[Association of high altitude-induced hypoxemia to lipid profile and glycemia in men and women living at 4,100m in the Peruvian Central Andes]Gustavo F Gonzales
Departamento de Ciencias Fisiologicas, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
Endocrinol Nutr 60:79-86. 2013
..It is not known whether higher hypoxemia levels (as measured by higher Hb values) affect basal glucose and lipid profile at an altitude of 4,100mg (Carhuamayo and Junln)...
[Mother's hemoglobin in perinatal and mother health in the highlands: implications in the andean region]Gustavo F Gonzales
Unidad de Reproducción Humana, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Rev Peru Med Exp Salud Publica 29:570-4. 2012
..It is discussed whether iron supplementation should change its target population from pregnant women to infants aged 6 to 36 months...
- Resistance of sperm motility to serum testosterone in men with excessive erythrocytosis at high altitude
G F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Horm Metab Res 44:987-92. 2012
..In conclusion, low sperm motility was observed in men with EE despite elevated serum testosterone levels suggesting a resistance of sperm motility...
- Association of hemoglobin values at booking with adverse maternal outcomes among Peruvian populations living at different altitudes
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru
Int J Gynaecol Obstet 117:134-9. 2012
..To determine hemoglobin values associated with adverse maternal outcomes among Peruvian populations at different altitudes...
- [Impact of high altitude on pregnancy and newborn parameters]
Gustavo F Gonzales
Unidad de Reproducción Humana, Instituto de Investigaciones de Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Rev Peru Med Exp Salud Publica 29:242-9. 2012
..5 g/dl). In conclusion, a pregnant woman exposed briefly, intermittently, or permanently to high altitudes results in increased risk of adverse outcomes when compared to pregnancies observed at sea level...
- [Maternal hemoglobin in Peru: regional differences and its association with adverse perinatal outcomes]
Gustavo F Gonzales
Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
Rev Peru Med Exp Salud Publica 28:484-91. 2011
....
- Maternal hemoglobin concentration and adverse pregnancy outcomes at low and moderate altitudes in Peru
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Lima, Peru
J Matern Fetal Neonatal Med 25:1105-10. 2012
..To identify associations of maternal hemoglobin (Hb) with perinatal outcomes at low and moderate altitudes in Peru...
- Aromatase activity after a short-course of letrozole administration in adult men at sea level and at high altitude (with or without excessive erythrocytosis)
G F Gonzales
Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Horm Metab Res 44:140-5. 2012
..In conclusion, higher serum testosterone levels in men with excessive erythrocytosis were associated with an increased rate of conversion from DHEAS to testosterone rather than to a lower aromatase activity...
- High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes
Gustavo F Gonzales
Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Endocrine 40:472-80. 2011
..In conclusion, higher serum testosterone levels and Zn levels were associated with EE, and low scores of signs/symptoms of CMS were associated with higher Zn and nitric oxide levels...
- [Hemoglobin and testosterone: importance on high altitude acclimatization and adaptation]
Gustavo F Gonzales
Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Peru
Rev Peru Med Exp Salud Publica 28:92-100. 2011
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Maternal hemoglobin level and fetal outcome at low and high altitudesGustavo F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Am J Physiol Regul Integr Comp Physiol 297:R1477-85. 2009
..Our data suggest, that maternal hemoglobin above 11 g/dl but below 13 g/dl is the area of minimal risk of poor adverse outcomes. Living at HA had an adverse effect independent of hemoglobin level...
- Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats
Carla Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, P.O. Box 1843, Lima, Peru
J Ethnopharmacol 103:448-54. 2006
..In conclusion, there were differences in the biological response of the three ecotypes of Maca (Yellow, Red and Black). Black Maca appeared to have more beneficial effect on sperm counts and epididymal sperm motility...
- Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats
Sandra Yucra
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Lima, Peru
Fertil Steril 89:1461-7. 2008
..To evaluate the effect of different fractions of Black Maca (Lepidium meyenii), obtained from the hydroalcoholic extract, on spermatogenesis...
- Dose-response effects of Lepidium meyenii (Maca) aqueous extract on testicular function and weight of different organs in adult rats
Francisco Chung
Department of Biological and Physiological Sciences and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Postal Office 1843, Lima, Peru
J Ethnopharmacol 98:143-7. 2005
..2 g dry Maca hypocotyls/kg...
- High serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men
Gustavo F Gonzales
Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Alberto Cazorla Tálleri Universidad Peruana Cayetano Heredia, Ave Honorio Delgado 430, Lima 31, Peru
Am J Physiol Endocrinol Metab 296:E1319-25. 2009
..In conclusion, high androgen activity could be involved in the etiopathogeny of CMS. This evidence provides an opportunity to develop new therapeutic strategies...
- Lepidium meyenii (Maca) reversed the lead acetate induced -- damage on reproductive function in male rats
Julio Rubio
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Food Chem Toxicol 44:1114-22. 2006
..Maca prevented LA-induced spermatogenic disruption in rats and it may become in a potential treatment of male infertility associated with lead exposure...
- Lepidium meyenii (Maca): a plant from the highlands of Peru--from tradition to science
Gustavo F Gonzales
Instituto de Investigaciones de la Altura, and Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Forsch Komplementmed 16:373-80. 2009
..The exact mechanisms of action are still unclear, but so far research clearly indicates that various bioactive constituents contribute to the clinical effects reported...
- Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters
Sandra Yucra
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Environ Health 7:59. 2008
..We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru...
- Effects of different varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized rats
Carla Gonzales
Biological and Physiological Science Department, Universidad Peruana Cayetano Heredia, Lima, Peru
Forsch Komplementmed 17:137-43. 2010
..This study was designed to determine the effect of different varieties of maca (Lepidium meyenii) on bone structure in ovariectomized (OVX) rats...
- Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia
Gustavo F Gonzales
Biological and Physiological Sciences, Cayetano Heredia University, Lima, Peru
Asian J Androl 9:245-51. 2007
..To determine the effect of two different extracts of red maca in male rats...
- Semen quality and reproductive sex hormone levels in Peruvian pesticide sprayers
Sandra Yucra
Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Int J Occup Environ Health 12:355-61. 2006
..These findings provide further evidence that occupational exposures to OP pesticides adversely affect semen quality and sex hormones...
- Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice
Julio Rubio
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
BMC Complement Altern Med 6:23. 2006
..Maca is a cultivated plant and different cultivars are described according to the color of the hypocotyls...
- Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate
Karina Paola Leiva
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia, Lima, Peru
Toxicol Mech Methods 21:495-502. 2011
..EEP showed an antioxidant activity similar to that of AA. EEP prevented LA-induced spermatogenic disruption in rats and its antioxidant activity could explain its capacity to reverse the damage produced by LA on spermatogenesis...
- Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination
Luis Noriega-Portella
PRANOR, Group of Assisted Reproduction, Universidad Peruana Cayetano Heredia, Lima, Peru
Fertil Steril 90:1818-25. 2008
..To determine the effect of combined therapy of letrozole (2.5 mg or 5.0 mg) with recombinant follicle-stimulating hormone (FSH) in comparison with the administration of recombinant FSH alone in an intrauterine insemination (IUI) program...
- Red maca (Lepidium meyenii) reduced prostate size in rats
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Reprod Biol Endocrinol 3:5. 2005
..The absolute content of glucosinolates in Maca hypocotyls is relatively higher than that reported in other cruciferous crops. Therefore, Maca may have proapoptotic and anti-proliferative effects in the prostate...
- Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
Julio Rubio
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Toxicol Mech Methods 21:628-34. 2011
..Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose-response manner due, in part, to its content of polyphenolic compounds...
- Birth weight charts for gestational age in 63,620 healthy infants born in Peruvian public hospitals at low and at high altitude
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Acta Paediatr 98:454-8. 2009
..To construct distribution curves for birth weight, length and head circumference using a large sample of infants born at low (150 m) and high (3000-4400 m) altitude...
- Association between biofuel exposure and adverse birth outcomes at high altitudes in Peru: a matched case-control study
Sandra Yucra
Instituto de Investigaciones de la Altura, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Int J Occup Environ Health 17:307-13. 2011
..The use of biofuel for cooking was found to be strongly associated with increased risks of LBW, but was not significantly linked to preterm births...
- Hypocotyls of Lepidium meyenii (maca), a plant of the Peruvian highlands, prevent ultraviolet A-, B-, and C-induced skin damage in rats
Cynthia Gonzales-Castañeda
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Photodermatol Photoimmunol Photomed 24:24-31. 2008
..Lepidium meyenii (maca) is a plant that grows exclusively in the Peruvian Central Andes, where ultraviolet radiation (UVR) is predominant. Objective: Determine if two extracts of maca can provide dermal protection against UVR...
- Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice
Julio Rubio
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, P O Box 1843, Lima, Peru
Food Chem Toxicol 45:1882-90. 2007
..Black Maca extracts inhibited AChE activity, whereas MAO activity was not affected. These results indicate that Black Maca improves scopolamine-induced memory deficits...
- Peruvian contributions to the study on human reproduction at high altitude: from the chronicles of the Spanish conquest to the present
Gustavo F Gonzales
Instituto de Investigaciones de la Altura High Altitude Research Institute and Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima 31, Peru
Respir Physiol Neurobiol 158:172-9. 2007
..Clearly, antiquity and genetics are important components in determining survival and quality of life at high altitude...
- Lepidium meyenii (Maca) increases litter size in normal adult female mice
Ana C Ruiz-Luna
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Reprod Biol Endocrinol 3:16. 2005
..The present study was aimed to investigate the effects of Maca on several fertility parameters of female mice at reproductive age...
- Stillbirth rates in Peruvian populations at high altitude
Gustavo F Gonzales
High Altitude Research Institute, Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Int J Gynaecol Obstet 100:221-7. 2008
..To compare the stillbirth rates in 4 cities at different altitudes in Peru...
- Cycloheximide prevents production of arresting, a fraction of 30-50 kDa obtained from seminiferous tubule conditioned medium
Gustavo F Gonzales
Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Asian J Androl 6:359-64. 2004
..To evaluate the effect of a protein synthesis inhibitor cycloheximide on arresting activity in spermatogenesis and sperm count in male rats...
- Arterial oxygen saturation in healthy newborns delivered at term in Cerro de Pasco (4340 m) and Lima (150 m)
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Av, Honorio Delgado 430, Urb, Ingenieria, Lima, Peru, PO Box 1843, Lima, Peru
Reprod Biol Endocrinol 3:46. 2005
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- Mercury exposures in informal gold miners and relatives in southern Peru
Jasmin Hurtado
Department of Micdrobiology, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Av Honorio Delgado N 430 Lima 31, Apartado Postal 4314, Lima 100, Peru
Int J Occup Environ Health 12:340-5. 2006
..5 microg/m3 (12-55) during amalgamation, and 12 microg/m3 (3-23) in the mining town. Smelters are highly contaminated with mercury, as are the people living around smelters...
- Maternal and perinatal outcomes in second hemoglobin measurement in nonanemic women at first booking: effect of altitude of residence in peru
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Universidad Peruana Cayetano Heredia, Lima 31, Peru
ISRN Obstet Gynecol 2012:368571. 2012
..Prevalence of anemia increases as pregnancy progress, and that a normal value at first booking may not be considered sufficient as Hb values should be observed throughout pregnancy. BMI was a risk for anemia in a second measurement...
- Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Postal Office 1843, Lima, Peru
Asian J Androl 5:349-52. 2003
..To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesis in male rats...
- Medicinal plants from Peru: a review of plants as potential agents against cancer
Gustavo F Gonzales
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Anticancer Agents Med Chem 6:429-44. 2006
..In addition, this review will discuss areas requiring future study and the inherent limitations in their experimental use as anti-cancer agents...
- Blood lead levels among police officers in Lima and Callao, 2004
Wilfredo Mormontoy
Departament of Statistics, Demography, Humanity and Social Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
Int J Hyg Environ Health 209:497-502. 2006
..This may be a consequence of the policy to eliminate leaded gasoline in Peru. However, it is still necessary to monitor this policy to ensure the elimination of lead in gasoline...
- Sperm chromatin stability and its relationship with fertilization rate after intracytoplasmic sperm injection (ICSI) in an assisted reproduction program
Javier Garcia
Laboratory of Assisted Reproduction, PRANOR Group of Assisted Reproduction, Instituto de Ginecología y Reproducción, Lima, Peru
J Assist Reprod Genet 24:587-93. 2007
..Evaluate sperm chromatin stability and its relationship with the rate of fertilization after procedures of intracytoplasmic sperm injection (ICSI) in a program of assisted reproduction...
