M A Gonzalez-Gay

Summary

Publications

  1. ncbi request reprint Psoriasis: a skin disease associated with increased cardiovascular risk
    M A Gonzalez-Gay
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Actas Dermosifiliogr 103:595-8. 2012
  2. pmc Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, IPBLN C S I C, Granada, Spain
    PLoS ONE 7:e47166. 2012
  3. pmc Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis
    Fernanda Genre
    Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain
    Biomed Res Int 2014:860651. 2014
  4. pmc Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN C S I C, Granada, Spain
    PLoS ONE 7:e49214. 2012
  5. pmc Metabolic syndrome in rheumatoid arthritis
    Ivan Ferraz-Amaro
    Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain
    Mediators Inflamm 2013:710928. 2013
  6. pmc SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Granada, Spain
    PLoS ONE 8:e77695. 2013
  7. pmc A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis
    Lara Bossini-Castillo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avenida del Conocimiento s n, Granada, 18100, Spain
    Arthritis Res Ther 14:R85. 2012
  8. pmc Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avda, del Conocimiento s n, 18010, Granada, SpainArmilla Granada, Spain
    Arthritis Res Ther 14:R154. 2012
  9. ncbi request reprint Lack of association between carotid intima-media wall thickness and carotid plaques and markers of endothelial cell activation in rheumatoid arthritis patients undergoing anti-TNF therapy
    Miguel A Gonzalez-Gay
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Acta Reumatol Port 37:155-9. 2012
  10. ncbi request reprint Psoriasis: a skin disease associated with increased cardiovascular risk
    M A Gonzalez-Gay
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain Electronic address
    Actas Dermosifiliogr 103:595-8. 2012

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Psoriasis: a skin disease associated with increased cardiovascular risk
    M A Gonzalez-Gay
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Actas Dermosifiliogr 103:595-8. 2012
    ..Clinical practice guidelines on the management of cardiovascular risk will define a new integrated approach to the care of patients with psoriasis and psoriatic arthritis...
  2. pmc Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, IPBLN C S I C, Granada, Spain
    PLoS ONE 7:e47166. 2012
    ..Since interferon-gamma (IFN-γ) has a direct effect on inflammation, in this study we assessed the potential association of the IFNG functional gene variant rs2430561 with CV disease in patients with RA...
  3. pmc Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis
    Fernanda Genre
    Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain
    Biomed Res Int 2014:860651. 2014
    ..The assessment of adipokines and biomarkers of endothelial cell activation and MeS may be of potential relevance in the stratification of the CV risk of patients with AS. ..
  4. pmc Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN C S I C, Granada, Spain
    PLoS ONE 7:e49214. 2012
    ....
  5. pmc Metabolic syndrome in rheumatoid arthritis
    Ivan Ferraz-Amaro
    Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain
    Mediators Inflamm 2013:710928. 2013
    ..Biologic therapies, such as TNF-α antagonists, that block proinflammatory cytokines have beneficial effects on the insulin resistance that is often observed in patients with RA...
  6. pmc SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Granada, Spain
    PLoS ONE 8:e77695. 2013
    ....
  7. pmc A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis
    Lara Bossini-Castillo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avenida del Conocimiento s n, Granada, 18100, Spain
    Arthritis Res Ther 14:R85. 2012
    ..The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population...
  8. pmc Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avda, del Conocimiento s n, 18010, Granada, SpainArmilla Granada, Spain
    Arthritis Res Ther 14:R154. 2012
    ..The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc)...
  9. ncbi request reprint Lack of association between carotid intima-media wall thickness and carotid plaques and markers of endothelial cell activation in rheumatoid arthritis patients undergoing anti-TNF therapy
    Miguel A Gonzalez-Gay
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Acta Reumatol Port 37:155-9. 2012
    ....
  10. ncbi request reprint Psoriasis: a skin disease associated with increased cardiovascular risk
    M A Gonzalez-Gay
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain Electronic address
    Actas Dermosifiliogr 103:595-8. 2012
    ..Clinical practice guidelines on the management of cardiovascular risk will define a new integrated approach to the care of patients with psoriasis and psoriatic arthritis...
  11. pmc Implication of new atherosclerotic carotid plaques in the cardiovascular outcome of patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Avenida de Valdecilla S N, E 39008, Santander, Spain
    Arthritis Res Ther 14:105. 2012
    ..Active treatment of the disease may decrease the inflammatory burden, leading to a reduction in the progression of subclinical atherosclerosis in these patients...
  12. pmc The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis
    Raquel López-Mejías
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Arthritis Res Ther 14:R42. 2012
    ....
  13. doi request reprint Lack of association between the CXCL12 rs501120 polymorphism and cardiovascular disease in Spanish patients with rheumatoid arthritis
    Raquel López-Mejías
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, 39008 Santander, Spain
    Hum Immunol 73:543-6. 2012
    ..In conclusion, our results do not confirm an association of the CXCL12 rs501120 polymorphism with atherosclerosis or with CV disease in RA...
  14. doi request reprint Carotid ultrasound in the cardiovascular risk stratification of patients with rheumatoid arthritis: when and for whom?
    Miguel A Gonzalez-Gay
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Ann Rheum Dis 71:796-8. 2012
    ..The presence of abnormal carotid IMT (>0.90 mm) or carotid plaques would lead to these patients being considered as having high CV risk regardless of the results derived from the modified SCORE...
  15. pmc Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avd, del Conocimiento s n, 18010, Granada, Spain
    Arthritis Res Ther 13:R116. 2011
    ....
  16. pmc Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis
    Ann W Morgan
    Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK
    Arthritis Res Ther 8:R109. 2006
    ..These findings may ultimately provide new insights into disease pathogenesis...
  17. pmc A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis
    Rogelio Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n Armilla, Granada 18100, Spain
    Arthritis Res Ther 12:R71. 2010
    ....
  18. pmc Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis
    Rogelio J Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n Armilla, Granada 18100, Spain
    Arthritis Res Ther 12:R51. 2010
    ..The objective was to investigate the potential implication of the IL18 gene promoter polymorphisms in the susceptibility to giant-cell arteritis (GCA)...
  19. pmc Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease
    Carlos Gonzalez-Juanatey
    Cardiology Division, Hospital Xeral Calde, c Dr Ochoa s n, Lugo E 27004, Spain
    Arthritis Res Ther 13:R101. 2011
    ....
  20. doi request reprint Asymptomatic hyperuricemia and serum uric acid concentration correlate with subclinical atherosclerosis in psoriatic arthritis patients without clinically evident cardiovascular disease
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 39:157-62. 2009
    ....
  21. ncbi request reprint Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 26:311-6. 2008
    ..We further assessed associations of circulating resistin concentrations with CRP and ESR levels, platelet counts and metabolic syndrome and demographic characteristics in RA patients on periodical treatment with infliximab...
  22. ncbi request reprint Anti-TNF-alpha therapy does not modulate leptin in patients with severe rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 27:222-8. 2009
    ..We also assessed whether the infusion of infliximab may alter circulating leptin concentrations in patients with severe RA...
  23. ncbi request reprint Cancer in biopsy-proven giant cell arteritis. A population-based study
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 37:156-63. 2007
    ....
  24. ncbi request reprint Giant cell arteritis in northwestern Spain: a 25-year epidemiologic study
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 86:61-8. 2007
    ..In conclusion, the current study confirms a progressive increase in the incidence of biopsy-proven GCA in northwestern Spain, and suggests that there has been a change in the clinical spectrum of the disease...
  25. ncbi request reprint HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    Arthritis Rheum 57:125-32. 2007
    ..We assessed the contribution of epidemiologic features, clinical features, routine laboratory markers of inflammation, and HLA-DRB1 alleles to CV mortality in patients with RA prospectively followed at a single referral center in Spain...
  26. ncbi request reprint Localized vasculitis of the gastrointestinal tract: a case report and literature review
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 26:S101-4. 2008
    ..Due to this, in cases of localized gastrointestinal vasculitis a complete evaluation of the patient to exclude the presence of a systemic a potentially threatening systemic vasculitis is required...
  27. ncbi request reprint Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis
    M A Gonzalez-Gay
    Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 27:116-9. 2009
    ..Also, interactions between NOS2A or NOS3 gene polymorphisms and HLA-DRB1 alleles for the risk of developing CV events were assessed...
  28. ncbi request reprint Systemic vasculitides
    Miguel A Gonzalez-Gay
    Rheumatology Division, Hospital Xeral Calde, Dr Ochoa s n, 27004, Lugo, Spain
    Best Pract Res Clin Rheumatol 16:833-45. 2002
    ..Moreover, the polymorphisms of other genes, such as interleukin-1 receptor antagonist, seem to be implicated in disease severity in patients with cutaneous vasculitis...
  29. doi request reprint Strokes at time of disease diagnosis in a series of 287 patients with biopsy-proven giant cell arteritis
    Miguel A Gonzalez-Gay
    Divisions of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 88:227-35. 2009
    ..Results also suggest a potential protective role of anemia against the development of these cerebrovascular complications...
  30. ncbi request reprint Visfatin is not associated with inflammation or metabolic syndrome in patients with severe rheumatoid arthritis undergoing anti-TNF-alpha therapy
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 28:56-62. 2010
    ..We also assessed whether the infusion of infliximab may alter circulating visfatin concentrations in patients with severe RA...
  31. doi request reprint Medical management of polymyalgia rheumatica
    Miguel A Gonzalez-Gay
    Divison of Rheumatology, Hospital Universitario Marques de Valdecilla and School of Medicine of Cantabria, Santander, Spain
    Expert Opin Pharmacother 11:1077-87. 2010
    ..Polymyalgia rheumatica (PMR) is a relatively frequent condition in individuals older than 50 who originate from Western countries. Corticosteroids constitute the cornerstone therapy in the management of patients with PMR...
  32. doi request reprint Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-alpha therapy
    Miguel A Gonzalez-Gay
    Rheumatology Division, Hospital Xeral Calde, Lugo, Spain
    Ann N Y Acad Sci 1193:153-9. 2010
    ..These results highlight the importance of therapies that act blocking TNF-alpha function to reduce the mechanisms implicated in the development of the metabolic syndrome observed in RA...
  33. doi request reprint Giant cell arteritis: epidemiology, diagnosis, and management
    Miguel A Gonzalez-Gay
    Rheumatology Division, Hospital Universitario Marques de Valdecilla, Avenida de Valdecilla S N, 39008, IFIMAV, Santander, Cantabria, Spain
    Curr Rheumatol Rep 12:436-42. 2010
    ....
  34. pmc CCR5Δ32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study
    Luis Rodríguez-Rodríguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n Armilla, Granada E 18100, Spain
    Arthritis Res Ther 13:R133. 2011
    ..The aim of our study was to analyze the influence of the CCR5Δ32 polymorphism in the risk of cardiovascular (CV) events and subclinical atherosclerosis among patients with rheumatoid arthritis (RA)...
  35. ncbi request reprint Cardiovascular disease in rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Rheumatology Division, Hospital Xeral Calde, c Dr Ochoa s n, 27004 Lugo, Spain
    Biomed Pharmacother 60:673-7. 2006
    ..Recent studies have also emphasized the positive effect of anti-TNF-alpha blockade in improving endothelial dysfunction in RA patients. However, this effect seems to be transient and in line with the persistence of chronic inflammation...
  36. ncbi request reprint Giant cell arteritis and polymyalgia rheumatica: pathophysiology and management
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Drugs Aging 23:627-49. 2006
    ..Alternative corticosteroid-sparing therapies and some therapeutic agents aimed at restoring balanced bone cell activity in patients taking corticosteroids are potentially useful in the management of GCA and PMR...
  37. ncbi request reprint Visual manifestations of giant cell arteritis. Trends and clinical spectrum in 161 patients
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 79:283-92. 2000
    ..The presence of other ischemic complications constitutes an alarm for the development of irreversible blindness. In contrast, a higher inflammatory response may be a protective factor against the development of cranial ischemic events...
  38. ncbi request reprint Rheumatoid arthritis: a disease associated with accelerated atherogenesis
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 35:8-17. 2005
    ..In this article, a review of mechanisms implicated in the development of accelerated atherogenesis in RA was performed. The potential role of treatment to reduce the incidence of CV events in RA was also discussed...
  39. ncbi request reprint High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Divisions of Rheumatology and Cardiology, Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 32:1219-23. 2005
    ..We examined the relationship between carotid IMT to C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are the most commonly assessed markers of inflammatory response in patients with RA...
  40. ncbi request reprint IL-6 promoter polymorphism at position -174 modulates the phenotypic expression of polymyalgia rheumatica in biopsy-proven giant cell arteritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 20:179-84. 2002
    ..To investigate further the genetic influence of IL-6 in GCA and PMR we have examined the IL-6 promoter polymorphism (G to C) at position -174 in the 5' region in a series of patients from Northwest Spain diagnosed with GCA and/or PMR...
  41. ncbi request reprint Audiovestibular manifestations in giant cell arteritis: a prospective study
    Juan C Amor-Dorado
    Division of Otolaryngology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 82:13-26. 2003
    ..The present study confirms a high frequency of audiovestibular manifestations in GCA. It also suggests that audiovestibular damage may be reversible in some patients with GCA...
  42. ncbi request reprint Endothelial dysfunction in rheumatoid arthritis: influence of HLA-DRB1 alleles
    Miguel A Gonzalez-Gay
    Rheumatology Division, Hospital Xeral Calde, Lugo 27004, Spain
    Autoimmun Rev 3:301-4. 2004
    ..HLA-DRB1 shared epitope alleles, in particular HLA-DRB1*0404, seem to be implicated in the development of endothelial dysfunction. These results underline the influence of genetic factors in the risk of atherosclerosis in RA patients...
  43. ncbi request reprint Ischemic heart disease in patients from Northwest Spain with biopsy proven giant cell arteritis. A population based study
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, c Dr Ochoa s n, 27004 Lugo, Spain
    J Rheumatol 32:502-6. 2005
    ..To assess the incidence, mortality, and predictors of ischemic heart disease (IHD) in patients from the Lugo region of Northwest Spain with biopsy-proven giant cell arteritis (GCA)...
  44. ncbi request reprint Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatica
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 22:S18-20. 2004
    ..In this study we have examined the potential association of a CA repeat polymorphism in the first intron of the interferon gamma (IFN-gamma) gene with disease susceptibility and clinical expression of these conditions...
  45. ncbi request reprint The epidemiology of the primary systemic vasculitides in northwest Spain: implications of the Chapel Hill Consensus Conference definitions
    Miguel A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    Arthritis Rheum 49:388-93. 2003
    ..To assess the epidemiology of the primary systemic vasculitides (PSV) in a well-defined population of southern Europe over a 14-year period using the Chapel Hill Consensus Conference (CHCC) definitions...
  46. ncbi request reprint Implications of upper respiratory tract infections and drugs in the clinical spectrum of Henoch-Schönlein purpura in children
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 22:781-4. 2004
    ....
  47. ncbi request reprint Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 33:38-48. 2003
    ..In this article, we examine the role of different genes as markers of disease susceptibility and severity in GCA and PMR...
  48. ncbi request reprint Influence of traditional risk factors of atherosclerosis in the development of severe ischemic complications in giant cell arteritis
    Miguel A Gonzalez-Gay
    Division of Rheumatology, University of Cantabria, Santander, Spain
    Medicine (Baltimore) 83:342-7. 2004
    ..80; 95% CI, 1.00-3.25; p = 0.05). The current study suggests that the presence of atherosclerosis risk factors at the time of diagnosis of GCA may influence the development of severe ischemic manifestations of the disease...
  49. ncbi request reprint Aortic aneurysm and dissection in patients with biopsy-proven giant cell arteritis from northwestern Spain: a population-based study
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 83:335-41. 2004
    ..GCA patients having these features should be monitored for the existence of aortic aneurysm and dissection...
  50. ncbi request reprint Cutaneous vasculitis: a diagnostic approach
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 21:S85-8. 2003
  51. ncbi request reprint Fever in biopsy-proven giant cell arteritis: clinical implications in a defined population
    Miguel A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    Arthritis Rheum 51:652-5. 2004
    ....
  52. ncbi request reprint Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, c Dr Ochoa s n, 27004, Lugo, Spain
    Rheumatology (Oxford) 43:1182-5. 2004
    ..To assess the influence of inducible and endothelial nitric oxide synthase (iNOS and eNOS) polymorphisms in susceptibility to rheumatoid arthritis (RA)...
  53. ncbi request reprint Giant cell arteritis: disease patterns of clinical presentation in a series of 240 patients
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 84:269-76. 2005
    ....
  54. ncbi request reprint Giant cell arteritis without clinically evident vascular involvement in a defined population
    Miguel A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    Arthritis Rheum 51:274-7. 2004
    ..To assess whether differences exist between this group of patients and the rest of biopsy-proven GCA patients...
  55. ncbi request reprint Influence of anti-TNF-alpha infliximab therapy on adhesion molecules associated with atherogenesis in patients with rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 24:373-9. 2006
    ....
  56. ncbi request reprint Polymyalgia manifestations in different conditions mimicking polymyalgia rheumatica
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 18:755-9. 2000
    ..The importance of the differential diagnosis in patients presenting with polymyalgia symptoms is underlined...
  57. ncbi request reprint Biopsy-negative giant cell arteritis: clinical spectrum and predictive factors for positive temporal artery biopsy
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 30:249-56. 2001
    ....
  58. ncbi request reprint Short-term effect of anti-TNF-alpha therapy on nitric oxide production in patients with severe rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, 27004, Lugo, Spain
    Clin Exp Rheumatol 27:452-8. 2009
    ..In the present study we investigated whether the infusion of the anti-TNF-alpha-infliximab may yield a short-term effect altering circulating NO oxidation products in patients with severe RA...
  59. ncbi request reprint Giant cell arteritis: diagnosis and therapeutic management
    Miguel A Gonzalez-Gay
    Rheumatology Division, Hospital Xeral Calde, Lugo, Spain
    Curr Rheumatol Rep 8:299-302. 2006
    ..Corticosteroids are the cornerstone treatment of GCA. Studies using other drugs have yielded contradictory results...
  60. ncbi request reprint Clinical approach to cutaneous vasculitis
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Curr Opin Rheumatol 17:56-61. 2005
    ..It outlines the work-up for assessing patients with cutaneous vasculitis and discusses the essential features of the main conditions included within this category...
  61. ncbi request reprint Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 24:83-6. 2006
    ....
  62. pmc Genetic epidemiology. Giant cell arteritis and polymyalgia rheumatica
    M A Gonzalez-Gay
    Rheumatology Division, Hospital Xeral Calde, Lugo, Spain
    Arthritis Res 3:154-7. 2001
    ..However, additional studies are required to clarify the genetic influence on susceptibility to these conditions...
  63. ncbi request reprint Giant cell arteritis: laboratory tests at the time of diagnosis in a series of 240 patients
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 84:277-90. 2005
    ..30-0.94; p = 0.03). In conclusion, our results suggest that some laboratory markers of inflammation, in particular the presence of anemia, may negatively predict the risk of severe ischemic complications in GCA patients...
  64. ncbi request reprint Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 20:133-8. 2002
    ..To investigate the possible implications of the CRH promoter polymorphisms in PMR and GCA susceptibility we have examined a series of patients with these conditions...
  65. ncbi request reprint Epidemiology of the vasculitides
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Rheum Dis Clin North Am 27:729-49. 2001
    ..Increased physician awareness and the routine use of ANCA tests may contribute to an increase in the recognition of conditions such as WG and MPA...
  66. ncbi request reprint Steroid therapy improves endothelial function in patients with biopsy-proven giant cell arteritis
    Carlos Gonzalez-Juanatey
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 33:74-8. 2006
    ..We assess whether endothelial dysfunction was also present in patients with biopsy-proven giant cell arteritis (GCA) and whether it might be improved following steroid treatment...
  67. pmc Epidemiology of biopsy proven giant cell arteritis in northwestern Spain: trend over an 18 year period
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, 27004 Lugo, Spain
    Ann Rheum Dis 60:367-71. 2001
    ..To investigate further the epidemiology of GCA in southern Europe the trend in incidence and fluctuations of this vasculitis over 18 years in the Lugo region of northwestern Spain were examined...
  68. ncbi request reprint Lack of association of NAMPT rs9770242 and rs59744560 polymorphisms with disease susceptibility and cardiovascular risk in patients with rheumatoid arthritis
    M Garcia-Bermudez
    Instituto de Parasitología y Biomedicina López Neyra, C S I C, Granada, Spain
    Clin Exp Rheumatol 29:681-8. 2011
    ..In this study we assessed the potential association of two NAMPT gene polymorphisms with disease susceptibility and cardiovascular (CV) risk in patients with rheumatoid arthritis (RA)...
  69. ncbi request reprint No primary association of MICA polymorphism with systemic lupus erythematosus
    E Sanchez
    Instituto de Biomedicina, CSIC, Hospital Virgen de las Nieves, Granada, Spain
    Rheumatology (Oxford) 45:1096-100. 2006
    ..To replicate the described association between MHC class I chain-related A (MICA) gene polymorphism and susceptibility to systemic lupus erythematosus (SLE)...
  70. ncbi request reprint Lack of association between macrophage migration inhibitory factor-173 gene polymorphism with disease susceptibility and cardiovascular risk in rheumatoid arthritis patients from northwestern Spain
    R Palomino-Morales
    Instituto de Parasitologia y Biomedicina, Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 28:68-72. 2010
    ....
  71. ncbi request reprint Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 7:433-6. 2006
    ..001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173(*)C allele and CATT(7)-MIF -173(*)C haplotype, confer susceptibility to SLE in our population...
  72. ncbi request reprint Interleukin-6 gene -174 promoter polymorphism is associated with endothelial dysfunction but not with disease susceptibility in patients with rheumatoid arthritis
    R Palomino-Morales
    Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 27:964-70. 2009
    ..To determine whether the interleukin (IL)6 -174 gene polymorphism may influence the development of subclinical atherosclerosis manifested by the presence of endothelial dysfunction in RA patients...
  73. ncbi request reprint Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis
    R Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 28:695-701. 2010
    ....
  74. ncbi request reprint High-grade inflammation, circulating adiponectin concentrations and cardiovascular risk factors in severe rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 26:596-603. 2008
    ....
  75. ncbi request reprint Association study of ghrelin receptor gene polymorphisms in rheumatoid arthritis
    G Robledo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Clin Exp Rheumatol 28:25-9. 2010
    ..In this study we investigated the possible contribution of several polymorphisms in the functional Ghrelin receptor to RA susceptibility...
  76. doi request reprint No evidence for genetic association of interferon regulatory factor 3 in systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Lupus 18:230-4. 2009
    ..Our data suggest that the IRF3 polymorphisms do not appear to play a major role in the susceptibility or severity of SLE in a Spanish population...
  77. doi request reprint The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Ann Rheum Dis 68:253-6. 2009
    ..The aim of the current study was to investigate the possible implication of the IL23R gene in SSc susceptibility and/or clinical phenotype...
  78. doi request reprint The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Ann Rheum Dis 67:1451-4. 2008
    ..The aim of the current study was to investigate, for the first time, the possible involvement of the IL23R gene in genetic susceptibility to ankylosing spondylitis (AS)...
  79. ncbi request reprint Study of a functional polymorphism in the p53 gene in systemic lupus erythematosus: lack of replication in a Spanish population
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Lupus 15:658-61. 2006
    ..In conclusion, the p53 codon 72 polymorphism associated with SLE in a Korean population does not appear to play a major role in the susceptibility or severity of SLE in the Spanish population...
  80. ncbi request reprint Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis
    M Garcia-Bermudez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Granada, Spain
    Clin Exp Rheumatol 29:293-8. 2011
    ..To assess the potential association between LEP rs2167270 (19 G>A) gene polymorphism and disease susceptibility and cardiovascular disease (CV) in patients with rheumatoid arthritis (RA)...
  81. ncbi request reprint Seronegative rheumatoid arthritis in elderly and polymyalgia rheumatica have similar patterns of HLA association
    M A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 28:122-5. 2001
    ..To examine whether polymyalgia rheumatica (PMR) and late onset rheumatoid arthritis have identical or similar HLA-DRB1 genetic associations...
  82. ncbi request reprint Short-term adalimumab therapy improves endo-thelial function in patients with rheumatoid arthritis refractory to infliximab
    C Gonzalez-Juanatey
    Cardiology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 24:309-12. 2006
    ..In this study we aimed to assess whether adalimumab, a fully human monoclonal antibody directed against TNF-alpha, was able to improve endothelial function in RA patients with long-standing disease refractory to infliximab...
  83. ncbi request reprint Implication of the age in the clinical spectrum of giant cell arteritis
    M J Lopez-Diaz
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 26:S16-22. 2008
    ..To assess the potential influence of the age in the clinical spectrum of giant cell arteritis (GCA)...
  84. ncbi request reprint Contribution of MHC class I region to genetic susceptibility for giant cell arteritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Rheumatology (Oxford) 46:431-4. 2007
    ..The aim of this study was to assess the potential contribution of HLA-class I MICA and HLA-B gene polymorphisms towards the pathogenesis of giant cell arteritis (GCA)...
  85. ncbi request reprint Predictive factors for renal sequelae in adults with Henoch-Schönlein purpura
    C Garcia-Porrua
    Rheumatology Division of Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 28:1019-24. 2001
    ..To examine the outcome and risk factors for renal sequelae in an unselected population of adults with Henoch-Schonlein Purpura (HSP)...
  86. ncbi request reprint Rheumatic manifestations of infective endocarditis in non-addicts. A 12-year study
    C Gonzalez-Juanatey
    Division of Cardiology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 80:9-19. 2001
    ..The presence of musculoskeletal or vasculitic manifestations may be of some help, as warning signs, for the recognition of patients with severe disease who require rapid diagnosis and therapy...
  87. ncbi request reprint Non-typhi Salmonella infection in patients with rheumatic diseases on TNF-alpha antagonist therapy
    J L Peña-Sagredo
    Division of Rheumatology, Hospital Universitario Marques de Valdecilla, University of Cantabria, Santander, Spain
    Clin Exp Rheumatol 27:920-5. 2009
    ....
  88. ncbi request reprint The 11q23.3 genomic region-rs964184-is associated with cardiovascular disease in patients with rheumatoid arthritis
    R López-Mejías
    Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Tissue Antigens 82:344-7. 2013
    ..91, 95% confidence interval (CI): 1.36-6.26, P = 0.006] after adjusting the results for sex, age at diagnosis and traditional CV risk factors. Our results indicate that rs964184 polymorphism is associated with CV disease in RA. ..
  89. ncbi request reprint Hypersensitivity vasculitis in adults: a benign disease usually limited to skin
    C Garcia-Porrua
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 19:85-8. 2001
    ..To examine the clinical spectrum of hypersensitivity vasculitis (HV) in an unselected population of adults and establish differences between patients with HV limited to the skin and those with systemic involvement...
  90. ncbi request reprint Microscopic polyangiitis following recurrent Staphylococcus aureus bacteremia and infectious endocarditis
    J A Miranda-Filloy
    Rheumatology Division, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 24:705-6. 2006
    ..We emphasize the potential pathogenic role of infection as the trigger factor for the development of systemic vasculitis...
  91. ncbi request reprint Predictors of cerebrovascular accidents in giant cell arteritis in a defined population
    R Pego-Reigosa
    Division of Neurology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 22:S13-7. 2004
    ..To examine the frequency and predictors of cerebrovascular accidents (CVA) in giant cell arteritis (GCA) patients from a defined population...
  92. doi request reprint Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis
    R López-Mejías
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Tissue Antigens 78:438-41. 2011
    ..In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA...
  93. ncbi request reprint Prevalence of HLA-B27 and subtypes of HLA-B27 associated with ankylosing spondylitis in Galicia, Spain
    J L Fernandez-Sueiro
    Rheumatology Division, Hospital Juan Canalejo, La Coruna, Galicia, Spain
    Clin Exp Rheumatol 22:465-8. 2004
    ..To assess the prevalence of HLA-B27 and its subtypes in both the normal population and in patients with Ankylosing Spondylitis (AS) in Galicia, Northwest Spain...
  94. ncbi request reprint Listeria monocytogenes infection in patients with rheumatic diseases on TNF-alpha antagonist therapy: the Spanish Study Group experience
    J L Peña-Sagredo
    Divisions of Rheumatology and Infectious Diseases, Hospital Universitario Marques de Valdecilla, University of Cantabria, Spain
    Clin Exp Rheumatol 26:854-9. 2008
    ....
  95. ncbi request reprint Generalized granuloma annulare and giant cell arteritis
    S Yáñez
    Division of Dermatology, Hospital Universitario M Valdecilla, Facultad de Medicina, Santander, Cantabria, Spain
    Clin Exp Rheumatol 26:S108-10. 2008
    ..Although the etiology of generalized Gan and GCA remains still unknown, they seem to be immunologically mediated conditions showing predominance of T-cells in the inflammatory infiltrate...