Flávia Carvalho Alcantara Gomes

Summary

Publications

  1. Tinoco Veras C, Santos A, Stipursky J, Meloni M, Araujo A, Foschetti D, et al. Transforming Growth Factor β1/SMAD Signaling Pathway Activation Protects the Intestinal Epithelium from Clostridium difficile Toxin A-Induced Damage. Infect Immun. 2017;85: pubmed publisher
    ..Together, these data show that TcdA induces TGF-β1 signaling pathway activation and suggest that this pathway might play a protective role against the effect of C. difficile-toxin. ..
  2. Diniz L, Matias I, Siqueira M, Stipursky J, Gomes F. Astrocytes and the TGF-β1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword. Mol Neurobiol. 2018;: pubmed publisher
  3. Garcia D, de Castro Faria Neto H, da Silva C, de Souza e Souza K, Gonçalves de Albuquerque C, Silva A, et al. Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. Mol Cancer. 2015;14:105 pubmed publisher
    ..A signaling mechanism mediated by NKA may have an important role in the anti-tumor action of POH in GBM cells. ..
  4. Matias I, Buosi A, Gomes F. Functions of flavonoids in the central nervous system: Astrocytes as targets for natural compounds. Neurochem Int. 2016;95:85-91 pubmed publisher
    ..Finally, we discuss how the effects of flavonoids on astrocytes might contribute to the development of alternative therapeutic approaches to the treatment of neural diseases. ..
  5. Buosi A, Matias I, Araújo A, Batista C, Gomes F. Heterogeneity in Synaptogenic Profile of Astrocytes from Different Brain Regions. Mol Neurobiol. 2018;55:751-762 pubmed publisher
    ..These findings highlight the heterogeneity of astrocytes and suggest that their synaptogenic potential may be different in each brain region, mainly due to distinct gene expression profiles. ..
  6. Diniz L, Tortelli V, Matias I, Morgado J, Bérgamo Araujo A, Melo H, et al. Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against A? Oligomers in Alzheimer's Disease Model. J Neurosci. 2017;37:6797-6809 pubmed publisher
    ..Our results describe a new mechanism underlying the toxicity of A?Os and indicate novel therapeutic targets for Alzheimer's disease, mainly focused on TGF-?1 and astrocytes. ..