A P Goldstone

Summary

Publications

  1. ncbi request reprint Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution
    A P Goldstone
    Endocrine Unit, MRC Clinical Sciences Centre, London, United Kingdom
    J Clin Endocrinol Metab 86:4330-8. 2001
  2. ncbi request reprint Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    J Clin Endocrinol Metab 90:2681-90. 2005
  3. ncbi request reprint Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:1718-26. 2004
  4. ncbi request reprint Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects
    Anthony P Goldstone
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The Netherlands
    J Clin Endocrinol Metab 87:927-37. 2002
  5. ncbi request reprint Prader-Willi syndrome: advances in genetics, pathophysiology and treatment
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Trends Endocrinol Metab 15:12-20. 2004
  6. ncbi request reprint Leptin prevents the fall in plasma osteocalcin during starvation in male mice
    A P Goldstone
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Biochem Biophys Res Commun 295:475-81. 2002
  7. ncbi request reprint Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity
    Anthony P Goldstone
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 58:743-55. 2003
  8. ncbi request reprint Magnetic resonance imaging of total body fat
    E L Thomas
    The Robert Steiner Magnetic Resonance Imaging Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom
    J Appl Physiol 85:1778-85. 1998
  9. ncbi request reprint Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
    E L Thomas
    The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Lipids 35:769-76. 2000
  10. doi request reprint Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome
    A P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Int J Obes (Lond) 36:1564-70. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution
    A P Goldstone
    Endocrine Unit, MRC Clinical Sciences Centre, London, United Kingdom
    J Clin Endocrinol Metab 86:4330-8. 2001
    ..05) but not visceral adiposity (P = 0.3-0.6), supporting their association. The cause of the reduced visceral adiposity in Prader-Willi syndrome may reflect novel hormonal, hypothalamic, and/or genetic influences on body fat distribution...
  2. ncbi request reprint Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    J Clin Endocrinol Metab 90:2681-90. 2005
    ....
  3. ncbi request reprint Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:1718-26. 2004
    ..The hyperghrelinemia in PWS adults is therefore not solely explained by their reduced visceral adiposity and relative hypoinsulinemia. Its cause and consequences await further elucidation...
  4. ncbi request reprint Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects
    Anthony P Goldstone
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The Netherlands
    J Clin Endocrinol Metab 87:927-37. 2002
    ..The implications for pharmacological treatment of human obesity are discussed...
  5. ncbi request reprint Prader-Willi syndrome: advances in genetics, pathophysiology and treatment
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Trends Endocrinol Metab 15:12-20. 2004
    ..This could have benefits for a wide spectrum of endocrine, paediatric and neuropsychiatric diseases...
  6. ncbi request reprint Leptin prevents the fall in plasma osteocalcin during starvation in male mice
    A P Goldstone
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Biochem Biophys Res Commun 295:475-81. 2002
    ..These studies support the hypothesis that the fall in leptin during starvation and weight loss is responsible for the associated reduction in osteoblast activity, and suggest a role for leptin in regulating bone turnover...
  7. ncbi request reprint Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity
    Anthony P Goldstone
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 58:743-55. 2003
    ..Prader-Willi syndrome (PWS) is a genetic obesity syndrome, with GH deficiency a feature independent of obesity. Reduced GH secretion may result from decreased hypothalamic release of GH-releasing hormone (GHRH)...
  8. ncbi request reprint Magnetic resonance imaging of total body fat
    E L Thomas
    The Robert Steiner Magnetic Resonance Imaging Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom
    J Appl Physiol 85:1778-85. 1998
    ....
  9. ncbi request reprint Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
    E L Thomas
    The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Lipids 35:769-76. 2000
    ....
  10. doi request reprint Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome
    A P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Int J Obes (Lond) 36:1564-70. 2012
    ..We investigated whether differences in appetite hormones may explain the development of abnormal eating behaviour in young children with PWS...
  11. doi request reprint Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI
    E L Thomas
    Metabolic and Molecular Imaging Group, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, UK
    Eur J Clin Nutr 64:525-33. 2010
    ..The objective of this study was to analyse the validity of the ViScan to assess adult abdominal adiposity across a range of body fatness...
  12. ncbi request reprint Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
    Anthony P Goldstone
    Endocrine Unit, the Department of Dietetics, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Clin Nutr 75:468-75. 2002
    ..Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR)...
  13. ncbi request reprint A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
    M Rossi
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Endocrinology 139:4428-31. 1998
    ..In conclusion, Agrp(83-132) administered i.c.v. increases feeding with long lasting effects and is able to inhibit the action of alphaMSH. This interaction may be mediated by the MC3-R and/or MC4-R...
  14. ncbi request reprint Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome
    Tricia M M Tan
    Department of Endocrinology, Royal Free and University College Hospital Medical School, Royal Free Hospital, Hampstead, London NW3 2QG, United Kingdom
    J Clin Endocrinol Metab 89:4162-5. 2004
    ..Somatostatin analogues may therefore not be an effective therapy for obesity in PWS. Larger chronic studies with long-acting somatostatin analogues will be needed to determine their benefits and risks in treating PWS obesity...
  15. doi request reprint Recommendations for the diagnosis and management of Prader-Willi syndrome
    A P Goldstone
    Department of Investigative Medicine, Medical Research Center Clinical Sciences Centre and Endocrine Unit, Hammersmith Hospital, Imperial College London, UK
    J Clin Endocrinol Metab 93:4183-97. 2008
    ..The objective of the study was to provide recommendations for the diagnosis and management of Prader-Willi syndrome throughout the life span to guide clinical practice...
  16. doi request reprint Genetic obesity syndromes
    Anthony P Goldstone
    MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, UK
    Front Horm Res 36:37-60. 2008
    ....
  17. ncbi request reprint Leptin receptor gene variation and obesity: lack of association in a white British male population
    T Gotoda
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Hum Mol Genet 6:869-76. 1997
    ..In these subjects, there was no evidence for a significant effect of the common variants on obesity or obesity-related phenotypes. These results suggest that mutations in the leptin receptor gene are not a common cause of human obesity...
  18. ncbi request reprint The hypothalamus, hormones, and hunger: alterations in human obesity and illness
    Anthony P Goldstone
    Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK
    Prog Brain Res 153:57-73. 2006
    ..Functional neuroimaging studies, using PET and fMRI, will also allow us to tease apart the hormonal and brain pathways responsible for controlling human appetite, and their defects in obesity...
  19. pmc Impact of resistant starch on body fat patterning and central appetite regulation
    Po Wah So
    Biological Imaging Centre, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    PLoS ONE 2:e1309. 2007
    ..This study was performed to investigate the impact of resistant starch (RS) on adipose tissue deposition and central regulation of appetite in mice...
  20. doi request reprint Fasting biases brain reward systems towards high-calorie foods
    Anthony P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, UK
    Eur J Neurosci 30:1625-35. 2009
    ..These results demonstrate an interaction between homeostatic and hedonic aspects of feeding behaviour, with fasting biasing brain reward systems towards high-calorie foods...
  21. doi request reprint The combined effects on neuronal activation and blood-brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI
    Yu Ting Kuo
    Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College School of Medicine, Du Cane Road, London, W12 0HS, UK
    Neuroimage 50:1384-91. 2010
    ..We conclude that MEMRI is able to detect the combined effects of the integrity of neuronal activity and blood-brain barrier permeability in the hypothalamus associated with dietary manipulation and aging...
  22. ncbi request reprint Ghrelin--a hormone with multiple functions
    Marta Korbonits
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Front Neuroendocrinol 25:27-68. 2004
    ..Increasing data link ghrelin to the overall control of energy use and flow in situations where there is a limitation of energy sources and ghrelin appears to play a pivotal role in energy homeostasis...
  23. ncbi request reprint Neurocognitive findings in Prader-Willi syndrome and early-onset morbid obesity
    Jennifer Miller
    Department of Pediatrics and the Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida 32610 0296, USA
    J Pediatr 149:192-8. 2006
    ..To examine whether early-onset morbid obesity is associated with cognitive impairment, neuropathologic changes, and behavioral problems...
  24. pmc Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome
    Jennifer L Miller
    Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida, USA
    J Neurol Neurosurg Psychiatry 78:615-9. 2007
    ..We hypothesised that the abnormal appetite in PWS results from aberrant reward processing of food stimuli in these neural pathways...
  25. ncbi request reprint Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity
    Jennifer L Miller
    Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida 32610 0296, USA
    Am J Med Genet A 146:570-7. 2008
    ....