Nithya J Gogtay

Summary

Publications

  1. ncbi request reprint The use and safety of non-allopathic Indian medicines
    N J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai Bombay, India
    Drug Saf 25:1005-19. 2002
  2. ncbi request reprint Therapeutic drug monitoring as a tool to identify medication errors
    Nithya J Gogtay
    Drug Saf 27:143-4. 2004
  3. pmc Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction
    Shaunak P Kulkarni
    Department of Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
    Indian J Pharmacol 45:330-3. 2013
  4. ncbi request reprint Frequency and causes for exclusion from randomization of healthy volunteers screened for a phase 1 study in India
    N J Gogtay
    Seth G S Medical College and K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
    Natl Med J India 25:18-20. 2012
  5. pmc Evaluation of the prevalence and economic burden of adverse drug reactions presenting to the medical emergency department of a tertiary referral centre: a prospective study
    K J Patel
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital Parel, Mumbai, India
    BMC Clin Pharmacol 7:8. 2007
  6. pmc Principles of sample size calculation
    Nithya J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India
    Indian J Ophthalmol 58:517-8. 2010
  7. ncbi request reprint Anticonvulsant hypersensitivity syndrome: a review
    Nithya J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Expert Opin Drug Saf 4:571-81. 2005
  8. ncbi request reprint A study of warning letters issued to clinical investigators and institutional review boards by the United States Food and Drug Administration
    N J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai 400 012, India
    Indian J Med Ethics 8:211-4. 2011
  9. pmc A randomized, parallel study of the safety and efficacy of 45 mg primaquine versus 75 mg bulaquine as gametocytocidal agents in adults with blood schizonticide-responsive uncomplicated falciparum malaria [ISCRTN50134587]
    N J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College and K E M Hospital, Parel, Mumbai 400 012, India
    BMC Infect Dis 6:16. 2006
  10. ncbi request reprint Off-label drug use in a Pediatric Intensive Care Unit
    S B Bavdekar
    Department of Pediatrics, Seth GS Medical College and KEM Hospital, Acharya Donde Road, Parel, Mumbai, India
    Indian J Pediatr 76:1113-8. 2009

Collaborators

  • D R Karnad
  • Sandeep B Bavdekar
  • D Bajpai
  • Urmila Mukund Thatte
  • P S Kulkarni
  • Shobhona Sharma
  • Neena Valecha
  • Tanmay S Panchabhai
  • S Kannan
  • P R Deshmukh
  • K C Kain
  • Sulabha Pathak
  • S Karande
  • N A Kshirsagar
  • Shaunak P Kulkarni
  • Santosh R Taur
  • Prashant P Kadam
  • Niteen D Karnik
  • Kannan Sridharan
  • Maulik Sumantbhai Doshi
  • Akanksha N Thakkar
  • K D Kamtekar
  • D D Rajgor
  • Abbas H Rupawala
  • B G Kirodian
  • Nilima A Kshirsagar
  • Surabhi S Jain
  • Uday P Kulkarni
  • K J Patel
  • S S Sanath
  • V S Kadam
  • A R Chogle
  • U Aigal
  • S S Dalvi
  • Canna J Ghia
  • Raghu K Naidu
  • Vishal Gupta
  • Sanjana R Shah
  • Rahul D Namjoshi
  • Sonali P Jadhav
  • Partha P Shetty
  • Namrata B Kulkarni
  • Nivrutti K Hase
  • Jaideep A Gogtay
  • Mangesh S Gore
  • Preeti R Mehta
  • Pallavi V Surase
  • Shital R Bendkhale
  • Sanish Davis
  • Pranjali A Sadawarte
  • Balkrishna D Swar
  • Anil M Patwardhan
  • S S Mehta
  • M S Kedia
  • A M Mehendale
  • J K Lazdins-Helds
  • N S Ingole
  • L Fleckenstein
  • J Karbwang
  • B S Garg
  • L S Bichile
  • V P Udani

Detail Information

Publications36

  1. ncbi request reprint The use and safety of non-allopathic Indian medicines
    N J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai Bombay, India
    Drug Saf 25:1005-19. 2002
    ..There is an urgent need for the practitioners of the allopathic and non-allopathic systems to work together to optimise the risk-benefit profile of these medicines...
  2. ncbi request reprint Therapeutic drug monitoring as a tool to identify medication errors
    Nithya J Gogtay
    Drug Saf 27:143-4. 2004
  3. pmc Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction
    Shaunak P Kulkarni
    Department of Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
    Indian J Pharmacol 45:330-3. 2013
    ..This study attempts to evaluate the pharmacokinetics of a single oral dose (15 mg) of primaquine in severely impaired renal function and end stage renal dysfunction patients compared to healthy participants...
  4. ncbi request reprint Frequency and causes for exclusion from randomization of healthy volunteers screened for a phase 1 study in India
    N J Gogtay
    Seth G S Medical College and K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
    Natl Med J India 25:18-20. 2012
    ..We aimed to assess the challenges in defining who is a normal volunteer and the issues that affect volunteer recruitment and thus accrual...
  5. pmc Evaluation of the prevalence and economic burden of adverse drug reactions presenting to the medical emergency department of a tertiary referral centre: a prospective study
    K J Patel
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital Parel, Mumbai, India
    BMC Clin Pharmacol 7:8. 2007
    ..9-7.9%. They also constitute a significant economic burden. We thus aimed at determining the prevalence and the economic burden of ADRs presenting to Medical Emergency Department (ED) of a tertiary referral center in India..
  6. pmc Principles of sample size calculation
    Nithya J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India
    Indian J Ophthalmol 58:517-8. 2010
    ..Over and above this, sample size calculations must take into account all available data, funding, support facilities, and ethics of subjecting patients to research...
  7. ncbi request reprint Anticonvulsant hypersensitivity syndrome: a review
    Nithya J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Expert Opin Drug Saf 4:571-81. 2005
    ..Adverse event monitoring programs must also actively seek AHS reports to estimate its true incidence...
  8. ncbi request reprint A study of warning letters issued to clinical investigators and institutional review boards by the United States Food and Drug Administration
    N J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai 400 012, India
    Indian J Med Ethics 8:211-4. 2011
    ..Warning letters (WLs) issued by the US FDA (United States Food and Drug Administration) mention the nature of violations by clinical investigators and institutional review boards (IRBS) and can help as training tools...
  9. pmc A randomized, parallel study of the safety and efficacy of 45 mg primaquine versus 75 mg bulaquine as gametocytocidal agents in adults with blood schizonticide-responsive uncomplicated falciparum malaria [ISCRTN50134587]
    N J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College and K E M Hospital, Parel, Mumbai 400 012, India
    BMC Infect Dis 6:16. 2006
    ..An earlier pilot study suggested that 75 mg of bulaquine (BQ), of which PQ is a major metabolite, may be a useful alternate to PQ...
  10. ncbi request reprint Off-label drug use in a Pediatric Intensive Care Unit
    S B Bavdekar
    Department of Pediatrics, Seth GS Medical College and KEM Hospital, Acharya Donde Road, Parel, Mumbai, India
    Indian J Pediatr 76:1113-8. 2009
    ..05) in off-label use between patients with multiple system affection and those with single system affection and between those requiring artificial ventilatory support and those not requiring it...
  11. ncbi request reprint Anticonvulsant hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro
    Sunil Karande
    Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, India
    Indian J Med Sci 60:59-63. 2006
    ..The potential of first-line aromatic anticonvulsants to cause AHS should be remembered in a patient who has developed AHS on exposure to lamotrigine. Timely recognition of this rare but potentially fatal drug reaction is important...
  12. ncbi request reprint A prospective study evaluating the efficacy of a single, 45-mg dose of primaquine, as a gametocytocidal agent, in patients with Plasmodium falciparum malaria in Mumbai, India
    K D Kamtekar
    Department of Clinical Pharmacology, Seth G S Medical College and K E M Hospital, Parel, Mumbai 400 012, India
    Ann Trop Med Parasitol 98:453-8. 2004
    ....
  13. ncbi request reprint Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment
    Sandeep B Bavdekar
    Seth GS Medical College and KEM Hospital, Mumbai, India
    Ann Pharmacother 38:1648-50. 2004
    ..To report a case of anticonvulsant hypersensitivity syndrome (AHS) precipitated by exposure to phenobarbital...
  14. ncbi request reprint Preliminary report of the evaluation of the gametocytocidal action of bulaquine, in adult patients with acute, Plasmodium falciparum malaria
    N J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College and K E M Hospital, Parel, Mumbai 400012, India
    Ann Trop Med Parasitol 98:525-8. 2004
  15. ncbi request reprint Poor gametocytocidal activity of 45 mg primaquine in chloroquine-treated patients with acute, uncomplicated, Plasmodium falciparum malaria in Mumbai (Bombay): an issue of public-health importance
    N J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College, Parel, Mumbai, India
    Ann Trop Med Parasitol 93:813-6. 1999
    ..There therefore appears to be a need to review the current, gametocytocidal, primaquine-dosage schedule and to re-treat patients who remain gametocytaemic with higher doses of primaquine, as an important, transmission-blocking strategy...
  16. doi request reprint An audit of therapeutic drug monitoring services of anticonvulsants at a tertiary care hospital in India
    Santosh R Taur
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
    Ther Drug Monit 35:183-7. 2013
    ....
  17. ncbi request reprint Reporting ethical processes in two Indian journals
    Sandeep B Bavdekar
    Department of Pediatrics, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
    Indian J Med Sci 62:134-40. 2008
    ....
  18. ncbi request reprint Efficacies of 5- and 14-day primaquine regimens in the prevention of relapses in Plasmodium vivax infections
    N J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College, Parel, Mumbai, India
    Ann Trop Med Parasitol 93:809-12. 1999
    ....
  19. pmc Evaluation of cytochrome P450 2D6 phenotyping in healthy adult Western Indians
    Nithya J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India
    Indian J Pharmacol 46:266-9. 2014
    ..This study aimed at finding the prevalence of CYP2D6 polymorphisms using dextromethorphan as a probe drug...
  20. doi request reprint A retrospective analysis of adverse events in the elderly in a tertiary referral center in Mumbai (Bombay), India
    Abbas H Rupawala
    Department of Clinical Pharmacology, Seth G S Medical College and K E M Hospital, Mumbai, India
    Indian J Med Sci 63:167-73. 2009
    ..Inappropriate medication usage has been regarded as an important factor contributing to AEs in them. Beers criteria are a set of standard criteria for guiding drug prescription in elderly...
  21. ncbi request reprint A cost-effectiveness analysis of three antimalarial treatments for acute, uncomplicated Plasmodium falciparum malaria in Mumbai, India
    N J Gogtay
    Department of Clinical Pharmacology, 100 Bedded Building, 4th Floor, TN Medical College and BYL Nair Ch Hospital, Dr AL Nair Road, Mumbai Central, Mumbai 400 008, India
    J Assoc Physicians India 51:877-9. 2003
    ..3% of the overall global disease burden. The cost of treatment of malaria continues to rise as older drugs and insecticides become less effective and are replaced by more effective, but also more expensive products...
  22. doi request reprint Evaluation of factors that motivate participants to consent for non-therapeutic trials in India
    Maulik Sumantbhai Doshi
    Department of Clinical Pharmacology, 1st Floor, MSB, Seth GS Medical College and KEM Hospital, Acharya Donde Marg, Parel, Mumbai, Maharashtra 400012, India
    J Med Ethics 39:391-6. 2013
    ..Several factors that motivate individuals to participate in non-therapeutic studies have been identified. This study was conducted as limited data is available regarding these motivations from developing countries...
  23. pmc Age-dependent sex bias in clinical malarial disease in hypoendemic regions
    Sulabha Pathak
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
    PLoS ONE 7:e35592. 2012
    ..This study investigates whether clinical malaria in hypoendemic regions exhibits a sex bias and whether this bias is age-dependent. We also consider the role of vector exposure in this bias...
  24. pmc Evaluation of the activity of CYP2C19 in Gujrati and Marwadi subjects living in Mumbai (Bombay)
    Tanmay S Panchabhai
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400012, India
    BMC Clin Pharmacol 6:8. 2006
    ..The present study evaluated the activity of CYP2C19 in normal, healthy Gujrati and Marwadi subjects by phenotyping (a western Indian population)...
  25. pmc A pilot study of the association of pharmacokinetic and pharmacodynamic parameters of warfarin with the dose in patients on long-term anticoagulation
    Uday P Kulkarni
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400012, India
    Br J Clin Pharmacol 65:787-90. 2008
    ..CYP2C9 and VKORC1 polymorphisms have been shown to affect warfarin dose requirement. However a large amount of the variation in warfarin dose remains unaccounted for...
  26. ncbi request reprint Efficacy of a 14-day primaquine regimen in preventing relapses in patients with Plasmodium vivax malaria in Mumbai, India
    D D Rajgor
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Trans R Soc Trop Med Hyg 97:438-40. 2003
    ....
  27. ncbi request reprint A randomized, parallel-group study in Mumbai (Bombay), comparing chloroquine with chloroquine plus sulfadoxine-pyrimethamine in the treatment of adults with acute, uncomplicated, Plasmodium falciparum malaria
    N J Gogtay
    Department of Clinical Pharmacology, Seth G S Medical College, Parel, Mumbai, India
    Ann Trop Med Parasitol 94:309-12. 2000
    ..The combination was found to be significantly more effective, in terms of 28- or 42-day cure rates, and to be more cost-effective...
  28. doi request reprint Pharmacokinetics of colistin in critically ill patients with multidrug-resistant Gram-negative bacilli infection
    Niteen D Karnik
    Department of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, 400012, India
    Eur J Clin Pharmacol 69:1429-36. 2013
    ..The aim of our study was to study the single-dose and steady-state pharmacokinetics of colistin in patients with multidrug-resistant Gram-negative bacilli infections...
  29. doi request reprint Association of CYP2C9 polymorphisms with phenytoin toxicity in Indian patients
    Akanksha N Thakkar
    Department of Clinical Pharmacology, Seth GS Medical College, Mumbai, Maharashtra, India
    Neurol India 60:577-80. 2012
    ..Polymorphic alleles CYP2C9 FNx01 2 and CYP2C9 FNx01 3 occur in the Indian population and this may serve as the basis for using genotyping as a tool to predict phenytoin toxicity...
  30. doi request reprint Off-label drug use in children
    Surabhi S Jain
    Department of Pediatrics, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
    Indian J Pediatr 75:1133-6. 2008
    ..To determine the extent and nature of off-label drug use in children admitted to a pediatric general ward in a tertiary health care centre..
  31. ncbi request reprint Safety, tolerability, efficacy and plasma concentrations of diethylcarbamazine and albendazole co-administration in a field study in an area endemic for lymphatic filariasis in India
    N A Kshirsagar
    Department of Clinical Pharmacology, New MS Building, 1st Floor, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Trans R Soc Trop Med Hyg 98:205-17. 2004
    ..While the safety of the combination has been ascertained, the incorporation or otherwise of ALB into national programmes for greater efficacy must await results of studies with longer follow up...
  32. pmc Therapeutic drug monitoring in a developing country: an overview
    N J Gogtay
    Department of Clinical Pharmacology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Parel, Mumbai, India
    Br J Clin Pharmacol 52:103S-108S. 2001
    ....
  33. ncbi request reprint Treatment of Menkes disease with parenteral copper histidine
    B G Kirodian
    Department of Clinical Pharmacology, Seth G S Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Indian Pediatr 39:183-5. 2002
  34. ncbi request reprint A randomized, crossover, assessor-blind study of the bioequivalence of a single oral dose of 200 mg of four formulations of phenytoin sodium in healthy, normal Indian volunteers
    N J Gogtay
    Department of Clinical Pharmacology, Seth GS Medical College, KEM Hospital, Bombay, India
    Ther Drug Monit 25:215-20. 2003
    ..The results of the study show that in India switching phenytoin brands could have significant implications and is not advisable once a patient is carefully titrated on one formulation...
  35. ncbi request reprint Post-marketing study to assess the safety, tolerability and effectiveness of Fungisome: an Indian liposomal amphotericin B preparation
    S S Sanath
    Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    J Postgrad Med 51:S58-63. 2005
    ..The present post marketing study assessed the safety and effectiveness of Fungisome in actual clinical practice. Setting and Design: Retrospective post marketing surveillance from four cities of India...
  36. ncbi request reprint Improving drug safety monitoring
    Sunil Karande
    Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai 400022, India
    Indian Pediatr 40:1167-75. 2003
    ..To achieve this aim, establishing in-hospital computerized event monitoring program in major hospitals and an effective national post- marketing drug surveillance network are the need of the hour...