Danijela Gnjidic

Summary

Publications

  1. doi request reprint Clinical implications from drug-drug and drug-disease interactions in older people
    Danijela Gnjidic
    Faculty of Pharmacy and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 40:320-5. 2013
  2. pmc High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Bank Building A15, Science Rd, Sydney, NSW, Australia
    BMC Public Health 13:115. 2013
  3. pmc Mild cognitive impairment predicts institutionalization among older men: a population-based cohort study
    Danijela Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, New South Wales, Australia
    PLoS ONE 7:e46061. 2012
  4. doi request reprint Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes
    Danijela Gnjidic
    Department of Clinical Pharmacology, 11C Main Building, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Clin Epidemiol 65:989-95. 2012
  5. doi request reprint Effects of drug burden index on cognitive function in older men
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    J Clin Psychopharmacol 32:273-7. 2012
  6. doi request reprint Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, 11C Main Building, Royal North Shore Hospital, St Leonards NSW 2065, Australia
    Clin Geriatr Med 28:237-53. 2012
  7. doi request reprint High-risk prescribing and incidence of frailty among older community-dwelling men
    D Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, Australia
    Clin Pharmacol Ther 91:521-8. 2012
  8. pmc How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over
    Fiona F Stanaway
    Sydney School of Public Health, University of Sydney, Sydney, Australia
    BMJ 343:d7679. 2011
  9. pmc Drug Burden Index and physical function in older Australian men
    Danijela Gnjidic
    Department of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    Br J Clin Pharmacol 68:97-105. 2009
  10. doi request reprint Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Education and Research on Ageing, Concord Hospital, Concord, NSW, Australia Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    Fundam Clin Pharmacol 28:10-9. 2014

Detail Information

Publications19

  1. doi request reprint Clinical implications from drug-drug and drug-disease interactions in older people
    Danijela Gnjidic
    Faculty of Pharmacy and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 40:320-5. 2013
    ..Clinical implications of interactions between drugs and geriatric syndromes such as frailty, falls, cognitive impairment, immobility and urinary incontinence should also be considered in older people...
  2. pmc High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Bank Building A15, Science Rd, Sydney, NSW, Australia
    BMC Public Health 13:115. 2013
    ..The aims of this project are to determine the prevalence, risk factors, clinical consequences, and costs of high risk prescribing, and to assess the impact of interventions on high risk prescribing in older people...
  3. pmc Mild cognitive impairment predicts institutionalization among older men: a population-based cohort study
    Danijela Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, New South Wales, Australia
    PLoS ONE 7:e46061. 2012
    ..There is a lack of evidence on the contribution of mild cognitive impairment (MCI) to institutionalization in older adults. This study aimed to evaluate a range of risk factors including MCI of institutionalization in older men...
  4. doi request reprint Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes
    Danijela Gnjidic
    Department of Clinical Pharmacology, 11C Main Building, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Clin Epidemiol 65:989-95. 2012
    ..This study aimed to determine an optimal discriminating number of concomitant medications associated with geriatric syndromes, functional outcomes, and mortality in community-dwelling older men...
  5. doi request reprint Effects of drug burden index on cognitive function in older men
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    J Clin Psychopharmacol 32:273-7. 2012
    ..In this study of community-dwelling older men, DBI was not associated with limitations on objective cognitive performance measures or with a clinical diagnosis of mild cognitive impairment or dementia...
  6. doi request reprint Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, 11C Main Building, Royal North Shore Hospital, St Leonards NSW 2065, Australia
    Clin Geriatr Med 28:237-53. 2012
    ..Large RCTs evaluating multidisciplinary interventions and clinical outcomes of changes in medicines regimen across different settings are required to confirm the findings of the studies performed so far...
  7. doi request reprint High-risk prescribing and incidence of frailty among older community-dwelling men
    D Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, Australia
    Clin Pharmacol Ther 91:521-8. 2012
    ..45 (95% CI: 1.42-4.23) for polypharmacy, 2.50 (95% CI: 0.76-8.26) for hyperpolypharmacy, and 2.14 (95% CI: 1.25-3.64) for DBI exposure. High-risk prescribing may contribute to frailty in community-dwelling older men...
  8. pmc How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over
    Fiona F Stanaway
    Sydney School of Public Health, University of Sydney, Sydney, Australia
    BMJ 343:d7679. 2011
    ..To determine the speed at which the Grim Reaper (or Death) walks...
  9. pmc Drug Burden Index and physical function in older Australian men
    Danijela Gnjidic
    Department of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    Br J Clin Pharmacol 68:97-105. 2009
    ..The Drug Burden Index is a measure of total exposure to anticholinergic and sedative medications that incorporates the principles of dose-response and maximal effect...
  10. doi request reprint Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Education and Research on Ageing, Concord Hospital, Concord, NSW, Australia Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    Fundam Clin Pharmacol 28:10-9. 2014
    ..Higher sedative load was not associated with poorer physical performance or cognitive impairment in older Australian men...
  11. ncbi request reprint Thinking through the medication list - appropriate prescribing and deprescribing in robust and frail older patients
    Sarah N Hilmer
    Northern Clinical School, Sydney Medical School, University of Sydney, New South Wales, Australia
    Aust Fam Physician 41:924-8. 2012
    ..Medicines in older patients have the potential to provide great gains as well as significant harms...
  12. doi request reprint Drug Burden Index associated with function in community-dwelling older people in Finland: a cross-sectional study
    Danijela Gnjidic
    Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Ann Med 44:458-67. 2012
    ....
  13. doi request reprint A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people
    Danijela Gnjidic
    Clinical Pharmacology Department, University of Sydney, St Leonards, New South Wales, Australia
    Ann Pharmacother 44:1725-32. 2010
    ..Higher DBI has been associated with functional impairment in observational studies of older people...
  14. doi request reprint Prescription and administration of opioids to hospital in-patients, and barriers to effective use
    Bridin P Murnion
    Drug Health Services, Royal Prince Alfred Hospital, Royal North Shore Hospital, Sydney, NSW, Australia
    Pain Med 11:58-66. 2010
    ..Secondary aims were assessment of staff knowledge of opioid pharmacology and available preparations, and of perceived barriers limiting opioid use...
  15. doi request reprint Associations between drug burden index and mortality in older people in residential aged care facilities
    Nicholas M Wilson
    Kolling Institute of Medical Research, Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, NSW, Australia
    Drugs Aging 29:157-65. 2012
    ..In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls...
  16. doi request reprint Impact of High Risk Drug Use on Hospitalization and Mortality in Older People with and without Alzheimer's Disease: A National Population Cohort Study
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia Departments of Clinical Pharmacology and Aged Care, and Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia Centre for Education and Research on Ageing and Concord RG Hospital, Sydney, New South Wales, Australia
    PLoS ONE 9:e83224. 2014
    ..This retrospective cohort study investigated the relationship between cumulative exposure to anticholinergic and sedative drugs and hospitalization and mortality in people with and without AD in Finland...
  17. doi request reprint Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study
    Alexander Bennett
    University of Sydney, Northern Clinical School, Sydney, NSW, Australia
    Drugs Aging 31:225-32. 2014
    ..Several measures of medication exposure are associated with adverse outcomes in older people. Exposure to and the clinical outcomes of these measures in robust versus frail older inpatients are not known...
  18. pmc Gentamicin pharmacokinetics in old age and frailty
    Sarah N Hilmer
    Sydney Medical School, University of Sydney, Sydney, Australia
    Br J Clin Pharmacol 71:224-31. 2011
    ....
  19. doi request reprint Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults
    Sarah N Hilmer
    Department of Clinical Pharmacology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Gerontol A Biol Sci Med Sci 67:181-8. 2012
    ..Where possible, findings of pharmacoepidemiologic studies should be tested with well-conducted interventional randomized trials in relevant populations of older people...