methods for assessing change in aortic (AR), mitral (MR) and tricuspid (TR) valvular regurgitation...
- Smoking and obesity are associated with the progression of aortic stenosis
M V Ngo
Division of Cardiology, Georgetown University Medical Center, Washington, DC, USA
Am J Geriatr Cardiol 10:86-90. 2001
..The effect of controlling atherosclerosis risk factors on the rate of progression of aortic stenosis remains to be determined...
Black-white differences in mortality in idiopathic dilated cardiomyopathy: the Washington, DC, dilated cardiomyopathy studyS S Coughlin
Department of Medicine, Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, DC
J Natl Med Assoc 86:583-91. 1994
..Poorer survival among blacks may be caused by a greater severity of disease at the time of diagnosis or by racial differences in cardiac care, comorbid conditions, or biologic factors affecting survival...
- Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)
Eddy Barasch
Department of Research and Education, St Francis Hospital, Roslyn, New York, USA
Am J Cardiol 97:1281-6. 2006
..Elderly patients with these findings represent a high-risk group and may require close medical attention...
- Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study
Mark H Drazner
Heart Failure Research Unit, Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Am Coll Cardiol 43:2207-15. 2004
..Our aim in this study was to determine whether increased left ventricular mass (LVM) is a risk factor for the development of a reduced left ventricular ejection fraction (LVEF)...
- Congestive heart failure in the elderly: the Cardiovascular Health Study
Sunil T Mathew
Division of Cardiology, St. Francis Hospital, State University of New York at Stony Brook, Roslyn, NY 11576, USA
Am J Geriatr Cardiol 13:61-8. 2004
..Since most clinical trials have studied younger patients with predominantly systolic heart failure, the appropriate therapy for heart failure in elderly persons remains to be determined...
- Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study)
John S Gottdiener
Division of Cardiology, University of Maryland Medical Center, Baltimore, Maryland, USA
Am J Cardiol 97:83-9. 2006
..LA size is associated with the new development of HF. These findings highlight the important role of the left atrium in HF, with or without a decreased ejection fraction...
- Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression
Willem J Kop
Department of Medicine, Division of Cardiology, University of Maryland Medical Center, Baltimore, MD 21201, USA
Psychosom Med 72:626-35. 2010
..To investigate prospectively whether autonomic nervous system (ANS) dysfunction and inflammation play a role in the increased cardiovascular disease (CVD)-related mortality risk associated with depression...
- Burden of valvular heart diseases: a population-based study
Vuyisile T Nkomo
Mayo Clinic, Rochester, MN 55905, USA
Lancet 368:1005-11. 2006
..In the community, women are less often diagnosed than are men, which could indicate an important imbalance in view of the associated lower survival. Valve diseases thus represent an important public-health problem...
N-terminal pro-B-type natriuretic peptide is a major predictor of the development of atrial fibrillation: the Cardiovascular Health StudyKristen K Patton
Division of Cardiology, University of Washington, Seattle, WA 98115, USA
Circulation 120:1768-74. 2009
..Elevated B-type natriuretic peptide levels have been associated with the risk of heart failure, AF, and mortality...
- Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS)
Eddy Barasch
Department of Research and Education, St Francis Hospital, SUNY at Stony Brook, Roslyn, NY, USA
Am Heart J 151:39-47. 2006
..CONCLUSIONS: In free-living elderly, MAC, AAC, and AVS are highly prevalent and are associated with CVD. Mitral annular calcification in particular has strong association with CVD, and with an adverse biomedical profile...
- Comparison of mental stress-induced myocardial ischemia in coronary artery disease patients with versus without left ventricular dysfunction
Ola Akinboboye
Saint Francis Hospital, Roslyn, State University of New York at Stony Brook, Stony Brook, New York, USA
Am J Cardiol 95:322-6. 2005
..These data suggest that mental stress ischemia may be of particular clinical importance in patients who have coronary artery disease and LV dysfunction...
- Evidence for early right ventricular and septal mechanical activation (interventricular dyssynchrony) in pulmonary hypertension
Daniel J Schwartz
Department of Internal Medicine, Division of Cardiology, University of Maryland Medical Systems, Baltimore, Maryland, USA
Am J Cardiol 102:1273-7. 2008
..In conclusion, PAH is associated with interventricular dyssynchrony manifested by accelerated RV free wall and septal activation times. Whether such dyssynchrony should serve as a therapeutic target remains to be determined...
- Left atrial dimensions determined by M-mode echocardiography in black and white older (> or =65 years) adults (The Cardiovascular Health Study)
Teri A Manolio
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
Am J Cardiol 90:983-7. 2002
..Thus, LA dimension is strongly associated with weight and with several echocardiographic valvular abnormalities; its relation with LV fractional shortening is U-shaped with a nadir at the borderline of LV functional impairment...
- Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study
Giovanni de Simone
Department of Clinical and Experimental Medicine, Federico II University Hospital, Via S Pansini 5, 80131 Napoli, Italy
Eur Heart J 29:741-7. 2008
..The relationship of left ventricular hypertrophy (LVH) to incident heart failure (HF) not attributable to myocardial infarction (MI) has not been defined. We assessed whether LVH is an independent predictor of MI-independent HF...
- Effects of acute mental stress and exercise on inflammatory markers in patients with coronary artery disease and healthy controls
Willem J Kop
University of Maryland Medical Center, Baltimore, Maryland, USA
Am J Cardiol 101:767-73. 2008
..These stress-induced increases are larger than in healthy subjects, occur in the absence of myocardial ischemia, and are related to the neurohormonal stress response...
- Mental stress hemodynamic responses and myocardial ischemia: does left ventricular dysfunction alter these relationships?
Sari D Holmes
Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD 20814, USA
Psychosom Med 69:495-500. 2007
..To assess if mental stress hemodynamic responses are impaired and related to mental stress (MS) ischemia in patients with left ventricular (LV) dysfunction...
- Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study
Lawrence Liao
Duke Clinical Research Institute, Durham, NC, USA
Am Heart J 153:245-52. 2007
..In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term costs and resource use of elderly patients with HF...
- Alcohol consumption and risk and prognosis of atrial fibrillation among older adults: the Cardiovascular Health Study
Kenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am Heart J 153:260-6. 2007
..The relationship of alcohol consumption with risk of atrial fibrillation (AF) is inconsistent in previous studies, and its relationship with prognosis of AF is undetermined...
- Costs of the metabolic syndrome in elderly individuals: findings from the Cardiovascular Health Study
Lesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
Diabetes Care 30:2553-8. 2007
..Little is known about how the metabolic syndrome and its individual components translate into long-term medical costs...
- Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study
Hassan A Chami
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Circulation 117:2599-607. 2008
..We assessed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-aged and older adults...
- Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health study
Nicolas Rodondi
Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
J Am Coll Cardiol 52:1152-9. 2008
..The goal of this study was to determine whether subclinical thyroid dysfunction was associated with incident heart failure (HF) and echocardiogram abnormalities...
- Clinical factors, but not C-reactive protein, predict progression of calcific aortic-valve disease: the Cardiovascular Health Study
Gian M Novaro
Department of Cardiology, Cleveland Clinic Florida, Weston, Florida 33331, USA
J Am Coll Cardiol 50:1992-8. 2007
..The purpose of this study was to examine the relationship between C-reactive protein (CRP) and calcific aortic valve disease in a large, randomly selected, population-based cohort...
- Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study
Lesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Curr Med Res Opin 24:41-50. 2008
..To explore relationships between beta-cell function and incident cardiovascular events, death, and medical costs among elderly individuals...
- Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study
Phyllis K Stein
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Am Geriatr Soc 56:315-21. 2008
..To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults...
- Cystatin C concentration as a predictor of systolic and diastolic heart failure
Andrew Moran
Department of Medicine, University of California at San Francisco, San Francisco, California, USA
J Card Fail 14:19-26. 2008
..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study...
- Adiponectin and risk of coronary heart disease in older men and women
Jorge R Kizer
Department of Medicine and Public Health, Weill Medical College of Cornell University, New York, New York 10065, USA
J Clin Endocrinol Metab 93:3357-64. 2008
..Despite established insulin-sensitizing and antiatherogenic preclinical effects, epidemiological investigations of adiponectin have yielded conflicting findings, and its relationship with coronary heart disease (CHD) remains uncertain...
- Aortic valve bypass for the high-risk patient with aortic stenosis
James S Gammie
Division of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
Ann Thorac Surg 81:1605-10. 2006
..We have undertaken a programmatic effort to perform aortic valve bypass surgery as an alternative to conventional aortic valve replacement in selected high-risk patients, and now report our recent experience...
- Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia
Willem J Kop
Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Am J Cardiol 89:419-24. 2002
..Thus, depression and exhaustion are associated with low-grade inflammation and elevated coagulation factors in persons aged > 65 years...
- The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study
Tien Yin Wong
Singapore Eye Research Institute, Singapore, Republic of Singapore
Ophthalmology 110:658-66. 2003
..To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons...
- Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals
Linda F Fried
Renal Section, VA Pittsburgh Healthcare System, Pennsylvania 15240, USA
J Am Coll Cardiol 41:1364-72. 2003
..This study was designed to evaluate the relationship between elevated creatinine levels and cardiovascular events...
- Risk factors for myocardial infarction during vacation travel
Willem J Kop
Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
Psychosom Med 65:396-401. 2003
..Vacation activities include physical and emotional triggers for myocardial infarction (MI). This study examines characteristics of vacation travel as risk factors for MI...
- The association between the length of the QT interval and mortality in the Cardiovascular Health Study
John Robbins
Division of General Medicine, Department of Medicine, University of California, Davis, Sacramento, California 95817, USA
Am J Med 115:689-94. 2003
..A long QT interval is a risk factor for arrhythmic events and sudden death. Whether moderate QT prolongation is associated with clinical events in community-dwelling elderly patients is uncertain...
- Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls
Willem J Kop
Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Circulation 109:1864-9. 2004
..Exercise-induced T-wave alternans (TWA) is an established marker of cardiac electrical instability. However, the effects of acute mental stress on TWA have not been investigated as a vulnerability marker in humans...
- Predictors of falling cholesterol levels in older adults: the Cardiovascular Health Study
Teri A Manolio
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
Ann Epidemiol 14:325-31. 2004
..To estimate 4-year change in serum total cholesterol levels in a population-based sample of older adults and identify independent predictors of cholesterol decline...
- The association of fasting glucose levels with congestive heart failure in diabetic adults > or =65 years: the Cardiovascular Health Study
Joshua I Barzilay
Kaiser Permanente of Georgia and the Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
J Am Coll Cardiol 43:2236-41. 2004
..The purpose of this study was to determine if fasting glucose levels are an independent risk factor for congestive heart failure (CHF) in elderly individuals with diabetes mellitus (DM) with or without coronary heart disease (CHD)...
- American Society of Echocardiography recommendations for use of echocardiography in clinical trials
John S Gottdiener
University of Maryland Hospital, Baltimore, USA
J Am Soc Echocardiogr 17:1086-119. 2004
- Time trends in the use of beta-blockers and other pharmacotherapies in older adults with congestive heart failure
Nicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Wash, USA
Am Heart J 148:710-7. 2004
..We describe beta-blocker and other medication temporal treatment trends of CHF in the Cardiovascular Health Study, a community-based cohort study of 5888 adults > or =65 years of age...
- The role of immune system parameters in the relationship between depression and coronary artery disease
Willem J Kop
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Psychosom Med 67:S37-41. 2005
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- Relationship of socioeconomic markers to daily life ischemia and blood pressure reactivity in coronary artery disease patients
Sonia Suchday
Albert Einstein College of Medicine, Department of Clinical Health Psychology, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY 10461, USA
Ann Behav Med 30:74-84. 2005
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- Left atrial size: renewed interest in an old echocardiographic measurement
John S Gottdiener
Am Heart J 147:195-6. 2004
- Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics
Dariush Mozaffarian
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 97:216-22. 2006
..These findings suggest potential specific physiologic mechanisms that may, in part, account for the effects of fish intake on cardiovascular health...
- The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study
Ronald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53705 2397, USA
Br J Ophthalmol 86:84-90. 2002
..To describe the association of retinopathy with atherosclerosis and atherosclerotic risk factors in people with diabetes...
