Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinomaKan Gong
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing, PR China
Cancer Biol Ther 5:582-5. 2006
..Coexpression of Epo and EpoR was detected in 50 out of 54 tumors regardless of their VHL mutation status. The results suggest that coexpression of Epo and EpoR plays an important role in tumorigenesis of sporadic CCRCC...
- [Clinical study of Sunitinib in the treatment of metastatic renal clear cell carcinoma: a single center 23 cases experience]
Xue Song Li
Department of Urology, Peking University First Hospital, Institute of Urology Peking University, Beijing 100034, China
Zhonghua Wai Ke Za Zhi 48:375-7. 2010
..To evaluate the efficacy and safety of Sunitinib in the treatment of metastatic renal clear cell carcinoma in our institution...
Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical interventionXue Song Li
Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, National Urological Cancer Center, No 8 Xishiku St, Xicheng District, Beijing, 100034, China
J Cancer Res Clin Oncol 138:269-74. 2012
..This report investigated the growth rate and stage progression of incidentally discovered RCC following a long period of active surveillance...
- Multilocular cystic renal cell carcinoma: an experience of clinical management for 31 cases
Kan Gong
Department of Urology, Peking University First Hospital, Beijing 100034, China
J Cancer Res Clin Oncol 134:433-7. 2008
..In general, MCRCC is a frequent subtype of RCC in the clinic. A nephron-sparing procedure should be considered in the preoperative plan when a complex multicystic renal mass with enhanced density is observed...
- [Analysis of biallelic inactivation of the von Hippel-Lindau tumor suppressor gene VHL in patients of renal cell carcinoma patient]
Ning Liu
Department of Urology, The First Hospital, Peking University, Beijing 100034, China
Zhonghua Wai Ke Za Zhi 43:115-7. 2005
..To investigate biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) in patient of renal cell carcinoma (RCC) patient...
- [The expression of hypoxia inducible factor-1,2 alpha in sporadic clear cell renal cell carcinoma and their relationships to the mutations of von Hippel-Lindau gene]
Kan Gong
Department of Urology, The First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Wai Ke Za Zhi 43:390-3. 2005
..To evaluate the expression of hypoxia inducible factor (HIF)-1alpha, 2alpha in sporadic clear cell renal cell carcinoma and their relationships to the mutations of von Hippel-Lindau (VHL) gene...
- [Frequent somatic mutations of the von Hippel-Lindau (VHL) tumor suppressor gene and its meaning in sporadic human renal clear cell carcinoma]
Kan Gong
Department of Urology, Peking University First Hospital, Beijing 100034, China
Beijing Da Xue Xue Bao 36:169-72. 2004
..To investigate the mutation of VHL gene, an important tumor suppressor gene in primary sporadic human renal cell carcinoma (RCC) and analyse its relationships with pathological stage and grade of renal cell carcinoma...
- [Mutation of von Hippel-Lindau gene and expression of vascular endothelial growth factor in sporadic clear cell renal cell carcinoma and their relationships to angiogenesis]
Ning Zhang
Department of Urology, The First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 84:1620-4. 2004
..The high level of MVD of the cases with VHL gene mutation may be related to the high malignant potential of CCRCC...
- Analysis of two single nucleotide polymorphisms and loss of heterozygosity detection in the VHL gene in Chinese patients with sporadic renal cell carcinoma
Ning Liu
Urology Research Institute, Peking University First Hospital, Beijing 100034, China
Chin Med J (Engl) 118:1291-4. 2005
- Efficacy and safety of sunitinib in the treatment of metastatic renal cell carcinoma
Xue Song Li
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China
Chin Med J (Engl) 124:2920-4. 2011
..The objective of this study was to investigate the efficacy and safety of sunitinib in treating metastatic clear-cell RCC and to confirm if hypertension is an effective predictive factor...
- The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1α and -2α in sporadic clear cell renal carcinoma
Kan Gong
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, No 8 Xishiku Street, Xicheng, Beijing, P R China
Int J Mol Med 26:907-12. 2010
..Although both forms of HIF up-regulate expression of EPO, the relationship to HIF-2α appears to be more pronounced. The VHL-HIF-EPO pathway requires further study, as it may represent a potential molecular target for therapy of sCCRCC...
- [Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof]
Ning Zhang
Department of Urology, First Hospital, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 86:1526-9. 2006
..CONCLUSION: HIF-2alpha is expressed more frequently in sporadic CCRCC than HIF-1alpha. Both HIF-1alpha and HIF-2alpha upregulate the VEGF expression and angiogenesis, especially HIF-2alpha...
- [The surgical treatment and prognosis of bilateral sporadic renal tumors]
Ning Zhang
Department of Urology, The First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Wai Ke Za Zhi 45:121-3. 2007
..To evaluate the surgical management and prognostic characteristics of bilateral sporadic renal tumors (BSRTs)...
- [Diagnosis and treatment of multilocular cystic renal cell carcinoma: a study of 22 cases]
Kan Gong
Department of Urology, The First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 84:740-2. 2004
..Intraoperative frozen-section or nephron sparing surgery will benefit the patients if the preoperative diagnosis is unclear, especially for the patients of category 3 or 4 of Bosniak's system...
- [Laparoscopic radical cystectomy: analysis of a single-surgeon learning curve of 60 cases]
Wei Zheng
Department of Urology, Peking University First Hospital, Beijing, China
Beijing Da Xue Xue Bao 44:558-62. 2012
..To evaluate the changes in perioperative outcomes that might refect progress along the learning curving by a single-surgeon's experience in our institution with laparoscopic radical cystectomy (LRC)...
- [Viviperception on renal vessel variation by retroperitoneal laparoscopy a report of 525 cases]
Gang Song
Department of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 91:683-5. 2011
..To study the variation of renal vessels with retroperitoneal laparoscopy so as to increase the safety of retroperitoneal laparoscopic surgeries...
- [Quality of life among patients with advanced prostate cancer: a survey using functional assessment of cancer therapy-prostate in China]
Kai Zhang
Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 88:665-8. 2008
..To assess the quality of life of patients with advanced prostate cancer in China and compare the influences of different stage and different forms of therapy...
- Prognostic factors in Chinese patients with penile invasive squamous cell carcinoma
Xiaopeng Chen
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China
J Androl 33:1276-81. 2012
..In our series, chronological age and LNM were independent prognostic factors for CSS. The histological grade, not the tumor stage, was still an influential predictive factor of LNM in Chinese patients with penile SCC...
- [Predictive value of prostate-specific antigen and Gleason sum for results of radionuclide bone scintigraphy in patients with prostate cancer]
Tian Yu Wang
Department of Urology, Peking University First Hospital, China
Beijing Da Xue Xue Bao 44:528-34. 2012
....
- [Differential transcription of Bcl-2 and Bax through the cell cycle in prostate cancer cell line]
Xue Song Li
Department of Urology, Institute of Urology, Peking University First Hospital, Beijing 100034, China
Zhonghua Wai Ke Za Zhi 46:768-71. 2008
..To investigate the differential expression of apoptosis associated gene Bcl-2 and Bax through cell cycle and its possible clinical meaning...
- [Primary artery erectile dysfunction: one case report]
Jian Lin
Department of Urology, The First Hospital of Peking University, Insititute of Urology, Peking University, Beijing 100034, China
Zhonghua Nan Ke Xue 11:217-8, 222. 2005
..To evaluate the relationship between the deformation of penile artery and the primary artery erectile dysfunction, and to improve the treatment and diagnosis of primary artery erectile dysfunction...
- [Report of a case of penile epithelioid sarcoma]
Kan Gong
Department of Urology, Fist Hospital, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Nan Ke Xue 10:205-7. 2004
..To enhance the knowledge and the effect of the diagnosis and treatment of primary epithelioid sarcoma of the penis...
- [Treatment and prognosis of scrotal extramammary Paget's disease: a report of 23 cases]
Ning Zhang
Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Nan Ke Xue 12:1102-4. 2006
..Scrotal EMPD tends to occur as a slowly growing lesion, mainly in the elderly, and has a good prognosis in cases of non-invasion. Otherwise the prognosis is poor...
- [Role of CD2-associated protein and nephrin expression in multilocular cystic renal cell carcinoma]
Kan Gong
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 89:543-7. 2009
....
The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cellsPengjie Wu
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, People s Republic of China
PLoS ONE 7:e45122. 2012
..Our results suggested that Epo/EpoR pathway was involved in cell growth, invasion, survival, and sensitivity to the multi-kinases inhibitor Sunitinib in RCC cells...
- [Somatic mutations of VHL gene and HIF-1alpha expression in primary renal clear cell carcinomas]
Hong feng GUO
Department of Urology, First Hospital of Peking University, Beijing 100034, China
Zhonghua Wai Ke Za Zhi 42:196-200. 2004
..To evaluate the significance of somatic mutations of VHL gene and hypoxia-inducible factor-1alpha (HIF-1alpha) expression in primary renal clear cell carcinoma (RCC)...
- [Wnt/Frizzled signaling pathway in renal carcinoma]
Kan Gong
Institute of Urology, Department of Urology, First Hospital of Peking University. Beijing 100034, China
Zhonghua Yi Xue Za Zhi 83:1270-3. 2003
..TCF(4), its important signal factor, interacts with beta-catenin and forms homodimer or homocopolymer by itself, thus displaying its constitutive transcriptional activity...
